5098910 combination of angiotensin-converting enzyme inhibitors with calcium antagonists as well as...

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330 PATENT ABSTRACTS 5098887 ANGIOTENSIN CONVERTING ENZYME INHIBITOR Tstlt0mtl Mimura, Yasuhiro Kohama, Kazuhiko Nagata, Ryoichi Tsurutani, Osaka, Japan assigned to Unitika Ltd An angiotensin converting enzyme inhibitor containing Gly-Lys-Glu-Ile-Ile Val-Lys-Ala- Glu-Arg (SEQ ID No: I) Gly-Lys-Met-Val-Lys- Val-Val Ser-Trp-Tyr (SEQ ID No: 2) or Ala- Tyr-Be-Ala-Ser-Lys-Gly-Leu (SEQ ID No: 3) as an active component. 5098910 COMBINATION OF ANGIOTENSIN-CONVERTING ENZYME INHIBITORS WITH CALCIUM ANTAGONISTS AS WELL AS THEIR USE IN DRUGS Reinhard Becker, Rainer Henning, Wolfgang Ruger, Volker Teetz, Hansjorg Urbach, Wies- baden, Federal Republic Of Germany assigned to Hoechst Aktiengesellschaft The invention relates to combinations of angiotensin-converting enzyme inhibitors with calcium antagonists, processes for their prepara- tion and their use as medicaments. 5104622 SYSTEM FOR BROAD SPECTRUM DRUG DETECTION Steven Binder assigned to Bio-Rad Laboratories Inc Biological Ruid test samples are analyzed for a broad spectrum of drugs, including ben- zodiazepines, amphetamines, tricyclic anti- depressants and opiates, in a single isocratic analysis using a chromatographic column sys- tem containing three analytical columns-an anion exchange column, a reversed phase column and a cation exchange column. A pre- column is also included to purge the sample of salts, proteins, peptides and hydrophilic anions. Carrier liquids containing acetonitrile at various strengths are used for distribution of the various drugs among the columns, elution of the drugs from the columns, and column purging and con- ditioning. The system readily lends itself to auto- mation, automatic periodic sampling, and component identification and quantification.

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330 PATENT ABSTRACTS

5098887

ANGIOTENSIN CONVERTING ENZYME INHIBITOR

Tstlt0mtl Mimura, Yasuhiro Kohama, Kazuhiko Nagata, Ryoichi Tsurutani, Osaka, Japan assigned to Unitika Ltd

An angiotensin converting enzyme inhibitor containing Gly-Lys-Glu-Ile-Ile Val-Lys-Ala- Glu-Arg (SEQ ID No: I) Gly-Lys-Met-Val-Lys- Val-Val Ser-Trp-Tyr (SEQ ID No: 2) or Ala- Tyr-Be-Ala-Ser-Lys-Gly-Leu (SEQ ID No: 3) as an active component.

5098910

COMBINATION OF ANGIOTENSIN-CONVERTING ENZYME INHIBITORS WITH CALCIUM ANTAGONISTS AS

WELL AS THEIR USE IN DRUGS

Reinhard Becker, Rainer Henning, Wolfgang Ruger, Volker Teetz, Hansjorg Urbach, Wies- baden, Federal Republic Of Germany assigned to Hoechst Aktiengesellschaft

The invention relates to combinations of angiotensin-converting enzyme inhibitors with calcium antagonists, processes for their prepara- tion and their use as medicaments.

5104622

SYSTEM FOR BROAD SPECTRUM DRUG DETECTION

Steven Binder assigned to Bio-Rad Laboratories Inc

Biological Ruid test samples are analyzed for a broad spectrum of drugs, including ben- zodiazepines, amphetamines, tricyclic anti- depressants and opiates, in a single isocratic analysis using a chromatographic column sys- tem containing three analytical columns-an anion exchange column, a reversed phase column and a cation exchange column. A pre- column is also included to purge the sample of salts, proteins, peptides and hydrophilic anions. Carrier liquids containing acetonitrile at various strengths are used for distribution of the various drugs among the columns, elution of the drugs from the columns, and column purging and con- ditioning. The system readily lends itself to auto- mation, automatic periodic sampling, and component identification and quantification.