4. pemrosesan, presentasi antigen & aktivasi sel
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D I A N E U R I K E S E P T Y A N I N G T R I A S
F A C U L T Y O F M E D I C I N E
U N I V E R S I T A S G A D J A H M A D A
Antigen Processing, Antigen Presentation, & Dendritic cell Activation
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Antigen uptake by dendritic cells
Dendritic cells take up pathogens.
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Antigen processing
The dendritic cells process the pathogens. So that the pathogens
can be recognized by T cells.
Antigen processing.
T cells can only recognize a peptide presented on the surface of antigen-
presenting cell through MHC molecule.
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Dendritic cell migration
The dendritic cells migrates to the draining lymph node.
DC migration
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Antigen presentation to T lymphocytes
The dendritic cell presents an antigen to naïve specific T lymphocyte.
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Intracellular Pathogens Processing & Presentation
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Intracellular pathogens
• Virus
• Intracellular bacteria
Presented to T cell by MHC class I
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Intracellular antigen processing
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Extracellular Pathogens Processing & Presentation
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Extracellular antigen processing
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Extracellular antigen processing
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Review
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MHC molecules expression on human cells
All nucleated cells express MHC class I .
Only certain cells express MHC class II .
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MHC molecules expression on human cells
Dendritic cells, B cells, and macrophages express both MHC
class I and class II.
But only dendritic cells is known as professional antigen presenting cell.
Those cells are antigen-presenting cells.
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Dendritic cells as proffesionalantigen-presenting cells
Express co-stimulatory molecules.
Migrate to the lymphoid organs to present the antigen to T cell.
Distributed throughout the body and have processes which help in antigen uptake.
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Dendritic Cell Activation
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Dendritic Cells Maturation
Ag processing
Dendritic cells begin a maturation process as they migrate via the
lymphatics to the draining lymph node
DC maturation
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Dendritic Cell Maturation
Changes occur in the surface marker of dendritic cell by which change
the nature of dendritic cell.
Play role in DC migration to T cell zone of lymphoid organ.
Co-stimulatory molecule which play role in T cell activation.
Able to phagocyte pathogens.
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Mature vs Immature Dendritic Cells
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Mature dendritic cell migrates to T cell zone of the secondary
lymphoid organ
DC maturation
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Mature dendritic cell activates antigen-specific T lymphocyte.
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