New Patents . . . 111

flammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manu- facture of the formula I compounds, as well as intermediates for use in such manufacture.

4999979

MACHINE FOR CONTINUOUSLY PACKING IN PARTICULAR FOOD

OR PHARMACEUTICAL PRODUCTS IN PLASTIC

MATERIAL CONTAINERS

Jean-Marie Vicq, Paris, France assigned to A R GIL

A machine is provided for continuously packing food or pharmaceutical products in thermo- formed plastic material containers, comprising a station for receiving and unwinding reels of plas- tic material film, heating stations, a thermo- forming station, a dosing station, a sealing station and a cutting station, and chains for moving the plastic material film step by step from one end of the machine to the other, which are driven without slipping over drive wheels having a smooth surface.

5000886

SILICONE-HARDENED PHARMACEUTICAL

MICROCAPSULES AND PROCESS OF MAKING THE SAME

James R Lawter, Michael G Lanzilotti assigned to American Cyanamid Company

There is disclosed a process for preparing com- positions comprising microcapsules by phase separation microencapsulation wherein the hardening agent employed is a volatile silicone fluid and with the compositions prepared thereby. The use of the volatile silicone fluid as a hardening agent permits the production of microcapsules substantially free of any alkane hardening agent, eliminating potential combust- ability problems of the prior art processes and toxicity problems of the prior art compositions.

5ooo936

METHODS FOR LOCALLY- TREATING ALLERGIC

DISORDERS WITH PHARMACEUTICAL

PREPARATIONS CONTAINING N-ACETYL-ASPARTYL

GLUTAMIC ACID OR ITS SALTS

Henri Chibret, Clermont Ferrand, France as- signed to THEA (Therapeutique et Applica- tions) S A

Pharmaceutical preparations with anti-allergic activity for local administration, which contains, a pharmaceutically acceptable salt of N-acetyl- (alpha, beta)-aspartyl glutamic acid in the form of ophthalmic preparations, nasal solutions, bronchial aerosols, and skin ointments.

5000958

ENHANCEMENT OF PHARMACEUTICAL ACTIVITY

Michael Fountain, Steven Weiss, Robert Lenk, Mircea C Popescu, Richard Ginsberg assigned to The Liposome Company Inc

The invention encompasses mixtures of anti- microbial agents coencapsulated in liposomes which when administered in vivo exert an en- hanced therapeutic effect. The therapeutic effec- tiveness of the coencapsulated antimocrobial agents is greater than that of the same combina- tion administered either in solution or as a mix- ture of liposome populations each containing one of the antimicrobial agents.

5ooo961

TERT-BUTYL DERIVATIVES OF BENZYLIDENECAMPHOR, PROCESS FOR PREPARING

THEM, THEIR USE AS ANTIOXXDANT AGENTS AND

COSMETIC AND PHARMACEUTICAL

COMPOSITIONS CONTAINING THEM

Gerard Lang, Serg Forestier, Alain Lagrange, Claudine Moire, Andr Deflandre, Saint Gratien, France assigned to L’Oreal