29 th annual symposium...icrs2019 preliminary programme – subject to changes 15.00 adi drori*,...

29 T H ANNUAL

SYMPOSIUM OF THE

INTERNATIONAL CANNABINOID

RESEARCH SOCIETY

BETHESDA

M A R Y L A N D , U S A

JUNE 29 – JULY 4, 2019

PRELIMINARY PROGRAMME

ICRS2019 Preliminary Programme – Subject to Changes

Registration: June 29th, 2019 (16.00 – 18.00)

MARRIOTT NORTH CONFERENCE CENTER BETHESDA, MD USA

Welcome Reception: 18.30 – 20.00

Day 1 Sunday, June 30th

7.30 Breakfast

8.30 Welcome and Opening Remarks

Oral Session 1. Cannabis Compounds, Genetics, chemovars and Extraction Methods

CHAIRS: JÜRG GERTSCH AND JANA HAJSLOVA

8.45 John M. McPartland* and Geoffrey W. Guy

RENAMING DINOSAURS: EXHUMING THE ANCESTORS OF “SATIVA” AND “INDICA”

1

9.00 Carrie Cuttler*,

Alexander Spradlin and Rebecca Craft

SHORT- AND LONG-TERM ACUTE EFFECTS OF CANNABIS ON

HEADACHE AND MIGRAINE: A NATURALISTIC STUDY OF MEDICAL CANNABIS USERS

2

9.15

Lipin Ji, Yingpeng Liu, Fei Tong, Marsha Eno, Shalley Kudalkar, Alex

Straiker, Ai-ling Li, Othman Benchama, Chandrashekhar

Honrao, Anisha Korde, Amey Dhopeshwarkar, Paula Morales, Shu Xu, Michaela

Dvorakova, Dow Hurst, Simiao Wu, JodiAnne T. Wood, Nikolai Zvonok,

Patricia Reggio, Ken Mackie, Lawrence Marnett,

Andrea G. Hohmann, Alexandros Makriyannis

and Spyros P. Nikas*

CHIRAL ENDOCANNABINOID

LIGANDS 3


9.30

L. Cinnamon Bidwell*, Jarrod Ellingson,

Sophie YorkWilliams, Hollis Karoly, Leah N.

Hitchcock, Cristina Sempio, Jost Klawitter,

Brian Tracy, Angela D. Bryan

and Kent E. Hutchison

ACUTE SELF-ADMINISTRATION OF LEGAL MARKET FLOWER AND

CONCENTRATED CANNABIS: CANNABINOID BLOOD LEVELS,

SUBJECTIVE INTOXICATION, AND NEUROBEHAVIORAL OUTCOMES

4

9.45

Jana Hajslova*, Marie Fenclova, Frantisek Benes, Ethan Russo

and Pavel Kubu

ASSESSING TRENDS OF CBD OILS QUALITY AT THE EU MARKET

5

10.00 Coffee Break

Oral Session 2. Cannabidiol

CHAIRS: MICHELLE GLASS AND SAOIRSE O’SULLIVAN

10.30

Salahaden R. Sultan, Timothy J. England

and Saoirse E. O`Sullivan*

ACUTE AND CHRONIC EFFECTS OF CANNABIDIOL ON HAEMODYNAMICS IN

HEALTHY MALES

6

10.45

Staci A. Gruber*, Ashley M. Lambros, Rosemary T. Smith,

M. Kathryn Dahlgren, Kelly A. Sagar, David P. Olson

and Scott E. Lukas

HIGH ANXIETY? EXAMINING THE IMPACT OF FOUR WEEKS OF

TREATMENT WITH A NOVEL HIGH CANNABIDIOL PRODUCT

7

11.00

Tory Spindle*, Edward Cone, John Mitchell,

George Bigelow, Ron Flegel

and Ryan Vandrey

ACUTE PHARMACOKINETICS AND PHARMACODYNAMICS OF ORAL AND VAPORIZED CANNABIDIOL

IN HEALTHY ADULTS

8

11.15 Ewa Galaj*, Guo-Hua Bi

and Zheng-Xiong Xi

CANNABIDIOL ATTENUATES COCAINE REWARD BY CB2, 5-HT1A

AND TRPV1 RECEPTOR MECHANISMS IN RATS

9


11.30 - 12.30

Plenary Speaker

US CANNABIS POLICY: IMPLICATIONS FOR PUBLIC HEALTH

Susan Weiss, Ph.D.

Director Division of Extramural Research

National Institutes of Health

12.30 Lunch

12.30

NIDA Student Training Session

OVERVIEW OF NIH/NIDA RESEARCH TRAINING AND GRANT OPPORTUNITIES IN CANNABINOID RESEARCH

BETH BABECKI AND RAO RAPAKA

13.30 - 14.30

ICRS Lifetime Achievement Award

CANNABINOID PHARMACOLOGY: MY FIRST HALF CENTURY

Roger Pertwee, M.a., D.Phil, D.Sc.

Emeritus Professor Institute of Medical Sciences

University of Aberdeen, Scotland

Oral Session 3. CB1 Pharmacology

CHAIRS: RESAT CINAR AND YOSSI TAM

14.30

Thuy Nguyen, Ann M. Decker, Thomas F. Gamage, Jun-Xu Li,

Jenny L. Wiley, Brian F. Thomas, Terry P. Kenakin

and Yanan Zhang*

ALLOSTERIC MODULATORS OF THE CANNABINOID CB1 RECEPTOR: DIARYL UREAS

10

14.45 Allyn C Howlett*, William T. Booth

and W. Todd Lowther

STRUCTURAL ANALYSIS OF THE CB1 CANNABINOID RECEPTOR

INTERACTING PROTEIN 1A (CRIP1A)

11


15.00

Adi Drori*, Asaad Gamal, Shahar Azar, Liad Hinden, Rivka

Hadar, Daniel Wesley, Alina Nemirovski,

Maayan Salton, Boaz Tirosh and Joseph Tam

CANNABINOID-1 RECEPTOR REGULATES SOLUBLE LEPTIN RECEPTOR LEVELS VIA C/EBP

HOMOLOGOUS PROTEIN (CHOP), CONTRIBUTING TO OBESITY-

RELATED HEPATIC LEPTIN RESISTANCE

12

15.15

Resat Cinar*, Nathan J. Coffey, Steven P. Bodine, Joshua K.

Park, Malliga R Iyer, Bernadette R.

Gochuico, William A. Gahl, May Christine V.

Malicdan and George Kunos

MRI-1867, A THIRD GENERATION CB1R ANTAGONIST,

FOR EFFECTIVE THERAPY OF A RARE DISEASE,

HERMANSKY-PUDLAK SYNDROME PULMONARY

FIBROSIS

13

15.30

Michaela Dvorakova, Wesley Corey,

Anaelle Zimmowitch, Alex Straiker*

and Ken Mackie

A CRITICAL EVALUATION OF TERPENOID SIGNALING AT

CANNABINOID CB1 RECEPTORS IN A NEURONAL MODEL

14

15.45

Tania Muller, Julia Leemput, Chloé Buch,

Laurent Demizieux, Patricia Passilly-

Degrace, Resat Cinar, Malliga R Iyer, George Kunos, Bruno Vergès,

Pascal Degrace and Tony Jourdan*

HYBRID INHIBITOR OF PERIPHERAL CANNABINOID-1 RECEPTOR AND INDUCIBLE NITRIC OXIDE SYNTHASE

MITIGATES THE DEVELOPMENT OF DYSLIPIDEMIA

15

16.00 – 18.00 Poster Session 1

Reception

P1

Notes: Presenting Author*


Day 2 Monday, July 1st

7.30 Breakfast

8.30 Opening Remarks

Oral Session 4. CB2 Pharmacology

CHAIRS: UWE GRETHER AND MELANIE KELLY

8.45

U. Grether*, K. Atz, B. Brennecke, E. M.

Carreira, C. Davies, J. Fingerle, T. Gazzi, J. Gertsch, W. Guba, A. Kimbara, C. Korn, M.

Maccarrone, H. Mandhair, R. E. Martin, A. Mason, T. Miljus, M. Nazare, M. Nettekoven, S. Oddi, P. Pacher, A. Pavlovic, A. Pedrina-McCarthy, P. Pfaff, C. Raposo, M. Rogers-Evans, E. Roome, S. Röver, A. Rufer, R.

Sarott, M. Soethoudt, C. Ullmer, M. van der Stelt, D. Sykes, Z. Varga, D.

B. Veprintsev, M. Weise and M. Westphal

FLUORESCENTLY LABELED TYPE-2 CANNABINOID RECEPTOR (CB2R) LIGANDS: FROM INITIAL ATTEMPTS TOWARD A HIGHLY

VERSATILE CHEMICAL TOOLBOX

16

9.00

M. Nazare*, T. Gazzi, B. Brennecke, M. Weise U. Grether, K. Atz, E. M. Carreira, J. Fingerle, J. Gertsch, W. Guba, C.

Korn, M. Maccarrone, H. Mandhair, T. Miljus, S.

Oddi, P. Pacher, A. Pavlovic, P. Pfaff, C. Raposo, A. Rufer, R. Sarott, C. Ullmer, M.

van der Stelt, D. Sykes, Z. Varga, D. B.

Veprintsev and M. Westphal

CB2 RECEPTOR DETECTION BY NEW FLUORESCENTLY

LABELED SYNTHETIC LIGANDS 17


9.15

Zoltan V. Varga*, Katalin Erdelyi, Uwe

Grether, Eszter Trojnar, Catarina Raposo, Jürgen

Fingerle, Christoph Ullmer, Ozge Gunduz-Cinar, Michelle Glass,

Bela Szabo, Miklos Palkovits, Andrew

Holmes, Jürg Gertsch, Julian Romero, Cecilia Hillard and Pal Pacher

CANNABINOID 2 RECEPTOR (CB2) EXPRESSION REVISITED:

DETECTION OF CB2 mRNA WITH NEW SENSITIVE TOOLS

18

9.30

Tomohiro Kimura, Alexei Yeliseev, Mihaela

Mihailescu, Diane L. Lynch, Walter E. Teague

Jr., Kirk G. Hines, Lioudmila Zoubak,

Alan Grossfield, Patricia H. Reggio

and Klaus Gawrisch*

2-AG LOCATION, STRUCTURE AND DYNAMICS IN MEMBRANES

AND ITS INTERACTION WITH CB2 RECEPTORS

19

9.45

Jakub Mlost*, Marta Bryk,

Magdalena Kostrzewa and Katarzyna Starowicz

CB2 BIASED AGONISTS AND THEIR THERAPEUTIC POTENTIAL

IN OSTEOARTHRITIS 20

10.00 Coffee Break

Oral Session 5. Cannabinoids and Reward

CHAIRS: DAVID FINN AND STEPHANIE LAKE

10.30

Chloe J. Jordan*, Bree Humburg, Yi He, Xiao Han, Guo-hua Bi, Eliot Gardner, Xiang-qun Xie

and Zheng-Xiong Xi

DISSECTING THE REWARDING VS. AVERSIVE EFFECTS OF CANNABINOIDS: FINDINGS

FROM OPTOGENETIC BRAIN-STIMULATION REWARD

MAINTAINED BY ACTIVATION OF VTA DOPAMINE NEURONS

21

10.45 Joseph F. Cheer* ENDOGENOUS CANNABINOIDS AND REWARD PREDICTION 22


11.00 Matthew L. Eckard* and Steven G. Kinsey

GABAPENTIN ATTENUATES SOMATIC SIGNS OF Δ9-THC

WITHDRAWAL IN MICE 23

11.15

Stephanie Lake*, Thomas Kerr, Jane

Buxton, Zach Walsh, Kanna Hayashi, Evan Wood and M-J Milloy

FREQUENT CANNABIS USE IS ASSOCIATED WITH LOWER

LIKELIHOOD OF FREQUENT ILLICIT OPIOID USE AMONG PEOPLE WHO USE DRUGS WITH CHRONIC PAIN:

A LONGITUDINAL ANALYSIS

24

11.30 - 12.30

Plenary Speaker

THE NEUROBIOLOGY OF DRUG ADDICTION: FROM DRUG REWARD TO HYPERKATIFEIA

TO NEGATIVE REINFORCEMENT

George Koob, Ph.D.

Director, National Institute on Alcohol Abuse and Alcoholism

National Institutes of Health

12.30 Lunch

13.30 - 14.00

ICRS Young Investigator Award

ANANDAMIDE, FAAH, STRESS AND ANXIETY: A TRANSLATIONAL JOURNEY

Matt Hill, Ph.D.

Associate Professor The Hotchkiss Brain Institute

University of Calgary, Alberta, Canada

Oral Session 6. Clinical Studies

CHAIRS: NALIN PAYAKACHAT AND ETHAN RUSSO

14.00 Adi Zuloff-Shani*,

Ephraim Brener and Ascher Shmulewitz

EFFICACY AND SAFETY OF THX-110, A PROPRIETARY

THERAPEUTIC COMBINATION OF Δ9-

TETRAHYDROCANNABINOL AND

PALMITOYLETHANOLAMIDE

25


14.15

Nalin Payakachat*, Ryan Vandrey, William E. Fantegrossi, Lauren Russell and Marcel O. Bonn-Miller

DOES CANNABIS HELP IMPROVE INSOMNIA

AMONG PATIENTS WITH POSTTRAUMATIC STRESS

DISORDER?

26

14.30 Carrie Cuttler*, Emily LaFrance and Aria Petrucci

ACUTE EFFECTS OF HIGH POTENCY CANNABIS ON

EVERYDAY LIFE MEMORY 27

14.45

Bitya Raphael*, Natalya Kogan, Malka Attar-Namdar, Mukesh Chourasia, Maria G. Cascio, Avital Shurki, Joseph Tam,

Moshe Neuman, Joseph Foldes, Roger G. Pertwee,

Andreas Zimmer, Itai Bab and Yankel Gabet

HISTONE H4 ENCODES AN ENDOGENOUS PEPTIDE THAT SIGNALS VIA THE

CB2 CANNABINOID RECEPTOR

28

15.00

Mark A. Ware*, Antonio Vigano, Pierre Beaulieu, Andrée Néron, Yola Moride, Michelle Canac-

Marquis, Maja Kalaba, Marc O. Martel, Jordi Perez, Julie

Desroches and William Barakett

THE QUEBEC CANNABIS REGISTRY, A DATABASE

ON THE USE OF CANNABIS FOR MEDICAL

PURPOSES: FINAL RESULTS

29

15.15

Marcel O. Bonn-Miller*, Megan Brunstetter ,

Alexandra Simonian, Hal Wortzel

and Ryan Vandrey

A CONTROLLED PROSPECTIVE

OBSERVATIONAL STUDY OF THE LONGITUDINAL

ASSOCIATIONS BETWEEN CANNABIS USE AND PTSD

SYMPTOMATOLOGY

30

15.30

Dylan Zylla*, Justin Eklund, Grace Gilmore, Alissa

Gavenda, Gabriella VazquezBenitez, Pamala Pawloski, Tom Arneson,

Angela Birnbaum, Stephen Dahmer, Matthew Tracy

and Arkadiusz Dudek

A RANDOMIZED TRIAL OF MEDICAL CANNABIS

IN PATIENTS WITH ADVANCED CANCERS

TO ASSESS IMPACT ON OPIOID USE

AND CANCER-RELATED SYMPTOMS: A PILOT AND

FEASIBILITY STUDY

31

15.45

Joshua Rein*, Lindsay Texter, Mark Wurfel, Edward Siew, Amit Garg, Thida Tan, Paul Kimmel, James Kaufman,

Vernon Chinchilli and Steven Coca

MARIJUANA USE AND KIDNEY OUTCOMES IN

THE ASSESS-AKI COHORT 32


16.00 – 18.00 Poster Session 2

Reception

P2

18.00 Business Meeting



Day 3 Tuesday, July 2nd

7.30 Breakfast


Oral Session 7. Development, Reproductive Function, Smell and Cancer

CHAIRS: ANNA KALINOVSKY AND JULIAN ROMERO

8.45

Kylie Black, Shawyon Baygani, Ricardo Martinez,

Tristen Mier, Alexandria Bell, Ken Mackie

and Anna Kalinovsky*

CANNABINOID SIGNALING REGULATES

CEREBELLAR DEVELOPMENT

33

9.00 Shahnaza Hamidullah*,

Claudia D. Lutelmowskij and Jibran Y. Khokhar

BEHAVIOURAL AND COGNITIVE

EFFECTS OF ADOLESCENT

CANNABIS AND ALCOHOL CO-USE IN

ADULTHOOD

34

9.15 Xiaofei Sun*, Yingju Li,

Fenghua Bian and Sudhansu K. Dey

MICE MISSING CNR1 AND CNR2 SHOW IMPLANTATION

DEFECTS

35

9.30

Ali Mokhtar Mahmoud*, Viviana Marolda, Magdalena

Kostrzewa, Vincenzo Di Marzo, Roberto Ronca

and Alessia Ligresti

NON-PSYCHOTROPIC CANNABINOIDS

SUPPRESS TUMOR GROWTH BY ACTING

ON METABOLIC REPROGRAMMING AND ONCOGENIC PATHWAYS

IN HORMONE REFRACTORY

PROSTATE CANCER

36


9.45 Huizhi Du, Maya Ploss,

Alex Straiker and Thomas Heinbockel*

CANNABINOID RECEPTOR-MEDIATED

MODULATION OF INTERNEURONS IN THE

MAIN OLFACTORY BULB

37

10.00 Coffee Break

Oral Session 8. Pain, Stress, Sleep and Psychiatric Disorders

CHAIRS: ANDREA HOHMANN AND DAVE LOVINGER

10.30

Andrea Chicca*, Ines Reynoso-Moreno,

Martina Blunder and Jürg Gertsch

SELECTIVE ENDOCANNABINOID

REUPTAKE INHIBITORS TO TREAT ANXIETY

AND STRESS-RELATED DISORDERS: FROM BASIC SCIENCE TO TRANSLATIONAL

RESEARCH

38

10.45 David M Lovinger*, Karina P Abrahao and Matthew J Pava

ENDOCANNABINOID ROLES IN SLEEP

STABILITY AND SLEEP DISRUPTION BY

CANNABINOID DRUGS

39

11.00

Madhusudhanan Narasimhan*, Henry Blanton, Jennifer

Brelsfoard, Diana E. Sepulveda, Angela N. Henderson-Redmond,

Daniel J. Morgan and Josée Guindon

CP55,940 ANTINOCICEPTIVE

EFFECT, DEVELOPMENT OF TOLERANCE AND ACTIVATION OF JNK SIGNALING IN THE

CISPLATIN-INDUCED NEUROPATHIC PAIN

MODEL

40


11.15 Douglas E. Brenneman*,

William A. Kinney and Sara Jane Ward

MOLECULAR AND PHARMACLOGICAL EVIDENCE FOR THE SODIUM-CALCIUM

EXCHANGER-1 (mNCX-1) AS A MEDIATOR OF

CBD- AND KLS-13019-APPLIED PROTECTION

AGAINST PACLITAXEL-INDUCED TOXICITY IN

DORSAL ROOT GANGLION CULTURES

41

11.30

Catharine A. Mielnik*, Chun Kit Li, Iain R. Greig, Mostafa H. Abdelrahman, Laurent A. Trembleau, WM Burnham,

Ali Salahpour, Amy J. Ramsey and Ruth A. Ross

NOVEL NEGATIVE ALLOSTERIC

MODULATOR (NAM) OF CANNABINOID RECEPTOR 1 (CB1)

AMELIORATES SYMPTOMS DUE TO DOPAMINE

DYSREGULATION IN PSYCHIATRIC

DISORDERS

42

11.45

Giulia Donvito*, Ryan Mischel, Virginia McLane, Daisuke Ogasawara, Hamid

Akbarali, Ku-Lung Hsu, Benjamin F Cravatt

and Aron H Lichtman

THE DIFFERENTIAL ROLE OF

DIACYLGLYCEROL LIPASES IN REVERSING

MECHANICAL SENSITIVITY IN A MOUSE MODEL OF CHEMOTHERAPY-

INDUCED PERIPHERAL NEUROPATHY (CIPN)

43

12.00 – 13.00

Kang Tsou Memorial Lecture

VEGAS AND ULTRA-LSD: NEW CHEMICAL AND

SYNTHETIC BIOLOGICAL TECHNOLOGIES

Bryan Roth, M.D., Ph.D.

Director, NIMH Psychoactive Drug Screening Program Distinguished Professor, Department Of Pharmacology

UNC Chapel Hill , NC


13.00 Lunch

13.00 Industry Breakouts

14.00 – 16.00

NIDA Networking Session

CANNABINOID RESEARCH FINDINGS AND FUTURE RESEARCH DIRECTIONS

Division of Neuroscience and Behavior Research

Division of Epidemiology, Services, and Prevention Research

Division of Treatment and Medical Consequences



Day 4 Wednesday, July 3rd

7.30 Breakfast


Oral Session 9. Immune Function, Neurodegenerative and Cardiovascular Disorders

CHAIRS: IRENE BENITO-CUESTA AND SABINE STEFFENS

8.45

Ines Reynoso-Moreno*, Silvia Tiezt,

Britta Engelhardt, Jürg Gertsch

and Andrea Chicca

NEW STRATEGIES TARGETING THE ENDOCANNABINOID SYSTEM

TO ATTENUATE DISEASE PROGRESSION IN A MOUSE

MODEL OF MULTIPLE SCLEROSIS

44

9.00

Douglas J. Hermes*, Changqing Xu, Rick B. Meeker, Micah J.

Niphakis, Benjamin F. Cravatt, Ken Mackie, Aron H. Lichtman,

Bogna M. Ignatowska-Jankowska

and Sylvia Fitting

GPR18 MEDIATES MICROGLIAL NEUROTOXICITY INDUCED BY HIV-1 TAT PROTEIN IN VITRO

45

9.15

Kevin S. Murnane*, Lindsey Phillips-

Lindsey, Cedrick M. Daphney,

Aboagyewaah Oppong-Damoah,

Richard D. Khusial, Ayman Akil

and Peter N. Uchakin

β-CARYOPHYLLENE IMPROVES MEMORY FUNCTION

AND DECREASES KEY INFLAMMATORY CYTOKINES

IN AGED MICE

46


9.30

Irene Benito-Cuesta*, Samuel Ruiz de Martín

Esteban, Ana M. Martínez Relimpio, M.

Asunción Barreda-Manso, Rosa M. Tolón, Cecilia J.

Hillard, Julián Romero and M. Teresa Grande

THE ROLE OF MICROGLIAL CB2 RECEPTORS IN BETA AMYLOID PHAGOCYTOSIS: IN VITRO AND

IN VIVO STUDIES

47

9.45

Janos Paloczi*, Csaba Matyas, Zoltan V.

Varga, Resat Cinar, György Hasko,

Thomas H. Schindler, George Kunos and Pal Pacher

ALCOHOL BINGE-INDUCED CARDIOVASCULAR

DYSFUNCTION INVOLVES ENDOCANNABINOID-CB1-R

SIGNALING

48

10.00 Coffee Break

Oral Session 10. Endogenous Signaling Systems

CHAIRS: LINDA PARKER AND MARIO VAN DER STELT

10.30 Ephraim Brener*,

Adi Zuloff-Shani and Ascher Shmulewitz

PALMITOYLETHANOLAMIDE MODULATES CB1 AFFINITY

TO THC 49

10.45

Sergiy Tyukhtenko*, Xiaoyu Ma, Kiran

Vemuri, Spyros Nikas, Michael Malamas

and Alexandros Makriyannis

MONOACYLGLYCEROL LIPASE INHIBITION: BIOPHYSICAL AND

MECHANISTIC INSIGHTS 50

11.00 Emma Leishman*, Ken Mackie and

Heather B Bradshaw

ELEVATED LEVELS OF ARACHIDONIC ACID-DERIVED

LIPIDS, INCLUDING PROSTAGLANDINS AND

ENDOCANNABINOIDS, ARE PRESENT THROUGHOUT ABHD12

KO BRAINS: NOVEL INSIGHTS INTO THE NEURODEGENERATIVE

PHENOTYPE

51


11.15

Josephine Watson, Lauren Carnevale, William Arnold, Austin Weigle and Aditi Das*

METABOLISM OF ENDOCANNABINOIDS AND PHYTOCANNABINOIDS BY

CYTOCHROME P450 TO PRODUCE NOVEL BIOACTIVE METABOLITES

52

11.30

Caroline Turcotte, Anne-Sophie Archambault,

Élizabeth Dumais, Cyril Martin, Marie-

Renée Blanchet, Elyse Bissonnette,

Alain Veilleux, Michel Laviolette, Vincenzo Di Marzo

and Nicolas Flamand*

ENDOCANNABINOID HYDROLYSIS INHIBITION

UNRAVELS THAT UNSATURATED FATTY ACIDS INDUCE A ROBUST

SYNTHESIS OF ENDOCANNABINOID-GLYCEROLS

IN HUMAN MYELOID LEUKOCYTES

53

11.45

Linda A. Parker*, Gavin N. Petrie, Kiri

L.Wills, Fabiana Piscitelli, Reem

Smoum , Cheryl L. Limebeer, Erin M. Rock, Samantha Ayoub, Ashlyn

Humphrey, Alexia Gene, Madeleine

Sheppard-Perkins, Marieka DeVuono, Aron H. Lichtman, Vincenzo Di Marzo

and Raphael Mechoulam

OLEOYL GLYCINE INTERFERES WITH ACUTE NALOXONE-PRECIPITATED MORPHINE WITHDRAWAL, BUT NOT

MORPHINE REWARD

54

12.00 Lunch

12.30 Industry Breakouts

Oral Session 11. Wound Healing, Microbiota and Obesity

CHAIRS: TAMAS BIRO AND ADI DRORI

13.30

Natalia Murataeva*, Emma Leishman, Heather Bradshaw and Alex Straiker

A CENTRAL ROLE FOR 2-OLEOYLGLYCEROL IN

CORNEAL WOUND HEALING 55


13.45

Sam R C Johnson*, James J Burston, Victoria J Tyrrell,

Maceler Aldrovandi, Rossa Inglis, Robert

Andrews, Jenna Cash, Paul Martin,

Christopher P Thomas and Valerie B

O'Donnell

12/15 LIPOXYGENASE ORCHESTRATES CELLULAR

REMODELLING DURING WOUND REPAIR

56

14.00

Tania Muller, Laurent Demizieux, Pablo

Ortega-Deballon, Tony Jourdan, Bruno Vergès and Pascal Degrace*

ACTIVATION OF CANNABINOID-1 RECEPTORS (CB1R) IN ADIPOSE

TISSUE CONTRIBUTES TO METABOLIC RISK BY INHIBITING

FAT MOBILIZATION AND ALTERING INSULIN SENSITIVITY

57

14.15

Kathryn Miranda*, William Becker, Brandon Busbee,

Nicholas Dopkins, Yin Zhong, Prakash S. Nagarkatti and Mitzi

Nagarkatti

ENDOCANNABINOID SIGNALING MEDIATES SUSCEPTIBILITY TO

HIGH FAT DIET-INDUCED INTESTINAL DYSBIOSIS AND

REGULATES METABOLIC HEALTH

58

14.30

Cristoforo Silvestri*, Claudia Manca, Niokhor Dione,

Sebastien Lacroix, Ulrike Taschler

Nicolas Flamand, Frederic Raymond and Vincenzo Di

Marzo

BIDIRECTIONAL INTERACTION BETWEEN THE GUT

MICROBIOME AND THE ENDOCANNABINOIDOME

59

14.45

Amira Mohammed*, Hasan Alghetaa,

Marcus Kaul, Prakash Nagarkatti and Mitzi

Nagarkatti

THC TREATMENT IMPROVED NEUROTOXICITY BY ALTERING

THE MICROBIOTA 60


15.00 – 16.00

President’s Lecture

The Structures and Functions of

the Cannabinoid Receptors

Alexandros Makriyannis, Ph.D.

George D Behrakis Chair, Chemistry and Chemical Biology Bouve College Health Sciences, Center For Drug Discovery

Northeastern University, Boston, MA

16.00 – 18.00 Poster Session 3 P3

18.30 Reception

19.00

ICRS BANQUET

AND

AWARDS CEREMONY

Departure: Thursday, July 4th


29 th annual symposium...icrs2019 preliminary programme – subject to changes 15.00 adi drori*,...

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