THE UNIVERSITY OF IOWA

DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY

2019 Year in Review

In this IssueMessage from the Department.......1 Faculty Honors and Awards.............2Faculty Research in the News..........3Faculty Funding...............................3Faculty Publications.....................4-9 Recent Graduates..........................10Graduate Student News................10Undergraduate Student News.......11 Training Programs.........................12 Patrick Schlievert..........................13 Alumni Focus................................13 Emeritus Professor Focus.........14-15 Contact Us....................................16

Li Wu, Ph.D., Chair and DEO

MESSAGE FROM THE DEPARTMENT

Li Wu, Ph.D., was named Chair and Departmental Executive Officer of the Department of Microbiology and Immunology in The University of Iowa Roy J. and Lucille A. Carver College of Medicine following a national search for the position in 2019. Professor Wu came to the UI Carver College of Medicine from The Ohio State University. His research focuses on molecular and cellular mechanisms of HIV replication and viral pathogenesis.

Dr. Wu is very excited about this great opportunity to work with outstanding faculty, staff, and trainees in the department. He and his lab members joined the department in November 2019. Dr. Wu appreciates the trust and kind support from the college leadership and the search committee, as well as department faculty and staff. His goal is to learn, serve, and lead the department to promote research, education, and academic service in Microbiology and Immunology. Dr. Wu is also grateful to Dr. Patrick Schlievert for his important leadership and contributions to the Department since 2011.

Read the full CCOM story

The Department’s COVID-19 ResponseThe Department’s COVID-19 Response

In our preparation of this newsletter, all of In our preparation of this newsletter, all of us have experienced unprecedented global us have experienced unprecedented global challenges from the coronavirus disease challenges from the coronavirus disease 2019 (COVID-19) pandemic caused by its 2019 (COVID-19) pandemic caused by its viral agent SARS-CoV-2. To limit COVID-19 viral agent SARS-CoV-2. To limit COVID-19 spread, classes have gone online with remote teaching, and spread, classes have gone online with remote teaching, and research activities have been significantly curtailed. At the same research activities have been significantly curtailed. At the same time, several labs in the department are continuing or specifically time, several labs in the department are continuing or specifically retooling their research activities to focus on developing therapies retooling their research activities to focus on developing therapies and vaccines against the virus. University of Iowa Hospitals & and vaccines against the virus. University of Iowa Hospitals & Clinics have treated patients with COVID-19 and are preparing and Clinics have treated patients with COVID-19 and are preparing and bracing for many more to come in the immediate future. Healthcare bracing for many more to come in the immediate future. Healthcare workers are on the front line and need all of our support. The workers are on the front line and need all of our support. The department has risen to the challenge of donating much-needed department has risen to the challenge of donating much-needed personal protective equipment. Van-loads of masks, face shields, personal protective equipment. Van-loads of masks, face shields, gloves, isolation gowns, and swabs have already been sent to the gloves, isolation gowns, and swabs have already been sent to the hospital. The future of this pandemic is uncertain, but by working hospital. The future of this pandemic is uncertain, but by working together we will help to lessen its life-threatening impact.together we will help to lessen its life-threatening impact.

FACULTY NEWS AND RECOGNITION

University of Iowa hosts the Tenth Biennial All Iowa Virology Symposium

The All Iowa Virology Symposium took place in March 2019. Graduate students, postdoctoral researchers, and faculty from The University of Iowa, Des Moines University, and Iowa State University presented their virology-related research as talks or posters. One of the keynote speakers, Dr. Vincent Racaniello, from Colum-bia University, broadcast a TWiV (This Week in Virology) podcast from the meeting and had

special interviews with Drs. Wendy Maury and Stanley Perlman. Professors Wendy Maury, Richard Roller, and Jack Stapleton organized the meeting and support was provided by the Helen C. Levitt Center for Viral Pathogenesis, Iowa State University, and the Carver College of Medicine.

Bishop named Distinguished Fellow from two prestigious scientific associations

Professor Gail Bishop, Ph.D., was named a Fellow of the American Association for the Advancement of Science (AAAS), the world’s largest general-scientific society and publisher of the journal Science. Gail was elected for her distinguished contributions to the field of immunology, particularly for insights into regulation of T and B lymphocyte activation. Election as an AAAS Fellow is an honor bestowed upon AAAS members by their peers.

Bishop has also been named as a 2019 Distinguished Fellow of The American Association of Immunologists (AAI). This program recognizes members for distinguished careers and outstanding scientific contributions as well as their service to AAI and the immunology community.

McCarter named ICRU Distinguished Mentor and recipient of the 2019 Jack Kenney Award for Outstanding Service

Professor Linda McCarter, Ph.D., has been selected to receive the Iowa Center for Research by Undergraduates (ICRU) 2019 Distin-guished Mentor Award. Current students nominate faculty or professional and scientific staff who have contributed significantly to the overall support of undergraduates in research.

McCarter also received the 2019 Jack Kenney Award for Outstanding Service. This award was given for her truly outstanding performance as an Editorial Board member for the Journal of Bacteriology.

Top 25 Peer Reviewer for the Journal of Virology

Associate Professor Balaji Manicassamy, Ph.D., was recognized as one of the top 25 peer reviewers for the Journal of Virology (JVI). These reviewers have helped to make JVI the #1 cited journal out of 36 journals in the Virology category.

Excellent lecturer evaluations in 2019 MOHD IV

Drs. Ho, Roller, and Schlievert received a composite “overall quality of lecture” score of > 4.56 out of 5 on one or more of their lecture evalu-ations from Mechanism of Health and Disease (MOHD) IV course in 2019. Dr. Theresa Ho received the highest evaluations for the lecturers in the course this year! The average from all MOHD IV lecturers was 4.46 out of 5.0. Also thanks to MOHD IV Lab instructors, particularly Dr. Linda Knudtson.

Department of Microbiology and Immunology

Chair and Department

Executive Officer Li Wu, Ph.D.

Primary FacultyLee-Ann Allen, Ph.D.

Gail Bishop, Ph.D.Noah Butler, Ph.D.

Craig Ellermeier, Ph.D.Hillel Haim, M.D., Ph.D.

John Harty, Ph.D.Jon Houtman, Ph.D.Bradley Jones, Ph.D.

Aloysius Klingelhutz, Ph.D. Dominique Limoli, Ph.D.

Balaji Manicassamy, Ph.D.Wendy Maury, Ph.D.

Linda McCarter, Ph.D.Stanley Perlman, M.D., Ph.D.Lilliana Radoshevich, Ph.D.

Richard Roller, Ph.D.Patrick Schlievert, Ph.D.

Steven Varga, Ph.D.Mary Weber, Ph.D.David Weiss, Ph.D.Mary Wilson, M.D.

Hai-Hui Xue, M.D., Ph.D.Timothy Yahr, Ph.D.

Secondary FacultyVladimir Badovinac, Ph.D.

Damian Krysan, M.D., Ph.D. Kevin Legge, Ph.D.Paul McCray, M.D.

Steven McElroy, M.D. William Nauseef, M.D.

Patrick Sinn, Ph.D.Jack Stapleton, M.D.Jerrold Weiss, Ph.D.

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FACULTY RESEARCH IN THE NEWS

Dominique Limoli, Ph.D., Assistant Professor

Bacterial warfare: Harnessing strategies bacteria use to compete with each other may lead to new antimicrobial therapies - When it comes to competition for space and nutrients, certain bacteria really do not like to share. A new study by University of Iowa researchers led by Professor Limoli shows that when the bacterium Pseudomonas aeruginosa senses the presence of other bacterial species, they attack. The team hopes that identifying

and understanding the strategies used by bacteria when they interact with one another might lead to new approaches for treating bacterial infections that threaten human health.

Interspecies interactions induce exploratory motility in Pseudomonas aeruginosa. Limoli DH*, Warren EA, Yarrington KD, Donegan NP, Cheung AL, O’Toole G. eLife. 2019 Nov 12;8. pii: e47365. *Corresponding author

Lilliana Radoshevich, Ph.D., Assistant Professor

Map of protein modification sites may reveal antimicrobial targets - Using a new approach, Professor Radoshevich’s lab at the University of Iowa Carver College of Medicine and resarchers at the VIB-UGent Center for Medical Biotechnology in Belgium, are investigating a poorly understood mechanism used by the immune system to fight infections. The mechanism involves a small protein called ISG15, which “tags” other proteins and modifies their function.

The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection. Zhang Y, Thery F, Wu NC, Luhmann EK, Dussurget O, Foecke M, Bredow C, Jiménez-Fernández D, Leandro K, Beling A, Knobeloch KP, Impens F, Cossart P, Radoshevich L.Nat Commun. 2019 Nov 26;10(1):5383.

Patrick Schlievert, Ph.D., Professor

Study identifies molecule that allows bacteria to breach cellular barriers.

A new study from Professors Schlievert's lab identifies a single molecule as a key entry point used by two types of dangerous bacteria to break through cellular barriers and cause disease. The findings, published in the journal mBio, suggest that blocking the interaction between the molecule, known as CD40, and bacteria may represent a universal strategy for preventing life-threatening illnesses, including toxic shock syndrome.

Breast milk could help fight allergies, inflammation. A group of researchers led by Professor Schlievert say breast feeding babies can bring significant health benefits as children get older. Professor Schlievert says a compound known as glycerol monolaurate can help children gain a stronger immune system to help fight off developing certain allergies and inflammation.

NEW FUNDING (2019)

David Weiss, Ph.D., and Linda McCarter, Ph.D. US National Science Foundation Research Experience for Undergraduates (REU) in Microbiology at The University of Iowa

Dominique Limoli, Ph.D., and Michael Welsh, M.D.Cystic Fibrosis Foundation Modulating Interspecies Interactions in Cystic Fibrosis Respiratory Disease

Craig Ellermeier, Ph.D.National Institutes of Health (R21)Extra-Cytoplasmic Function Sigma Factor Senses and Responds to Beta-Lactam Stress in Gram-Positive Bacteria

Lee-Ann Allen, Ph.D., and John Harty, Ph.D.National Institutes of Health (T32)Interdisciplinary Immunology Postdoctoral Training Program

Gail Bishop, Ph.D.US Department of Defense Tumor-Initiating Cell as a Novel Therapeutic Target in Myeloma

Stanley Perlman, M.D., Ph.D., Professor of Microbiology and Immunology and Professor of Pediatrics, has studied coronaviruses for 38 years. Dr. Perlman continues his work on SARS and MERS and has initiated

studies on SARS-CoV-2, the causative virus of COVID-19. He published an editorial entitled “Another Decade, Another Coronavirus” that appeared recently in the New England Journal of Medicine. Dr. Perlman’s research has attracted significant attention nationally and locally. Coronavirus lab at University of Iowa part of scientific community’s race for answers

Visit link to Dr. Perlman’s comments from various news outlets

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SELECTED RECENT PUBLICATIONS FROM PRIMARY FACULTY Lee-Ann Allen

Allen LH, Criss AK (2019) Cell intrinsic functions of neutrophils and their manipulation by pathogens. Curr Opin Immunol 60:124-129 PMC6800601 PMID:31302568

Baruah S, Murthy S, Keck K, Galvan I, Prichard A, Allen LH, Farrelly M, Klesney-Tait J (2019) TREM-1 regulates neutrophil chemotaxis by promoting NOX-dependent superoxide production. J Leukoc Biol 105:1195-1207 PMC6708376 PMID:30667543

Gail BishopHornick EE, Dagvadorj J, Zacharias ZR, Miller AM, Langlois RA, Chen P, Legge KL, Bishop GA, Sutterwala FS, Cassel SL (2019) Dendritic cell NLRC4 regulates influenza A virus-specific CD4 T cell responses through FasL expression. J Clin Invest 129:2888-2897 PMC6597209 PMID:31038471

Whillock AL, Mambetsariev N, Lin WW, Stunz LL, Bishop GA (2019) TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells. Sci Rep 9:12884 PMC6733949 PMID:31501481

Noah ButlerBrunton B, Rogers K, Phillips EK, Brouillette RB, Bouls R, Butler NS, Maury W (2019) TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis. PLoS Negl Trop Dis 13:e0006983 PMC6615641 PMID:31242184

Kurup SP, Butler NS, Harty JT (2019) T cell-mediated immunity to malaria. Nat Rev Immunol 19:457-471 PMC6599480 PMID:30940932

Craig EllermeierHo TD, Ellermeier CD (2019) Activation of the extracytoplasmic function sigma factor sigma(V) by lysozyme. Mol Microbiol 112:410-419 PMC6703919 PMID:31285685

Ho TD, Nauta KM, Muh U, Ellermeier CD (2019) Activation of the Extracytoplasmic Function sigma Factor sigma(P) by beta-Lactams in Bacillus thuringiensis Requires the Site-2 Protease RasP. mSphere 4:e00511-19 PMC6686233 PMID:31391284

Hillel Haim

Salimi H, Johnson J, Flores MG, Zhang MS, O’Malley Y, Houtman JC, Schlievert PM, Haim H (2020) The lipid membrane of HIV-1 stabilizes the viral envelope glycoproteins and modulates their sensitivity to antibody neutralization. J Biol Chem 295:348-362 PMC6956520 PMID:31757809

John HartyKurup SP, Anthony SM, Hancox LS, Vijay R, Pewe LL, Moioffer SJ, Sompallae R, Janse CJ, Khan SM, Harty JT (2019) Monocyte-Derived CD11c(+) Cells Acquire Plasmodium from Hepatocytes to Prime CD8 T Cell Immunity to Liver-Stage Malaria. Cell Host Microbe 25:565-577 PMC6459714 PMID:30905437

Lefebvre MN, Harty JT (2020) You Shall Not Pass: Memory CD8 T Cells in Liver-Stage Malaria. Trends Parasitol 36:147-157 PMC6937381 PMID:31843536

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Jon HoutmanSieng M, Hayes MP, O’Brien JB, Andrew Fowler C, Houtman JC, Roman DL, Lyon AM (2019) High-resolution structure of RGS17 suggests a role for Ca(2+) in promoting the GTPase-activating protein activity by RZ subfamily members. J Biol Chem 294:8148-8160 PMC6527179 PMID:30940727

Salimi H, Johnson J, Flores MG, Zhang MS, O’Malley Y, Houtman JC, Schlievert PM, Haim H (2020) The lipid membrane of HIV-1 stabilizes the viral envelope glycoproteins and modulates their sensitivity to antibody neutralization. J Biol Chem 295:348-362 PMC6956520 PMID:31757809

Bradley JonesMartini AM, Moricz BS, Ripperger AK, Tran PM, Sharp ME, Forsythe AN, Kulhankova K, Salgado-Pabon W, Jones BD (2020) Association of Novel Streptococcus sanguinis Virulence Factors With Pathogenesis in a Native Valve Infective Endocarditis Model. Front Microbiol 11:10 PMC7005726 PMID:32082276

Aloysius KlingelhutzGourronc FA, Perdew GH, Robertson LW, Klingelhutz AJ (2019) PCB126 blocks the thermogenic beiging response of adipocytes. Environ Sci Pollut Res Int 27:8897-8904 PMC7098842 PMID:31721030

Kolb R, Kluz P, Tan ZW, Borcherding N, Bormann N, Vishwakarma A, Balcziak L, Zhu P, Davies BS, Gourronc F, Liu LZ, Ge X, Jiang BH, Gibson-Corley K, Klingelhutz A, Tan NS, Zhu Y, Sutterwala FS, Shen X, Zhang W (2019) Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. Oncogene 38:2351-2363 PMC6440811 PMID:30518876

Dominique LimoliLimoli DH, Hoffman LR (2019) Help, hinder, hide and harm: what can we learn from the interactions between Pseudomonas aeruginosa and Staphylococcus aureus during respiratory infections? Thorax 74:684-692 PMC6585302 PMID:30777898

Limoli DH, Warren EA, Yarrington KD, Donegan NP, Cheung AL, O’Toole GA (2019) Interspecies interactions induce exploratory motility in Pseudomonas aeruginosa. eLife 8:e47365 PMC6910820 PMID:31713513

Balaji ManicassamyGaisina IN, Peet N, Cheng H, Li P, Du R, Cui Q, Furlong K, Manicassamy B, Caffrey M, Thatcher GR, Rong L (2020) Optimization of 4-aminopiperidines as inhibitors of influenza A viral entry that are synergistic with oseltamivir. J Med Chem 63:3120-3130 PMID:32069052

Kandasamy M, Furlong K, Perez JT, Manicassamy S, Manicassamy B (2020) Suppression of Cytotoxic T Cell Functions and Decreased Levels of Tissue Resident Memory T cell During H5N1 infection. J Virol (Epub ahead of print) PMID:32075925

Wendy MauryRogers KJ, Brunton B, Mallinger L, Bohan D, Sevcik KM, Chen J, Ruggio N, Maury W (2019) IL-4/IL-13 polarization of macrophages enhances Ebola virus glycoprotein-dependent infection. PLoS Negl Trop Dis 13:e0007819 PMC6905523 PMID:31825972

Brunton B, Rogers K, Phillips EK, Brouillette RB, Bouls R, Butler NS, Maury W (2019) TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis. PLoS Negl Trop Dis 13:e0006983 PMC6615641 PMID:31242184

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Linda McCarter Lamb E, Trimble MJ, McCarter LL (2019) Cell-cell communication, chemotaxis and recruitment in Vibrio parahaemolyticus. Mol Microbiol 112:99-113 PMC6615966 PMID:30938898

Kimbrough JH, Cribbs JT, McCarter LL (2020) Homologous c-di-GMP-binding Scr transcription factors orchestrate biofilm development in Vibrio parahaemolyticus. J Bacteriol 202:e00723-19 PMID:31932310

Stanley PerlmanChannappanavar R, Fehr AR, Zheng J, Wohlford-Lenane C, Abrahante JE, Mack M, Sompallae R, McCray PB, Jr., Meyerholz DK, Perlman S (2019) IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes. J Clin Invest 130:3625-3639 PMC6715373 PMID:3135579

Perlman S (2020) Another Decade, Another Coronavirus. N Engl J Med 382:760-762 PMID:3197844

Lilliana RadoshevichZhang Y, Thery F, Wu NC, Luhmann EK, Dussurget O, Foecke M, Bredow C, Jimenez-Fernandez D, Leandro K, Beling A, Knobeloch KP, Impens F, Cossart P, Radoshevich L (2019) The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection. Nat Commun 10:5383 PMID:31772204

Richard RollerFeutz E, McLeland-Wieser H, Ma J, Roller RJ (2019) Functional interactions between herpes simplex virus pUL51, pUL7 and gE reveal cell-specific mechanisms for epithelial cell-to-cell spread. Virology 537:84-96 PMID:31493658

Patrick SchlievertFischer AJ, Kilgore SH, Singh SB, Allen PD, Hansen AR, Limoli DH, Schlievert PM (2019) High Prevalence of Staphylococcus aureus Enterotoxin Gene Cluster Superantigens in Cystic Fibrosis Clinical Isolates. Genes (Basel) 10:E1036 PMC6947208 PMID:31842331

Schlievert PM (2020) Effect of non-absorbent intravaginal menstrual/contraceptive products on Staphylococcus aureus and production of the superantigen TSST-1. Eur J Clin Microbiol Infect Dis 39:31-38 PMID:31853743

Steven VargaSchmidt ME, Meyerholz DK, Varga SM (2019) Pre-existing neutralizing antibodies prevent CD8 T cell-mediated immunopathology following respiratory syncytial virus infection. Mucosal Immunol (Epub ahead of print) PMID:31844172

Schmidt ME, Oomens AGP, Varga SM (2019) Vaccination with a Single-Cycle Respiratory Syncytial Virus Is Immunogenic and Protective in Mice. J Immunol 202:3234-3245 PMC6529240 PMID:31004010

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Mary WeberFaris R, Andersen SE, McCullough A, Gourronc F, Klingelhutz AJ, Weber MM (2019) Chlamydia trachomatis Serovars Drive Differential Production of Proinflammatory Cytokines and Chemokines Depending on the Type of Cell Infected. Front Cell Infect Microbiol 9:399 PMC6988789 PMID:32039039

Faris R, Merling M, Andersen SE, Dooley CA, Hackstadt T, Weber MM (2019) Chlamydia trachomatis CT229 Subverts Rab GTPase-Dependent CCV Trafficking Pathways to Promote Chlamydial Infection. Cell Rep 26:3380-3390 PMID:30893609

David WeissMuh U, Pannullo AG, Weiss DS, Ellermeier CD (2019) A Xylose-Inducible Expression System and a CRISPR Interference Plasmid for Targeted Knockdown of Gene Expression in Clostridioides di icile. J Bacteriol 201:e00711-18 PMC6597395 PMID:30745377

Mary WilsonBorbon TY, Scorza BM, Clay GM, Lima Nobre de Queiroz F, Sariol AJ, Bowen JL, Chen Y, Zhanbolat B, Parlet CP, Valadares DG, Cassel SL, Nauseef WM, Horswill AR, Sutterwala FS, Wilson ME (2019) Coinfection with Leishmania major and Staphylococcus aureus enhances the pathologic responses to both microbes through a pathway involving IL-17A. PLoS Negl Trop Dis 13:e0007247 PMC6527190 PMID:31107882

Ozanne MV, Brown GD, Oleson JJ, Lima ID, Queiroz JW, Jeronimo SMB, Petersen CA, Wilson ME (2019) Bayesian compartmental model for an infectious disease with dynamic states of infection. J Appl Stat 46:1043-1065 PMC6752225 PMID:31537954

Li WuLu W, Chen S, Yu J, Behrens R, Wiggins J, Sherer N, Liu SL, Xiong Y, Xiang SH, Wu L. (2019). The polar region of the HIV-1 envelope protein determines viral fusion and infectivity by stabilizing the gp120-gp41 association. J Virol 93(7), e02128-18 PMC6430531 PMID:30651369

Qin Z, Bonifati S, St Gelais C, Li TW, Kim SH, Antonucci JM, Mahboubi B, Yount JS, Xiong Y, Kim B, Wu L (2020) The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells. J Biol Chem 295:1575-1586 PMC7008377 PMID:31914403

Hai-Hui XueRaghu D, Xue HH, Mielke LA (2019) Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1. Trends Immunol 40:1149-1162 PMID:31734149

Shao P, Li F, Wang J, Chen X, Liu C, Xue HH (2019) Cutting Edge: Tcf1 Instructs T Follicular Helper Cell Differentiation by Repressing Blimp1 in Response to Acute Viral Infection. J Immunol 203:801-806 PMC6684471 PMID:31300510

Timothy YahrWilliams McMackin EA, Marsden AE, Yahr TL (2019) H-NS Family Members MvaT and MvaU Regulate the Pseudomonas aeruginosa Type III Secretion System. J Bacteriol 201:e00054 PMC6597382 PMID:30782629

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SELECTED RECENT PUBLICATIONS FROM SECONDARY FACULTY

Vladimir BadovinacDanahy DB, Kurup SP, Winborn CS, Jensen IJ, Harty JT, Griffith TS, Badovinac VP (2019) Sepsis-Induced State of Immunoparalysis Is Defined by Diminished CD8 T Cell-Mediated Antitumor Immunity. J Immunol 203:725-735 PMC6650357 PMID:31189573

Martin MD, Jensen IJ, Ishizuka AS, Lefebvre M, Shan Q, Xue HH, Harty JT, Seder RA, Badovinac VP (2019) Bystander responses impact accurate detection of murine and human antigen-specific CD8 T cells. J Clin Invest 130:3894-3908 PMC6715387 PMID:31219804

Damian KrysanKrysan DJ, Zhai B, Beattie SR, Misel KM, Wellington M, Lin X (2019) Host Carbon Dioxide Concentration Is an Independent Stress for Cryptococcus neoformans That Affects Virulence and Antifungal Susceptibility. mBio 10: e01410-19 PMC6606813 PMID:31266878

Montoya MC, Beattie S, Alden KM, Krysan DJ (2020) Derivatives of the antimalarial drug mefloquine are broad spectrum antifungal molecules with activity against drug-resistant clinical isolates. Antimicrob Agents Chemother 64:e02331-19 PMID:31907188

Kevin LeggeHornick EE, Zacharias ZR, Legge KL (2019) Kinetics and Phenotype of the CD4 T Cell Response to Influenza Virus Infections. Front Immunol 10:2351 PMC6783515 PMID:31632414

Zacharias ZR, Legge KL (2019) Chronic Ethanol Consumption Reduces Existing CD8 T Cell Memory and Is Associated with Lesions in Protection against Secondary Influenza A Virus Infections. J Immunol 203:3313-3324 PMC6904436 PMID:31712384

Paul McCrayKrishnamurthy S, Wohlford-Lenane C, Kandimalla S, Sartre G, Meyerholz DK, Theberge V, Hallee S, Duperre AM, Del’Guidice T, Lepetit-Stoffaes JP, Barbeau X, Guay D, McCray PB, Jr. (2019) Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia. Nat Commun 10:4906 PMC6817825 PMID:31659165

Berkebile AR, Bartlett JA, Abou Alaiwa M, Varga SM, Power UF, McCray PB, Jr. (2020) Airway Surface Liquid Has Innate Antiviral Activity That Is Reduced in Cystic Fibrosis. Am J Respir Cell Mol Biol 62:104-111 PMC6938132 PMID:31242392

Steven McElroy Elgin TG, Fricke EM, Gong H, Reese J, Mills DA, Kalantera KM, Underwood MA, McElroy SJ (2019) Fetal exposure to maternal inflammation interrupts murine intestinal development and increases susceptibility to neonatal intestinal injury. Dis Model Mech 12 ePub PMC6826024 PMID:31537532

Stanford AH, Gong H, Noonan M, Lewis AN, Gong Q, Lanik WE, Hsieh JJ, Lueschow SR, Frey MR, Good M, McElroy SJ (2019) A direct comparison of mouse and human intestinal development using epithelial gene expression patterns. Pediatr Res ePub PMC6930976 PMID:31242501

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William NauseefKremserova S, Nauseef WM (2019) Frontline Science: Staphylococcus aureus promotes receptor-interacting protein kinase 3- and protease-dependent production of IL-1beta in human neutrophils. J Leukoc Biol 105:437-447 PMC6927048 PMID:30548986

Nauseef WM (2019) The phagocyte NOX2 NADPH oxidase in microbial killing and cell signaling. Curr Opin Immunol 60:130-140 PMC6800624 PMID:31302569

Patrick SinnCooney AL, Thornell IM, Singh BK, Shah VS, Stoltz DA, McCray PB, Jr., Zabner J, Sinn PL (2019) A Novel AAV-mediated Gene Delivery System Corrects CFTR Function in Pigs. Am J Respir Cell Mol Biol 61:747-754 PMC6890402 PMID:31184507

Singh BK, Pfaller CK, Cattaneo R, Sinn PL (2019) Measles Virus Ribonucleoprotein Complexes Rapidly Spread across Well-Differentiated Primary Human Airway Epithelial Cells along F-Actin Rings. mBio 10:e02434-19 PMC6879720 PMID:31772054

Jack StapletonWelch JL, Kaufman TM, Stapleton JT, Okeoma CM (2019) Semen exosomes inhibit HIV infection and HIV-induced proinflammatory cytokine production independent of the activation state of primary lymphocytes. FEBS Lett 594:695-709 PMID:31665815

Kaddour H, Lyu Y, Welch JL, Paromov V, Mandape SN, Sakhare SS, Pandhare J, Stapleton JT, Pratap S, Dash C, Okeoma CM (2020) Proteomics Profiling of Autologous Blood and Semen Exosomes from HIV-infected and Uninfected Individuals Reveals Compositional and Functional Variabilities. Mol Cell Proteomics 19:78-100 PMC6944229 PMID:31676584

Jerrold Weiss

Barker JH, Weiss JP (2019) Detecting lipopolysaccharide in the cytosol of mammalian cells: Lessons from MD-2/TLR4. J Leukoc Biol 106:127-132 PMC6597272 PMID:30694581

HIV/AIDS Clinic Celebrates 30th Anniversary

The first HIV and AIDS clinic in Iowa opened over 30 years ago, led by Jack Stapleton, M.D., Professor of Internal Medicine and Professor of Microbiology and Immunology. Sinceopening, the clinic has participated in more than 50 clinical and epidemiological trials thanksto funds from the NIH and the pharmaceutical industry. These trials assisted in the licensureof many HIV medications and contributed to the 1992 NIH AIDS Clinic Trials Group. Today,the clinic consists of several providers, a benefits specialist, a program nurse, a behavioral

health consultant, support staff, and six social workers. The team provides medical andpsychosocial support and care services to approximately 800 active patients, particularly those from the low-income HIV and AIDS population. In April 2019, the clinic celebrated its 30th anniversary through films and talks that were sponsored by The University of Iowa, the Bijou, Film Scene, and the Iowa City Public Library.

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The department would like to congratulate our graduate students who defended their Ph.D. theses and graduated from the Microbiology Graduate Program in 2019.

Matt Grunewald

Jacklyn Killpack (formerly Johnson) Marie Morabe

Kai Rogers

GRADUATE STUDENT FELLOWSHIPS AND AWARDS

Ryan Callahan (Radoshevich lab), Graduate Program in Microbiology

• National Science Foundation Graduate Fellowship

Andrea Sánchez-Peña (Limoli lab), Graduate Program in Microbiology

• Carver College of Medicine Inclusive Excellence Awardee

Kody Waldstein (Varga lab), Interdisciplinary Graduate Program in Immunology

• Spring 2020 Graduate College Post-Comprehensive Research Fellowship award

Amy Whillock (Bishop lab), Interdisciplinary Graduate Program in Immunology

• US Department of Defense funding for research entitled, “CD24 Tumor-Initiating Cellas a Novel Therapeutic Target in Myeloma”

Xavier Tijerina (Limoli lab), Medical Scientist Training Program

• William Johnson Award for Research in Microbiology and Immunology

RECENT Ph.D. DEFENSES

Four students successfully defended their theses in the Graduate Program in Microbiology in 2019: Matthew Grunewald (Perlman lab), Jacklyn Killpack (Haim lab), Maria Morabe (McCarter lab) and Kai Rogers (Maury lab)

The Graduate Program in Microbiology offers research training for the Doctor of Philosophy (Ph.D.) with specific research disciplines, including immunology, bacterial genetics and physiology, pathogenic bacteriology, virology, parasitology, and bioinformatics. Several of these areas involve interdisciplinary training within and outside the department.

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UNDERGRADUATE NEWS AND ACCOMPLISHMENTS

Undergraduate microbiology student Alexandria (Alex) Sturtz was awarded the Stinski Undergraduate Research Fellowship for 2019-2020. The fellowship’s purpose is to support undergraduates in pursuit of research in the field of microbiology. Along with a monthly stipend, it covers full tuition for the 2019-2020 academic school year.

Undergraduate Microbiology Research Poster SessionEleven undergraduate microbiology students presented their research at the 2019 Undergraduate Microbiology Research Poster Session on April 18, 2019. Undergraduate students Shelby Andersen and Evan Lamb (2018-2019 Stinski Fellow) won the Allen J. Markovetz Award for best poster presentations. Allen J. Markovetz, Ph.D., served as Interim Department Head in 1977 and 1989 - 1992.

Undergraduate Honors Symposium Six students were a part of the Undergraduate Honors Symposium held in May 2019: Robert Nordell IV (Yahr lab); Evan Lamb (McCarter lab); James Girsch (Klingelhutz & Grose labs), Sarah Mullen (Klingelhutz & Stipp labs), and Molly Sharp (Jones lab).

University of Iowa Student Employee of the Year

Undergraduate student Changze Han was awarded the 2019 University of Iowa Student Employee of the Year. He wrote computer code and tracked how HIV-1 changes in the population in Dr. Hillel Haim’s lab. Changze is pictured with Dr. Haim.

MUSA The Microbiology Undergraduate Student Association (visit link: MUSA) is an active student-run organization that provides undergraduate microbiology majors opportunities to attend conferences, field trips, and related research activities to gain exposure to the microbiology field. In 2019, they assisted with the Girls GO STEM, a community outreach event. Through fundraising activities, selected members are planning to attend the American Society of Microbiology meeting in Chicago this year.

Shelby Andersen Evan Lamb

Summer Research Experience for Undergraduates (REU) in Microbiology The REU program is funded by the National Science Foundation and provides a 10-week summer research opportunity to foster the careers of the next generation of microbiologists. The department hosted nine REU program participants in 2019. Among them, Laurel Woods and Paige Richards have been accepted to the Graduate Program in Microbiology for Fall 2020.

2019-2020 Stinski Undergraduate Research Fellowship

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DEPARTMENT TRAINING PROGRAMSInterdisciplinary Immunology Postdoctoral Training Program

PIs: Lee-Ann Allen, Ph.D., and John Harty, Ph.D.The training program is supported by a T32 training grant from NIH/National Institute of Allergy and Infectious Diseases. The goal is to produce outstanding independent investigators in immunology who will make meaningful contributions to

immunological sciences through academic, biotechnology, public policy, or other relevant careers. 2019-2020 Trainees

Lisa Drewry (Harty lab) Emma Hornick (Bishop lab)

Brian Juber (McElroy lab) Breanna Scorza (Petersen lab)Zeb Zacharias (Legge lab)

Training in Molecular Virology & Viral Pathogenesis PI: Richard Roller, Ph.D.

The training program is supported by a T32 training grant from NIH/National Institute of Allergy and Infectious Diseases.The goal is to train graduate students in the study of virology and to promote interaction among students and faculty

at The University of Iowa. 2019 Trainees

Christopher Ball (Price lab) Dana Bohan (Maury lab)Amy Whillock (Bishop lab)

Training in Mechanisms of ParasitismPIs: Mary Wilson, M.D., and Patrick Schlievert, Ph.D.

The training program is supported by a T32 training grant from NIH/National Institute of Allergy and Infectious Diseases. The goal is to train students and postdoctoral scholars in the field of parasitology to allow trainees to adopt a more

comprehensive view of the intricate relationships between host, microbe, and environment that contribute to parasitism.2019-2020 Trainees

Gabriela Kaus (Ellermeier lab) Hank Kimbrough (McCarter lab)Isaac Jensen (Badovinac lab) Jordan Johnson (Butler lab)Ellen Kiser (Wilson lab) Angela Pack (Butler lab)Emily McMackin (Yahr lab)

Research Experience for Undergraduates (REU) in MicrobiologyPIs: David Weiss, Ph.D., and Linda McCarter, Ph.D.

The summer training program is supported by a grant from the National Science Foundation. The goal is to encourage students who are interested in science to pursue a research career by providing a solid basic research experience and by helping them to

become competitive for admission to graduate programs. 2019 Trainees:

Caleb Huntington (Manicassamy lab) Nia Johnson (Ellermeier lab) Kimberley Kissoon (Yahr lab) Jenna Klingebiel (McElroy lab)Miguel Lopez (Butler lab) Aolani Perry (Allen lab)Paige Richards (Roller lab) Megan Wassom (McCarter lab)Laurel Woods (Weber lab)

In October 2019, the Department of Microbiology and Immunology organized and hosted a Scientific Careers Retreat for graduate students and postdoctoral trainees. A panel of guests from academia and industry with connections to the University of Iowa were invited to present and participate in discussions on scientific careers. The retreat was sponsored by NIH-funded T32 training programs (Mechanisms of Parasitism, Graduate Immunology, Immunology Postdoctoral Program, Genetics, and Infectious Diseases), the Department of Microbiology and Immunology, and the Carver College of Medicine.

Scientific Careers Retreat

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ALUMNI FOCUS

Microbiology Graduate Program Alumni Couple Land Jobs at the University of Alabama

Former graduate students, Nicholas Lenneman (Maury Lab, 2008-2014) and Megan Kiedrowski (Horswill Lab, 2007-2012)recently accepted job offers at the University of Alabama, Birmingham. Nick and Megan met while attending graduate school

in the Department of Microbiology at the University of Iowa. As a graduate student, Nick worked on Ebola virus entry. Megan performed her thesis research on the role of Staphylococcus aureus in biofilm development. After graduating, Nick joined Dr. Carolyn Coyne’s laboratory as a postdoctoral fellow at the University of Pittsburgh, focusing on virus-host interactions at the maternal-fetal interface and regulation of infection by autophagy. Megan spent two years as a postdoctoral fellow with Dr. Jo Handelsman at Yale University researching bacterial factors required for persistence and pathogenesis in the gut using insect model systems. The two were finally reunited when Megan started a second postdoctoral fellowship in Dr. Jennifer Bomberger’s group at the University of Pittsburgh studying viral-bacterial interactions in cystic fibrosis respiratory infections. Megan and Nick were married last summer in Iowa City. They will be starting their new positions at Alabama in 2020. Nick will join the Department of Microbiology as an Assistant Professor and continue studies on virus-host interactions with a focus on understanding the mechanisms involved in the remodeling of the host cell during positive-strand RNA virus infection using novel live-cell imaging tools and proteomics. Megan will join the Department of Pulmonary, Allergy, and Critical Care Medicine as an Assistant Professor and continue her work on host-pathogen interactions, studying Gram positive bacteria and how host responses and interactions with commensal microbes alter antimicrobial tolerance and transcriptional responses during chronic respiratory infections. WE WISH THEM THE BEST OF LUCK IN THEIR NEW POSITIONS!

Thank you Dr. Patrick Schlievert

After serving in the position since 2011, Patrick Schlievert, Ph.D., decided last summer that it was time to step down as chair of the department. During his tenure as DEO, Pat successfully shepherded the department through tough funding times by implementing a developmental grant program to help faculty maintain their research. This approach was extremely successful, with many of the supported faculty obtaining lucrative and long-term NIH grants, and overall funding in the department significantly increased during Pat’s time as chair. Pat worked diligently to retain faculty and recruit outstanding new faculty members. In addition to his support for research, Pat was a constant champion of high quality teaching and service in the department. Pat will continue his research on superantigens and cytolysin exotoxins produced by S. aureus and group A streptococci. He is also writing a book describing his discovery of how

the S. aureus superantigen TSST-1 causes toxic shock syndrome. In addition, Pat will continue teaching microbiology to medical and dental students. The department thanks Pat for all that he has done and wishes him well in the next phase of his productive career.

Patrick Schlievert honored on the Wall of Scholarship

The University of Iowa Carver College of Medicine Wall of Scholarship was established to highlight biomedical research by acknowledging a distinct group of current UI Carver College of Medicine faculty members whose published research articles have made a significant impact on a particular field of science or medicine. Professor Patrick Schlievert, Ph.D., was among those honored in 2019.

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A short list of some alumni from the Butler lab:

John C. Cambier (Ph.D. 1975)Former Chair and Endowed Professor of Immunology and Microbiology, University of Colorado Medical School and National Jewish Hospital and Clinic

Ferri Habe (Ph.D. 1975)Professor and past Head of Biotechnology, Institute of Animal Science, Ljubljana, Slovenia

Christine Martens Mocarski (Ph.D. 1978)Currently at Vanderbilt University, Retired from Affymetric and Stanford University, Palo Alto, CA

Luis Cantarero (Ph.D. 1980)Currently professional consultant and retired immunodiagnostic specialist for Abbott and Cyclomation

Deborah Pringnitz (Ph.D. 1980)Currently Professor of Biology, University of Maine

Hubert Heyermann, M.D. (Postdoctoral Fellow 1984-87)Currently Biosafety Manager and past Head of Hep C immunodiagnostic Division for Abbott Laboratories, Germany

Thomas Koertge (Ph.D. 1984)Currently Head, Orthodontics, Virginia Commonwealth University, Richmond, VA

Laszlo Frenyo, M.D. (Postdoctoral Fellow 1983-85)Currently Professor of Physiology, past president, University of Veterinary Science, Budapest, Hungary

Mark Suter, D.V.M. (Postdoctoral Fellow 1985-86)Currently Professor Emeritus Zurich Veterinary School, Switzerland

Steven Dierks (Ph.D. 1988)Currently Site Director of Operations for Abbott Laboratories, Wiesbaden, Germany

Margaret (Peggy) Dillender (Ph.D. 1990)Former Head of Pfizer Animal Health for Europe, Düsseldorf, Germany

Imre Kacskovics, D.V.M., Ph.D. (Postdoctoral Fellow 1992-94)Currently Dean of Faculty of Science and Head of Immunology, Eotvos Lorand University, Budapest, Hungary

William (Rick) Brown (Ph.D. 1994)Currently Manager of Process Engineering and formerly Head of Immunodiagnostics, Abbott business team, Abbott Laboratories, Lake Forest, IL

Rashmi Mueller, M.B.B.S. (Visiting Scholar 1995)Currently a Clinical Associate Professor of Anesthesia, University of Iowa

Marek Sinkora, Ph.D. (Visiting Scholar 1999)Currently Senior immunologist, Institute of Gnotobiology, Czech Republic

Jeremy McAleer (Undergraduate Researcher 2003)Received a Ph.D. at the Universityof Connecticut and is currently an Assistant Professor, Marshall University, West Virginia

EMERITUS PROFESSOR FOCUS

John E. Butler, Ph.D., Professor Emeritus in the Department of Microbiology and Immunology, retired in 2013, after an extremely productive and fulfilling

career. Upon graduation from the University of Wisconsin-River Falls (UW-RF) in 1961, he served as a Ranger-Naturalist for Crater Lake National Park in Oregon. He received his Ph.D. in Zoology/Biochemistry at the University of Kansas in 1965 and stayed on as an acting assistant professor and USPHS postdoctoral trainee. He then spent four years at Allergens Investigations of the USDA in Washington, DC. Dr. Butler was part of the SE Pacific Oceanographic Expedition in 1967. He joined The University of Iowa in 1971. In his 42 years at The University of Iowa, he trained dozens of doctoral and postdoctoral scholars from 17 countries and published more than 260 peer-reviewed articles and book chapters. During his tenure he spent ~3 years in Germany on fellowships from the Max-Planck Society and the Fogarty International Program of the NIH. Dr. Butler is recognized for his work on antibodies and antibody genes of cattle and swine, mucosal immunity and development of solid phase immunoassays. He was twice honored as a Distinguished Veterinary Immunologist and was the 2015 Distinguished Alumnus at UW-RF. John was a first-generation college student from a farm family of seven. During his tenure at the University of Iowa, he taught immunology to undergraduate, graduate, and professional students. After retirement he taught a Senior College course on the microbiome, co-edited a volume of Frontiers in Immunology, serves on the editorial board of Developmental and Comparative Immunology, and with colleagues is currently leading a book project entitled The Critical Window of Development. He currently endows the J.E. Butler Professorship in Comparative and Mucosal Immunology at UW-Madison. He is an experienced pilot, restored a WWII Stearman biplane, and still enjoys biking, wine making and gardening. He lives with his partner and his two dogs on an acreage north of Iowa City.

Did you know?Did you know?

Bacteriology courses have been taught since Bacteriology courses have been taught since

1889 at the State University of Iowa (now 1889 at the State University of Iowa (now

University of Iowa). In 1938 the Department University of Iowa). In 1938 the Department

of Bacteriology was given full departmental of Bacteriology was given full departmental

status, known today as the Department of status, known today as the Department of

Microbiology and Immunology!Microbiology and Immunology!

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It has been nearly 8 years since Dr. Mark Stinski, Ph.D., retired and became an Emeritus Professor in the Department of Microbiology and Immunology, but his legacy at The University of Iowa remains strong. He received his B.S from Michigan

State University in 1964, followed by an M.S. in 1966, and a Ph.D. in 1969 from thesame institute. He initially worked as aResearch Virologist and Chemical Officer inthe 8th U.S. Army Medical Sciences Lab atFort Detrick from 1969-1971 and then wenton to do a postdoctoral fellowship from1971-1973 with Dr. H.S. Ginsberg at theUniversity of Pennsylvania, studyingadenoviruses. He joined the Department of

Microbiology at The University of Iowa in 1973, where he started his seminal research on cytomegalovirus (CMV). It was during this time that his laboratory mapped the CMV genome and cloned the CMV immediate early promoter. Dr. Stinski realized early on that this robust promoter was unique in its high activity and that it could be used for high level expression of genes in mammalian cells. Thankfully, he had the foresight to work with the University to patent the promoter. The patent was widely licensed from 1992-2009, generating over $160 million. This royalty greatly benefitted The University of Iowa, the College of Medicine, and the Department of Microbiology and Immunology in their research endeavors, providing resources for research support, core facilities, recruitment, faculty retention, endowments for a Chair in Microbial Immunology, and an Endowed Lectureship in the department. Dr. Stinski also established the Mark Stinski Undergraduate Research Fellowship in the department. Forhis invention, Dr. Stinski received the Iowa Inventor of the Year Award in 2003 and the University of Iowa Distinguished Inventor Award in 2004. In addition to patent revenue, the CMV promoter has been utilized extensively in academic research for efficient gene expression, including uses for gene therapy in clinical trials.

Throughout his career, Dr. Stinski trained many students and postdocs in his laboratory and taught virology and molecular biology to undergraduate, graduate, and professional students. Dr. Stinski had an exemplary career studying CMV, with a particular focus on how the virus regulated viral and cellular gene expression. He published a vast array of papers on this topic and is considered a leading expert in the field of CMV. His studies have been important for understanding how CMV infects and causes disease. As a professor, Dr. Stinski cared a great deal about teaching and training his mentees to be rigorous and creative scientists. Many of the alumni from his lab have gone on to successful careers in research (see side panel). Dr. Stinski has received accolades for his research, including the Alexander Von Humboldt Award in Germany in 1991, election as Fellow of the American Academy of Microbiology in 1994, and election to Fellow of the American Association for the Advancement of Science in 2008.

In his retirement, Dr. Stinski maintains a busy lifestyle. When in town, he likes to come back to the department to attend the Helen C. Levitt Center for Viral Pathogenesis Journal Club. He enjoys spending time with his wife, Mary Ellen, and their children and grandchildren. He loves to bike, hunt, and travel.

A short list of some alumni from the Stinski lab:

Edward Mocarski, Jr. (Ph.D. 1979)Currently Robert W. Woodruff Professor, Department of Microbiology and Immunology, Emory University

Michael Wathen (Ph.D. 1981)Currently Senior Research Scientist, Upjohn Company, Kalamazoo, MI

Richard Stenberg, Ph.D. (Postdoctoral Fellow 1981-1985)Currently Professor of Microbiology, Virginia Medical College

Chia-Ping Chang (Ph.D. 1989)Currently Research Scientist Bristol-Myers Squibb, Wallingford, CT

Terry Hermiston (Ph.D. 1989)Currently Research Scientist Berlex Laboratories, Inc., Richmond, CA

David Gretch, M.D. (Ph.D. 1990) Currently Professor, Department of Laboratory Science, University of Washington

Kam Yeung, Ph.D. (Postdoctoral Fellow 1992-1994)Currently Associate Professor, Department of Cancer Biology, University of Toledo

Jeffery Meier, M.D. (Postdoctoral Fellow 1993-1995)Currently Associate Professor of Internal Medicine, University of Iowa

Elke Bogner, Ph.D. (Postdoctoral Fellow 1995-1996)Currently Professor, Institute for Clinical and Molecular Virology, Erlangen, Germany

Liping Huang (Ph.D. 1995)Currently Professor, University of California, Davis, CA

Eain Murphy (Ph.D. 2000)Currently Associate Professor, SUNY Upstate Medical University, Syracuse, NY

Grant Bullock (M.D./Ph.D. 2001)Currently Assistant Professor of Pathology, University of Pittsburgh

Hiroki Isomura, Ph.D. (Postdoctoral Fellow 2002-2004)Currently Research Scientist at the Division ofVirology, Aichi Cancer, Center Research Institute, Chikusa-ku, Nagoya, Japan

Yoon-Jae Song (Ph.D. 2004)Currently faculty, Gachon University, Seongnam, South Korea

Dustin Petrik (Ph.D. 2007)Currently Senior Research Scientist at MatMaCorp, Lincoln, NE

A L U M N I , R E C O N N E C T W I T H U S A T M I C R O B I O L O G Y - A L U M N I @ U I O W A . E D U !15

The University of IowaRoy J. and Lucille A. Carver College of Medicine Department of Microbiology and Immunology 51 Newton Road3-403 Bowen Science BuildingIowa City, IA 52242

Address: Department of Microbiology and Immunology51 Newton Road3-403 Bowen Science BuildingIowa City, IA 52242

Phone: (319) 335-7810Fax: (319) 335-9006Email: Microbiology-Alumni@uiowa.edu

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