110

not effect the other cell types. The material is ad- ded prior to centrifugation of the blood sample. An example of a bonding agent is a monoclonal antibody.

4695562

S Y N T H E T I C P E P T I D E C O M P O U N D S

Edwin H Beachey, Andr Tartar, Helene Gras- Masse, Michel Jolivet, Francoise Audibert, Louis Chedid assigned to Univ of Tennessee Research Corp

Peptide fragment of M protein of S. pyrogenes elecit opsonic antibodies which are type-specific for type 24 streptococci.

4695623

C O N S E N S U S H U M A N L E U K O C Y T E I N T E R F E R O N

Yitzha Stabinsky assigned to Amgen

Described are rapid and highly efficient pro- cedures for the total synthesis of linear, double stranded DNA sequences in excess of about 200 base pairs in length, which sequences may com- prise entire structural genes. Novel sequences are prepared from two or more DNA subunits pro- vided with terminal regions comprising restric- tion endonuclease cleavage sites facilitating insertion of subunits into a selected vector for purposes of amplification during the course of the total assembly process. The total, finally- assembled assembled sequences include at least one, and preferably two or more, unique restric- tion endonuclease cleavage site(s) at intermediate positions along the sequence, al- lowing for easy excision and replacement of sub- units and the correspondingly facile preparation of multiple structural analogs of polypeptides coded for by the sequences. Manufactured genes preferably include codons selected from among alternative codons specifying the same amino acid on the basis of preferential expression in a projected host microorganism (e.g., E. coil) to be transformed. Illustrated is the preparation and expression of manufactured genes capable of directing synthesis of human immune and leukocyte interferons and of other biologically active proteinaceous products, which products differ from naturally-occurring forms in terms of the identity and/or relative position of one or more amino acids, and in terms of one or more

PATENT ABSTRACTS

biological and pharmacological properties but which substantially retain other such properties.

4696895

M O N O C L O N A L A N T I - P R O T E I N C A N T I B O D Y , I T S P R E P A R A T I O N

A N D U S E T H E R E O F

Tatsuo Yamashita, Masafumi Terada, Koji Suzuki, Kobe, Japan assigned to Fujisawa Pharmaceutical Co Ltd

Monoclonal anti-human protein C antibodies which bind to the heavy chain of protein C are disclosed.

4696896

G O N O C O C C A L P I L l P R O C E S S E S F O R T H E P R E P A R A T I O N T H E R E O F A N D T H E U S E

T H E R E O F F O R T H E D E T E C T I O N O F A N D P R E V E N T I O N O F I N F E C T I O N S C A U S E D BY

N E I S S E R I A G O N O R R H O E A E

Charles C Brinton, John C McMichael assigned to Bactex Inc

There are provided a crystalline and single rod products derivable from the Pili of Type 1 and Type 2 Neisseria gonorrhoese organisms. There are provided methods of growing said organisms to produce the maximum yield of Pili and pro- cedures for purifying said Pill to produce said crystalline material. There are further provided methods of utilizing said Pili to determine the presence, in a system infectable by N. gonorr- hoese organisms, of antibodies to the Pili of said organisms, and methods of serotyping said Pili. There is also provided a mode of utilizing said crystalline material to provide a substantial degree of immunization infection by N. gonorr- hoese in mammalian systems susceptible to such infection.

4696899

P R O C E S S F O R T H E P R E P A R A T I O N O F H U M A N L E U K O C Y T E A N D H U M A N

G A M M A I N T E R F E R O N

Miklos Toth, Valeria Endresz, llona Beladi, Sandor Toth, Szeged, Hungary assigned to EGYT Gyogyszervegyeszeti Gyar