48m feelings of ankle instability. dr. tudor h. hughes m.d., frcr department of radiology university...
TRANSCRIPT
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48MFeelings of ankle instability
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Dr. Tudor H. Hughes M.D., FRCR
Department of Radiology
University of California School of Medicine
San Diego, California
MOCK ORAL BOARDS 2005MOCK ORAL BOARDS 2005GENERAL RADIOLOGY
Don Fleischli, M.D., M.B.A.
Associate Clinical Professor, U.C.S.D. School of Medicine
Assistant Professor of Radiology & Radiological
Sciences, U.S.U.H.S.
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GENERAL SUGGESTIONS• What is the exam? What are the findings?• You have seen one like this in your review!
• Obvious findings - long DDX or detailed discussion?• Aunt Minnie? It looks like…but could be….• Corner of film type trick that looks normal?
• Have a script in mind so when your mind goes blank…• Usually you get no history until you ask• Don’t ask until you have run through your script
• An example of a category script…don’t step INIT• Infection…bacterial, viral, fungus, immune sys…• Neoplasm…benign, malignant, pseudotumor…• Inflammation…arthritis, collagen vasc, drugs…• Trauma/Other…extrinsic, mechanical, rupt, vasc…
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GENERAL SUGGESTIONS• Pick a category and pursue it until exhausted or the
examiner directs you away from it• Don’t jump to another category quickly, it may take
you down the wrong path…“this could be tumor…”• When exhausted go to other categories, say “this
looks inflammatory but could be trauma or infection or neoplasitic…”; “I would recommend…”
• Couch your discussion in terms of assumed clinical findings…“if this pt is immune compromised I would consider…if not I would consider”
• Start by stating the obvious category and diagnosis• Don’t mumble/shout/run on/interrupt/joke/ask for Dx• If examiners says “is there anything else you would
consider”…go back to INIT then ask for more history…or mercy
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ACTUAL SCORE SHEET FROM ABR
• Case # • -- - +
++ +++• Observation• Synthesis/Imp• Management• 68 69 70
71 72• Score
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CASE #1
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CASE #1
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CASE #1 - DISCUSSION
• Findings• Multiple erosions/uniform joint space narrowing• Ulnar styloid erosions; pisoform/triquetrum early• Subluxations; mention SLE best seen in Norgaard view• Osteoporosis; juxta-articular>>diffuse• Little fusiform soft tissue swelling; early sign• Bilateral symmetrical• No swan neck and boutonniere deformities distal
phalanges
• Differential Diagnosis Infection• Differential Diagnosis Neoplasm
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CASE #1 - DISCUSSION
• Differential Diagnosis Inflammation• Rheumatoid Arthritis• HLA-B27 Arthropathies-mineralization-bone formation• Erosive Osteoarthritis-1st CMC and DIPs, central seagulls• Gout-no overhanging edges with sclerosis
• Differential Diagnosis Trauma/Other• This does not look like primary or secondary OA
• Diagnosis: Rheumatoid Arthritis (advanced)• Short Read:
• Discuss types of erosions in other arthritis• Bare area of joint within capsule not covered by cartilage• Lack of bone formation seen in Psoriatic, not in DIPs• Ankylosis of carpals but not distal to them
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CASE #4
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CASE #4
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CASE #4 - DISCUSSION
• Findings• Calcified stone in distal left ureter• Scattered calcifications in soft tissues• Typical ovoid elongated calcifications in muscles
• Differential Diagnosis Infection/Inflammation• Cysticercosis with calcified left ureteral calculus• Trichinosis cysts are tiny, round, punctate (mammo)• Guinea worm dz, Echinococcosis, Sarcosporidosis,
Loiasis also have soft tissue calcification• Dermatomyositis and other collagen vascular dz
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CASE #4 - DISCUSSION
• Differential Diagnosis Neoplasm• Differential Diagnosis Trauma/Other
• Myositis ossificans• Vascular calcifications
• Diagnosis: Cysticercosis & ureteral calculus• Short Read:
• Taenia solium (helminth)=pork tape worm (cestode)• Humans are the only definitive host of adult worm in the
intestine; hog and human are intermediate hosts• Larval form in muscles and viscera >>die>>Ca++
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CASE #5
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CASE #5
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CASE #5
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CASE #5 - DISCUSSION
• Findings• Complex vertical fx probably stable• Interpedicular distance wider than above or below• Posterior superior corner fragment>>spinal canal• Posterior ligaments and bones intact• L-2; typically 67% T-12, L-1, L-2 junction stable to mobile
• Differential Diagnosis Infection• Differential Diagnosis Neoplasm• Differential Diagnosis Inflammation
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CASE #5 - DISCUSSION
• Differential Diagnosis Trauma/Other• Simple wedge fracture in osteoporosis (insuff) or normal bone• Burst fracture is vertical (ant/mid column); stable or unstable• Chance fracture (lapbelt only) is horizontal; no anterior
column compression like burst fx; bone/ST; stable or unstable• Flexion distraction injury; combination of both; ant column +
• Diagnosis: Burst fracture• Short Read:
• Three columns (Denis); CT for middle and posterior columns• Simple wedge anterior column only…mechanism of injury• Anterior/middle columns in 85%; 25% middle column miss• Posterior column and/or ligaments involved on CT=unstable• CT the night of injury then MR the next day for ligaments• Unstable (two columns + ligs)>>further neurological injury
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CASE #6
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CASE #6
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CASE #6
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CASE #6 - DISCUSSION
• Findings• Chondrocalcinosis both hips• Protrusio acetabuli with uniform joint space narrowing
• Differential Diagnosis Infection• Differential Diagnosis Neoplasm• Differential Diagnosis Inflammation
• CPPD crystal deposition disease• Gout (if chondrocalcinosis it is not CA++ urate but CPPD)• Pseudogout
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CASE #6 - DISCUSSION
• Differential Diagnosis Trauma/Other• Chronic trauma>>DJD with chondrocalcinosis
• Diagnosis: CPPD “pseudo-rheumatoid arthritis”• Short Read:
• Calcium PyroPhosphate Dihydrate (CPPD) deposition dz• Chondrocalcinosis with secondary DJD• May be aggressive and look like neuropathic joint• May look like RA “pseudo-rheumatoid” but no erosions vs
true RA with erosions and CPPD; unusual secondary OA• Diagnosis by CPPD crystal identification• Knees, hands, hips, shoulder, elbow; need two areas for
DX• Arthropathy of CPPD resembles secondary OA usually
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CASE #15
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CASE #15
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CASE #15
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CASE #15 - DISCUSSION
• Findings• Erosions with overhanging edge, sclerotic cortical rims• Normal mineralization, joint spaces preserved• Look for faint soft tissue calcification=tophus
• Differential Diagnosis Infection• Differential Diagnosis Neoplasm• Differential Diagnosis Inflammation
• Gout (if chondrocalcinosis they also have CPPD)• Rheumatoid arthritis• Osteoarthritis • HLA-B27 arthropathies
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CASE #15 - DISCUSSION
• Differential Diagnosis Trauma/Other• Diagnosis: Gout• Short Read:
• M:F=20:1, elevated uric acid, monosodium urate monohydrate deposits (tophi) which may calcify and be seen on films
• Many diseases cause elevated uric acid (myeloproliferative)• Uncommon before age 20 yrs, oldest recognized arthropathy• Must have untreated disease for years to see changes on films• Feet (1st MTP), hands, elbow, wrist, knee, shoulder, hip, SI Jnt• Asymmetrical polyarticular distribution, indolent, remodeling• Secondary gout with increase production or diminished excrete of
uric acid usually have no radiographic changes
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CASE #16
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CASE #16 - DISCUSSION
• Findings• Bubbly lesion with fracture no periostitis; chondroid matrix
• Differential Diagnosis Infection• Osteomyelitis (bacterial or fungus)
• Differential Diagnosis Neoplasm• Enchondroma• FOGMACHINES or FEGNOMASHIC for benign cystic lesion• Chondroid matrix=popcorn, speckle, swirled, punctate Ca++• Osteoid matrix=denser, cloud-like, mashed potatoes Ca++• Zone of transition=narrow benign, wide malignant; slow
growth time to retreat in orderly manner; rapid permeative• Periostitis may be benign (benign lesion) or aggressive
(either)
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CASE #16 - DISCUSSION
• Differential Diagnosis Inflammation• Differential Diagnosis Trauma/Other
• Healing displaced fracture
• Diagnosis: Enchondroma with Fracture• Short Read:
• Most common lesion of phalanges, diaphyseal, lytic, expansile, thin sclerotic rim, may not have chondroid matrix in hand
• Ollier’s dz multiple unilateral, Maffucci syndrome multiple A/W hemangiomata more likely to degenerate into malignancy
• Films underestimate true size; MR/CT better• Geographic lesions=those with distinct margin sclerotic or
not
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CASE #17
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CASE #17
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CASE #17 - DISCUSSION
• Findings• Cocktail hot dogs or sausages (soft tissue swelling beyond
joint)• Normal mineralization• Bone proliferation=hypertrophic bone at ligament
attachments
• Differential Diagnosis Infection• Osteomyelitis
• Differential Diagnosis Neoplasm• Differential Diagnosis Inflammation
• Psoriatic arthritis• Rheumatoid arthritis, Reiter’s dz, HLA-B27 arthropathies• Osteoarthritis• Gout, amyloid, sarcoid
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CASE #17 - DISCUSSION
• Differential Diagnosis Trauma/Other• Fracture or soft tissue hemorrhage and periostitis• Exostosis
• Diagnosis: Psoriatic Arthritis• Short Read:
• Erosions and bone formation (DDX RA)• Mouse ear hypertrophy next to marginal erosion• Pencil in cup central erosions (late) may widen joint• Soft tissue swelling beyond joints, normal mineral• 1)DIP/PIP joints involved, 2)rays 1-3 all joints, 3)like RA
but DIP, bone prolif, normal mineralization• Feet more than hands; bilateral asymmetrical; Achilles
and plantar aponeurosis bone proliferation
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CASE #22
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CASE #22
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CASE #22
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CASE #22
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CASE #22
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CASE #22 - DISCUSSION
• Findings• Periosteal new bone 3rd metacarpal• Sclerosis (not quite bubbly)• Bubbly/lytic/sclerotic process distal left clavicle• Positive three phase bone scan in above and spine• Chest shown no coin lesion or cavity
• Differential Diagnosis Infection• Cocci osteomyelitis• TB or fungus, pseudomonas (addicts), salmonella (sickle
cell)
• Differential Diagnosis Neoplasm• FOGMACHINES/FEGNOMASHIC• Lymphoma, leukemia, mets, multifocal osteogenic
sarcoma
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CASE #22 - DISCUSSION
• Differential Diagnosis Inflammation• Differential Diagnosis Trauma/Other
• Fracture with healing• FEGNOMASHIC/FOGMACHINES
• Diagnosis: Cocci Osteomyeltis• Short Read:
• Brodie abscess subacute or chronic osteomyeltis• Involucrum is a shell of periosteal reactive bone formation
surrounding infected bone (sequestrum)• Sequestrum is a segment of necrotic bone with organisms
separated from viable bone by granulation tissue• Cloaca are holes in involucrum through which pus
extrudes• MRI low signal dark on T1, high signal bright on T2
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CASE #23
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CASE #23
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CASE #23
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CASE #23
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CASE #23 - DISCUSSION
• Findings• Bilateral symmetrical , postage stamp edge erosions,
sclerosis• No squaring of T12/L1 vert bodies, ivory corner, no
ankylosis• Normal mineralization, no syndesmophytes
• Differential Diagnosis Infection• Septic arthritis (bacterial, fungal, TB)
• Differential Diagnosis Neoplasm• Differential Diagnosis Inflammation
• Ankylosing spondylitis• IBD, Psoriatic, Reiter’s, RA, CPPD, Gout, OCI
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CASE #23 - DISCUSSION
• Differential Diagnosis Trauma/Other• Post traumatic secondary OA
• Diagnosis: Ankylosing Spondylitis• Short Read:
• Least erosive most ossifying of all inflammatory arthropathies• RF neg; HLA-B27 antigen positive in many especially caucas• Fibrocartilage (1 mm) iliac first, Hyaline (3-5 mm) sacral later• Anteroinferior half to 2/3 is a true synovial joint; posterosuper
half to 1/3 is a cleft between bones with ligs (no cartilage)• DDX 1) width of joint space 2) presence and type of erosions
3) presence and type of sclerosis 4) presence and type of bony bridging 5)distribution of above changes
• Septic unilateral; AS, IBD, CPPD, OCI bilateral symmetrical; Psoriatic, Reiter’s, Gout, OA bilateral asymmetrical
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CASE #29
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CASE #29 - DISCUSSION
• Findings• Fragmentation of tibial tuberosity, soft tissue swelling• Thickened patellar tendon indistinct posterior margin
• Differential Diagnosis Infection• Osteomyelitis (stretch)
• Differential Diagnosis Neoplasm• Differential Diagnosis Inflammation
• Apophysitis tibial tubercle
• Differential Diagnosis Trauma/Other• Osgood-Schlatter disease
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CASE #29 - DISCUSSION
• Diagnosis: Osgood Schlatter Disease• Short Read:
• Due to repetitive micro trauma involving patellar tendon• Apophysitis lower pole patella=jumper’s knee (Sinding-
Larsen-Johansson disease)• Apophysitis tibial tubercle=Osgood Schlatter Dz• Normal pt can have multiple centers of ossification in both
tibial tuberosity & lower pole patella>>DDX no pain or STS• Combined clinical and Radiologic diagnosis• Ultrasound may show above findings• MRI>>edema & abnormal signal in tendon, fragmentation
TT
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CASE #31
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CASE #31
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CASE #31 - DISCUSSION
• Findings• Soft tissue calcifications• Atrophic tapering of distal phalanges• Major erosions and minor subluxations• Osteoporosis and soft tissue swelling, joint space
narrowing• DIP, PIP, MCP, Carpal, Radius/Ulna involvement
• Differential Diagnosis Infection• Differential Diagnosis Neoplasm• Differential Diagnosis Inflammation
• Rheumatoid Arthritis• Scleroderma, dermatomyositis, polymyositis, Systemic
Lupus Erythematosis
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CASE #31 - DISCUSSION
• Differential Diagnosis Trauma/Other• Superimposed DJD
• Diagnosis: Mixed Connective Tissue Disease• Short Read:
• Originally RA with SLE and Scleroderma• Now may be RA with Polymyositis, SLE,
Dermatomyositis, Scleroderma• Defined serologically plus x-ray changes since connective
tissue diseases overlap• Very high titers of circulating antinuclear antibody to a
nuclear ribonucleoprotein antigen
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CASE #35
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CASE #35
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CASE #35
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CASE #35 - DISCUSSION
• Findings• Lateral femoral notch deeper than 1.5 mm• Hemarthrosis or effusion• ACL gone, kissing contusions
• Differential Diagnosis Infection• Differential Diagnosis Neoplasm• Differential Diagnosis Inflammation• Differential Diagnosis Trauma/Other
• Medial and lateral femoral condylar notches seen in lateral• Internal derangement, meniscal tear, ACL tear• Chondral/Subchondral fracture
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CASE #35 - DISCUSSION
• Diagnosis: Positive Lateral Condylar Notch Sign• Short Read:
• Deeper than 1.5 mm (1.2 mm + 2 SD per Resnick)• A/W anterior cruciate ligament tear, hemarthrosis• Kissing contusions lat fem condyle>>lat tib plateau
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CASE #37
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CASE #37
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CASE #37
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CASE #37 - DISCUSSION
• Findings• Erosions with overhanging edge, sclerotic cortical rims• Normal mineralization, joint spaces preserved• Look for faint soft tissue calcification=tophus
• Differential Diagnosis Infection• Differential Diagnosis Neoplasm• Differential Diagnosis Inflammation
• Gout (if chondrocalcinosis they also have CPPD)• Rheumatoid arthritis• HLA-B27 arthropathies
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CASE #37 - DISCUSSION
• Differential Diagnosis Trauma/Other• Secondary OA
• Diagnosis: Gout• Short Read:
• M:F=20:1, elevated uric acid, monosodium urate monohydrate deposits (tophi) which may calcify and be seen on films
• Many diseases cause elevated uric acid (myeloproliferative)• Uncommon before age 20 yrs, oldest recognized arthropathy• Must have untreated disease for years to see changes on films• Feet (1st MTP), hands, elbow, wrist, knee, shoulder, hip, SI Jnt• Asymmetrical polyarticular distribution, indolent, remodeling• Secondary gout with increase production or diminished excrete
of uric acid usually have no radiographic changes
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CASE #38
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CASE #38
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CASE #38 - DISCUSSION
• Findings• Periarticular STS, juxta-articular osteoporosis, narrowing
of DIP/PIP/MCP joints; MCP subluxations; growth deformity rather than erosive dz dominant like adult RA
• Overgrowth/ballooning of MC head epiph & premature fusion, flattening of heads & cupping of prox pahalanges, short MCs
• Ankylosis of irregularly shaped carpals; wrists more involved than hands; erosions and sclerosis of carpals and ulnar styloids
• Differential Diagnosis Infection• Differential Diagnosis Neoplasm
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CASE #38 - DISCUSSION
• Differential Diagnosis Inflammation• Juvenile RA (JRA) or Juvenile Chronic Arthritis (JCA)
• Differential Diagnosis Trauma/Other• Diagnosis: Juvenile Chronic Arthritis (JRA) Still’s
Disease (seronegative)• Short Read:
• Used to lump all under JRA; may not be able to differentiate one from the other at a specific time within course of dz >JCA
• JCA=juvenile onset ank spondy, psoriatic arthritis of IBD, juvenile onset adult type (seropositive) RA, Still’s dz=seroneg JCA
• Still’s dz makes up about 70% of JCA, occurs at younger age during growth while others act more like their adult counterparts
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CASE #41
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CASE #41
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CASE #41
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CASE #41 - DISCUSSION
• Findings• Erosions both humeri• Tapering & erosions of clavicles• Interstitial process in lungs• Advance RA both feet
• Differential Diagnosis Infection• Viral pneumonia (stretch)
• Differential Diagnosis Neoplasm• Lymphangitic metastasis (stretch)
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CASE #41 - DISCUSSION
• Differential Diagnosis Inflammation• Rheumatoid Arthritis• Collagen vascular disease
• Differential Diagnosis Trauma/Other• Diagnosis: Advanced Rheumatoid Arthritis• Short Read:
• Corner of film trick• If the findings you found aren’t enough keep looking
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CASE #43
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CASE #43
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CASE #43
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CASE #43
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CASE #43 - DISCUSSION
• Findings• Subtle sclerosis on compressive side of femoral neck• Positive bone scan femoral neck• Positive MRI femoral neck (T1 dark, T2 bright)
• Differential Diagnosis Infection• Osteomyelitis
• Differential Diagnosis Neoplasm• Osteoid osteoma• Metastasis, lymphoma
• Differential Diagnosis Inflammation
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CASE #43 - DISCUSSION
• Differential Diagnosis Trauma/Other• Stress fracture• Traumatic fracture• Pitt’s pit (synovial herniation pit)
• Diagnosis: Stress fracture L femoral neck• Short Read:
• Fatigue fx: normal bone with repetitive excess muscular forces
• Insufficiency fx: bone that lost elasticity with normal forces• Peds=rickets, osteomalacia, ost imperfecta, osteopetrosis,
scurvy; osteoclastic activity outpaces osteoblastic activity• Tibia, metatarsal, femur, rare in upper extremity• Splint and rest before fracture becomes complete
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CASE #46
Abdominal PainAbdominal Pain
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CASE #46
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CASE #46
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CASE #46
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CASE #46
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CASE #46
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CASE #46
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CASE #46 - DISCUSSION
• Findings• Differential Diagnosis Infection• Differential Diagnosis Neoplasm
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CASE #46 - DISCUSSION
• Differential Diagnosis Inflammation• Differential Diagnosis Trauma/Other
• Diagnosis: Intra-osseous Lipoma and Arcuate Ligaments of Levator Ani
• Short Read:• Rare; may be intraosseous, intracortical, parosteal• Esp long tubular bones fibula, femur (intertroch), tibia, calcaneous• Well circumscribed lytic thin sclerotic rim with fat and CA++• Appearance varies with degree of involution & necrosis (Stage 1-3)• DDX=fibrous dysp, abc, simple cyst, infarct, chondroid matrix
tumors, liposclerosing myxofibrous tumor (>>sarcoma 10-16%)
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CASE #47
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CASE #47
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CASE #47
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CASE #47 - DISCUSSION
• Rheumatoid Lung with effusion
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Interstitial Process Acronym(Michael D’Alessandro & Jeffrey Galvin)
Sarcoid
Histiocytosis X
Idiopathic pulmonary fibrosis (UIP), Infection (viral, DIP)
Tumor (lymphangitic), TB
Failure (interstitial pulm edema)
Asbestosis and other dusts (silica, coal, pneumoconiosis)
Collagen vascular disease (Wegener’s/Lupus/RA)
Environmental, Ex Alrg Alv=org & inorg hypersens
Drugs (chemoRx, antibio, amiodarone, contrast, O2)
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CASE #65
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CASE #65
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CASE #65
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CASE #65 DISCUSSION
• Lung transplant (host vs graft?) for bronchiectasis
• Insufficiency fractures on steroids• Keep an open mind for a case you may
never have seen
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CASE #66
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CASE #66
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CASE #66
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CASE #66
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CASE #66 DISCUSSION
• Posterior mediastinal Neurofibroma