110 PATENT ABSTRACTS

4956453 ~ 5 6 4 7 9

A N T I - H U M A N O V A R I A N C A N C E R I M M U N O T O X I N S A N D

M E T H O D S O F U S E T H E R E O F

2 3 - D E O X Y - 2 7 - C H L O R O D E R I V A T I V E S O F LL-F28249

C O M P O U N D S

Michael J Bjorn, Arthur E Frankel, Walter Laird, David B Ring, Jeffrey L Winkelhake as- signed to Cetus Corporation

Immunotoxins comprising a cytotoxic moiety and an antigen binding portion selected from the group consisting of Fab, Fab' and F(ab')2 frag- ments of a monoclonal antibody, which binds to human ovarian cancer tissue, having one of the following capabilities are claimed: cytotoxic ID50 of about 10 nM or less against human ovarian cancer cells, retardation of human ovarian cancer tumor growth in mammals, or ex- tension of survival of a mammal carrying a human ovarian cancer tumor. Antigens or epi- topes to which the monoclonal antibodies bind are identified and characterize the immuno- toxins. In a preferred embodiment an immunotoxin comprising at least an antigen bi- nding portion of a monoclonal antibody, which binds to human transferrin receptor, but does not block binding of transferrin to the receptor, is described and claimed. Immunotoxin com- prising the F(ab')2 region of the antitransferrin monoclonal antibody are also claimed. Methods of killing human ovarian cancer cells, retarding the growth of human ovarian cancer tumors in mammals and extending the survial of mammals carrying human ovarian cancer tumors are claimed.

Susan Y Tamura, Goro Asato, Hamilton Sq, N J, United Statee assigned to American Cyanamid Company

The present invention relates to novel derivatives of LL-F28249 compounds. These LL-F28249 compounds preferably are derived via a controlled microbiological fermentation of Streptomyces cyaneogriseus subspecies non- cyanogenus having deposit accession number NRRL 15773. The 23-deoxy-27-halo(chloro) derivatives have the 23-hydroxy group of the LL-F28249 compounds replaced by hydrogen and a halogen such as chlorine in the 27-position with the double bond shifted to the 26,26'- position. The novel derivatives of the present in- vention possess activity as anthelmintic, ectoparasitic, insecticidal, acaricidal and nematicidal agents and are useful in areas of human and animal health and in agricultural crops. Compositions containing the present compounds also are presented herein.

4957686

U S E O F B A C T E R I O P H A G E S T O I N H I B I T D E N T A L C A R I E S

4956454

M O N O C L O N A L A N T I B O D Y - P L A T I N U M C O - O R D I N A T I O N

C O M P O U N D C O M P L E X

James G Heffernan, Paul C Hydes, Donald Picker, Pangbourne, United Kingdom assigned to Johnson Matthey PLC

Platinum co-ordination compounds comprising at least one amine ligand and a functional group remotely bonded to the amine ligand, which functional group may be linkable to a mono- clonal antibody to provide a moiety which stabilizes the antibody against in vivo hydrolysis.

Alan H Norris

Because S. Sanguis is the first colonizer of newly cleaned teeth and because other bacteria then attach to it, the formation of dental plaque is reduced on newly cleaned teeth by introducing into the mouth bacteriophages which are para- sitic to S. Sanguis. Because S. Sanguis is the means of attachment of plaque forming bacterial colonies to tooth surfaces and forms 10-15% of the organisms in plaque, destruction of S. Sangnis by introduction of its parasitic bac- teriophages will remove plaque from teeth sur- faces. And removal of plaque containing acid forming bacteria and other harmful bacteria reduces the incidence of dental caries and other disease.