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The Third edition of the Handbook is renamed the Hayes’ Handbook of Pesticide Toxicology and dedicated to the memory of Wayland J. Hayes, Jr., whose major contri-butions to pesticide science are chronicled, in part, in the Dedication. The cover design includes the whimsical 3-segmented, 6-legged doodle by Hayes used on the First and Second editions of the Handbook.

This edition of Hayes’ Handbook of Pesticide Toxicology includes primarily new and revised chapters concerning fundamentals of the past and new insights gained from more recent research in pesticide science. More complete exposition of the concepts which have guided preparation of these volumes is contained in the Preface to the Second edition included herein.

Pests and organisms that would devour our residences, personal property and food supply remain ever-present competitors in human environments. In response, pesti-cides delivered in developed nations with increasing precision and regulation represent a chemical technology that is refined, extensively used and studied in detail. Chemical exposures, particularly those related to the economic class pesticide, are an analytical reality that remains problematic for many persons in spite of overwhelming environ-mental monitoring which reveals that exposures occur at levels benign to health. The Handbook is expected to contribute to clarification, and even resolution, of some imperfections or limitations in available knowledge.

Numerous experts, more than 200 in all, have contributed their time and expertise to the Third edition. Their contributions are particularly noteworthy and appreciated in con-tinued times of economic uncertainty, emerging. Regulatory priorities, and considerable instability in private and public institutions as priorities and programs take new forms. The authors have provided in-depth review and exposition of the particular topics that are included in this edition. References will allow interested readers to pursue topics of interest.

Each of the Associate Editors, including John Doull, Joop van Hemmen (deceased), Ernest Hodgson, Howard Maibach, Lawrence Reiter, Leonard Ritter, John Ross, and William Slikker is acknowledged and thanked for his important and particular con-tributions to the development and production of the Hayes’ Handbook of Pesticide Toxicology. These volumes represent the tireless dedication and exemplary service of Helen Vega, Administrative Assistant in the Personal Chemical Exposure Program here at Riverside and Editorial Assistant for the Hayes’ Handbook of Pesticide Toxicology. We are both grateful to Kirsten Chrisman, Rebecca Garay, April Graham, and Caroline Jones of Elsevier who effectively moved the author’s copy to text.

Robert I. KriegerUniversity of California, Riverside

PREFACE FROM HAYES’ HANDBOOK OF PESTICIDE TOXICOLOGY, THIRD EDITION