2013 faseb science research conferences advisory … biology of cilia and flagella.pdfreno/las...

Proposal #: 15-03

2013 FASEB SCIENCE RESEARCH CONFERENCES ADVISORY COMMITTEE MEETING

TOPIC FOR CONSIDERATION TOPIC NAME: THE BIOLOGY OF CILIA AND FLAGELLA PREVIOUS TITLE: The Biology of Cilia and Flagella SUBMITTED BY: Maureen M. Barr, Rutgers University Iain Drummond, Massachusetts General Hospital

Jagesh Shah, Harvard Medical School YEAR REQUESTED FOR

SCHEDULING: 2015

SITE REQUESTS: 1. Keystone, CO

2. University of Wisconsin Memorial Union, Madison, WI 3. Nassau, Bahamas

DATE REQUESTS: 1. July 12-17, 2015

2. July 19-25, 2015 3. August 9-14, 2015 4. August 16-21, 2015

YEAR(S) CONFERENCE

HAS BEEN HELD: 2007, 2010, 2013

NOTES: To the best of our knowledge, there is not a direct conflict with any other

FASEB SRC or other society or industry meeting.

Section 2: Conference Title & Organizer Information: Please insert the title of the Conference as you would like it to be advertised in future publications. List the organizing committee below and complete contact information and attach a brief CVs (maximum 3 pages) in NIH format for each. TITLE OF CONFERENCE: # of EXPECTED ATTENDEES: Preferred Primary Point of Contact for Proposal Questions: Name: Full Address: Telephone #: Email Address: Science Categories (select up to 3)

1) 2) 3) (see Attachment A - for marketing and audience generation purposes) Organizing Committee: Organizer Chair: __________________________ __Title: ____________________ Affiliation: ___________________________________________________________________ Full Address: ________________________________________________________________ ___________________________________________________________________________ Phone: _______________________ Email: ________________________________________ Organizer Co-Chair __________________________________Title: ____________________ Affiliation: ___________________________________________________________________ Full Address: ________________________________________________________________ ___________________________________________________________________________ Phone: _______________________ Email: ________________________________________ Committee member: __________________________________Title: ____________________ Affiliation: ___________________________________________________________________ Full Address: ________________________________________________________________ ___________________________________________________________________________ Phone: _______________________ Email: ________________________________________ Committee member: __________________________________Title: ____________________ Affiliation: ___________________________________________________________________ Full Address: ________________________________________________________________ ___________________________________________________________________________ Phone: _______________________ Email: ________________________________________

Committee member: __________________________________Title: ____________________ Affiliation: ___________________________________________________________________ Full Address: ________________________________________________________________ ___________________________________________________________________________ Phone: _______________________ Email: ________________________________________ Committee member: __________________________________Title: ____________________ Affiliation: ___________________________________________________________________ Full Address: ________________________________________________________________ ___________________________________________________________________________ Phone: _______________________ Email: ________________________________________

Section 3: Program Submission Requirements & Outline:

Please insert program details in day order as requested below. Session titles should be listed with session chairs and affiliations. Indicate the proposed tentative talk titles within each session and list up to at least 4 speakers per session (not including short talks selected from submitted abstracts). Please remember to also include the required “Meet the Expert” session. The FASEB SRC Advisory Committee requires all session chairs to be confirmed before the submission of the application. Be sure to indicate with a "C" if the session chair is confirmed, indicate with a “CS” if the speaker is confirmed, indicate with a "W" which session chairs and speakers are women, indicate with an "M" which session chairs and speakers are of a minority group and indicate with the word “NEW” which session chairs and speakers are new to the program. (Note: The committee defines new speakers as one that has NOT spoken at the last two (2) Conferences.) Overview of Program Flow # of Days: # of Sessions per day: # of Speaker per day: # of Session chairs per day: # of Breakouts per day: # of Abstracts per day: SUNDAY To include: Conference Registration 4 p.m. – 9 p.m., FASEB SRC Welcome Reception 5 p.m. – 6 p.m., Dinner 6 p.m. – 7 p.m. Title of Session: ______________________________________________________________ Session Chair & Affiliation:_____________________________________________________ Additional Session Titles (if applicable): Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________ Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________

Speaker 1: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 2: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 3: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 4: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Title of Session: ______________________________________________________________ Session Chair & Affiliation:_____________________________________________________ Speaker 1: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 2: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 3: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 4: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Number of short talks selected from abstracts: _____ MONDAY To include: Group photo during morning break Title of Session: ______________________________________________________________ Session Chair & Affiliation:_____________________________________________________ Additional Session Titles (if applicable): Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________ Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________

Speaker 1: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 2: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 3: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 4: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Title of Session: ______________________________________________________________ Session Chair & Affiliation:_____________________________________________________ Speaker 1: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 2: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 3: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 4: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Number of short talks selected from abstracts: _____ TUESDAY Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________ Additional Session Titles (if applicable): Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________ Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________ Speaker 1: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________

Speaker 2: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 3: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 4: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Title of Session: ______________________________________________________________ Session Chair & Affiliation:_____________________________________________________ Speaker 1: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 2: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 3: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 4: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Number of short talks selected from abstracts: _____ WEDNESDAY Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________ Additional Session Titles (if applicable): Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________ Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________ Speaker 1: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 2: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________

Speaker 3: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 4: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Title of Session: ______________________________________________________________ Session Chair & Affiliation:_____________________________________________________ Speaker 1: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 2: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 3: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 4: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Number of short talks selected from abstracts: _____ THURSDAY To include: Group activity 1 p.m. – 5 p.m. (optional) Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________ Additional Session Titles (if applicable): Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________ Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________ Speaker 1: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 2: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________

Speaker 3: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 4: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Title of Session: ______________________________________________________________ Session Chair & Affiliation:_____________________________________________________ Speaker 1: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 2: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 3: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 4: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Number of short talks selected from abstracts: _____ Possible Group Activity:________________________________________________________ FRIDAY Option 1: Half-day session, departures at 12 p.m. w/box lunch Option 2: Breakfast, departures at 9 a.m. Title of Session: ______________________________________________________________ Session Chair & Affiliation:_____________________________________________________ Additional Session Titles (if applicable): Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________ Title of Session: ______________________________________________________________ Session Chair & Affiliation:______________________________________________________ Speaker 1: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 2: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________

Speaker 3: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 4: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Title of Session: ______________________________________________________________ Session Chair & Affiliation:_____________________________________________________ Speaker 1: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 2: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 3: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Speaker 4: __________________________________________________________________ Affiliation: ___________________________________________________________________ Tentative Title of Talk: _________________________________________________________ Number of short talks selected from abstracts: _____

End of Conference

Section 4: Content Assessment: Please complete the grid below which will assist the FASEB SRC Advisory Committee in assessing the requirements of the proposal. Positive reviews are given to proposals with confirmation of session chairs and invited speakers, new speakers to the program, a good representation of women, and a sufficient number of short talks from junior level investigators. Indicate the number of session chairs that have confirmed their participation: Indicated the number of women included with the entire program: Indicate the number of session chairs/speakers of a minority group: Indicate the number of new speakers to the Conference: Indicate the number of speakers that have confirmed their participation in the Conference: Indicated the number of talks set aside for junior level investigators to present their work: Indicated the number of poster sessions that will be organized: Please provide a brief description of the how the poster sessions will be organized: Indicate (if known) if there is a potential of a conflict with any other FASEB SRC or any other society or industry meeting. If yes, please explain the conflict in detail.

Section 5: Scheduling & Location Preferences:

Select three (3) choices of dates that you wish to hold the Conference. Define the pattern flow, start date, and end date of your Conference Week 1: ___________________ Week 2: ___________________ Week 3: _______________ Select at least three (3) cities/venues for consideration. Venue #1 should be the most preferred. (Note: We will do our best to give you your first choice but it cannot be guaranteed). Please mark the type of facility you would like to host the program. Hotel Conference Center University, Academic Setting (summer only)

Cities/venues Preference 1 2 3 1 2 3 1 2 3

Big Sky, MT TRADITIONAL VENUES:

Chicago, IL Saxtons River, VT (University setting) Snowmass, CO Steamboat Springs, CO Nassau, Bahamas (passport required, government funding may be limited)

Keystone, CO NEW:

Liverpool, England (passport required, government funding may be limited) Palm Beach, FL Palm Springs, CA Reno/Las Vegas, NV Locations are contingent upon group interest. Every effort will be given to the Organizer’s choice of venue and date choice. Due to limited availability and scheduling site and date preferences are not guaranteed. For each conference year, a minimum of four (4) conference proposals should have interest in a potential venue in order for that venue to be used as a conference location.

Section 6: Justification:

The SRC Advisory Committee requires all proposals to include answers to the following nine (9) questions. In a separate Microsoft Word document, answer each individual question accordingly. Once completed, name the document the title of your Conference and attach this file to your email when submitting the final proposal. 1. Explain why this topic is of high current interest to the scientific community. 2. Is this a rapidly growing field? 3. Have there been previous Conferences of this topic? If so, where and when were the Conferences held? How many participants attended? (Additionally, consider whether or not another similar Conference /meeting is scheduled that might cause a conflict). 4. How many participants do you expect to attend the Conference? 5. What is the percentage of women have participated in this Conference in the past (if it has been previously held)? 6. How will you recruit young investigators to attend and participate in the Conference? 7. How will you recruit and select new speakers? 8. Who will attend the Conference? (Provide specifics).

9. Where will the Conference be advertised? What types of media will be used to advertise your Conference? (Provide specifics).

Section 7: Submitting Your Proposal: Please read the directions below for submitting your proposal. Feel free to contact the SRC Office should you have any questions or need guidance in submitting your proposal. Instructions for submitting your proposal: 1. Print or save a copy of this form for your own records. 2. Email Robin Crawford, CMP at [email protected]. 3. Enter the title of your Conference and the year of the conference in the subject line. 4. Attach the following items to your e-mail:

• The file with the answers to the nine questions in Section 6: Justification • CVs (in NIH Format) for all Organizers and Co-Organizers (maximum of 3 pages).

Thank you in advance for your proposal submission! We look forward to helping you plan a successful Conference.

For more information, please contact:

Marcella Jackson, Director, Office of Meetings and Conferences 301-634-7010, [email protected] Robin Crawford, Conference Manager, FASEB Science Research Conferences 301-634-7093, [email protected] Kristen Hagy, CMP, Conference Manager, FASEB Science Research Conferences 301-634-7094, [email protected] Trina Eacho, Conference Coordinator, FASEB Science Research Conferences 301-634-7206, [email protected] Clay Pencek, Administrative Assistant, FASEB Science Research Conferences 301-634-7018, [email protected]

mailto:[email protected]�






The Biology of Cilia and Flagella FASEB Application 2015

Maureen M. Barr, Ph.D. Organizer

Iain Drummond, Ph.D. and Jagesh Shah, Ph.D., Vice-Organizers

Section Four: Justification and Co-organizer affiliations 1 & 2) Topic is of High Current Interest in a Rapidly Growing Field: Cilia and flagella are of profound medical importance. The understanding of cilia and flagella has increased in depth and breadth as we learn more about these remarkable organelles and the extent to which they have been exploited during evolution to carry out multiple, seemingly unrelated tasks. The growing interest is reflected in the number of cilia-related publications and attendees at past FASEB meeting on the Biology of Cilia and Flagella. On some cells (e.g. sperm, respiratory and reproductive epithelium), the cilium/flagellum is an organelle of motility. On others (e.g. kidney tubule epithelial cells), the (non-motile) primary cilium functions as a mechanosensor. And, on yet others (e.g. olfactory epithelial cells, neuronal cells, mesenchymal cells), the primary cilium is a focal point for organizing receptor-ligand based signaling pathways including those that regulate the sense of satiety, wound repair, and embryonic development. Most recently, the cilium has been shown to be a secretory organelle, releasing ectosomes that are involved in extracellular communication. Hence, the cilium is both a sender and receiver of information. Importantly, the organelle is also a “keeper of the key” to cell division, because one of the centrioles in the centrosome is the base for assembly of the cilium; and, thus, the cilium must be resorbed during cell cycle entry to free the centriole for its role in mitosis. Only in the past decade have biologists come to understand that almost every mammalian cell possesses a primary cilium, and that the organelle plays broad and central roles in development and tissue homeostasis. The ciliary diseases or “ciliopathies,” include the most common life-threatening inherited disease of humans, polycystic kidney disease (PKD), in which ciliary malfunctions lead to cell over proliferation and destruction of the organ. Other ciliary diseases include retinitis pigmentosa, in which dysfunction in the rod and cone outer segments, which are modified cilia, cause photoreceptor cell degeneration and blindness. Also of great interest are a diverse group of inherited diseases that may include as many as a hundred different human syndromes; the best studied being Bardet-Biedl, Meckel Gruber, Joubert and Sensenbrenner syndromes. While the role of the cilium is now accepted in these syndromic diseases, the role of the cilium in the nervous system is just becoming appreciated and this will be a significant focus at the planned 2015 meeting. At the 2013 Conference, cutting-edge research provide a glimpse of technological advances in ciliary imaging, signal transduction manipulation, and structural biology, and this will be another emphasis in the 2015 meeting. It was the desire of the organizers of the 2007, 2010, and 2013 conferences to have a comprehensive meeting in which those doing research on the basic cell biology of cilia and flagella would meet with the workers concentrating on the role of these organelles in development and disease. Given the overwhelming interest in the 2013 meeting (sold out before the early-bird registration deadline), the organizers and cilia community opted for a biannual meeting. Given the success of the last meetings, the program we have developed for the 2015 conference continues and extends this theme. Leaders in research on disorders such as PKD, retinitis pigmentosa, structural birth defects, and neurological

disorders, will meet with others researching the biochemistry, structure and assembly of cilia and flagella. 3a) Previous conferences: 2007, held at Saxton’s River 180 participants 2010, held at Saxton’s River 139 participants 2013, held at Niagara Falls 245 participants 3b) Possibly conflicting meetings: To our knowledge, this meeting is not in direct conflict with other FASEB meetings or conferences on this topic. The closest conflict is the Gordon Conference on Cilia and Mucociliary Clearance. This conference focuses on motile cilia, the formation of the respiratory mucus layer and how interactions between the two lead to diseases like cystic fibrosis. The motile cilia component will have some overlap with our conference but the two meetings have quite different themes and tend to attract different participants. Additionally there is a Keystone meeting on Cilia, Development, and Human Disease (February 2014) and European Cilia Meeting (November 2014). Organizers for these meetings have discussed and agreed to stagger cilia-related meetings to avoid potential conflicts. Moreover, we know of no other conferences that cover the broad range of basic and clinical research topics that focus on cilia and flagella and that are the theme for this conference. 4) Number of participants expected: Based on the attendance at the 2013 meeting (245) and given the continued growing interest in cilia and flagella, we expect to have a similar number of participants and selected a site that can accommodate our numbers. 5) Percent of 2013 conference attendees that were women: 104 6) Methods for recruiting young investigators to attend and participate: Many young investigators were recruited to participate in the 2013 conference. A similar approach will be used for the 2015 conference. The organizers will contact the major labs working in the area to encourage the PIs and importantly, their students and postdocs to attend. The organizers also attend several meetings, such as American Society for Cell Biology (ASCB) annual meeting and Gordon Conferences that relate to cilia and will become aware of new discoveries and new investigators to recruit. Finally, between now and the conference, we will also pay close attention to the literature to identify and recruit new researchers who have made important discoveries in the field. 7) Methods for recruiting and selecting new speakers: Over 25% of the invited speakers are new to our application for the 2015 FASEB Conference Biology of Cilia and Flagella. The speakers in the preliminary program were chosen because they have active research programs and have made significant contributions to the field of ciliary biology. As this field is rapidly expanding and many new investigators are starting to work in the field, we reserved many slots for speakers that will be selected from the submitted abstracts and/or identified by the organizers from newly published work. Based on the continued rapid growth in this area, the enthusiastic responses from the session leaders, and our knowledge of the field, we are confident that we be able to attract many new clinical and basic scientists as speakers not yet on our list that are doing outstanding research. 8) Sources/resources to be used to solicit funds: Previous conferences received support from several sources including the PKD Foundation, Burroughs Wellcome, FEI/Philips, March of Dimes, the Porter Foundation, the PCD Foundation, NIH-NIDDK,

the Company of Biologists, Nikon, Amgen, and several others. We will solicit funds from these same organizations, and also approach the RP Foundation (retinal degeneration), the Cystic Fibrosis Foundation, and other non-profit and corporate sources that we feel will contribute. 9) Societies and disciplines to be attracted to attend the conference: Many of the participants at the previous conferences are members of the ASCB, and we expect them to return. In addition, we anticipate attracting members of the American Society for Nephrology, which hosts many of the PKD researchers, the Society for Developmental Biology, which attracts many of the researchers working the roles of cilia in development, and the Genetics Society of America (GSA), which attracts scientists studying ciliopathies in humans and genetic model systems. The many functions of cilia in many aspects of human disease (e.g. nervous system, kidney, obesity, vision) and its role in cellular signaling has attracted a diverse group of investigators from clinical genetics to basic cell and structural biology. 10) Media, location, and timing of advertising: We plan to advertise in Molecular Biology of the Cell (ASCB Journal), The Journal of Cell Biology, Current Biology (a CELL Press journal that publishes many papers on cilia and flagella, PKD and other cilia-related diseases), Nature, Nature Cell Biology, Developmental Cell and Cell. We will also advertise in the monthly newsletter of the ASCB and GSA. In addition, we will have the meeting listed on the websites of organizations supporting research into the origin of cilia-based diseases, including The PKD (Polycystic Kidney Disease) Foundation, the RP (Retinitis Pigmentosa) Foundation, the PCD (Primary Ciliary Dyskinesia) Foundation, and others. In addition, we will contact each of the NIH-sponsored PKD core centers and ask them to distribute the information to their members. Once our application is approved and we know the dates and location of the conference, we will send a “Save the date” email announcement to the previous attendees using a list of email addresses available from FASEB. Finally, we will seek additional guidance from the FASEB SRC office for the optimum manner and timing of advertising. Organizer:

Maureen M. Barr, Ph. D. Department of Genetics Rutgers University 145 Bevier Road, Room 324 Piscataway, NJ 08854 T: 732-445-1639 email: [email protected]

VCo-organizers: Iain Drummond, Ph.D. Massachusetts General Hospital, Nephrology 149 13th Street Charlestown, MA 02129 617-726-5647 [email protected] Jagesh Shah, Ph.D. Harvard Medical School

Department of Systems Biology 4 Blackfan Circle Harvard Institutes of Medicine, Room 564 Boston, MA 02115 (617) 525-5912 [email protected]

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors.

Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME Maureen M. Barr eRA COMMONS USER NAME mmbarr

POSITION TITLE Professor of Genetics

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) FIELD OF STUDY

Rutgers University, NJ B.A. 1990 Biology Columbia University, NY Ph.D. 1995 Genetics & Development California Institute of Technology postdoc 1995-2000 Neurogenetics

A. Personal Statement The PI has a long-standing commitment to develop and use simple animal models to study processes relevant to human health and disease, including autosomal dominant polycystic kidney disease (ADPKD), Nephronophthisis, and Meckel Gruber Syndrome. Since our initial discovery over one decade ago that the C. elegans ADPKD gene products, the polycystins, localize to and function in cilia, the mammalian polycystins were found on renal primary cilia and shown to act as a flow sensor in vitro, and many human cystic kidney disease genes were cloned that affect cilia. My laboratory pioneered the use of C. elegans as a system to dissect the molecular mechanisms underlying ciliary receptor trafficking. We have continued to drive the field forward by identifying genes required for polycystin ciliary localization and function, as well as modifiers of the C. elegans kidney disease mutant phenotypes. Most of these worm genes have mammalian counterparts. We plan on testing evolutionary conservation of function, and intend to extend our studies in the nematode to mammalian cells and mouse models to determine if new regulators of polycystin trafficking perform similar functions in mammals. The goal of our multidisciplinary approach is to provide deeper mechanistic insight to ciliary signaling and trafficking, which has important implications for human development, sensory biology, and disease. B. Positions and Honors. Positions and Employment 2000-2006 Assistant Professor, Pharmaceutical Sciences University of Wisconsin Madison 2006-2008 Associate Professor with tenure, Pharmaceutical Sciences University of Wisconsin 2007-2012 Associate Professor with tenure, Genetics Department, Rutgers University 2012-2013 Visiting Scientist (sabbatical), Princeton University 2012-present Professor with tenure, Genetics Department, Rutgers University Honors and Awards 1986-1990 Douglass College Scholar, Rutgers University 1990 Summa cum laude 1990-1993 NIH Genetics and Development Training Grant 1996-1999 Howard Hughes Medical Institute Research Fellow 2005-2006 Teacher of the Year, 3rd year Doctor of Pharmacy Program Professional Activities and Organizations -External Referee: NIH: Special Emphasis Panels and ad hoc reviewer 2001-present, CMBK study section, February 2004, October 2006; Ad hoc reviewer Biological Rhythms and Sleep (BRS) and Neuroendocrinology, Neuroimmunology and Behavior (NNB) study section, October 2008, February 2009; Shared Instrumentation S10 panel ZRG1 IMST-A(30); Ad hoc reviewer Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section (NCSD) October 2012; NSF: Ad hoc reviewer, 2003 - present; Alzheimers Association: Ad hoc reviewer, 2003; The Wellcome Trust: Ad hoc reviewer, 2005; Polycystic Kidney Disease Foundation 2006 – 2008; European Commission FP7 evaluations, 2009 -Reviewer for American Journal of Physiology, BBA-Molecular Cell Research, Biochemistry, BMC Biology, Cell Research, Current Biology, Current Topics in Developmental Biology, Developmental Biology, Developmental

Cell, Disease Models and Mechanisms, EMBO, Genetics, Human Molecular Genetics, Journal of the American Society of Nephrology, Journal of Cell Biology, Journal of Cell Science, Journal of Neurophysiology, Journal of Neuroscience, Molecular Biology of the Cell, Molecular and Cellular Neuroscience, Nature, Nature Genetics, Nature Protocols, PLoS Biology, PLoS Genetics, PLoS One, PNAS, Science, Traffic, Trends in Cell Biology, Trends in Neuroscience, Trends In Molecular Medicine -Meeting Organizer, International C. elegans Neuroscience Meeting, Madison, WI (2006, 2008) -Core Faculty, Summer Neurobiology Course Woods Hole Marine Biological Laboratory 2009; 2010 -Editorial Board, BMC Cell Biology 2009 – present -FASEB Meeting on Cilia and Flagella: Vice organizer (2013), Organizer (2015)

C. Selected peer-reviewed, corresponding publications (in chronological order). Barr, M.M. and Sternberg, P. (1999) A polycystic kidney-disease gene homologue required for male mating behaviour in Caenorhabditis elegans. Nature 401, 386-389. Qin, H., Rosenbaum, J.S., and Barr, M.M. (2001) An ARPKD gene homologue is involved in Intraflagellar transport in C. elegans ciliated sensory neurons. Current Biology,11, 457-461. Barr, M.M., DeModena, J., Braun, D.,Nguyen, C.Q,. Hall, D.H. and Sternberg, P. (2001) The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway, Current Biology 11, 1341-6. Hu, J. and Barr, M. M. (2005) The PLAT domain of LOV-1 interacts with ATP-2 to regulate polycystin signaling in C. elegans. Molecular Biology of the Cell 16, 458-469 Peden, E. M. and Barr, M.M. (2005) KLP-6 is a Kinesin Required for Polycystin Ciliary Localization and Male Mating Behavior in Caenorhabditis elegans. Current Biology 5, 394-404. Qin, H., Burdette, D., Bae, Y.K., Forscher, P., Barr, M.M., and Rosenbaum, J.L. 2005. Intraflagellar transport is required for the vectorial movement of TRPV channels in the ciliary membrane. Current Biology 15, 1695-9. (co-corresponding author with J.L.Rosenbaum) Hu, J., Bae, Y.K., Knobel, K.M. and Barr, M.M. (2006) Regulation of ciliary sensory receptors by opposing activities of casein kinase II and calcineurin, Molecular Biology of the Cell, 17, 2200-11. Bae, Y-K., Qin, H., Knobel, K.M., Hu, J., Rosenbaum, J.L. and Barr, M.M. (2006) General and cell type specific mechanisms target TRPP2/PKD-2 to cilia. Development 133, 3859-3870. Liu, T., Kim, K, Li, C., and Barr, M.M. (2007) Neuropeptide modulation of a sex-specific mechanosensory behavior in C. elegans. Journal of Neuroscience 27, 7174-82. Hu, J., Wittekind, S.G., and Barr, M.M. (2007) STAM and Hrs downregulate ciliary receptors and signaling in C. elegans. Molecular Biology of the Cell. 18(9):3277-89. Jauregui A.R., Nguyen, K.C., Hall, D.H., and Barr M.M. (2008) The C. elegans nephrocystins act as global modifiers of cilium structure. The Journal of Cell Biology. 180(5):973-88. Bae, Y.-K., Lyman-Gingerich, J., Barr, M.M., and Knobel, K.M. Identification of genes involved in the ciliary trafficking of C. elegans PKD-2. Invited research article. Developmental Dynamics. Aug;237(8):2021-9. Bae, Y.-K., Kim, E., L’Hernault, S.W., and Barr, M.M. (2009) The CIL-1 phosphoinositide 5-phosphatase regulates ciliary localization of the TRP polycystins and sperm function in C. elegans. Current Biology, Oct 13;19(19):1599-607. Epub 2009 Sep 24. Wang, J., Schwartz, H.T., and Barr, M.M. (2010) Functional specialization of Sensory Cilia by an RFX

transcription Factor Isoform. Genetics, 186(4):1295-307. Morsci, N. and Barr, M.M. (2011) Kinesin-3 KLP-6 regulates intraflagellar transport in male-specific cilia of

Caenorhabditis elegans. Current Biology 21:1239-44. Morsci NS, Haas LA, Barr MM. (2011) Sperm status regulates sexual attraction in C. elegans. Genetics

189:1341-6. O’Hagan, R., Piasecki, B., Silva, M., Phirke, P., Nguyen, K., Hall, D.H., Swoboda, P., and Barr, M.M. (2011) The Tubulin Deglutamylase CCPP-1 Regulates the Function and Stability of Sensory Cilia in C. elegans. Current Biology, Current Biology 21:1685-94. Warburton-Pitt S.R., Jauregui A.R., Li C., Wang J., Leroux M.R., and Barr M.M. (2012) Ciliogenesis in Caenorhabditis elegans requires genetic interactions between ciliary middle segment localized NPHP-2 (inversin) and transition-zone associated proteins. J Cell Sci 125(11): 2592-603. Barrios, A., Ghosh, R., Fang, C. Emmons, S.W. and Barr, M.M. (2012) PDF-1 neuropeptide signaling modulates a neural circuit for mate searching behavior in C. elegans. Nature Neuroscience 15(12): 1675- 82. Schroeder, N.E., Androwski, R.J., Rashid, A., Lee, H., Lee, J., and Barr, M.M. (2013) Dauer specific dendrite arborization in C. elegans is regulated by KPC-1/Furin. Current Biology 23: 1-9.

D. Research Support ACTIVE 1) Title: Polycystins and Cilia in C. elegans Principal Investigator: Maureen M. Barr, Ph.D. Agency: NIH/NIDDK Type: R01 DK59418 Period: 05/01/01-03/31/15 2) Title: A model for Nephronophthisis in C. elegans Principal Investigator: Maureen M. Barr, Ph.D. Agency: NIH/NIDDK Type: R01 DK074746 Period: 04/01/06 - 07/31/15 3) Title: The NNA-1 Carboxypeptidase and C. elegans Axon Regeneration fellowship to Robert O’Hagan Ph.D. (Mentor: Barr) NJ Commission on Spinal Cord Research Period: 09/01/2010-08/31/2013 4) Title: Stress-Induced Neuroplasticity in C. elegans: A New Paradigm to Study Neuronal Outgrowth Following Spinal Cord Injury fellowship to Nathan Schroeder Ph.D. (Mentor: Barr) NJ Commission on Spinal Cord Research Period: 06/01/12 – 05/30/14 Several undergraduate and graduate students in the Barr laboratory have received intramural fellowship awards.

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.


NAME Iain A. Drummond eRA COMMONS USER NAME IADRUMMOND

POSITION TITLE Associate Professor of Medicine and Genetics

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) FIELD OF STUDY

Union College, Schenectady, NY B.S. 1978 Biology

Universtiy of California at Berkeley Ph.D. 1986 Cell and Developmental Biology

A. Personal Statement My lab established the zebrafish as a relevant model of kidney development and human disease pathologies. We have taken advantage of zebrafish genetics and cell biology to understand the cellular mechanisms of kidney cell differentiation, cystic kidney disease, and cilia function. I have 19 years experience working with zebrafish and am expert in zebrafish mutant analysis. In addition, my graduate training in cell electrophysiology and calcium imaging provides an intellectual foundation for using in vivo fluorescent reporters of cell signaling. My post-doctoral training in gene regulation and DNA binding proteins will be brought to bear analyzing cis-regulatory elements in the foxj1a promoter that signal stretch sensitivity. My lab has collaborated with mammalian geneticists on several papers to identify mouse and human disease gene mutations by using functional assays we developed in zebrafish. Our forward genetic studies in zebrafish have lead to the cloning of novel genes that we show are mutated in human disease. We have also phenotyped several mouse mutants (jck/nek8 and PKD1) by immunostaining, in vivo functional assays, histology, and electron microscopy. My combined experience in mammalian and fish genetics and cell biology gives me a broad perspective on modeling organogenesis, cell signaling, and human disease pathology. B. Positions and Honors Positions and Employment 1987-1990 Postdoctoral Fellow, Laboratory of Dr. Rex Chisholm, Cell and Molecular Biology, Northwestern

University, Chicago, IL 1990-1992 Research Associate, Laboratory of Dr. Vikas P. Sukhatme, Howard Hughes Medical Institute,

University of Chicago. 1993-1995 Instructor, Harvard Medical School, Beth Israel Hospital, Boston, MA. 1995-1997 Assistant Biologist, MGH Renal Unit, Charlestown, MA. 1997- Associate Biologist, MGH Renal Unit, Charlestown, MA. 1997-2006 Assistant Professor, Department of Medicine, Harvard Medical School, Boston MA. 2006- Associate Professor, Department of Medicine, Harvard Medical School, Boston MA. 2007- Department of Genetics, Harvard Medical School, Boston MA. 2008- Developmental and Regenerative Biology program, Harvard Medical School, Boston MA.

Other Experience and Professional Memberships 1986 Mentor, Minority Access to Research Careers Program (NIH) 1989-1990 N.I.H. Post-doctoral Fellowship 1996 National Kidney Foundation. Young Investigator Grant Award American Society for Nephrology American Society for Cell Biology 2002- Editorial Board - American Journal of Physiology 2007- Editorial Board - Journal of the American Society for Nephrology

C. Selected Peer-reviewed Publications (Selected from 69 peer-reviewed publications)

Most relevant to the current application

1. Hellman, N. E., Liu, Y., Merkel, E., Austin, C., Le Corre, S., Beier, D. R., Sun, Z., Sharma, N., Yoder, B. K.,

Drummond, I.A., 2010. The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proc Natl Acad Sci U S A. 107:18499–18504.

2. Vasilyev, A., Liu, Y., Hellman, N., Pathak, N. and Drummond, I.A. 2012. Mechanical stretch and PI3K signaling link cell migration and proliferation to coordinate epithelial tubule morphogenesis in the zebrafish pronephros. PLOS One 7(7):e39992.

3. Panizzi, J.R., Becker-Heck, A., Castleman, V.H., Al-Mutairi, D.A., Liu, Y., Loges, N.T., Pathak, N., Austin-Tse, C., Sheridan, E., Schmidts, M., Olbrich, H., Werner, C., Haffner, K., Hellman, N., Chodhari, R., Gupta, A., Kramer-Zucker, A., Olale, F., Burdine, R.D., Schier, A.F., O'Callaghan, C., Chung, E.M., Reinhardt, R., Mitchison, H.M., King, S.M., Omran, H., Drummond, I.A., 2012. CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms. Nature genetics 44, 714-719.

4. Kramer-Zucker, A. G., Olale, F., Haycraft, C. J., Yoder, B. K., Schier, A. F., and Drummond, I. A. 2005. Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development 132:1907-1921.

5. Pathak, N., Obara, T., Mangos, S., Liu, Y., and Drummond, I.A. 2007. The Zebrafish fleer Gene Encodes an Essential Regulator of Cilia Tubulin Polyglutamylation. Mol Biol Cell 18:4353-4364.

6. Liu, Y., Pathak, N., Kramer-Zucker, A. and Drummond, I.A. 2007. Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros. Development, 134:1111-22.

Additional publications of importance to the field (in chronological order) 7. Drummond I.A., P. Rohwer-Nutter and Sukhatme V.P.. DNA recognition by splicing variants of the Wilms'

Tumor suppressor WT1. Mol. Cell Biol. 1994;14:3800-3809. 8. Drummond I.A., Majumdar A. Hentschel H., Elgar M., Solnica Krezel L., Schier A., Neuhauss S., Stemple

D., Zwartkruis F., Rangini Z., Driever W. and Fishman M.C.. Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development 1998; 125:4655-4667.

9. Liu S., W. Lu, T. Obara-Ishihara, S. Kuida, J. Lehoczky, K. Dewar, I.A. Drummond, D.R. Beier. 2002. A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development. Development 129: 5839-5846.

10. Serluca, F., I.A. Drummond, and M.C.Fishman. 2002 Endothelial signaling in kidney morphogenesis. A role for hemodynamic forces. Curr Biol. 12:492-7.

11. Sayer, J.A., E. A. Otto, J. F. O’Toole, G. Nurnberg, M. A. Kennedy, C. Becker, H. C. Hennies, J. Helou, M. Attanasio, B. V. Fausett, B. Utsch, H. Khanna, Y. Liu, I.Drummond, I. Kawakami, T. Kusakabe, M. Tsuda, L. Ma, H. Lee, R. G. Larson, S. J. Allen, C. J. Wilkinson, E. A. Nigg, C. Shou, C. Lillo, D. Williams, B. Hoppe, M. Kemper, T. Neuhaus, M. A. Parisi, I. A. Glass, M. Petry, A. Kispert, J. Gloy, A. Ganner, G. Walz, X. Zhu, D. Goldman, P. Nurnberg, A.Swaroop, M. R. Leroux, and F. Hildebrandt. 2006. A novel centrosomal protein, nephrocystin-6, is mutated in Joubert syndrome and activates transcription factor ATF4/CREB2. Nature Genetics, 2006. 38:674-81.

12. Insinna, C., Pathak, N., Perkins, B., Drummond, I., and Besharse, J.C. 2008. The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development. Dev. Biol. 316:160-70.

13. Vasilyev, A., Liu, Y., Mudumana, S.P., Steve Mangos, S., Lam, P., Majumdar, A., Jinhua Zhao, J., Poon, K-L, Kondrychyn, I., Korzh, V., and Iain A. Drummond, I.A. 2009. Collective Cell Migration Drives Morphogenesis of the Kidney Nephron. PLoS Biology Jan 6;7(1):e9

14. Pathak N, Austin CA, Drummond I.A. 2011 Tubulin tyrosine ligase like genes TTLL3 and TTLL6 maintain zebrafish cilia structure and motility. J Biol Chem. 286(13):11685-95.

15. Rothschild, S.C., Francescatto, L., Drummond, I.A. & Tombes, R.M. CaMK-II is a PKD2 target that promotes pronephric kidney development and stabilizes cilia. Development 138, 3387-97. 2011.

D. Research Support. Active Research Support: 1 R01 DK053093 (Drummond) 5/1/07-4/30/12 (no cost extension) NIH/NIDDK Genetic analysis of Zebrafish Kidney Development The Aims of the competing renewal are: 1) generate new transgenic tools to phenotype cilia defects and calcium signaling in zebrafish 2) conduct a systematic analysis of novel cilia proteome genes by morpholino knockdown in zebrafish and 3) positionally clone the schmalhans gene, a novel gene associated with cilia motility and a candidate gene for human primary ciliary dyskinesia. 1 R01 DK070263 (Drummond) 5/1/10-4/30/15 NIH/NIDDK Polycystin2 function in Kidney Development The Aims of the project are: 1) to conduct an in vivo functional analysis of the polycystin2 gene in zebrafish, 2) to measure calcium responses in zebrafish lacking a functional polycystin2 gene, and 3) to screen for modifiers of polycystin2 loss of function 1 R01 DK071041 (Drummond) 7/1/05-9/30/16 NIH/NIDDK The function of osr1 in nephrogenesis The Aims of the project are to examine the role of the zebrafish odd-skipped-related gene in mesodermal development. The role of osr1 in interpreting the bmp2b gradient will be assessed and the function of osr1 as a regulator of eve1 will be determined. Downstream targets of osr1 transcriptional activity will also be determined. (Awarded 6/1/2012 PI: Drummond) 6/1/2012-5/31/2013 Harvard Stem Cell Institute Zebrafish adult kidney stem cells The goals of this proposal are to generate new zebrafish transgenic lines using the fzd9b gene promoter in order to test the developmental potential and origins of adult kidney stem cells. Completed Research Support: PKD Foundation 2/1/09 - 1/31/10 Polycystin regulation of ER/Golgi calcium and its role in matrix assembly and secretion The aims of the project are to assess the role of ER calcium concentration in collagen processing and secretion defects in Polycystin-deficient embryos. The aims are to measure ER calcium, test whether increasing ER free calcium can rescue pkd morphant axis defects, and test whether ER stress and the unfolded protein response contributes to PKD pathology. DP-0097-11-00 (PI: Drummond) 5/1/11-4/30/12 Harvard Stem Cell Institute The role of wnt signaling in kidney tubule regeneration The objective of our work is to restore differentiation of kidney proximal tubules after injury and promote nephron regeneration by manipulating negative regulators of wnt signaling. This project will test whether activation of Wnt signaling in uninjured kidneys can mimic early responses to injury and whether blocking wnt signaling affects kidney regenerative responses.

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.


NAME Jagesh V. Shah

POSITION TITLE Associate Professor of Systems Biology (Harvard Medical School), Medicine (Brigham and Women’s Hospital) and Health Sciences and Technology

eRA COMMONS USER NAME (credential, e.g., agency login) jagsha EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION DEGREE (if applicable) MM/YY FIELD OF STUDY

University of Waterloo, Waterloo, Ontario, CANADA B. A. Sc. 1987-1992 Computer Engineering Massachusetts Institute of Technology, Cambridge, MA S. M. 1992-1994 Electrical Engineering Massachusetts Institute of Technology, Cambridge, MA Ph. D. 1994-1999 Medical Engineering Harvard Medical School, Boston, MA 1999 Biophysics University of California at San Diego, La Jolla, CA 1999-2005 Molecular Cell Biology

A. Personal Statement. My laboratory focuses on how cells make measurements. That is, how do cells quantitatively assess their external and internal environment and use this information to make decisions. One important goal of this research is to understand, from a systems level, how signaling architecture and protein interactions provide the basis for noise rejection and signal amplification – central elements to a measurement apparatus. We focus on three key cell biological processes: 1) the Spindle assembly checkpoint, 2) Cilium length regulation and 3) Gradient sensing in leukocytes. In each case we are using quantitative microscopy-based tools and microtechnology platforms to control cellular inputs and measure cellular response. These quantitative input-output assessments are used to generate computation models, both mechanistic and phenomenological, to dissect the logic of each cellular measurement apparatus. My own career path has been truly interdisciplinary weaving together training in the physical and biological sciences to study dynamical cellular processes. My own laboratory and teaching experiences have focused on how to integrate technological innovations, quantitative reasoning and computational modeling into modern biomedical research. Investigation in my own laboratory has provided an important template for success at this interface. Moreover, I have and will continue to pursue the development of didactic and practical programs and support for faculty opportunities that encourages a culture of interdisciplinarity at Harvard Medical School and our research hospitals. B. Positions and Honors. Positions and Employment: 1990-1992 Software Engineer, ComnetiX Corporation, Mississauga, ON, CANADA 1992-1994 Research Assistant, Biomedical Engineering Centre, Massachusetts Institute of Technology,

Cambridge, MA 1995-1999 Research Assistant, Division of Haematology, Brigham and Women’s Hospital, Boston, MA 1999 Clinical Preceptorship, BIOGEN Inc. Cambridge, MA and Brigham and Women’s Hospital,

Boston, MA 1999 Visiting Scientist, Institut Curie, Paris, France 1999-2005 Postdoctoral Fellow, Ludwig Institute for Cancer Research and Howard Hughes Medical

Institute, University of California at San Diego, La Jolla, CA 2005-2012 Assistant Professor. Department of Systems Biology, Harvard Medical School and

Medicine/Renal Division, Brigham and Women’s Hospital, Harvard-MIT Division of Health Sciences and Technology, Boston MA

2012-present Associate Professor, Department of Systems Biology, Harvard Medical School and Medicine/Renal Division, Brigham and Women’s Hospital, Harvard-MIT Division of Health Sciences and Technology, Boston MA

Other Experience and Professional Memberships: 1989-present Institute for Electrical and Electronic Engineers 1998-present American Society for Cell Biology 1998-present American Chemical Society 2008-present American Society of Nephrology Reviewer: Journal of Cell Biology, Molecular Biology of the Cell, Traffic, Molecular and Cellular Biology, Cell

and Tissue Research, Biophysical Journal, PLOS One, PLOS Biology, Current Biology, Proceedings of National Academy of Sciences, Tissue Engineering, Nature Genetics, Journal of Clinical Investigation, Journal of the Americal Society of Nephrology

Editorial Board: WILEY Wires Systems Biology, Current Synthetic and Systems Biology Honors and Fellowships: 1992-1996 Natural Sciences and Engineering Research Council 1967 (NSERC ‘67) Scholarship 1992-1994 Medical Engineering Fellowship, Harvard-MIT Division of Health Sciences and Technology 1998-1999 Biomedical Engineering Discovery Fund Fellowship 2003-2004 NIH Neurobiology Training Grant 2007-2009 Beckman Laser Institute Young Faculty Fellowship 2007 One of the Bachrach Massachusetts Biotech Leaders C. Peer-reviewed publications (from 44 peer-reviewed publications) Shah JV, Flanagan LA, Janmey PA, Leterrier JF 1999. Bidirectional motion of neurofilaments along microtubules mediated in part by the dynein/dynactin complex. Molecular Biology of the Cell. 11:3495-3508. Shah JV and Cleveland DW 2000. Waiting for anaphase: Mad2 and the spindle assembly checkpoint, Cell 103:997-1000. Shah JV, Botvinick E, Bonday ZB, Furnari F, Berns MW, Cleveland DW 2004. Dynamics of centromere and kinetochore proteins: implications for checkpoint signaling and silencing. Current Biology. 14:942-952. Wang Z*, Shah JV*, Berns MW, Cleveland DW 2006. Cdc20 complexes monitored throughout the cell cycle via fluorescence correlation spectroscopy. Biophysical Journal. 91:343-51. (co-first authorship) Botvinick EL and Shah JV 2007. Laser-based fluorescence measurements in living cells. In: Berns M. W. and Greulich. K. O. editors. Laser Scissors, Laser Capture, and Related Technologies. New York, Academic Press pp. 81-109 (Methods in Cell Biology vol. 82.) Ciliberto A and Shah JV 2009. A quantitative systems view of the spindle assembly checkpoint. EMBO Journal. 28:2162-2173. Besschetnova TY, Roy B, Shah JV 2009. Imaging intraflagellar transport in mammalian primary cilia. Methods in Cell Biology. 93:331-46. Albrecht DR, Underhill GH, Resnikoff J, Mendelson A, Bhatia SN, Shah JV 2010. Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics. Integrative Biology. 2:278-87. Besschetnova TY, Kolpakova-Hart E, Zhou J, Olsen BR, Shah JV 2010. Adaptation of cilium-mediated mechanotransductive signaling by regulation of cilium length. Current Biology. 20:182-187. Kops GJPL, van der Voet M, Manak MS, van Osch MHJ, Naini, SM, Brear A, McLeod IX, Hentschel DM, Yates III, JR, van den Heuvel S, Shah JV 2010. APC16 is a novel, conserved subunit of the Anaphase Promoting Complex/Cyclosome. Journal of Cell Science. 123:1623-33. Yang L, Tatiana Y. Besschetnova TY, Brooks CR, Shah JV, Bonventre JV 2010. Epithelial Cell Cycle Arrest in G2/M Mediates Kidney Fibrosis after Injury. Nature Medicine. 16:535-43. Zhang J, Wu M, Wang, S, Shah JV, Wilson PD, Zhou J. 2010. Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity. Human Molecular Genetics. 10:3306-19. Baker NM, Zeitlin SG, Shi LZ, Shah JV*, Berns MW* 2010. Chromosome tips damaged in anaphase inhibit

cytokinesis. PLOS One. 5:e12398. (*co-corresponding authors) Shah JV 2010. Cells in tight spaces: the role of cell shape in cell function. Journal of Cell Biology.191(2):233-6. Hagan R, Manak MS, Meraldi P, Kirkeby Buch H, Shah JV* and Sorger PK* 2011. p31comet acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment. Molecular Biology of the Cell. 22:4236-46. (*co-corresponding authors) Saunders, TE, Pan KZ, Angel A, Guan Y, Shah JV, Howard M and Chang F 2012. Noise Reduction in the Intracellular Pom1p Gradient by a Dynamic Clustering Mechanism. Developmental Cell. 22:558-72. Czarnecki PG and Shah JV 2012. The ciliary transition zone: from morphology and molecules to medicine. Trends in Cell Biology. 24:201-10. Kops GJPL and Shah JV 2012. Connecting up and Clearing out: How kinetochore attachment silences the spindle assembly checkpoint. Chromosoma. 121:509-25. Manning DK, Sergeev M, van Heesbeen RG, Wong MD, Oh JH, Liu Y, Henkelman RM, Drummond I, Shah JV, and Beier DR 2013. Loss of the Ciliary Kinase Nek8 Causes Left-Right Asymmetry Defects. Journal of the American Society of Nephrology. 24:100–112. Galglia G, Guan Y, Shah JV*, Lahav, G* 2013. Activation and control of p53 tetramerization in individual living cells. Proceedings of the National Academy of Sciences. (in press) (*co-corresponding authors)

Year Name Affiliation

2007 Joel Rosenbaum Yale UniversityRomano Dallai Univ. of SienaGeorge Witman Univ. of Massachusetts Medical School

2010 William J. Snell Univ. of Texas SW Medical CenterBradly K. Yoder UAB Medical SchoolGreg Pazour Univ. Mass. Medical School

2013 Greg Pazour Univeristy of Massachusetts Medical SchoolBradley Yoder UAB Medical SchoolMaureen Barr Rutgers University

Biology of Cilia and FlagellaPast Conference Organizers

Year# of

Applicants# of

Participants Commercial Non-

Commercial Government Total Raised2007 184 180 11,650.00$ 34,200.00$ 6,500.00$ 52,350.00$ 2010 182 181 9,901.70$ 21,000.00$ 11,750.00$ 42,651.70$ 2013 294 243 22,683.50$ 7,500.00$ 30,183.50$

ATTENDANCE FUNDING

Biology of Cilia and FlagellaComparison of Previous Conferences

Course Evaluation 2013 Science Research Conferences

Biology of Cilia & Flagellapresented 6/23/2013103 forms submitted

Print

Forms

Section 1 - Scientific Content

General Sessions

The most important areas of current active research were adequately discussed. 4.6

There was a sufficient amount of unpublished research presented. 4.1

The conference helped you generate new ideas for research. 4.3

There was adequate time provided for invited presentations and short talks selected from submitted abstracts. 4.5

The discussion periods were utilized effectively. 4.4

Poster Sessions

The time allocated for poster sessions was effective. 4.3

I am satisfied with the contribution of the poster sessions to the conference. 4.3

Scientific Content - Overall

Overall, I am satisfied with the scientific content. 4.5

What kinds of sessions would you like to see included at future conferences?

More focus on signaling pathways

Maybe nice to have a panel discussion of controversial topic, like ciliary pore size for diffusion, and requirement of cilia for nodal left-right symmetry decision.

Maybe a table session to network and find post-doctoral opportunities.

Perhaps keep only 2 poster sessions, opposed to the 4.

Infectious pathogens (giardia, trichimonas, trypanosomes, etc). Expanding field of ciliary usage.

Have sections better organized. See comments below, but for example, very few of the BBSome talks were anything about BBSome.

Focus on ciliogenesis but beyond just the IFT contribution and modes of ciliogenesis in different cell types.

it wasn't really a conference covering all aspects of "biology of cilia and flagella", more like "ciliogenesis, signaling and ciliary diseases"

cancer and cilia maybe?

Key note talk for each session, giving an overview of the session.

More signaling, more in vivo studies.

SIngle poster session would have been preferable.

more fast talks from poster abstracts e.g. 5 mins talks

There was very little focus on motile cilia or diseases of motile ciliary dysfunction in the general sessions. Most of the focus was on primary cilia. It would be nice to see alittle more balance.

I think they covered all appropriate areas for a current cilia meetings.

I think that the poster sessions were the correct length, however, because the meeting was so jam-packed with sessions people were too exhausted to spend a significantamount of time at the poster sessions. I would get rid of all of the 1-3pm afternoon sessions. This gives people a little breather and promotes more time to discussscience socially.

I would hope for more free time to mingle and have discussions with others of the scientific community.

More topics about flagella (including sperm flagella).

Longer Session about motile cilia and flagella

more on biophysics of flagellum beat and role of molecular motors

More participation from centrosome people would be desirable given the thematic overlap and the current lack of interaction between the centrosome and cilia communities.

Biology of Cilia & Flagella http://www.planion.com/Planion.Evals/ZZHWPBUU4Z?ACCOUNT=...

1 of 5 10/25/2013 4:07 PM

The lecture time is too long every day. Attendee feels a little too tired after the 12 hours listening.

I think the sessions had a nice breadth. Due to some cancellations, a few talks seemed out of place in their specific sessions.

Maybe a session devoted to left-right asymmetry, as there was a very interesting discussion at the meeting.

Ciliary cargo trafficking

More time for poster sessions

more of flagella research, instead of mainly cilia focused

Section 2 - Management

Program Management & Organization

How satisfied were you with the coordination and organization of the scientific program? 4.4

How satisfied were you the representation of international scientists in this field participating? 4.6

How satisfied were you with the conference materials provided? 4.1

Did you feel the length of conference sessions were too long, just about right, or too short? 2.3

(3=Too long; 2= Just about right; 1=Too short)

Logistics Management & Organization

How satisfied were you with the registration and abstract submission process? 4.2

How satisfied were you with the information found on the FASEB SRC website and from emails sent by the FASEB SRC Office? 4.0

Overall Management & Organization

The conference was well organized. 4.5

Conference onsite staff member was helpful and courteous. 4.6

Overall, I was satisfied with the conference facilities. 3.8

Where would you like to see future SRCs take place?

Anywhere BUT Niagara Falls. This place is the worst city I have been to in my 17 years in the US. What a terrible dump. The depressing environment made for much fewerinteractions that during the last editions of this meeting at Saxton River.FASEB needs to stop using this site.

Vermont or Oregon, not Niagara Falls!

Baltimore

Different facility. The food offered by this conference facility was not very good.

Denver, ColoradoPhoenix, ArizonaSeattle, WashingtonHonolulu, Hawaii

Vermont

1. Gleneden Beach, OR, 2. Barga, Lucca, Italy

Mid-atlantic region

Hawaii or the Mediterranean.

Not at Niagara Falls. Near international airport where weather conditions will not usually/likely be an issue.

Niagara Falls, Canada, Vancouver, Canada

West or midwest

NOT at this hotel again! Any other place is fine

New York City

Vermont

in a bigger city

Vermont

Bahamas

Not Niagara falls

Closer to an international airport with direct flights from europe

San Francisco

Oregon


2 of 5 10/25/2013 4:07 PM

Not in that place again.

No good reason to go to Niagara Falls, well known to be in a state of dis-repair. There are plenty of good meeting places in the mid-Atlantic region.and even in HY State. let alone the midwest.

San diego, CA

Peado harbor

Arizona or Colorado

anywhere that does not use the Niagara Falls Days Inn.. it was creepy walking back alone after dark and the halls were super creepy. Sites that let us mingle more arebetter- Asilomar?

I would like to see more future SRCs take place around the West Coast of USA.

niagara falls

West coast.

At a location that is closer to a large international airport. The conference location was inconvenient because it was complicated and expensive to reach for internationalparticipants.

The city is not important, it would only be helpful to be in a city near an international airport.

Destinations closer to international airports that are easy to access from Canada overseas. Venues that are better able to accommodate the large number of attendees wehave so that people aren't bumped to poor-quality hotels.

Not in Niagara Falls

a place that would be a bit easier to reach for oversea participants

Anywhere but Niagara Falls. Europe would be more convenient for me, but not I suspect for others.

Niagara Falls had a lot of distractions as a scientific venue

vermont

Somewhere in California

It would be nice if the conference were closer to an airport or if coordinated shuttle transportation was arranged.

Not at Niagara Falls Sheraton.

Hong Kong, China

An affordable place for students and postdocs

close to an international airport - as this would facilitate the travel for people from abroad (and the travel costs would decrease as well!)

Not Niagara Falls

Big Sky, MT

Lucca, Italy

NY/NJ/CT tristate area

U.S. east cost or west coast.

not in niagara falls NY

Which months are more convenient for you to attend a conference?

June - August: 68 (75.6%)

March - May: 17 (18.9%)September - November: 3 (3.3%)

December - February: 2 (2.2%)

Overall, how would you rate the FASEB SRC Staffs' professionalism and responsiveness to your questions and concerns? 4.6

Comments:

There were mold/mildew issues in the ballroom (venue for talks) of the Sheraton Niagara that were probably related to the adjacent pool or other water problems. This wasan unfortunate distraction from an otherwise excellent conference.

There two main projection screens which made speakers wonder which one to use for laser pointing. There were also occasions when remote slide controller took a longtime to respond, creating down time for presentation.

Taylor was great with letting us know what was going on during the day and any changes that took place.

There was no index in the abstract book, very difficult to search for people and abstracts.

The on-line registration process was aweful. After downloading things like CV and abstract, I could not save it and then came back to proceed it. I had to re-do everything.Also, at the time when I made my first registration, the "inside-facility accomodation registration" was full, but "outside facility accomodation registration" was still open.There was no message showing up these information. It was after I contacted the registration office that I found out the above said fact. When I came back to re-doeverything, the "outside registration" then became full. It was very frastrating, but luckly, more spaces were provided so I could come to the conference.

Thanks go to those who found out more spaces, though!

Not sure how or why this site was chosen, and don't tell me it was because itwas at sea level (that's bs). The food was average at best. and the locale was s8b-average. It would have been nice to have one of the next organizers befrom Europe as many attendees were from Europe. Obviously. we were not asked.

None.

Apart from the inconventient location of the conference site due to the reasons mentioned above, it would be nice if food could be a bit more healthy (less cake, morefruit!). Otherwise all was perfect!

One think that I would really appreciate is to get the abstract book as a pdf or similar via email or download server before the conference starts. Since now it is possible to


3 of 5 10/25/2013 4:07 PM

use the laptop or tablet in the plane, one could already "have a look" on all abstracts since it is (at least for me) almost not possible to do this during the conference...

no direct experience with FASEM SRC staff

Abstracts/registration system got overwhelmed on the last day for early submission.

Not satisfied with the food.

The food service was the worst among all the FASEB or GRC meetings I have attended.

Please can we pay by purchase order in the future? That was a LOT of money to put on a personal credit card.

Section 3 - General Information

Approximately how many conferences of this type do you attend annually?

1-2 per year: 85 (85%)3-4 per year: 13 (13%)

5-6 per year: 0 (0%)More than 6 per year: 1 (1%)

Don't usually attend conferences: 1 (1%)

Do you plan to attend this conference again in 2 or 3 years?

Yes: 97 (96%)

No: 4 (4%)

Would you recommend this conference to others?

Yes: 95 (94.1%)

No: 1 (1%)

Not Sure: 4 (4%)

No response: 1 (1%)

How would you rate this conference compared to other conferencesof this type that you have attended? 4.3

How did you learn of this conference?

Co-Worker: 50 (49.5%)

By Invitation: 20 (19.8%)Internet: 17 (16.8%)

Other: 7 (6.9%)FASEB Mailings: 4 (4%)

FASEB Emails: 2 (2%)Experimental

Biology/Neuroscience/CellBiology:

1 (1%)

FASEB Journal: 0 (0%)

If other, please specify:

Told by theorganisers: 1 (25%) Recommendation

from my boss: 1 (25%)

Previousattendee

-organiseremailed.:

1 (25%)

Emails fromorganizers

of theprevious

relatedconference:

1 (25%)

Please indicate your age group:

20's: 21 (21.4%)

30's: 39 (39.8%)40's: 27 (27.6%)

50's: 7 (7.1%)

60's: 3 (3.1%)70's: 1 (1%)

In what ways could this conference be improved?

A more logically organized abstract book.

None.

Clearer organizational instructions. (Letting speakers know in advance that the split is 10+5, rather than the more traditional 12+3, would help them to better prepare thelength of their talks. Split for poster sessions presentation days was unclear until the day of.) A little bit of downtime each afternoon would be nice to encourage informalinteractions and prevent fatigue. 14 hours per day gets to be a bit much. It was easier to focus on days that had afternoon breaks, similar to structure of Gordon orKeystone meetings.

Please donâ€™t have biscuits and gravy as a breakfast option.

Please have an authentic vegetarian option available for all meal periods.

I think a location such as Vermont would have been more conducive to interactions.

I registered pretty early and was placed in an alternate hotel. The alternate was relatively poor in quality and I did not enjoy my time there. For the same price, I got lessthan what others received with their registration.

better food. a couple organized social (outings) events.

It would be very helpful to make solid links between the very basic cellular biology and the relevance to the larger picture of overall cell function, tissue function orphysiology. This was not well addressed in the scientific program and, considering the majority of funding comes from NIH, this is probably a very important point that weshould all be focusing on.

The time schedule was too strict for talks. I don't want talks going over, but the constant threat of being gonged was ridiculous.

The talks did not align to the sections. For example, very few of the BBSome section talks were anything about the BBSome. Two of them (Nachury, Lechtrek) were almostexclusively about IFT and nothing to do with BBSome. When asked about BBSome, Lechtrek joked about lack of funding so he abandoned project to work on IFT. Therewere plenty of other IFT talks, and while this was all good work, anyone with BBS interest was let a little down.

Food was less than average...

Better location, the conference room was licensed for 99 people, there were >200 attendees...what if there was an emergency?


4 of 5 10/25/2013 4:07 PM

The venue was not ideal. The meals were not good and vegetarian options were extremely limited: even the salads had meat. The area for meals was crowded and theoverflow hotel was not a pleasant place to stay.

Another organized social activity besides the cocktail hour on the first day.

Find a place where 300 people could be accomodated.

I would have preferred more free time to talk with colleagues, the two afternoons were not sufficient

Improve the food quality. It's a shame that I needed to go and eat smewhere else because the food was just chicken over and over again.

Since this conference was not very near an airport, it would be great if there were an organized system for transport to/from

A better location

Provide an electronic program, eg pdf

The location/ venue was notably poorer than I would have expected. I would prefer longer/ later afternoon sessions and nothing after the dinner, as an alternative layout.The evening sessions tend to be a bit less dynamic, discussion-wise, than those before dinner...

Niagara falls was not a very nice town, it would have been good to have somewhere to socialise after the sessions

One of the reasons this conf was so good is not only because good people werechosen to speak (there are only so many good labs) but because we waited 3 years for good work to build up around the world.

Management could be better. Free time could be scheduled for tour with tourguide to explore the city.

Better hotel with better food

Better food!

Improved orhanisation of the abstract book so the tites of the posters were summarised to allow you to find whrer posters where more easily - a key of what posternumber corresponds to what abstract without having to search the whole book.

-More focus on unpublished data. Compared to 3 years ago, too many speakers presented only published data.-4 days instead of 5 (finish Thursday night)

The meals and coffe break quality should improve

Please hold it in avenue that is willing to provide better food options. The meals were horrible, especially for me because I am a vegetarian.

Better food!! The meals were inedible.

1) the field is starting to be a bit clique-driven with the same invited speakers at all the meetings so they feel like re-runs, one solution which has been done at some GRCsis to suggest to the next organizers that the folks who were invited speakers at this meeting should not be invited speakers at the next one (Joel Rossenbaum may be anexception as the patriarch- plus he provided invaluable color commentary during the discussion), by stating the "no 2 in a row invite" policy explicitly folks still show- theirpostdocs and students can still be selected for talks and it mixes things up and keeps the science fresh. 2) a site that was more "inclusive", despite the meeting's relativesmall size, hard to network- the hot bar in the middle of Vermont was way better 3) a tad more free time would be useful

Perhaps more time could be given to active discussions.

More convenient location, slightly more healthy food, e.g. provide fresh fruit as alternative to cake as dessert after dinner and serve more whole grain products forbreakfast

Besides my comment in "overall management and organization" I think the conference is excellent!

-increase unpublished data presentations, more free afternoon

This conference can be held every two years. And a little less talks each time, especially at night. If the hotel is better that will make people feel more comfortable and theregistration fee can a little higher to pay for the hotel.

better food, social hour(s)

It would be great if there were additional funding opportunities for researchers from smaller institutions to attend. I thought that the length of the poster sessions was alittle brief, though I did appreciate the afternoon time period. Also, scheduling in "free time" (to network, see the surrounding area, view posters) was a great idea - pleaseinclude this in future conferences.

It seemed a bit long. Maybe cutting the 2 "free time" slots and moving the talks from Friday to those times would end the conference on Thursday night.

better food (sorry, usually I don't complain about food - but this time I have to)!

I know a lot of people will complain about the food, but my main issue was not having food labeled. Please require caterer to label food for those with dietary restrictions orfood allergies.

1) Better organization around themes/structures. For example, talks on transition zone were scattered throughout.2) Be more inclusive, large sections of the cilia community were not included or had scant representation(e.g., sperm flagella, ciliary motility).3) More time for poster sessions.4) One large screen in front of room instead of two screens on each side of room.5) Better food -- the food was an embarrasement compared to food at similar/competing GRC conference in Il Ciocco or other meetings I have recently been to in Europe.

a meeting venue which better allows participants to interact outside of the sessions

The conference program was too intensive especially for the posters. Not enough time to cover many posters that I had planned for.

With a website dedicated to the conference

location

There was an unfortunate situation concerning accommodation. If the hotel where the conference is being held gets full, the participants that no longer get a room thereshould be placed in equivalent hotels, not if hotels of much, much inferior quality such as Days In Niagara Falls which was dirty. Or should be made aware of that factbeforehand.


5 of 5 10/25/2013 4:07 PM

FINAL REPORT FASEB SCIENCE RESEARCH CONFERENCE, NIAGARA FALLS, NEW YORK

The Biology of Cilia and Flagella June 23-28, 2013

Organizers: Gregory Pazour Bradley Yoder Maureen Barr The 2013 meeting “Biology of Cilia and Flagella” was held at Sheraton at the Falls, Niagara Falls, NY from June 23rd to 28th, 2013. Cilia and flagella are organelles of profound medical importance. The ciliary diseases or “ciliopathies,” include the most common life-threatening inherited disease of humans, polycystic kidney disease (PKD), in which ciliary malfunctions lead to cell over proliferation and destruction of the organ. This meeting is unique in bringing together clinicians and basic scientists including leaders in research on disorders such as PKD, retinitis pigmentosa, and structural birth defects, and those studying the fundamental biochemistry, structure and assembly of cilia and flagella. Internationally renowned scientists from North America and around the globe chaired the sessions and spoke at the conference, which was attended by undergraduates, graduate students, postdoctoral fellows, as well as junior and senior scientists. In total, there were 43 invited speakers (including the organizers and Keynote speaker) and 199 other attendees at this meeting.

Our meeting began on Sunday evening with a one-hour keynote address by Wallace Marshall from the University of California at San Francisco entitled “How cells measure – the flagellar length control system”. During the next five days, we heard full-length (25’) talks (+ 5’ questions) from 43 invited speakers in nine formal sessions arranged by topic. 14 of the invited speakers were 11 of the 22 session chairs were women. 50% of the invited speakers had not presented at the previous two meetings. In planning of the sessions we deliberately left slots open for short talks to cover hot-off-the-press research, especially from junior scientists. Therefore 28 additional abstracts were selected for 12’ presentations (+3’ questions) in the nine formal sessions. In this group, 14 speakers were women and 6 were young investigators (within 3-5 years of establishing their labs). Overall, 40% of the final program was selected from submitted abstracts.

The 11 major sessions and keynote address covered the breadth of cilia/flagella biology. The formal sessions were entitled: (1) Function of cilia in kidney development and PKD, (2) CIliary signal transduction, (3) The obesity ciliopathies, (4) Centrioles and ciliation, (5) Ciliary and flagellar motility, (6) The transition zone: Gateway to the cilium, (7) Ciliary signaling 2, (8) Structural biology of the IFT particle, and (9) Cilia in heart development, Left-right signaling, and more, (10) Bardet Biedl Syndrome, and (11) The human ciliopathies. Most of the sessions were held in the morning and evening, with afternoons free for informal discussions and poster sessions.

Four 2-hour poster sessions were held in which 146 posters were displayed and presented. The poster sessions were extremely well attended and highly interactive (the room was filled to capacity). Several attendees report that collaborations were formed as a result of this group

dynamic. A bound volume containing the abstracts of speaker presentations and poster presentations arranged by abstract number facilitated viewing and discussions.

The intimate and informal meeting scenario allowed for one-on-one and group interactions that were high in quality and frequency. Graduate and postdoctoral scientists interacted with junior and senior faculty during breaks, poster sessions, and free time. In fact, several attendees requested “more free time to mingle and have others of the scientific community,” which will be implemented in the 2015 meeting. The enthusiasm for this meeting was reflected by attendance numbers (242) and conference sell out before the early bird deadline. Meeting evaluations were overwhelmingly positive about the scientific content and management. The primary complaint was poor convention site (Sheraton at Niagara Falls).

There were two free afternoons, which offered optional excursions around Niagara Falls, including “Maid of the Mist” boat tour. Meeting attendees also took advantage of the free time to explore the US and Canadian sides of Niagara Falls.

Funding to support this meeting was obtained from a number of sources, including the FASEB Summer Research Conferences, NIH/National Institute of Diabetes, Digestive, and Kidney Diseases, the PKD Foundation, Amgen, The Porter Endowment, Nikon Instruments, University of Alabama at Birmingham, Primary Cilia Dyskinesia Foundation, March of Dimes, Company of Biologists Ltd, and Cytoskeleton. Funds were used to defray the expenses of invited speakers, two undergraduates, and the projectionist.

We held the business meeting after Session 9 on Thursday. The group elected Dr. Iain Drummond and Dr. Jagesh Shah as co-organizers to replace Dr. Greg Pazour and Dr. Brad Yoder. Dr. Drummond (Massachusetts General Hospital) is a renowned leader in the kidney cell differentiation, cystic kidney disease, and cilia function, and has a broad perspective on gives me a broad perspective on modeling organogenesis, cell signaling, and human disease pathology. Dr. Shah (Harvard) is expert in systems biology, using a range of biochemical, microscopy and spectroscopy-based techniques to investigate protein function through complex formation, dynamics and localization in living cells. Maureen Barr will be the Lead Organizer for the 2015 meeting, followed by Drs. Drummond and Shah for the 2017 meeting, if the meeting continues that far into the future. There was unanimous support to hold this meeting again, followed by discussion of having it every three years as in the past (2007, 2010, 2013) or two years. Pros and cons were discussed, and in the end it was decided to shift to an every two-year cycle, given the high enthusiasm and rapid progress in the field. Sites were discussed, with unanimous vote against the Niagara Falls site. There was concern about conference facilities being able to accommodate the conference size (200-250), and non-North American site being infeasible, due to the state of NIH funding. Hence, we are requesting the site in North America that can accommodate 200-250 and is situated nearby an international airport - Keystone, CO. In summary, the co-organizers and participants (see evaluations) felt this meeting was a spectacular success. With the addition of Drs. Drummond and Shah, we are gearing up for another exciting meeting on this topic in 2015. Maureen M. Barr, Ph.D. Co-Organizer, 2013 Biology of Cilia and Flagella

2013 faseb science research conferences advisory … biology of cilia and flagella.pdfreno/las...

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