2014 2015

CBMTG ANNUAL REPORT

MCGILL

KINGSTON

3

TABLE OF CONTENTSAbout...........................................................................4

Mission...................................................................4Vision.....................................................................4.Values....................................................................4Philosophy..............................................................4

Presidents.Message.....................................................5

Board.of.Directors.and.Head.Office.Staff.....................6

Membership.Statistics..................................................7

Strategic.Plan...............................................................8

Strategic.Achievements................................................9

Association.Programmes............................................10Webinar.Programme.............................................10National.Registry..................................................11GVHD.Symposium.................................................14Conference.Summary............................................15

2015...........................................................152016...........................................................152017...........................................................15

Awards.......................................................................16

Association.Sponsors.................................................17

Financial.Statements..................................................19

4

ABOUTThe.Canadian.Blood.and.Marrow.Transplant.Group.(CBMTG). is. a. Canadian. charitable. organization..CBMTG.is.led.by.an.elected.board.of.directors.

All.activities.of.CBMTG.are.open.to.both.members.and.non-members..CBMTG.provides.members.with.access.to. several. educational. opportunities. including. the.annual. conference,.an.annual.webinar.programme,.and. symposia. focused. on. timely. topics. of. interest..The.organization.has.developed.several.initiatives.to.support.blood.and.marrow.transplant.research.across.Canada.including.the.clinical.trials.network,.the.small.budget.research.grants,.and.the.national.Registry.

MISSION

The. Canadian. Blood. and. Marrow. Transplant.Group. is. the. voice. of. experts. working. in. the.field.of.blood.and.marrow.transplant.

VISION

Canada.will.be. the.best.place. in. the.world. to.have.a.blood.and.marrow.transplant.

VALUES

Excellence,.innovation,.integrity,.collaboration.and.professionalism.in.care,.education.and.research.in.blood.and.marrow.transplant.

PHILOSOPHY

CBMTG. believes. that. every. patient. has. a. right. of.equal. access. to. the. highest. quality. of. life. saving.care. that. can. be. provided. by. blood. and. marrow.transplant.professionals.in.Canada.

CBMTG BOARDCBMTG EXECUTIVE COMMITTEE:

President.(Chair.of.the.BOD.and.executive.committee),.Past.President,.President.Elect,.Treasurer,.Secretary,.and.Executive.Director.(ex-officio)

+

DIRECTOR OF RESEARCH AND DIRECTOR OF EDUCATION

CBMTG HEAD OFFICE

(Reports.to.BOD.via.the.President)

RESEARCH COMMITTEES

(Report.via..Dir..Research)

National.Registry.Steering.Committee

Clinical.Trials..Network

Small.Budget.Research.Grants.Committee

Symposia.Planning.Committee.

Laboratory.Special.Interest.Group

Pediatric.BMT.Subcommittee

Psycho-Social.Special.Interest.Group

Other

Webinar.Planning.Committee

National.Conference.Planning.Committee

EDUCATION COMMITTEES

(Report.via..Dir..Education)

SPECIAL INTEREST GROUPS

(Report.via..Secretary)

FOUNDATION COMMITTEE

(Comprised.Executive.and.two.patient.representatives.

Report.via.President)

ORGANIZATION CHART

5

PRESIDENT’S MESSAGEDear.CBMTG.Members,.

It.has.been.a.pleasure.to.serve.as.president.of.the.Canadian.Blood.and.Marrow.Transplant.Group.(CBMTG).over.the.last.year..

CBMTG.is.a.strong,.growing.association.that.exists.to.meet.the.needs.of.the.Canadian.BMT.field..Over.the.course.of.the.last.year,.my.goal.has.been.to.build.upon.the.successes.of.previous.boards.and.to.continue.to.advance.the.association..

I.was.pleased.that.we.successfully.obtained.charitable.status.for.the.organization..Thank.you.to.our.members.who.helped.this.happen.by.voting.at.our.special.general.meeting..This.was.a.real.grassroots.effort.and.we.could.not.have.done.it.without.you..

This.charitable.status.will.allow.us. to.grow.and.evolve. further..As.we.grow,.we.want. to.ensure. that. the.association.meets.your.needs..Therefore.we.are.holding.the.first.CBMTG.Town.Hall.in.conjunction.with.the.Montreal.conference..At.this.meeting.we.will.be.discussing.what.the.organization.will.look.like.in.the.future..What.is.clear,.however,.is.that.the.association.will.need.your.continued.participation.and.engagement.so.that.we.continue.to.advance..

Over.the.last.year.our.programmes.continued.to.grow!.Our.webinar.series,.now.free.to.members,.continues.to.present.very.high.quality.speakers.addressing.a.broad.range.of.topics.of.interest.to.members..Both.our.fall.GVHD.symposium.and.our.spring.conference.continue.to.bring.a.mix.of.core.education.and.the.latest.transplant.developments.to.our.members.in.a.convivial.atmosphere..Our.National.BMT.Registry.continues.to.move.towards.our.important.goal.of.having.participation.from.all.transplant.programmes.across.Canada..Kudos.to.Kristjan.Paulson.for.dedicating.himself.to.making.this.national.resource.a.reality!

On.a.final.note,.I.wish.to.thank.the.CBMTG.directors,.committee.chairs,.members.and.staff.who.are.dedicated.to.the.CBMTG.vision..I.encourage.all.members.to.use.their.strengths.and.find.a.way.to.contribute.to.CBMTG.initiatives..Everyone.is.welcome!

Cheers,.

Chris Bredeson, MD, MSc, FRCPC .President

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BOARD OF DIRECTORS AND HEAD OFFICE STAFF

BOARD OF DIRECTORS

HEAD OFFICE STAFF

Ana.Torres,.BA, MPb, Executive Director

Samantha.Wale, BA, Association Coordinator

Rahmath.Althaf,.BA, Administrative Assistant

President-Elect, Andrew.Daly,.MDCM, FRCPC

Past President, Silvy.Lachance,.MD, FRCPC, CSPQ

President, Christopher.Bredeson,.MD, MSc, FRCPC

Secretary, Jennifer.Wiernikowski,.MN, NP-Adult, CON(C)

Director-at-Large, ResearchDonna.Wall,MD

Director-at-Large, EducationNaheed.Alam,MD

Treasurer, Raewyn.Broady,.MBChB, FRACP, FRCPA, FRCPC

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MEMBERSHIP STATISTICS

Alberta 34 members 9%

British Colombia 38 members 11%

Manitoba 18 members 5%

New Brunswick 10 members 3%

Newfoundland 7 members 2%

Nova Scotia 10 members 3%

Ontario 127 members 36%

Quebec 75 members 21%

Saskatchewan 25 members 7%

International 11 members 3t%

2008

172

2009

154

2010

163

2011

162

2012

187

2013

249

2014

334

2015

335*

HISTORY*As of May 8, 2015

MEMBER T YPE

Member Types Number Percentage

Physician/PhD 167 47%

Nurses 54 15%

Laboratory Technologists 28 8%

Pharmacists 9 3%

Professor 3 1%

Research Scientist 4 1%

Data manager 4 1%

Other/Unknown 19 5%

In-Training 50 14%

Organization 17 5%

11%

11%

30%

22%

2%

3% 3%

4% International

5%8%

GEOGR APHIC DISTRIBUTION

47%

15%

14%

8%

1%1%

1% 3%

5%

5%

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STRATEGIC PLAN

To look at the complete Strategic Plan please visit www.cbmtg.org/stratplan

THE CBMTG VISION IS:

“Canada will be the best place in the world to

have a blood and marrow transplant.”

EDUCATION

Providing.high.quality.educational.programmes.that.advance.the.practice.of.blood.and.marrow.

transplantation.in.Canada.

RESEARCH

Establish.and.organize.an.effective.and.sustainable.research.infrastructure.for.translational.and.

clinical.research.

OUTREACH

Increase.the.visibility.and..influence.of.CBMTG.among.members.

and.the.public.

FINANCIAL CAPACITY

To.support,.education,.research.and.outreach.initiatives.through.fundraising,.partnerships.and.the..

establishment.of.a.charitable.organization.

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STRATEGIC ACHIEVEMENTS

EDUC ATION

•. Annual.Conference:.increased.attendance.and.abstract.submissions

•. Webinar.Programme:.now.free.to.members,.increased.number.of.sessions

•. GVHD.Symposium:.Now.under.the.leadership.of.Dr..Silvy.Lachance.continues.partnership.with.CBS.and.Hema-Quebec

RESEARCH

•. National.Registry:.Continued.traction.as.programmes.across.Canada.join..Data.on.16,416.patients

•. Clinical.Trials:.The.results.of.CBMTG.0801.lead.by.Dr..Irwin.Walker.were.reported.as.an.oral.presentation.at.ASH.2014

OUTREACH

•. Joint.scientific.sessions.at.our.spring.conference.with.CNTRP.and.ISCT

•. Partnership.with.ASBMT.and.ISCT.to. include.Canadian.trainee. in.the. inaugural.ASBMT/ISCT.Cellular.Therapy. Training. Course.. The. Canadian. Fellowship. supported. by. generous. educational. award. from.Otsuka.Canada.Pharmaceutical.Inc.

FINANCIAL C APACIT Y

•. Obtained.Charitable.Status

•. We.continued.to.increase.CBMTG.initiatives.and.investment.in.the.members.while.remaining.profitable.

.

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ASSOCIATION PROGRAMMES

WEBINAR PROGR AMME

Under. the. stewardship. of. Dr. Naheed. Alam,. Director. at. Large. Education,. our. webinar. programme. has.continued.to.grow.since.we.achieved.CME.accreditation..We.have.seen.hundreds.of.members.participate..Since.the.last.AGM,.here.is.a.list.of.webinar.presentations:.

. The.Role.of.Transplant.in.CML,.Dr..Jeffrey.Lipton,.MD, FRCPC, PhD

. Long-term.Complications.of.HCT,.Dr..Navneet.Majhail,.MD

. Psychosocial.Needs.of.Survivors.After.HCT,.Dr..Karen.Syrjala,.PhD

. Importance.of.CR.or.“BMT.CR”.Before.RIC.AlloHCT:.Basic.is.Still.Valid,.Dr..Celalettin.Ustun,.MD

. Cord.Blood.Transplant,.Donna.Wall,.MD

. Haplo.Transplant,.Irwin.Walker,.MD

. Advances.in.Progenitor.Cell.Mobilization:.Finding.the.Right.Fit,.Ronan.Foley,.MD, FRCPC

. CMV.Testing.of.Blood.and.Haploidentical.Transplantation,.Melanie.Tokessy,.MLT

The.following.webinars.are.planned.for.the.remainder.of.the.year:.

. NK.Cells.in.Cancer.and.Transplantation,.Jeffrey.Miller,.MD

. Fertility.Preservation.and.Restoration.for.Male.Cancer.Survivors,.Peter.Chan,.MD, CM, MSc, FRCS(C), FACS

. DLBCL.in.2015.–.What.is.the.Role.of.Transplantation?.John.Kuruvilla,.MD

. On.the.Origin.of.Relapse.in.AML,.John.Dick,.PhD

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NATIONAL REGISTRYWWW.CBMTGREGISTRY.COM

The. CBMTG. has. developed. a. comprehensive.outcomes. registry. containing. detailed. clinical.data.on.Canadians.undergoing.both.autologous.and. allogeneic. hematopoietic. cell. transplants.from.programmes.across.Canada..The.Registry.is.based. in.Winnipeg.and. is.under. the. leadership.of.Kristjan.Paulson..The.Registry.is.an.important.research.tool.for.CBMTG.members..Some.possible.benefits.of.having.country-wide.data:

1.. Transplant.activity.and.practices.across.Canada.can.facilitate.the.design.and.conduct.of.clinical.trials.by.CBMTG.member.centres.

2.. Transplant.outcomes.reflecting.Canadian.clinical.practice.

3.. Practice.patterns.and.outcomes.can.be.used.by.health.services.researchers.and.programmes.to.inform.policy.makers.and.payers.about.National.standards.of.practice.

The.majority.of.the.data.will.be.collected.through.our.partnership.with.CIBMTR..As.part.of.FACT.requirements.transplant.programmes. collect. Transplant. Essential.Data. (TED). as.defined.by. the.CIBMTR.. Through.data.sharing.agreements,.TED.forms.submitted. to. the.CIBMTR,.can.be. forwarded.to. the.CBMTG.for. inclusion.in.our.National.Registry..Canadian.programmes.can.also.submit.their.data.directly.to.the.CBMTG.Registry..Hopefully.be.this.time.next.year,.every.Canadian.Programme.will.be.contributing.their.data.to.our.National.Registry.and.involved.in.CBMTG.research.activities.

PARTICIPATING CENTRES

British.Columbia’s.Children’s.Hospital.University.of.British.Columbia,.Vancouver.BCAlberta.Children’s.Hospital,.Southern.Alberta.Children’s.Cancer.Programme,.Calgary.ABUniversity.of.Calgary.Tom.Baker.Cancer.Centre,.Calgary.ABCancerCare.Manitoba,.Winnipeg.MBHealth.Science.North,.Sudbury.ONHamilton.Health.Sciences,.Hamilton.ONPrincess.Margaret.Hospital,.Toronto.ONHopital.Maisonneuve-Rosemont,.Montreal.QCMontreal.Children’s.Hospital,.McGill.University.Health.Centre,.Montreal.QCCentre.Hospitalier.Universitaire.Sainte-Justine,.Montreal.QCCHA.Enfant.Jesus.Hospital,.Quebec.City.QCQE.II.Health.Sciences.Centre,.Dalhousie.Halifax.NSVancouver.General.Hospital,.Vancouver,.BCOttawa.Hospital,.Ottawa,.ON.(in.process)

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DATA SUMMARY

At.this.point,.there.is.data.available.on.16,416.patients,.dating.back.to.1990.

For.simple.clinical.questions.to.assist.in.patient.care,.a.simple.query.form.can.be.submitted.to.the.Registry..The.Registry.data.manager.will.provide.you.with.the.relevant.data.that.is.available..

NUMBER PERCENT

Transplant.Type

Allogeneic 7387 45

Autologous 8908 54.26

DLI 121 0.74

Gender

Male 9339 56.89

Female 6998 42.63

Graft.Type

Bone.Marrow 2897 19.16

Peripheral.blood 11838 78.29

Cord.blood 385 2.55

Transplant.Year

1990-2000 6726 40.97

2000-2005 4116 25.07

2006.- 5574 33.95

Age.Group

<18.years 3495 21.29

18-40 3883 23.65

40-60 6868 41.84

>60 2170 13.22

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TRANSPLANT INDICATIONS IN CBMTG REGISTRY*

DIAGNOSIS FREQUENCY PERCENT

AML 2676 16.3

ALL 1061 6.46

Other.Leukemia 367 2.24

CML 1025 6.24

MDS 813 4.95

Other.Acute.Leukemia 103 0.63

Non.Hodgkin.Lymphoma 3212 19.57

Hodgkin.Lymphoma 1126 6.86

Multiple.Myeloma 3940 24

Other.Malignancy 760 4.63

Breast.Cancer 562 3.42

Severe.Aplastic.Anemia 340 2.07

Red.Blood.Cell.Disorder 101 0.62

Immunodeficiency 139 0.85

Platelet.Disorder 3 0.02

Metabolic.Disorder 49 0.3

Histiocyte.Disorder 32 0.19

Autoimmune.Disease 16 0.1

Other 69 0.42

RESEARCH QUERIES

A.research.proposal.submitted.to.the.Registry.will.be.reviewed.by.the.Scientific.Director.and.Registry.data.manager.to.ensure.that.(a).the.request.is.feasible,.(b).the.data.requested.is.contained.within.the.Registry,.and.(c).the.project.will.not.require.an.excessive.amount.of.work.to.abstract.by.the.data.manager..As.noted.in.the.authorship.proposal,.if.more.than.20%.of.the.patients.in.the.data.series.are.from.one.centre,.then.the.proposal.will.be.sent.to.the.steering.committee.member.for.that.centre.for.comment.

For.more.a.more.detailed.report.please.connect.with.CBMTG.head.office.at.cbmtg@malachite-mgmt.com.

*Data.in.the.Registry.span.the.years.1990.to.2014..At.present.the.data.are.incomplete.and.do.not.represent.all.transplant.activity.during.this.time.period

14

GVHD S YMPOSIUM

.The.2014.GVHD.symposium.was.held.in.Montreal.in.the.fall.of.2014..Once.again.we.partnered.with.Canadian.Blood.Services.and.Hema.Quebec. to. put. on. an. exciting. scientific. programme.. Presentations.included:.

. A.TRANSPLANTER’S.PERSPECTIVE.ON.THE.MANAGEMENT.OF.PATIENTS.WITH.APLASTIC.ANEMIA.presented.by.Rainer.Storb,.MD

. FERTILITY.PRESERVATION.AND.RESTORATION.FOR.MALE.CANCER.SURVIVORS.presented.by..Peter.T..K..Chan,.MD, CM, MSc, FRCS(C), FACS

. ADENOVIRUSES.IN.THE.TRANSPLANT.PATIENT.presented.by.Christian.Renaud,.MD, MSc, FRCPC

. MINIMAL.RESIDUAL.DISEASE.TESTING.IN.ACUTE.LYMPHOBLASTIC.LEUKEMIA:.TECHNICAL.ASPECTS.AND.CLINICAL.IMPACT.presented.by.Jeffrey.Jorgensen,.MD, PhD

. EVALUATION.AND.TREATMENT.OF.MUCOCUTANEOUS.CHRONIC.GVHD.–.THE.ROLE.OF.PHOTOPHERESIS,.TOPICAL.IMMUNOSUPPRESSION.AND.SUPPORTIVE.CARE.presented.by..Mary.Flowers,.MD

. UNRELATED.DONOR.AND.CORD.BLOOD.UNIT.SELECTION.GUIDELINES.TO.OPTIMIZE.HEMATOPOIETIC.CELL.TRANSPLANTATION.OUTCOMES.presented.by.Stephen.Spellman,.MBS

. THE.BROADENING.APPLICABILITY.OF.ANTIGEN-SPECIFIC.T.CELL.THERAPIES.FOR.PATIENTS.POST.HSCT.presented.by.Catherine.Bollard,.MBChB, MD, FRACP, FRCPA

15

CONFERENCE SUMMARY

2015

The. Conference. planning. committee,. which. was. chaired. by. Dr.. Silvy.Lachance,.put.together.a.dynamic.scientific.programme..The.conference.includes. oral. and. poster. abstract. sessions,. lectures. and. debates.. As.well,.we.will.present.the.Till.and.McColough,.Fred.Saunders.and.Hans.Messner. Lectures.. Informal. networking. remains. a.major. draw.of. the.meeting.

Chair:.Silvy.Lachance,.MD, FRCPC, CSPQ

Committee.members:

Imran.Ahmad, MD Gizelle.Popradi, MD, FRCPC

Naheed.Alam,.MD Matthew.Seftel,.MD, MPH, MRCP, FRCPC

Stephen.Couban,.MD, FRCPC Pierre.Teira,.MD

Lisa.Martin,.MLT, CQE Marie-France.Vachon,.RN, MScN, CPON, CON(C), CHTC

2016

The.2016.conference.will.be.chaired.by.Dr..Raewyn.Broady. and. Dr.. Kirk. Schultz.. The. conference. is.scheduled.for.April.27.to.30,.2016.at.the.Westin.Bayshore,.Vancouver.BC..

2017

The.CBMTG.2017.conference.will.be.held.in.Ottawa.and. coincides. with. our. country’s. sesquicentennial.celebrations!. Please. keep. an. eye. out. for. an.announcement.with.details.later.this.year.

COMING SOON

16

AWARDS

DAVID SMYTH FELLOWSHIP

The.2014.David. Smyth. Fellowship.was. awarded. to:. Samantha.Mayo,. post-doctoral. fellow,.University. of.Toronto.for.her.research.titled.“Pilot.Study.to.Test.the.Feasibility.of.a.Brain.Fitness.Intervention.after.Stem.Cell.Transplantation”..The.CBMTG.David.Smyth.Fellowship.provides.funds.for.eligible.individuals.to.undertake.research.on.topics.that.will.have.a.relevance.to.blood.and.marrow.transplantation..The.primary.aim.of. the.grant.program. is. to.promote.pilot. and/or. feasibility. studies..Projects. that. require.augmented.funding.or.bridge.financing.may.also.be.considered..The.grant.is.offered.once.per.year.to.one.individual,.subject.to.approval.by.the.CBMTG.Board.

PATT Y BAKKESTAD-LEGARE AWARD

In.2014.the.awards.was.provided.to.two.indivudals--Nazir.Jamal.and.Carl.Simard..This.awards.is.provided.in.memory.of.Patty.Bakkestad-Legare.who.was.a.founding.member.of.the.Cellular.Therapy.Laboratory.of.the.Manitoba.Blood.and.Marrow.Transplant.Program..Patty’s.excellence.as.a.technologist,.teacher,.and.leader.was.reflective.of.her.dedication.to.quality,.and.to.her.own.scholarship..Patty.set.the.highest.of.standards.to. which. all. technologists. continue. to. aspire.. Patty. was. a. dedicated. member. of. the. CBMTG. Laboratory.Committee;.as.such.the. laboratory.community.will.always.be. indebted.to.her.contributions.. In.2013.the.Laboratory.committee.fundraised.$10,000.to.be.used.for.this.award..The.award.will.be.provided.when.funds.are.available..

CONFERENCE AWARDS:

At.the.2014.conference.the.following.awards.were.presented:.

. Best.Oral.2014.Award.Recipient:.Samantha.Mayo

. Best.Poster.2014.Award.Recipients:.Ronan.Foley,.Yayra.Amenudzie

17

ASSOCIATION SPONSORSCONFERENCE SPONSORS

We.wish.to.thank.the.sponsors.who.supported.our.annual.conference..

BRONZE SPONSORS

GOLD SPONSORS.

PLATINUM SPONSOR.

CONFERENCE SUPPORTERS

CONFERENCE EXHIBITORS

Alexion.Pharmaceuticals.•.Astellas.Pharma.Canada,.Inc..•.Biosafe.America,.Inc..•.Celgene,.Inc..•.Digi-Trax,.Inc...•.Fresenius.Kabi.Canada.Ltd..•.Hoffman-La.Roche.Ltd..•.Janssen,.Inc..•.Jazz.Pharmaceuticals.•.Lundbeck.Canada,.Inc..•.Merck.Canada.•.Miltenyi.Biotec,.Inc..•.Novartis.Pharmaceuticals.Canada,.Inc..•.OriGen.Biomedical,.Inc...•.Pfizer.Canada,.Inc..•.Sanofi.Canada.•.Seattle.Genetics,.Inc..•.Stemsoft.Software,.Inc..

SYMPOSIA SUPPORTERS

CONFERENCE CONTRIBUTORS

CONFERENCE APP SPONSOR

WIFI SPONSOR

18

ASSOCIATION SPONSORSGVHD S YMPOSIA

We.wish.to.thank.Sanofi.for.their.exclusive.sponsorship.of.the.GVHD.symposium.

NATIONAL REGISTRY SPONSORS

The.CBMTG.Registry.was.made.possible.from.founding.sponsorship.(via.unrestricted.educational.grants).from

In.2014.the.Registry.sponsor.was.Celgene. . In.2015.the.Registry.sponsor.is.Seattle.Genetics

.

. . .

. .

CORPOR ATE MEMBERS

CBMTG’s.corporate.members.are:

19

FINANCIAL STATEMENTSWe.are.presenting.the.audited.financial.statements.for.the.year.ending.2014..

We.are.pleased.to.inform.you.that.we.had.a.good.year!.We.had.net.revenues.of.$64,150.at.the.end.of.the.year..This.revenue.is.the.result.of.a.successful.annual.general.meeting..

This.has.allowed.us.to.re-invest.in.the.membership.by.providing:.

•. Free.webinars•. Additional.travel.grants.to.the.membership.for.our.conference..

Our.reserve.has.now.increased.to.$328,550..

20FINANCIAL STATEMENTS

21FINANCIAL STATEMENTS

22FINANCIAL STATEMENTS

23FINANCIAL STATEMENTS

24FINANCIAL STATEMENTS

25FINANCIAL STATEMENTS

26FINANCIAL STATEMENTS

27FINANCIAL STATEMENTS

28FINANCIAL STATEMENTS

29FINANCIAL STATEMENTS

30FINANCIAL STATEMENTS

MCGILL

NEWFOUNDLAND

SASKATOON

570.West.7th.Avenue,.Suite.400Vancouver,.BC,.Canada.V5Z.1B3

Phone:.(604).874-4944.Fax:.(604).874-4378

WWW.CBMTG.ORG