2013 2014 annual report...institute for breathing and sleep acn 093 685 879 address: institute for...

2013 – 2014 ANNUAL REPORT

INSTITUTE FOR BREATHING AND SLEEP

ACN 093 685 879

Address: Institute for Breathing and Sleep Bowen Centre Austin Health 145 Studley Road PO Box 5555 Heidelberg, Victoria, Australia 3084

Telephone: +61 (03) 9496 5390

Facsimile: +61 (03) 9496 5124

Website: www.ibas.org.au

Email: [email protected]

CONTENTS

1. EXECUTIVE SUMMARY ..................................................................................... 1

2. MISSION AND OBJECTIVES ............................................................................... 2

3. BOARD OF DIRECTORS ..................................................................................... 3

4. MEDICAL AND SCIENTIFIC RESEARCH COMMITTEE .......................................... 5

5. NEW PROJECTS ................................................................................................. 6

6. IBAS GRANTS .................................................................................................... 9

7. IBAS PUBLICATIONS ....................................................................................... 11

8. IBAS PRESENTATIONS ..................................................................................... 22

9. MEDIA AND AWARDS ..................................................................................... 32

10. IBAS PERSONNEL ............................................................................................ 34

11. FUNDING SOURCES ........................................................................................ 37

FINANCIAL REPORTS

DONATIONS

1. EXECUTIVE SUMMARY

This year has been one of change in IBAS, with two key people stepping down into what will probably be (for both) a not so “retiring” retirement. Kevin Ferguson FCPA has played a key role in IBAS since its inception and has steered the IBAS ship very firmly and well over the last 13 years since then. After years of loyal and incredibly “hands on” service, Kevin resigned from his position as IBAS Board Chair in April 2014, in order to concentrate on regaining his health – which, I am pleased to report ‐ has improved significantly since then. Fortunately Kevin remains an active Life Member of IBAS and we would like to thank him publicly for his remarkable drive and determination in overseeing IBAS’ development over the years since it was simply a “concept.” Kevin has supported the organisation, the Board and me personally over the years since IBAS’ inception in 2000. It has been a privilege to work with him.

We are most fortunate that Mr Bill Noonan OAM stepped into the role of Board Chair in April 2014 and feel confident that IBAS will continue to grow and flourish under his careful guidance.

Another IBAS stalwart, in the form of our Finance Manager, Bruce Abell, retired at the beginning of the 2014‐15 financial year. We are grateful for Bruce’s quiet, steady hand on the financial tiller over the last decade or so and wish him well in retirement. We are fortunate to have welcomed Rosalinda Polivka, former CFO of Ambulance Victoria as our new Finance Manager in June 2014. Rosalinda is rapidly becoming familiar with the issues and challenges associated with taking over the financial reins of an independent Medical Research Institute and we welcome her warmly.

On another personal note, one of our dearly loved IBAS Fellows (and former Director of the Respiratory Function laboratory here at Austin Health), Dr Jeff Pretto, sadly passed away suddenly from heart disease in early 2014. Several of the IBAS team attended his funeral in Newcastle. We honour his memory and continue to publish collaborative manuscripts that he has worked on. Vale Jeff!

In terms of research, IBAS researchers have had another productive year‐with evidence for this reflected in the full Annual Report accompanying this Summary. In later February 2014 IBAS hosted the annual Australasian Upper Airway Symposium which focuses on expanding understanding of the mechanisms underpinning the development of obstructive sleep apnoea with Dr O’Donoghue as Convenor.

A key educational activity was the Respiratory and Sleep Preceptorship for general practitioners, convened by Dr Christopher Worsnop. The RJ Pierce Prize for Best Respiratory or Sleep Poster at the Austin Research Week was won for the second year in a row by Justine Westlake. Dr Jeanette Tamplin was awarded one of the prestigious University of Melbourne Chancellor's Prizes for her doctoral thesis on the effect of group singing on respiratory function, voice, mood and quality of life for people with chronic quadriplegia. Dr David Berlowitz was successful in receiving an NHMRC Project Grant to complete the study entitled Continuous Positive Airway Pressure for Obstructive Sleep Apnoea in Quadriplegia: A Randomised Trial. This study is the final project of the large Victorian Neurotrauma Initiative‐funded suite of Sleep Health in Quadriplegia (SHiQ) studies which have involved over a hundred collaborators across Australia, New Zealand, Canada and the UK and have been a triumph of global co‐operation. The SHiQ program winds up in December this year, but the multi‐national study supported by the NHMRC grant will continue through 2016 until the full participant recruitment target is reached.

The Co‐operative Research Centre for Alertness, Safety and Productivity is ramping up with IBAS involved in three projects within the Healthcare Platform and two projects within the Sleep Disorders Phenotyping Platform. The first of the Healthcare Platform projects will be initiated at Austin Health, assessing the impact of shiftwork on intensive care unit staff.

The immediate future for IBAS looks bright but the medical research and health landscape is undergoing significant change and we must continue to build on our past successes with innovative strategies to ensure we thrive and grow. Initiating new and intensifying extant collaborations with national and international partners, the enhancement of strategic ties with other independent research institutes, and increasing our success in obtaining research funding from a range of government and other sources should assure IBAS’ continued growth in the medium and longer‐term.

Professor Christine McDonald

Chief Executive Officer

July 2014

2. MISSION AND OBJECTIVES

The mission of IBAS is: To promote, facilitate and co‐ordinate research,

education and public advocacy in respiratory and sleep health.

The objectives of the Institute are:

1. To promote and provide a focus for research and education in respiratory and sleep health. 2. To reduce morbidity and mortality and improve quality of life for persons with respiratory

and sleep disorders. 3. To promote occupational health, driver safety and clean air through respiratory and sleep

health programs. 4. To provide leadership and public education and advocacy in respiratory and sleep health. 5. To attract, co‐ordinate and manage funding programs for research and education in

respiratory and sleep health.

3. BOARD OF DIRECTORS

Mr Kevin David Ferguson, FCPA, (Chairman to 14 April 2014) Mr Ferguson is a Fellow of CPA Australia, having been admitted as a member in 1967. From 1978 to 2013 Mr Ferguson specialized in Litigation Support Reports, including Business Valuations, primarily for Family Law matters. Now semi‐retired he holds current Public Practice Certificate with CPA Australia and Tax Agents Registration to continue preparing financial accounts and tax returns. Mr Ferguson was Chairman of the IBAS Board of Directors since its inception in 2000 until April 2014. Mr Ferguson has been a Director of Mental Health First Aid International since August 2012. Other interests include being mentor for L2P Drivers and Parkville – Carlton Probus

Mr Bill Noonan, OAM (Chairman from 15 April 2014) Mr Noonan served as Branch Secretary of the Victorian/Tasmanian branch of the TWU from 1994 until his retirement from the Union in November 2009. He received an OAM in July 2006 for services to the Road Transport Industry particularly in respect to Road Safety and the Trade Union Movement. Mr Noonan is Chairman of the Victorian Police Blue Ribbon Foundation, and Vice Chairman of Western Melbourne Regional Development Australia Committee. In 2009, the Victorian Government appointed Mr Noonan as an Australia Day Ambassador. Mr Noonan was a founding Director of IBAS and was appointed Chairman and Secretary of the Board of Directors in April 2014.

Professor Christine McDonald, MBBS, FRACP, PhD, FCCP (CEO) Professor McDonald is the CEO of IBAS and the Director of Department of Respiratory and Sleep Medicine at Austin Health. Her special area of interest is chronic obstructive pulmonary disease (COPD) and its management, including respiratory outreach programs, pulmonary rehabilitation, smoking cessation, oxygen therapy and telehealth. Professor McDonald is also involved in collaborative research projects in the areas of lung cancer and interstitial lung disease.

Mr David Stanley, Grad Dip Adolescent Health Founding director and CEO of Convenience Group, an international public health agency, Mr Stanley has expertise in international, national, regional and community based health interventions that seek to change and/or sustain positive health behaviours in a range of contexts including sexual health, blood borne viruses, tobacco control, problem gambling, cancer prevention, and road safety. Mr Stanley is a member of the Australian Drug Law Reform Foundation. The founding Chairperson of the SEED Project (Sustainable Employment and Economic Development), and founding Director of COPE (Centre for Perinatal Excellence). David’s interests are public and population health based prevention, drug policy, leadership, politics, technology, cycling, boxing and sailing.

Dr Mark Howard, MBBS, FRACP, GDEB, PhD Dr Mark Howard is the Director of the Victorian Respiratory Support Service at Austin Health. He is a specialist physician in respiratory and sleep medicine with interests in long term ventilation of patients with respiratory failure and the impact of sleep disorders on driving. Mr Howard is a current board member for the Australasian Sleep Association and Theme Leader for the Co‐operative Research Centre for Alertness Safety and Productivity, in which IBAS is a partner

Dr Andrew Howard, MBBS, MBA Dr Andrew Howard is the Chief Information Officer at the Department of Health, Victoria. Previous roles include community and health ICT consultancy in the private sector, hospital management and hospital based medical practice.

Mr John McClelland, LLB, BA

Mr McClelland is principal of Carew Gartlan McClelland Solicitors. He is a former President of the Northern Suburbs Law Association and a Family Law Specialist accredited by the Law Institute of Victoria.

Mrs Tara Piazza GDAIS, MBIT Tara is an executive officer and program director at Public Transport Victoria where she is leading a team of specialists to implement complex changes to Victoria's public transport services. Tara was previously a senior Management Consultant with KPMG where she was the Victorian lead for organisational change in Financial Services. Her experience includes senior management in Victoria Police focused on strategic planning in Road Policing and the design and implementation of new business and governance frameworks in Professional Standards Command. Significant experience in top tier Financial Services has provided Tara with broad exposure to a range of practices, policies and methodologies, bringing expertise in strategic planning, business transformation, organisational change and project and program governance. Ms Piazza was appointed to the IBAS Board of Directors in October 2012.

Ms Eszter Vasenszky BA Ms Vasenszky is principal of Science PR Australia, a consultancy that helps science and medical research organisations better communicate their work to the public. She is a former News Corp journalist with extensive public relations experience in the not‐for‐profit sector. Ms Vasenszky was appointed to the IBAS Board of Directors in February 2014.

4. MEDICAL AND SCIENTIFIC RESEARCH COMMITTEE

MSRC Science

The Medical and Scientific Research Committee (MSRC) is a group of IBAS Fellows whose purpose is to provide overall guidance and ratification of IBAS project activities.

Terms of Reference

1. Set research, education and public advocacy directions and priorities

2. Assess and ratify new research proposals

3. Assist with preparation and review of grant applications

4. Facilitate grant funding sources

5. Monitor research output of the Institute

Membership

Dr Nicole Goh (Chair from March 2014)

Dr David Berlowitz (Chair until March 2014, then member)

Mr Danny Brazzale (from May 2014)

Dr Fergal O’Donoghue

Dr Melinda Jackson

Dr Amy Jordan (Maternity Leave from May 2014)

Prof Christine McDonald

Dr Christopher Worsnop

Ms Vivienne Pearson (non‐voting member)

MSRC Administration

Terms of Reference

1. Develop policies and protocols for the administration and conduct of research

2. Identify and develop infrastructure to support research

3. Administration of IBAS Grants

4. Administration of IBAS Fellow and Associate appointments

Membership

Ms Vivienne Pearson (ERO, Chair)

Mr Bruce Abell (Finance Manager)

Dr David Berlowitz (MSRC Science member)

Ms Allison Collins (Clinical Trials Manager)

Prof Christine McDonald (CEO)

Dr Fergal O’Donoghue (MSRC Science member)

Mr Peter Rochford (DRSM Head Scientist)

5. NEW PROJECTS

The following projects have been ratified by IBAS’ MSRC this year. Some of these projects are currently underway and some are still in the planning stage.

Influence of gender and bodyweight on lung volumes during sleep Ratified: July 2013 Abbreviated Name: Lung volumes during sleep IBAS Principal Investigator: Dr Amy Jordan

Obstructive sleep apnea (OSA) is a common disorder of repetitive upper airway collapse that occurs during sleep. The reason why the upper airway collapses during sleep in OSA is not completely understood. One factor that has been suggested to be important is a reduction in the amount of air in the lungs (lung volume) during sleep. This has been suggested because the upper airway is more collapsible when lung volume is low, and healthy young men have a reduction of lung volumes from wakefulness to sleep. However, lung volumes have been minimally studied during sleep. Many patients with OSA are overweight or obese and being overweight/obese is known to lower lung volumes during wakefulness. Therefore, the amount lung volumes fall during sleep may be different in people who are overweight compared to the healthy normal men who have been studied before. Furthermore, lung volumes are known to change with body position and gender during wakefulness and these factors also influence OSA. Therefore, we wish to accurately measure lung volumes in different body positions during wakefulness and sleep in people who are overweight/obese or of normal weight.

The findings of this study will be important for OSA but will also be relevant for other respiratory illnesses which are worse with obesity and sleep, such as asthma.

Do treatment interventions for obstructive sleep apnoea reduce depressive symptoms in patients with comorbid depression? Ratified: August 2013 Abbreviated Name: OSA, CPAP and Depression (COSAD) IBAS Principal Investigator: Dr Melinda Jackson

Obstructive Sleep Apnoea (OSA) is a highly prevalent, chronic illness, characterised by repetitive collapse of the airway during sleep producing oxygen desaturations and sleep disruption. OSA is associated with cognitive deficits, reduced quality of life, and depressed mood. The prevalence of both depressive symptoms and major depressive disorder (MDD) are significantly higher in OSA patients compared to the general community. Both conditions pose a significant health risk and significantly impact on brain function and general well‐being. Currently there is little clinical evidence to support whether treatment of OSA improves depressive symptoms in OSA patients with comorbid depressive symptoms or MDD. The aim of this study is to determine whether CPAP treatment improves depressive symptoms and cognitive functioning over the short and long term. This study will provide much‐needed clinical evidence of the efficacy of CPAP therapy for improving both depression and cognitive functioning in OSA.

Implementation of rapid on‐site evaluation for linear EBUS Ratified: August 2013 Abbreviated Name: Bronchoscopy ROSE TBNA project IBAS Principal Investigator: Dr Celia Lanteri

A bronchoscopy is a procedure that allows a doctor to look at a person's airway through a thin instrument. Bronchoscopies are done to help find out the cause of problems like difficulty breathing, cough or bleeding. Tissue samples can be taken during the procedure.

Traditionally, tissue samples are examined in the laboratory after the bronchoscopy has finished. The aim of this project is to evaluate the possible benefits of having the tissue samples examined during the bronchoscopy. The research is being undertaken with patients at Austin Health who are already booked in for bronchoscopies.

Does sleep disturbance bias memory towards negative events? Ratified: August 2013 Abbreviated Name: Sleep disturbance, memory and mood IBAS Principal Investigator: Dr Melinda Jackson

Insomnia is a common sleep disorder that affects 1/3 of Australians. It is associated with daytime impairments, including memory deficits and depressed mood. There is accumulating evidence that sleep disturbance is a precipitating factor in the onset of depression, however, the mechanisms underlying this link have gained little research attention. It is proposed that sleep disturbance influences the structure of memory, causing negative memory bias (where negative events are recalled more often) and producing a negative mood state (emotions including depression, sadness, anger, guilt). This study aims to determine whether Insomnia causes negative memory bias in patients with and without depression, compared to healthy controls. These results will provide a theoretical framework for understanding the role of sleep as a mechanism for depressed mood, and have implications for understanding the higher rates of depression in insomnia patients.

Music therapy as a potential aid in transition to NIV ‐ a pilot study Ratified: October 2013 Abbreviated Name: Music for NIV in MND pilot IBAS Principal Investigator: Dr David Berlowitz Overall Principal Investigator: A/Prof Felicity Baker (University of Melbourne)

Motor neurone disease (MND) is a condition characterised by muscle weakness. There is no known cure and weakness of the breathing muscles is usually the cause of death. Once a person's breathing muscles are no longer strong enough, breathing support can be provided by a machine which provides air via a mask placed over the person's nose and mouth. This is called non‐invasive ventilation (NIV).

As you can imagine, starting this kind of breathing support can be distressing. Negative experiences early on can result in someone not using the machine as much as they need, therefore affecting their health and quality of life.

Clinical experience shows that music therapy may help people make a smoother transition to using ventilation support. As well as reducing anxiety, music can help people sleep better, something that is important as night time is the most common time the ventilation support is used.

This project is an initial small study based at Austin Health and Calvary Healthcare Bethlehem to collect some information on how music therapy might help people starting on ventilation. The plan is for these results to inform an application for funding for a larger project.

Sleep disturbance effects on cognition, affect, metabolism and physiology Ratified: February 2014 Abbreviated Name: SCAMP IBAS Principal Investigator: Dr Melinda Jackson

Obstructive sleep apnoea (OSA) is a disorder characterised by repetitive upper airway collapse and frequent arousal from sleep. OSA adversely affects various health domains including neurocognitive function as well as cardiovascular, metabolic and airway physiology. These consequences are all likely to be at least in part a result of the sleep disturbance that occurs in OSA. Although several prior studies have investigated the effects of total or partial sleep deprivation on cognition and physiology, sleep disturbance, such as that which occurs in OSA has been studied much less. The overall aim of this study is to investigate the effects of sleep disturbance on previously un‐investigated aspects of cognition, mood, metabolism and physiology.

The effect of functional electronic stimulation (FES) cycling on periodic leg movements (PLMs) during sleep in patients with acute spinal cord injury: An observational pilot study Ratified: March 2014 Abbreviated Name: FES and PLMs in SCI IBAS Principal Investigator: Dr David Berlowitz

Periodic Limb Movement Syndrome (PLMS) is a common condition that occurs during sleep. The movements are abnormal and in many cases are associated with brief awakenings from sleep causing poor quality sleep, sleepiness and significant impairment of functioning during the daytime.

The diagnosis of PLMS usually involves overnight testing in a sleep laboratory to monitor leg movements. In 2007, the American Academy of Sleep Medicine (AASM) published a major revision of their guidelines for measuring sleep and associated events. However, there is little available evidence to support many of these guidelines and this is the case for PLMS.

This current project application focuses on methods for measuring PLMS. One of the methods is recommended by the AASM and the alternative is widely used in clinical practice. We expect our results to lead to improvements in diagnosis and treatment of this disorder and also inform the development of future standards.

Autobiographical memory in obstructive sleep apnoea: a neuroimaging study Ratified: March 2014

Abbreviated Name: fMRI study of memory in OSA IBAS Principal Investigator: Dr Melinda Jackson

Obstructive sleep apnoea (OSA) is a common respiratory disease, caused by collapse of the airway during sleep, which produces dips in oxygen levels and sleep disruption. Untreated OSA may lead to unrefreshing sleep, sleepiness during the day and difficulties with memory, learning and mood. Recent studies have shown that some memory changes in OSA patients are linked with depression. OSA patients have also been found to have structural and functional changes in the brain on neuroimaging compared to healthy people.

The aim of this study is examine memory and brain structure and function in OSA patients compared to healthy people without OSA. Specifically, this study will determine whether changes in brain structure and function observed in OSA patients are associated with memory impairments. This study will provide preliminary evidence about how functional changes in the brain affect memory in patients with OSA.

Investigation of relationship between respiratory muscle strength and body mass index (BMI) Abbreviated Name: Obesity and respiratory muscles Ratified: April 2014

IBAS Principal Investigator: Danny Brazzale

It is known that there is a relationship between obesity and how well some parts of the breathing system work. It is less well known what effect obesity has on the muscles that are used for breathing. This project aims to investigate the relationship between body mass index (a measure of obesity) and respiratory muscle strength.

We will also investigate any differences in respiratory muscle strength between those that do and don't have obesity hypoventilation syndrome (OHS). Other factors which could influence this relationship such as heart function and lung function will also be taken into account.

It is expected that there will be a relationship between BMI and respiratory muscle strength, with respiratory muscle getting weaker as BMI increases. It is also expected that those with OHS will have weaker muscles than those who don't.

6. IBAS GRANTS

IBAS offers internal grants to facilitate the meeting of its objectives. This year, IBAS offered funds for a Research Grant, Conference Funding, an Education Grant and Writing Scholarships.

RESEARCH GRANT IBAS Research Grants are intended to provide funding for projects that align with the aims, objectives and strategic direction of the Institute. Grants can be made for stand‐alone project, pilot projects, top‐up funding or equipment. Six projects applied for the 2013‐14 Research Grant, with a maximum of $40,000 available. The projects that were successful in gaining funding are:

1. Project Title: Lung Volume Recruitment in Neuromuscular Disorders

Lead Investigator: Nicole Sheers Amount awarded: $20,000

Not being able to take deep breaths or cough forcefully are two examples of the breathing problems that people with a disease affecting the nerves and muscles, such as Duchenne Muscular Dystrophy or Motor Neurone Disease, may face. In these diseases, breathing complications are one of the main causes of discomfort, disability and ultimately death. A technique called 'lung volume recruitment' (or 'breath stacking') uses a specially designed bag to deliver breaths of air to people via a face‐mask or mouthpiece, thereby allowing people to take a series of deep breaths occasionally. This may improve lung volume or breathing capacity, coughing ability and ease of clearing phlegm in this group of people. This project will investigate the effect of breath stacking on these factors. Improving breathing function is an important aim of treatment for people with neuromuscular diseases and may reduce symptoms, improve quality of life and survival.

2. Project Title: Exercise training and immunity in COPD

Lead Investigator: Anne Holland Amount awarded: $13,408

'Flare‐ups' of chronic obstructive pulmonary disease (COPD) are important events which often lead to deterioration in lung function and admission to hospital. Whole body exercise training prevents 'flareups' of COPD, but the mechanism by which this is achieved is not known. It is possible that exercise training can improve immunity in the lungs of people with COPD, preventing them from getting chest infections; however this hasn't ever been tested. The aim of this study is to see whether exercise training alters immunity in the lungs of people with COPD, by collecting a marker of immune function in saliva. If we can find out how exercise training alters immunity in COPD, this will allow us to tailor exercise programs so that people with COPD can stay well and stay out of hospital.

3. Project Title: The feasibility, reliability and responsiveness of tests of physical function in individuals with acute exacerbations of COPD

Lead Investigator: Christian Osadnik Amount awarded: $6,000

Individuals with COPD commonly present to hospital due to exacerbations of their respiratory symptoms. Quadriceps weakness, in particular, has been linked with increased likelihood of exacerbation, poorer health outcomes and increased mortality. Performance of basic mobility (e.g. walking) during an exacerbation of COPD is common, however the benefits of formal physical exercise regimens (e.g. lower limb endurance and strength training) are not well defined in the medical literature. A significant problem inherent in such literature is the absence of an appropriate tool to measure physical function. Traditional measures of exercise tolerance (e.g. 6‐minute walk test, incremental shuttle walk test) and muscle strength (cybex isokinetic ergometry) can be difficult to perform in the acute inpatient setting. A simple and quick instrument capable of measuring both physical function and strength could enable clinicians and researchers to better prescribe and measure the effect of physical rehabilitation during this important phase of their condition. Two emerging outcomes for use in COPD are the 60 second sit‐to‐stand test and four metre gait speed test. Both tests have been validated for use when clinically stable, however neither has been investigated during hospitalisation for an acute exacerbation of COPD. This study aims to determine the feasibility, reliability and responsiveness of the 60 second sit‐to‐stand test and four metre gait speed test for individuals with acute exacerbations of COPD.

4. Project Title: Examining brain structure in obstructive sleep apnoea

Lead Investigator: Fergal O’Donoghue Amount awarded: $592

Obstructive Sleep Apnoea (OSA) is a common disorder where a person experiences pauses in their breathing during sleep. OSA can result in daytime sleepiness and impaired thinking as well as lead to high blood pressure and other poor health outcomes.

This research will look at whether untreated OSA has an effect on the brain. Previous research has provided conflicting answers to this question but, with the development of new technology, more subtle changes can now be seen. This area of research is worth pursuing as it may help explain the impaired thinking that is associated with OSA and create an even greater incentive for people to seek treatment.

This project is being run in collaboration with the Brain Research Institute and is part of IBAS' Sleep Health in Quadriplegia program of research.

Calls for applications for the 2014‐15 Research Grant have been made, again with $40,000 available.

CONFERENCE FUNDING IBAS Conference Funding aims to facilitate attendance at relevant conferences by IBAS Personnel, in order to disseminate findings of IBAS research, increase knowledge and learning and facilitate the formation of collegial links. 2014‐2015 Conference Funding was decided in June 2014. Funding will support more than twenty five people to attend conferences (some people are supported to attend more than one conference).

WRITING SCHOLARSHIP IBAS Writing Scholarships are designed to facilitate submission of publications by decreasing barriers to the process of writing.

Project: Driver Education: Enhancing knowledge of sleep, fatigue and risky behaviour to improve decision making in young drivers (DEAD Alive)

Proposed output: Paper submitted to Accident Analysis and Prevention Journal or Sleep Medicine Journal. Thesis called: Driver Education: Enhancing knowledge of sleep, fatigue and risky behaviour to improve decision making in young drivers.

Grant recipient: Nicole Burnett

EDUCATION GRANT

The IBAS Education Grant is now an open grant round, with expressions of interest able to be submitted at any time. The aim is to provide funding for education and public advocacy projects that align with the aims, objectives and strategic direction of the Institute.

7. IBAS PUBLICATIONS

The following are papers published between July 2013 and June 2014. Published abstracts are not included in this list – these are included in the presentations section of this report. IBAS authors are listed in bold.

Abramson MJ, Crockett AJ, Dabscheck E, Frith PA, George J, Glasgow N, Jenkins S, McDonald C, McKenzie DK, Wood‐Baker R, Yang I on behalf of Lung Foundation Australia and the Thoracic Society of Australia and New Zealand (2013) The COPD‐X Plan: Australian and New Zealand Guidelines for the management of Chronic Obstructive Pulmonary Disease V2.35.

Abramson MJ, McDonald VM, Perret JL, Dharmage SC and McDonald CF (2014) Distinguishing adult‐onset asthma from COPD: a review and a new approach". International Journal of Chronic Obstructive Pulmonary Disease, accepted for publication 27 May 2014.

Almatroodi SA, McDonald CF and Pouniotis DS (2014) Alveolar macrophage polarisation in lung cancer. Lung Cancer International, 2014(Article ID 721087): 9.

Atan R, Crosbie DC and Bellomo R (2013) Techniques of extracorporeal cytokine removal: a systematic review of human studies. Renal Failure, 35(8): 1061‐70.

Aubron C, Bailey M, McQuilten Z, Pilcher D, Hegarty C, Martinelli A, Magrin G, Irving D, Cooper DJ and Bellomo R (2014) Duration of red blood cells storage and outcome in critically ill patients. Journal of Critical Care, 29(3): 476 e1‐8.

Aubron C and Bellomo R (2013) Infusion of hydroxyethyl starch‐containing fluids. Minerva Anestesiologica, 79(9): 1088‐92.

Aubron C, Suzuki S, Glassford NJ, Garcia‐Alvarez M, Howden BP and Bellomo R (2014) The epidemiology of bacteriuria and candiduria in critically ill patients. Epidemiology and Infection, published online 26 April 2014.

Bagshaw SM, Uchino S, Kellum JA, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Oudemans‐van Straaten HM, Ronco C and Bellomo R (2013) Association between renal replacement therapy in critically ill patients with severe acute kidney injury and mortality. Journal of Critical Care, 28(6): 1011‐1018.

Batchelor FA, Williams SB, Dow B, Lin X, Wilkinson V, Borschmann K, Russell MA, Crowley KE, Hill KD and Berlowitz DJ (2014) Subjective and objective sleep measures in older people with a history of falls. Journal of Sleep Disorders: Treatment & Care, 3(1): 1‐5.

Bellomo R (2013) The avoidable death of a boy and the relentless pursuit for evidence. Intensive Care Medicine, 39(10): 1847‐8.

Bellomo R (2013) Starch solutions in Australia: the empire strikes back (Editorial). Critical Care and Resuscitation, 15(4): 253‐254.

Bellomo R (2014) Issue and challenges of fluid removal in the critically ill. British Journal of Anaesthesia, published online 31 May 2014.

Bellomo R (2014) Critical care statistical analysis plans (In reply). Critical Care and Resuscitation, 16(1): 77.

Bellomo R, Bion J, Finfer S, Myburgh J, Perner A and Reinhart K (2014) Open Letter to the Executive Director of the European Medicines Agency concerning the licensing of hydroxyethyl starch solutions for fluid resuscitation. Acta Anaesthesiology Scandinavia, 58(3): 365‐70.

Bellomo R, Bion J, Finfer S, Myburgh J, Perner A and Reinhart K (2014) Open letter to the Executive Director of the European Medicines Agency concerning the licensing of hydroxyethyl starch solutions for fluid resuscitation. British Journal of Anaesthesia, 112(3): 595‐600.

Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Kim I, Lee J, Lo S, McArthur C, McGuiness S, Norton R, Myburgh J and Scheinkestel C (2014) The relationship between hypophosphataemia and outcomes during low‐intensity and high‐intensity continuous renal replacement therapy. Critical Care and Resuscitation, 16(1): 34‐41.

Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lee J, Lo S, McArthur C, McGuinness S, Myburgh J, Norton R, Scheinkestel C and Su S (2014) Calorie intake and patient outcomes in severe acute kidney injury: findings from The Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy (RENAL) study trial. Critical Care, 18(2): R45.

Bellomo R, Finfer S and Myburgh J (2014) Mortality in patients with hypovolemic shock treated with colloids or crystalloids (Letter). Journal of the American Medical Association, 311(10): 1067‐8.

Bellomo R, Forbes A, Akram M, Bailey M, Pilcher DV and Cooper DJ (2013) Why we must cluster and cross over. Critical Care and Resuscitation, 15(3): 155‐7.

Bellomo R and Schneider AG (2014) The real cost of conventional hemodialysis in critically ill patients. Critical Care Medicine, 42(4): 990‐1.

Benzinger TLS, Blazey T, Jack CR, Koeppe RA, Su Y, Xiong C, Raichle ME, Snyder AZ, Ances BM, Bateman RJ, Cairns NJ, Fagan AM, Goate A, Marcus DS, Aisen PS, Christensen JJ, Ercole L, Hornbeck RC, Farrar AM, Aldea P, Jasielec MS, Owen CJ, Xie X, Mayeux R, Brickman A, McDade E, Klunk W, Mathis CA, Ringman J, Thompson PM, Ghetti B, Saykin AJ, Sperling RA, Johnson KA, Salloway S, Correia S, Schofield PR, Masters CL, Rowe C, Villemagne VL, Martins R, Ourselin S, Rossor MN, Fox NC, Cash DM, Weiner MW, Holtzman DM, Buckles VD, Moulder K and Morris JC (2013) Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease. Proceedings of the National Academy of Sciences, 110(47): E4502‐E4509.

Berlowitz D. (2013) Physiotherapy research in MND. In Motion, 36.

Berlowitz DJ and O'Donoghue FJ (2014) Editorial Note on: Respiratory CO2 response in acute cervical spinal cord injury (CO2 response in spinal cord injury). Spinal Cord, 52(3): 174‐174.

Berlowitz DJ and Tamplin J (2013) Respiratory muscle training for cervical spinal cord injury. Cochrane Database of Systematic Reviews, Issue 7. Art. No.: CD008507. DOI: 10.1002/14651858.CD008507.pub2.

Bion J, Bellomo R, Myburgh J, Perner A, Reinhart K and Finfer S (2014) Hydroxyethyl starch: putting patient safety first. Intensive Care Medicine, 40(2): 256‐9.

Brazzale DJ, Hall GL and Pretto JJ (2013) Effects of Adopting the New Global Lung Function Initiative 2012 Reference Equations on the Interpretation of Spirometry. Respiration, published online 14 August 2013.

Brown BM, Bourgeat P, Peiffer JJ, Burnham S, Laws SM, Rainey‐Smith SR, Bartres‐Faz D, Villemagne VL, Taddei K, Rembach A, Bush A, Ellis KA, Macaulay SL, Rowe CC, Ames D, Masters CL, Maruff P and Martins RN (2014) Influence of BDNF Val66Met on the relationship between physical activity and brain volume. Neurology, 83(15): 1345‐52.

Buckley RF, Saling MM, Irish M, Ames D, Rowe CC, Lautenschlager NT, Maruff P, Macaulay SL, Martins RN, Masters CL, Rainey‐Smith SR, Rembach A, Savage G, Szoeke C and Ellis KA (2014) Personal memory function in mild cognitive impairment and subjective memory complaints: results from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) Study of Ageing. Journal of Alzheimer's Disease, 40(3): 551‐61.

Calzavacca P, Bailey M, Velkoska E, Burrell LM, Ramchandra R, Bellomo R and May CN (2014) Effects of renal denervation on regional hemodynamics and kidney function in experimental hyperdynamic sepsis. Critical Care Medicine, 42(6): e401‐9.

Calzavacca P, May CN and Bellomo R (2014) Glomerular haemodynamics, the renal sympathetic nervous system and sepsis‐induced acute kidney injury. Nephrology Dialysis Transplantation, published online 11 March 2014.

Chen J, Ou L, Hillman K, Flabouris A, Bellomo R, Hollis SJ and Assareh H (2014) The impact of implementing a rapid response system: a comparison of cardiopulmonary arrests and mortality among four teaching hospitals in Australia. Resuscitation, published online 21 June 2014.

Chhatwal JP, Schultz AP, Johnson K, Benzinger TL, Jack C, Jr., Ances BM, Sullivan CA, Salloway SP, Ringman JM, Koeppe RA, Marcus DS, Thompson P, Saykin AJ, Correia S, Schofield PR, Rowe CC, Fox NC, Brickman AM, Mayeux R, McDade E, Bateman R, Fagan AM, Goate AM, Xiong C, Buckles VD, Morris JC and Sperling RA (2013) Impaired default network functional connectivity in autosomal dominant Alzheimer disease. Neurology, 81(8): 736‐44.

Christie M and Verran H (2014) The Touch Pad Body: A Generative Transcultural Digital Device Interrupting Received Ideas and Practices in Aboriginal Health. Societies, 4(2): 256‐264.

Chua HR, Schneider AG, Sherry NL, Lotfy N, Chan MJ, Galtieri J, Wong GR, Lipcsey M, Matte CD, Collins A, Garcia‐Alvarez M and Bellomo R (2014) Initial and Extended Use of Femoral Versus Nonfemoral Double‐Lumen Vascular Catheters and Catheter‐Related Infection During Continuous Renal Replacement Therapy. American Journal of Kidney Diseases, published online 3 June 2014.

Delaney A, Peake SL, Bellomo R, Cameron P, Holdgate A, Howe B, Higgins A, Presneill J and Webb S (2013) Australasian Resuscitation In Sepsis Evaluation trial statistical analysis plan. Emergency Medicine Australasia, 25(5): 406‐15.

Delaney AP, Peake SL, Bellomo R, Cameron P, Holdgate A, Howe B, Higgins A, Presneill J and Webb S (2013) The Australasian Resuscitation in Sepsis Evaluation (ARISE) trial statistical analysis plan. Critical Care and Resuscitation, 15(3): 162‐71.

Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert M‐O, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P and Cummings JL (2014) Advancing research diagnostic criteria for Alzheimer's disease: the IWG‐2 criteria. The Lancet Neurology, 13(6): 614‐629.

Dulhunty JM, Roberts JA, Davis JS, Webb SA, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Starr T, Udy AA, Paul SK and Lipman J (2013) A protocol for a multicentre randomised controlled trial of continuous beta‐lactam infusion compared with intermittent beta‐lactam dosing in critically ill patients with severe sepsis: the BLING II study. Critical Care and Resuscitation, 15(3): 179‐85.

Dulhunty JM, Starr T, Bellomo R and Lipman J (2014) Randomised controlled trials: the long hard climb to the summit‐is there another way in the 21st century? Critical Care and Resuscitation, 16(2): 87‐9.

Eastwood GM, Bailey M and Bellomo R (2014) Targeted temperature management after cardiac arrest (Letter). New England Journal of Medicine, 370(14): 1359.

Eastwood GM, Peck L, Young H, Suzuki S, Garcia M and Bellomo R (2014) Intensive care clinicians' opinion of conservative oxygen therapy (SpO(2) 90‐92%) for mechanically ventilated patients. Australian Critical Care, published online 24 December 2013.

Eastwood GM, Suzuki S and Bellomo R (2014) Letter regarding article "Association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post‐cardiac arrest syndrome". Circulation, 129(1): e9.

Eastwood GM, Young PJ and Bellomo R (2014) The impact of oxygen and carbon dioxide management on outcome after cardiac arrest. Current Opinion in Critical Care, 20(3): 266‐72.

Ellis KA, Szoeke C, Bush AI, Darby D, Graham PL, Lautenschlager NT, Macaulay SL, Martins RN, Maruff P, Masters CL, McBride SJ, Pike KE, Rainey‐Smith SR, Rembach A, Robertson J, Rowe CC, Savage G, Villemagne VL, Woodward M, Wilson W, Zhang P and Ames D (2014) Rates of diagnostic transition and cognitive change at 18‐month follow‐up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL). International Psychogeriatrics, 26(4): 543‐54.

Fodero‐Tavoletti MT, Furumoto S, Taylor L, McLean CA, Mulligan RS, Birchall I, Harada R, Masters CL, Yanai K, Kudo Y, Rowe CC, Okamura N and Villemagne VL (2014) Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non‐Alzheimer's disease tauopathies. Alzheimer's Research and Therapy, 6(1): 11.

Fraser SA, Davies M, Katerelos M, Gleich K, Choy S‐W, Steel R, Galic S, Mount PF, Kemp BE and Power DA (2014) Activation of AMPK reduces the co‐transporter activity of NKCC1. Molecular Membrane Biology, 31(2‐3): 95‐102.

Frisoni GB, Bocchetta M, Chetelat G, Rabinovici GD, de Leon MJ, Kaye J, Reiman EM, Scheltens P, Barkhof F, Black SE, Brooks DJ, Carrillo MC, Fox NC, Herholz K, Nordberg A, Jack CR, Jr., Jagust WJ, Johnson KA, Rowe CC, Sperling RA, Thies W, Wahlund LO, Weiner MW, Pasqualetti P and Decarli C (2013) Imaging markers for Alzheimer disease: which vs how. Neurology, 81(5): 487‐500.

Frost S, Kanagasingam Y, Sohrabi H, Bourgeat P, Villemagne V, Rowe CC, Macaulay SL, Szoeke C, Ellis KA, Ames D, Masters CL, Rainey‐Smith S, Martins RN and Group AAR (2013) Pupil response biomarkers for early detection and monitoring of Alzheimer's disease. Current Alzheimer Research, 10(9): 931‐9.

Fujii T, Uchino S, Takinami M and Bellomo R (2014) Validation of the Kidney Disease Improving Global Outcomes criteria for AKI and comparison of three criteria in hospitalized patients. Clinical Journal of the American Society of Nephrology, 9(5): 848‐54.

Fujii T, Uchino S, Takinami M and Bellomo R (2014) Subacute kidney injury in hospitalized patients. Clinical Journal of the American Society of Nephrology, 9(3): 457‐61.

Gallagher M, Cass A, Bellomo R, Finfer S, Gattas D, Lee J, Lo S, McGuinness S, Myburgh J, Parke R and Rajbhandari D (2014) Long‐term survival and dialysis dependency following acute kidney injury in intensive care: extended follow‐up of a randomized controlled trial. PLoS Med, 11(2): e1001601.

Garcia‐Alvarez M, Marik P and Bellomo R (2014) Stress hyperlactataemia: present understanding and controversy. Lancet Diabetes and Endocrinology, 2(4): 339‐47.

Glassford NJ, Schneider AG, Xu S, Eastwood GM, Young H, Peck L, Venge P and Bellomo R (2013) The nature and discriminatory value of urinary neutrophil gelatinase‐associated lipocalin in critically ill patients at risk of acute kidney injury. Intensive Care Medicine, 39(10): 1714‐24.

Godfrey G, Hilton A and Bellomo R (2013) To treat or not to treat: withholding treatment in the ICU. Current Opinion in Critical Care, 19(6): 624‐629.

Green S, McDonald S, Holland AE and Elkins M (2014) Informing physiotherapy decisions with reliable evidence: how physiotherapists have contributed to Cochrane and how Cochrane has informed evidence‐based physiotherapy. Journal of Physiotherapy, 60(1): 1‐4.

Halpern J, Cohen M, Kennedy GA, Reece J, Cahan C and Baharav A (2014) Yoga for improving sleep quality and quality of life for older adults. Alternative Therapies in Health and Medicine, 20(3): 37‐46.

Hannan LM, Dominelli GS, Chen Y‐W, Darlene Reid W and Road J (2014) Systematic review of non‐invasive positive pressure ventilation for chronic respiratory failure. Respiratory Medicine, 108(2): 229‐243.

Hannan LM, Steinfort DP, Irving LB and Hew M (2014) Direct ultrasound localisation for pleural aspiration: Translating evidence into action. Internal Medicine Journal, 44(1): 50‐56.

Harrington KD, Lim YY, Ellis KA, Copolov C, Darby D, Weinborn M, Ames D, Martins RN, Sagvage G, Szoeke C, Rowe C, Villemagne VL, Masters CL and Maruff P (2013) The association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI. International Psychogeriatrics, 25(10): 1667‐1677.

Harvey P, Storer M, Berlowitz DJ, Jackson B, Hutchinson A and Lim WK (2014) Feasibility and impact of a post‐discharge geriatric evaluation and management service for patients from residential care: the Residential Care Intervention Program in the Elderly (RECIPE). BMC Geriatrics, 14(48):

Hayley AC, Williams LJ, Kennedy GA, Berk M, Brennan SL and Pasco JA (2014) Prevalence of excessive daytime sleepiness in a sample of the Australian adult population. Sleep Medicine, 15(3): 348‐54.

Heng H, Lee AL and Holland AE (2014) Repeating pulmonary rehabilitation: Prevalence, predictors and outcomes. Respirology, accepted for publication 16 May 2014.

Hill K and Holland AE (2014) Strategies to Enhance the Benefits of Exercise Training in the Respiratory Patient. Clinics in Chest Medicine, 35(2): 323‐336.

Hilton AK and Bellomo R (2013) The intensivist as nosocomial thanatologist. Current Opinion in Critical Care, 19(6): 613‐615.

Holland AE, Dowman L, Fiore J, Brazzale DJ, Hill CJ and McDonald C (2014) Cardiorespiratory responses to 6‐minute walk test in interstitial lung disease: not always a submaximal test. BMC Pulmonary Medicine, accepted for publication 16 June 2014.

Holland A, Mahal A, Hill C, Lee A, Burge A, Moore R, Nicolson C, O'Halloran P, Cox N, Lahham A, Ndongo R, Bell E and McDonald C (2013) Benefits and costs of home‐based pulmonary rehabilitation in chronic obstructive pulmonary disease ‐ a multi‐centre randomised controlled equivalence trial. BMC Pulmonary Medicine, 13(1): 57.

Holland AE, Fiore JF, Bell EC, Goh N, Westall G, Symons K, Dowman L and Glaspole I (2014) Dyspnoea and comorbidity contribute to anxiety and depression in interstitial lung disease. Respirology, accepted for publication 18 June 2014.

Holland AE, Wadell K and Spruit MA (2013) How to adapt the pulmonary rehabilitation programme to patients with chronic respiratory disease other than COPD. European Respiratory Review, 22(130): 577‐586.

Huang DT, Angus DC, Barnato A, Gunn SR, Kellum JA, Stapleton DK, Weissfeld LA, Yealy DM, Peake SL, Delaney A, Bellomo R, Cameron P, Higgins A, Holdgate A, Howe B, Webb SA, Williams P, Osborn TM, Mouncey PR, Harrison DA, Harvey SE, Rowan KM and Committee) TPAPMW (2013) Harmonizing international trials of early goal‐directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. Intensive Care Medicine, 39(10): 1760‐75.

Hutchinson AF, Rasekaba TM, Graco M, Berlowitz DJ, Hawthorne G and Lim KW (2013) Relationship between health‐related quality of life,and acute care re‐admission and survival in older adults with chronic illness. Health and Quality of Life Outcomes, 11(1): 136.

Johnson KA, Minoshima S, Bohnen NI, Donohoe KJ, Foster NL, Herscovitch P, Karlawish JH, Rowe CC, Hedrick S, Pappas V, Carrillo MC and Hartley DM (2013) Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cognitive impairment, and education. Amyloid Imaging Task Force of the Alzheimer's Association and Society for Nuclear Medicine and Molecular Imaging. Alzheimer's & Dementia, 9(4): e106‐9.

Jordan AS, Cori JM, Dawson A, Nicholas CL, O'Donoghue F, Catcheside PG, Eckert DJ, McEvoy RD and Trinder J (2014) Arousal from sleep does not lead to reduced dilator muscle activity or elevated upper airway resistance on return to sleep in healthy individuals. Sleep, accepted for publication 23 May 2014.

Jordan AS, McSharry DG and Malhotra A (2014) Adult obstructive sleep apnoea. The Lancet, 383(9918): 736‐747.

Jun M, Bellomo R, Cass A, Gallagher M, Lo S and Lee J (2014) Timing of renal replacement therapy and patient outcomes in the randomized evaluation of normal versus augmented level of replacement therapy study. Critical Care Medicine, published online 11 April 2014.

Kaufman M, Bebee B, Bailey J, Robbins R, Hart GK and Bellomo R (2014) Laboratory tests to identify patients at risk of early major adverse events: a prospective pilot study. Internal Medical Journal, published online 20 June 2014.

Kaukonen KM, Bailey M, Egi M, Orford N, Glassford NJ, Marik PE and Bellomo R (2014) Stress hyperlactatemia modifies the relationship between stress hyperglycemia and outcome: a retrospective observational study. Critical Care Medicine, 42(6): 1379‐85.

Kaukonen KM, Bailey M, Pilcher D, Orford N, Finfer S and Bellomo R (2013) Glycaemic control in Australia and New Zealand before and after the NICE‐SUGAR trial: a translational study. Critical Care, 17(5): R215.

Kaukonen KM, Bailey M, Suzuki S, Pilcher D and Bellomo R (2014) Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand. Journal of the American Medical Association, 311(13): 1308‐16.

Kaukonen KM, Vaara ST, Pettila V, Bellomo R, Tuimala J, Cooper DJ, Krusius T, Kuitunen A, Reinikainen M, Koskenkari J and Uusaro A (2013) Age of red blood cells and outcome in acute kidney injury. Critical Care, 17(5): R222.

Ke L, Calzavacca P, Bailey M, Li WQ, Bellomo R and May C (2013) Acid‐base changes after fluid bolus: sodium chloride vs. sodium octanoate. Intensive Care Medicine Experimental, 1(1): 4.

Ke L, Calzavacca P, Bailey M, May CN, Li WQ, Bertolini J and Bellomo R (2014) Systemic and renal haemodynamic effects of fluid bolus therapy: sodium chloride versus sodium octanoate‐balanced solution. Critical Care and Resuscitation, 16(1): 29‐33.

Kent BD, Garvey JF, Ryan S, Nolan G, Dodd JD and McNicholas WT (2013) Severity of obstructive sleep apnoea predicts coronary artery plaque burden: a coronary computed tomographic angiography study. European Respiratory Journal, 42(5): 1263‐1270.

Kezirian EJ, Goding GS, Malhotra A, O'Donoghue FJ, Zammit G, Wheatley JR, Catcheside PG, Smith PL, Schwartz AR, Walsh JH, Maddison KJ, Claman DM, Huntley T, Park SY, Campbell MC, Palme CE, Iber C, Eastwood PR, Hillman DR and Barnes M (2013) Hypoglossal nerve stimulation improves obstructive sleep apnoea: 12‐month outcomes. Journal of Sleep Research, 23(1): 77‐83.

Khor YH and McDonald CF (2013) Advances in COPD. Internal Medicine Journal, 43(8): 854‐862.

Khor YH, Smith R and McDonald CF (2014) Suboptimal management of unfractionated heparin compared with low‐molecular‐weight heparin in the management of pulmonary embolism. Internal Medicine Journal, 44(4): 339‐344.

Kruger P, Bellomo R and Venkatesh B (2013) Reply: Statins in sepsis. American Journal of Respiratory and Critical Care Medicine, 188(7): 874‐5.

Landoni G, Bove T, Szekely A, Comis M, Rodseth RN, Pasero D, Ponschab M, Mucchetti M, Azzolini ML, Caramelli F, Paternoster G, Pala G, Cabrini L, Amitrano D, Borghi G, Capasso A, Cariello C, Carpanese A, Feltracco P, Gottin L, Lobreglio R, Mattioli L, Monaco F, Morgese F, Musu M, Pasin L, Pisano A, Roasio A, Russo G, Slaviero G, Villari N, Vittorio A, Zucchetti M, Guarracino F, Morelli A, De Santis V, Del Sarto PA, Corcione A, Ranieri M, Finco G, Zangrillo A and Bellomo R (2013) Reducing mortality in acute kidney injury patients: systematic review and international web‐based survey. Journal of Cardiothoracic and Vascular Anesthesia, 27(6): 1384‐1398.

Langenberg C, Gobe G, Hood S, May CN and Bellomo R (2014) Renal histopathology during experimental septic acute kidney injury and recovery. Critical Care Medicine, 42(1): e58‐67.

Langham RG, Bellomo R, V DI, Endre Z, Hickey BB, McGuinness S, Phoon RK, Salamon K, Woods J and Gallagher MP (2014) KHA‐CARI guideline: KHA‐CARI adaptation of the KDIGO Clinical Practice Guideline for Acute Kidney Injury. Nephrology, 19(5): 261‐5.

Lee A, Hill C, Cecins N, Jenkins S, McDonald C, Burge A, Rautela L, Stirling R, Thompson P and Holland A (2014) The short and long term effects of exercise training in non‐cystic fibrosis bronchiectasis ‐ a randomised controlled trial. Respiratory Research, 15(1): 1‐4.

Lee AL, Hill CJ, Cecins N, Jenkins S, McDonald CF, Burge AT, Rautela L, Stirling RG, Thompson PJ and Holland AE (2014) Minimal important difference in field walking tests in non‐cystic fibrosis bronchiectasis following exercise training. Respiratory Medicine, 108(9): 1303‐1309.

Lee DHK, Gan P‐Y, Katerelos M, Fraser SA, Gleich K, Holdsworth SR and Power DA (2014) Absence of the lysosomal protein Limp‐2 attenuates renal injury in crescentic glomerulonephritis. Immunology & Cell Biology, 92(400‐408.

Lim YY, Maruff P, Pietrzak RH, Ames D, Ellis KA, Harrington K, Lautenschlager NT, Szoeke C, Martins RN, Masters CL, Villemagne VL and Rowe CC (2014) Effect of amyloid on memory and non‐memory decline from preclinical to clinical Alzheimer's disease. Brain, 137(Pt 1): 221‐31.

Lim YY, Maruff P, Pietrzak RH, Ellis KA, Darby D, Ames D, Harrington K, Martins RN, Masters CL, Szoeke C, Savage G, Villemagne VL and Rowe CC (2014) Abeta and cognitive change: Examining the preclinical and prodromal stages of Alzheimer's disease. Alzheimers and Dementia, published online 28 February 2014.

Lim YY, Villemagne VL, Laws SM, Ames D, Pietrzak RH, Ellis KA, Harrington K, Bourgeat P, Bush AI, Martins RN, Masters CL, Rowe CC and Maruff P (2014) Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer's disease: a preliminary study. PLoS ONE, 9(1): e86498.

Lipcsey M, Chua HR, Schneider AG, Robbins R and Bellomo R (2014) Clinically manifest thromboembolic complications of femoral vein catheterization for continuous renal replacement therapy. Journal of Critical Care, 29(1): 18‐23.

Lipcsey M, Hayward P, Haase M, Haase‐Fielitz A, Eastwood G, Peck L, Matalanis G and Bellomo R (2014) Neutrophil gelatinase‐associated lipocalin after off pump versus on pump coronary artery surgery. Biomarkers, 19(1): 22‐8.

Marik PE and Bellomo R (2013) Re‐thinking resuscitation goals: an alternative point of view! (Letter). Critical Care, 17(5): 458.

McDonald CF (2014) Low‐flow oxygen: How much is your patient really getting? (Editorial). Respirology, 19(4): 469‐470.

McDonnell MJ, Garvey J, Lohan DG, O'Sullivan GJ, Redmond K, Jackson JE and Rutherford RM (2014) An unusual cause of haemoptysis in a smoker. Thorax, 69(1): 93.

ANZICS‐CORE MET (2013) Mortality of rapid response team patients in Australia: A multicentre study. Critical Care and Resuscitation, 15(4): 273‐278.

Moore EM, Ames D, Mander AG, Carne RP, Brodaty H, Woodward MC, Boundy K, Ellis KA, Bush AI, Faux NG, Martins RN, Masters CL, Rowe CC, Szoeke C and Watters DA (2014) Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: combined data from three cohorts. Journal of Alzheimer's Disease, 39(3): 661‐8.

Myburgh J, Finfer S and Bellomo R (2013) Patient‐centered outcomes and trials of hydroxyethyl starch (Letter). Critical Care, 17(5): 452.

O'Donoghue FJ and Howard ME (2014) Obesity, COPD, NIV and reverse epidemiology. Respirology, 19(6): 777‐779.

Okamura N, Furumoto S, Fodero‐Tavoletti MT, Mulligan RS, Harada R, Yates P, Pejoska S, Kudo Y, Masters CL, Yanai K, Rowe CC and Villemagne VL (2014) Non‐invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F‐THK5105 PET. Brain, 137(Pt 6): 1762‐71.

Ong KT, Villemagne VL, Bahar‐Fuchs A, Lamb F, Langdon N, Catafau AM, Stephens AW, Seibyl J, Dinkelborg LM, Reininger CB, Putz B, Rohde B, Masters CL and Rowe CC (2014) Abeta imaging with 18F‐florbetaben in prodromal Alzheimer's disease: a prospective outcome study. Journal of Neurology, Neurosurgery and Psychiatry, published online 28 June 2014.

Orford NR, Bailey M, Kaukonen K, Elderkin T, Stow P, Cattigan C, Kotowicz M and Bellomo R (2014) Glycaemic control and long‐term outcomes following transition from modified intensive insulin therapy to conventional glycaemic control. Anaesth Intensive Care, 42(2): 239‐47.

Osadnik CR, McDonald CF and Holland AE (2013) Advances in airway clearance technologies for chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine, 7(6): 673‐685.

Osadnik CR, McDonald CF and Holland Anne E (2014) Clinical issues of mucus accumulation in COPD (letter). International Journal of Chronic Obstructive Pulmonary Disease, 9(301‐302.

Osadnik CR, McDonald CF, Miller BR, Hill CJ, Tarrant B, Steward R, Chao C, Stodden N, Oliveira CC, Gagliardi N and Holland AE (2013) The effect of positive expiratory pressure (PEP) therapy on symptoms, quality of life and incidence of re‐exacerbation in patients with acute exacerbations of chronic obstructive pulmonary disease: a multicentre, randomised controlled trial. Thorax, 69(2): 137‐143.

Panwar R, Capellier G, Schmutz N, Davies A, Cooper DJ, Bailey M, Baguley D, Pilcher V and Bellomo R (2013) Current oxygenation practice in ventilated patients‐an observational cohort study. Anaesthesia and Intensive Care Journal, 41(4): 505‐14.

Panwar R, Lanyon N, Davies AR, Bailey M, Pilcher D and Bellomo R (2013) Mean perfusion pressure deficit during the initial management of shock‐‐an observational cohort study. Journal of Critical Care, 28(5): 816‐24.

Parbat N, Sherry N, Bellomo R, Schneider AG, Glassford NJ, Johnson PD and Bailey M (2013) The microbiological and clinical outcome of guide wire exchanged versus newly inserted antimicrobial surface treated central venous catheters. Critical Care, 17(5): R184.

Perret JL, Walters EH, Abramson MJ, McDonald CF and Dharmage SC (2014) The independent and combined effects of lifetime smoke exposures and asthma as they relate to COPD. Expert Review of Respiratory Medicine, 1‐12.

Pettila V and Bellomo R (2014) Understanding acute kidney injury in sepsis. Intensive Care Medicine, published online 5 May 2014.

Peyton P (2014) Hybrid measurement to achieve satisfactory precision in peri‐operative cardiac output monitoring. Anaesthesia and Intensive Care, 42(3): 3340‐349.

Peyton PJ and Wu CY (2014) Nitrous Oxide–related Postoperative Nausea and Vomiting Depends on Duration of Exposure. Anesthesiology, 120(5): 1137‐1145.

Pietrzak RH, Scott JC, Neumeister A, Lim YY, Ames D, Ellis KA, Harrington K, Lautenschlager NT, Szoeke C, Martins RN, Masters CL, Villemagne VL, Rowe CC and Maruff P (2014) Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3‐year prospective cohort study. British Journal of Psychiatry, 204: 400‐1.

Plummer MP, Bellomo R, Cousins CE, Annink CE, Sundararajan K, Reddi BA, Raj JP, Chapman MJ, Horowitz M and Deane AM (2014) Dysglycaemia in the critically ill and the interaction of chronic and acute glycaemia with mortality. Intensive Care Medicine, published online 25 April 2014.

Porsbjerg CM, Gibson PG, Pretto JJ, Salome CM, Brown NJ, Berend N and King GG (2013) Relationship between airway pathophysiology and airway inflammation in older asthmatics. Respirology, 18(7): 1128‐1134.

Pretto JJ, Roebuck T, Beckert L and Hamilton G (2014) Clinical use of pulse oximetry: Official guidelines from the Thoracic Society of Australia and New Zealand. Respirology, 19(1): 38‐46.

Prowle JR, Kirwan CJ and Bellomo R (2014) Fluid management for the prevention and attenuation of acute kidney injury. Nature Reviews Nephrology, 10(1): 37‐47.

Quanjer PH, Pretto JJ, Brazzale DJ and Boros PW (2013) Grading the severity of airways obstruction: new wine in new bottles. European Respiratory Journal, 43(2): 505‐512.

Quanjer PH, Weiner DJ, Pretto JJ, Brazzale DJ and Boros PW (2013) Measurement of FEF25‐75% and FEF75% does not contribute to clinical decision making. European Respiratory Journal, 43(4): 1051‐1058.

Rajaratnam SM, Howard ME and Grunstein RR (2013) Sleep loss and circadian disruption in shift work: health burden and management. Medical Journal of Australia, 199(8): 11‐5.

Rembach A, Watt AD, Wilson WJ, Villemagne VL, Burnham SC, Ellis KA, Maruff P, Ames D, Rowe CC, Macaulay SL, Bush AI, Martins RN, Masters CL and Doecke JD (2014) Plasma amyloid‐beta levels are significantly associated with a transition toward Alzheimer's disease as measured by cognitive decline and change in neocortical amyloid burden. Journal of Alzheimer's Disease, 40(1): 95‐104.

Ronco C, Kellum JA, Bellomo R and Mehta RL (2013) Acute Dialysis Quality Initiative (ADQI). Contributions to Nephrology, 182(1‐4.

Rowe CC, Bourgeat P, Ellis KA, Brown B, Lim YY, Mulligan R, Jones G, Maruff P, Woodward M, Price R, Robins P, Tochon‐Danguy H, O'Keefe G, Pike KE, Yates P, Szoeke C, Salvado O, Macaulay SL, O'Meara T,

Head R, Cobiac L, Savage G, Martins R, Masters CL, Ames D and Villemagne VL (2013) Predicting Alzheimer disease with β‐amyloid imaging: Results from the Australian imaging, biomarkers, and lifestyle study of ageing. Annals of Neurology, 74(6): 905‐913.

Rozen TH, Mullane S, Kaufman M, Hsiao YF, Warrillow S, Bellomo R and Jones DA (2014) Antecedents to cardiac arrests in a teaching hospital intensive care unit. Resuscitation, 85(3): 411‐7.

Schmidt M, Bailey M, Kelly J, Hodgson C, Cooper DJ, Scheinkestel C, Pellegrino V, Bellomo R and Pilcher D (2014) Impact of fluid balance on outcome of adult patients treated with extracorporeal membrane oxygenation. Intensive Care Medicine, published online 18 June 2014.

Schneider AG, Goodwin MD, Schelleman A, Bailey M, Johnson L and Bellomo R (2013) Contrast‐enhanced ultrasound to evaluate changes in renal cortical perfusion around cardiac surgery: a pilot study. Critical Care, 17(4): R138.

Schneider AG, Thorpe C, Dellbridge K, Matalanis G and Bellomo R (2013) Electronic bed weighing vs daily fluid balance changes after cardiac surgery. Journal of Critical Care, published online 21 October 2013.

Sheers N and Berlowitz DJ. (2013) Physiotherapy practice and research in motor neurone disease ‐ Introduction. In Motion, 33.

Sheers N, Berlowitz DJ, Rautela L, Batchelder I, Hopkinson K and Howard ME (2014) Improved survival with an ambulatory model of non‐invasive ventilation implementation in motor neuron disease. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 15(3‐4): 180‐184.

Shehabi Y, Bellomo R, Reade MC, Bailey M, Bass F, Howe B, McArthur C, Murray L, Seppelt IM, Webb S and Weisbrodt L (2013) Early goal‐directed sedation versus standard sedation in mechanically ventilated critically ill patients: a pilot study. Critical Care Medicine, 41(8): 1983‐91.

Silvetti S, Meroni R, Bignami E, Bove T, Landoni G, Zangrillo A, Bellomo R and Pappalardo F (2014) Preoperative urinary neutrophil gelatinase‐associated lipocalin and outcome in high‐risk heart failure patients undergoing cardiac surgery. Journal of Cardiothoracic and Vascular Anesthesia, 28(2): 323‐7.

Spong J, Kennedy GA, Tseng J, Brown DJ, Armstrong S and Berlowitz DJ (2014) Sleep disruption in tetraplegia: a randomised, double‐blind, placebo‐controlled crossover trial of 3mg melatonin. Spinal Cord, 52(8): 629‐634.

Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, Rochester C, Hill K, Holland AE, Lareau SC, Man WDC, Pitta F, Sewell L, Raskin J, Bourbeau J, Crouch R, Franssen FME, Casaburi R, Vercoulen JH, Vogiatzis I, Gosselink R, Clini EM, Effing TW, Maltais F, van der Palen J, Troosters T, Janssen DJA, Collins E, Garcia‐Aymerich J, Brooks D, Fahy BF, Puhan MA, Hoogendoorn M, Garrod R, Schols AMWJ, Carlin B, Benzo R, Meek P, Morgan M, Rutten‐van Mölken MPMH, Ries AL, Make B, Goldstein RS, Dowson CA, Brozek JL, Donner CF and Wouters EFM (2013) An Official American Thoracic Society/European Respiratory Society Statement: Key Concepts and Advances in Pulmonary Rehabilitation. American Journal of Respiratory and Critical Care Medicine, 188(8): e13‐e64.

Story DA, Shelton A, Jones D, Heland M and Bellomo R (2013) Audit of co‐management and critical care outreach for high risk postoperative patients (the POST audit). Anaesthesia and Intensive Care, 41(6): 793‐798.

Suzuki S, Eastwood GM and Bellomo R (2014) Hyperoxemia in critically mechanical ventilation patients: a factor yet to be fit for intensivists (Authors' reply). Journal of Critical Care, 29(1): 173.

Suzuki S, Eastwood GM, Glassford NJ, Peck L, Young H, Garcia‐Alvarez M, Schneider AG and Bellomo R (2014) Conservative oxygen therapy in mechanically ventilated patients: a pilot before‐and‐after trial. Critical Care Medicine, 42(6): 1414‐22.

Suzuki S, Egi M, Schneider AG, Bellomo R, Hart GK and Hegarty C (2013) Hypophosphatemia in critically ill patients. Journal of Critical Care, 28(4): 536 e9‐19.

Tamplin J, Baker F, Grocke D and Berlowitz D (2014) Thematic Analysis of the Experience of Group Music Therapy for People with Chronic Quadriplegia. Topics in Spinal Cord Injury Rehabilitation, 20(3): 236‐247.

Tamplin J, Baker FA, Buttifant M and Berlowitz DJ (2014) The Effect of Singing Training on Voice Quality for People With Quadriplegia. Journal of Voice, 28(1): 128.e19 ‐ 128.e26.

Tamplin J, Baker FA, Jones B, Way A and Lee S (2013) 'Stroke a Chord': the effect of singing in a community choir on mood and social engagement for people living with aphasia following a stroke. NeuroRehabilitation, 32(4): 929‐41.

Tamplin J and Berlowitz DJ (2014) A systematic review and meta‐analysis of the effects of respiratory muscle training on pulmonary function in tetraplegia. Spinal Cord, 52(3): 175‐180.

The ProCESS/ARISE/ProMISE Methodology Writing Committee, Peake SL, Delaney A, Bellomo R (2013) Harmonizing international trials of early goal‐directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. Intensive Care Medicine, 39(10): 1760‐1775.

Vaara ST, Pettila V, Kaukonen KM, Bendel S, Korhonen AM, Bellomo R and Reinikainen M (2014) The attributable mortality of acute kidney injury: a sequentially matched analysis. Critical Care Medicine, 42(4): 878‐85.

Verdile G, Laws SM, Henley D, Ames D, Bush AI, Ellis KA, Faux NG, Gupta VB, Li QX, Masters CL, Pike KE, Rowe CC, Szoeke C, Taddei K, Villemagne VL and Martins RN (2014) Associations between gonadotropins, testosterone and beta amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry, 19(1): 69‐75.

Villemagne VL, Furumoto S, Fodero‐Tavoletti MT, Mulligan RS, Hodges J, Harada R, Yates P, Piguet O, Pejoska S, Dore V, Yanai K, Masters CL, Kudo Y, Rowe CC and Okamura N (2014) In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging, 41(5): 816‐26.

Wallbridge PD, Hannan LM, Joosten SA, Irving LB and Steinfort DP (2013) Clinical utility of sequential venous blood gas measurement in the assessment of ventilatory status during physiological stress. Internal Medicine Journal, 43(10): 1075‐1080.

Wang AY, Bellomo R, Ninomiya T, Lo S, Cass A, Jardine M and Gallagher M (2014) Angiotensin‐converting enzyme inhibitor usage and acute kidney injury: A secondary analysis of RENAL study outcomes. Nephrology, published online 5 June 2014.

Warrillow SJ and Bellomo R (2014) Preventing cerebral oedema in acute liver failure: the case for quadruple‐H therapy. Anaethesia and Intensive Care, 42(1): 78‐88.

Weinberg L, Faulkner M, Tan C, Liu D, Tay S, Nikfarjam M, Peyton P and Story D (2014) Fluid prescription practices of anesthesiologists managing patients undergoing elective colonoscopy: an observational study. BMC Research Notes, 7(1): 356.

Wilkinson V, Stanley D and Howard M. (2014) Ausgrid Workplace 2013 Preventative Health Screening Activity Report: a longitudinal study of health screening of the Ausgrid Workforce Y4. 106.

Wilkinson VE, Jackson ML, Westlake J, Stevens B, Barnes M, Swann P, Rajaratnam SM and Howard ME (2013) The accuracy of eyelid movement parameters for drowsiness detection. Journal of Clinical Sleep Medicine, 9(12): 1315‐24.

Williams MT, Lewis LK, McKeough Z, Holland AE, Lee A, McNamara R, Phillips A, Wiles L, Knapman L, Wootton S, Milross M and Effing T (2014) Reporting of exercise attendance rates for people with chronic obstructive pulmonary disease: A systematic review. Respirology, 19(1): 30‐37.

Woinarski NC, Suzuki S, Lipcsey M, Lumsden N, Chin‐Dusting J, Schneider AG, Bailey M and Bellomo R (2014) Near‐infrared spectroscopy of the thenar eminence to estimate forearm blood flow Critical Care and Resuscitation, 15(4): 323‐326.

Wong BT, Glassford NJ, Bion V, Chai SY and Bellomo R (2014) Invasive blood pressure recording comparing nursing charts with an electronic monitor: a technical report. Critical Care and Resuscitation, 16(1): 73‐5.

Yates PA, Desmond PM, Phal PM, Steward C, Szoeke C, Salvado O, Ellis KA, Martins RN, Masters CL, Ames D, Villemagne VL and Rowe CC (2014) Incidence of cerebral microbleeds in preclinical Alzheimer disease. Neurology, 82(14): 1266‐73.

Yates PA, Villemagne VL, Ellis KA, Desmond PM, Masters CL and Rowe CC (2014) Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations. Frontiers in Neurology, 4: 205.

Young PJ and Bellomo R (2014) Fever in sepsis: is it cool to be hot? Critical Care, 18(1): 109.

Young PJ, Weatherall M, Saxena MK, Bellomo R, Freebairn RC, Hammond NE, van Haren FM, Henderson SJ, McArthur CJ, McGuinness SP, Mackle D, Myburgh JA, Webb SA, Beasley RW and Group AaNZICSCT (2013) Statistical analysis plan for the HEAT trial: A multicentre randomised placebo‐controlled trial of intravenous paracetamol in intensive care unit patients with fever and infection. Critical Care and Resuscitation, 15(4): 279‐286.

Zhang AL, Di YM, Worsnop C, May BH, Da Costa C and Xue CCL (2013) Ear Acupressure for Smoking Cessation: A Randomised Controlled Trial. Evidence‐Based Complementary and Alternative Medicine, 2013 (Article ID 637073): 8.

Zhang AL, Di YM, Worsnop C, May BH and Xue CCL (2013) Ear Acupressure for Smoking Cessation: Study Protocol for a Randomised Controlled Trial. Forschende Komplementärmedizin / Research in Complementary Medicine, 20(4): 290‐294.

Zhou L, Salvado O, Dore V, Bourgeat P, Raniga P, Macaulay SL, Ames D, Masters CL, Ellis KA, Villemagne VL, Rowe CC and Fripp J (2014) MR‐less surface‐based amyloid assessment based on 11C PiB PET. PLoS ONE, 9(1): e84777.

8. IBAS PRESENTATIONS

The following presentations were authored by IBAS Personnel between July 2013 and June 2014. Bold type denotes the presenting author. Published abstract details are included if applicable.

EUROPEAN MUSIC THERAPY CONGRESS July 2013, Oslo, Norway

Poster

The effect of singing on respiratory and voice function following cervical spinal cord injury: a randomized controlled trial. Tamplin J, Baker F, Grocke D, Pretto JJ, Brazzale DJ, Ruehland WR, Buttifant M, Brown DJ, Berlowitz DJ.

AUSTRALIA & NEW ZEALAND SPINAL CORD SOCIETY (ANZSCoS) ANNUAL SCIENTIFIC MEETING August 2013, Sydney, Australia

Free Paper

Sleep disruption in tetraplegia, its hormonal basis and a randomised, double‐blind placebo‐controlled crossover trial of melatonin supplementation. Spong J, Kennedy GA, Tseng J, Graco M, Brown DJ, Berlowitz DJ.

Rapid Poster

How recruiting to more than one acute clinical trial in spinal cord injury affects recruitment, withdrawal and other trial processes: the COSAQ experience. Graco M, Schembri R, Brown DJ, Alexander J, Millard M, Berlowitz DJ.

To 3T‐MRI or not to 3T‐MRI? Issues with the use of 3T‐MRI in patients with quadriplegia and obstructive sleep apnoea. Meaklim HJ, Berlowtiz DJ, Jackson G, Brown DJ, Connelly A, Farquharson S, Bliston LE, Hatt A, Cistulli PA, Sutherland K, Skordilis C, O'Donoghue F.

EUROPEAN RESPIRATORY SOCIETY (ERS) ANNUAL CONGRESS September 2013, Barcelona, Spain

Symposium

Interpretation of the change in six‐minute walk distance in patients with chronic respiratory disease. Holland AE.

Oral

A multi‐centre, randomised controlled trial of positive expiratory pressure therapy for inpatients with acute exacerbations of COPD and sputum expectoration. Osadnik C, McDonald CF, Miller BR, Hill C, Tarrant R, Chao C, Stodden N, Oliveira C, Gagliardi N, Holland AE. (European Respiratory Journal 2013; 42: Suppl.57, 678s)

Poster

The effect of positive expiratory pressure for airway clearance on ventilation inhomogeneity in individuals with stable COPD and chronic sputum expectoration. Osadnik C, Stuart‐Andrews C, Ellis S, Thompson B, McDonald CF, Holland AE. (European Respiratory Journal 2013; 42: Suppl.57, 688s)

AUSTRALIAN AND NEW ZEALAND SOCIETY OF NEPHROLOGY (ANZSN) 49TH ANNUAL SCIENTIFIC MEETING September 2013, Brisbane Australia

Mini Oral

Identification of a Novel Pathway Promoting Salt‐Retention in Obesity. Davies M, Katerelos M, Fraser S, Gleich K. Mount P, Power D. Nephrology 2012, 18(Suppl.1):34

AUSTRALASIAN CHRONOBIOLOGY SOCIETY (ACS) ANNUAL SCIENTIFIC MEETING September 2013, Adelaide, Australia

Invited Speaker

The clinical application of chronobiology. Kennedy G

AUSTRALASIAN SOCIETY OF CLINICAL IMMUNOLOGY & ALLERGY (ASCIA) ANNUAL CONFERENCE September 2013, Perth, Australia

Poster

Does change in symptom score reflect change in lung function following six months of Omalizumab treatment? Rochford S, Rochford P, Sutherland M

KAROLINSKA INSTITUTE September 2013, Stockholm, Sweden

Guest Speaker The dangers of dogma in intensive care. Bellomo R

ADSM OF SWEDISH FEDERATION OF ANAESTHESIA AND INTENSIVE CARE September 2013, Are, Sweden

Guest Speaker

The dangers of dogma in intensive care. Bellomo R

Lactate as a biomarker. Bellomo R

End of life care and the ICU doctor. Bellomo R

Renal biomarkers. Bellomo R

High impact research. Bellomo R

WORLD CONFERENCE ON LUNG CANCER (WCLC) October 2013, Sydney, Australia

Oral

Intra‐operative scanning confocal endomicroscopy of pleural disease: in vivo diagnosis of malignancy. Mitchell PL, Knight S, Crowley P, Putt F, Gooi J, Seevenayagam S, Barnett S, McDonald CF, Delaney P. (Journal of Thoracic Oncology, Nov 2013, 8 (Suppl 2) S249)

AUSTRALIAN AND NEW ZEALAND INTENSIVE CARE (ANZICS) AND AUSTRALIAN COLLEGE OF CRITICAL CARE NURESES (ACCCN) ANNUAL SCIENTIFIC MEETING October 2013, Hobart, Australia

Invited Speaker

Oxygen targets in mechanically ventilated patients. Bellomo R

Free Paper

Critical illness induced hyperglycemia occurs frequently in patients without pre‐existing diabetes. Annink C, Plummer M, Zaknic A, Reddi B, Raj J, Sundarajan K, Chapman M, Horowitz M, Bellomo R, Deame A. (Anaesthesia and Intensive Care, Vol. 42 No. 1, 2014. 106)

Comprehensive epidemiology of bactereuria in critically ill patients. Aubron C, Glassford N, Suzuki S, Garcia‐Alvarez M, Howden B, Bellomo R. (Anaesthesia and Intensive Care, Vol. 42 No. 1, 2014.)

Dialysate fluid flow in CVVHD: does countercurrent flow increase clearance for small solutes? Baldwin I, Baldwin M, Fealy N, Carty P, Bellomo R. (Anaesthesia and Intensive Care, Vol. 42 No. 1, 2014.)

Glycaemia is substantially altered in survivors of critical illness with pre‐existing type 2 diabetes. Cousins C, Zaknic A, Plummer M, Annink C, Chapman M, Horowitz M, Bellomo R, Deane A. (Anaesthesia and Intensive Care, Vol. 42 No. 1, 2014.)

INTERNATIONAL SPINAL CORD SOCIETY (ISCoS) ANNUAL SCIENTIFIC MEETING October 2013, Istanbul, Turkey

Oral

A systematic review and meta‐analysis of respiratory muscle training in tetraplegia. Berlowitz DJ, Tamplin J

Pathogenesis of obstructive sleep apnea in quadriplegia. Gainche L, Le Guen M, Trinder JA, Rochford PD, O’Donoghue FJ, Berlowitz DJ

Attention and information processing performance in people with acute quadriplegia and obstructive sleep apnea. Schembri R, Spong J, Berlowitz DJ, COSAQ Study team

Sleep disruption in tetraplegia, its hormonal basis and a randomised, double‐blind, placebo‐controlled crossover trial of melatonin supplementation. Spong J, Kennedy GA, Tseng J, Graco M, Brown DJ, Berlowitz DJ

Poster

How recruiting to more than one acute clinical trial in SCI affects recruitment, withdrawal and other trial processes: the COSAQ experience. Graco M, Schembri R, Brown DJ, Alexander J, Millard M, Berlowitz DJ.

AUSTRALIAN PHYSIOTHERAPY ASSOCIATION (APA) CONFERENCE October 2013, Melbourne, Australia

Invited Speaker

An overview of physiotherapy and exercise intervention in cardio‐respiratory patient populations – what is the evidence, where have we come from and what needs to be done in the future? Denehy L

Respiratory: Year in review. Holland A

Tele‐rehabilitation in cardiorespiratory disease – new ways to deliver effective therapies. Holland A

Oral

Pulmonary rehabilitation: can we predict who responds if the program includes an education component? Blackstock FC, Webster KE, McDonald CF, Hill CJ.

Physical activity in obesity hypoventilation syndrome. Burge AT, Holland AE, Berlowitz D, Piper A, Howard M, Yee B, Dabscheck E, Mortimer D, Scott B, Flunt D, Buchan C, Rautela L, Sheers N, Hillman D

Low physical activity levels and functional decline in individuals with non‐small cell lung cancer. Granger CL, McDonald CF, Irving L, Clark RA, Denehy L

Global positioning system tracking in non‐small cell lung cancer: comparison of physical activity behaviour to healthy controls. Granger CL, McDonald CF, Irving L, Clark RA, Denehy L

Minimal important difference in six‐minute walk distance and incremental shuttle walk distance in non‐cystic fibrosis bronchiectasis. Lee AL, Hill CJ, Cecins N, Jenkins S, McDonald CF Burge AT, Rautela L, Stirling RG, Thompson PJ, Holland AE

A multi‐centre, randomised controlled trial of positive expiratory pressure therapy for inpatients with acute exacerbations of COPD and sputum expectoration. Osadnik C, McDonald CF, Miller BR, Hill C, Tarrant R, Chao C, Stodden N, Oliveira C, Gagliardi N, Holland AE.

The effect of positive expiratory pressure for airway clearance on ventilation inhomogeneity in individuals with stable COPD and chronic sputum expectoration. Osadnik C, Stuart‐Andrews C, Ellis S, Thompson B, McDonald CF, Holland AE.

Adherence to global initiative for chronic obstructive lung disease (GOLD) guidelines for inpatients with acute exacerbation of COPD. Tang CY, Taylor NF, McDonald CF, Blackstock FC

Validation of the chronic respiratory disease questionnaire in non‐cystic fibrosis bronchiectasis. Vodanovich DA, Bicknell TJ, Holland AE, Hill CJ, Cecins N, Jenkins S, McDonald CF, Burge AT, Lee AL

Poster

Evaluation of the implementation of interventional bronchoscopy: local data from the Austin Hospital, Melbourne. Khor YH, Wallbridge P, Jennings B. (Journal of Thoracic Oncology, Nov 2013, 8 (Suppl 2) S655)

Implementation of Rapid On‐Site Evaluation for Linear EBUS: Local experience from the Austin Hospital, Melbourne. Wong R, Khor YH, Thai A, Ireland‐Jenkin K, Mitchell G, Jennings B. (Journal of Thoracic Oncology, Nov 2013, 8 (Suppl 2) S1246)

SLEEP DOWNUNDER 2013 ‐ AUSTRALASIAN SLEEP ASSOCIATION (ASA) & AUSTRALIAN SLEEP TECHNOLOGISTS ASSOCIATION (ASTA) ANNUAL SCIENTIFIC MEETING October 2013, Brisbane, Australia

Symposium

Sleep and breathing in the pregnant woman. Wilson D

Plenary

Are the new numbers the same as the old numbers? Rochford P

Oral

Physical activity in obesity hypoventilation syndrome. Burge AT, Holland AE, Berlowitz D, Piper A, Howard M, Yee B, Dabscheck E, Mortimer D, Scott B, Flunt D, Buchan C, Rautela L, Sheers N, Hillman D. (Sleep and Biological Rhythms 2013, 11 (Suppl2) 76:233)

Does the level of CO2 after arousal affect upper airway dilator muscle activity on the return to sleep? Cori J, O’Dongohue F, Rochford P, Trinder J, Jordan A. (Sleep and Biological Rhythms 2013, 11 (Suppl2) 74:229)

Short term outcomes for obstructive sleep apnoea patients treated with hypoglossal nerve stimulation. Smart K, O’Donoghue FJ, Worsnop CJ, Collins A, Barnes M. (Sleep and Biological Rhythms 2013, 11 (Suppl2) 68:214)

Poster + Mini Oral

Excessive daytime sleepiness and body composition: a population‐based study of women. Hayley A, Williams L, Kennedy G, Pasco J, Berk M. (Sleep and Biological Rhythms 2013, 11 (Suppl2) 3:009)

Repeatability of supine related obstructive sleep apnoea phenotypes. Joosten S, Hamza K, Churchward T, O'Donoghue F, Barnes M, Rochford P, Berger P, Hamilton G. (Sleep and Biological Rhythms 2013, 11 (Suppl2) 21:072)

Validation of respiratory magnetometers to measure end expiratory lung volume (EELV) in the supine position in men and women. Jordan A, Bourke R, Trinder J, Rochford P, O’Dongohue F. (Sleep and Biological Rhythms 2013, 11 (Suppl2) 27:085)

Comparison of estimated and measured sleep latency during home polysomnography among patients with suspected obstructive sleep apnoea. Khor Y, Tolson J, Rochford P, Churchward T, Worsnop CJ. (Sleep and Biological Rhythms 2013, 11 (Suppl2) 62:189)

Investigation into periodic limb movements (PLM) muscle activation patterns and the impact of sensor type on PLM detection. Raubenheimer J, Churchward T, Ruehland W, O’Dongohue F, Tolson J, Rochford P. (Sleep and Biological Rhythms 2013, 11 (Suppl2) 20:068)

Cortical response to threshold resistive loads in severe obstructive sleep apnoea. Ruehland W, Rochford, Webster K, Trinder J, O’Donoghue F. (Sleep and Biological Rhythms 2013, 11 (Suppl2) 3:010)

Traditional Chinese medicine diagnosis of obstructive sleep apnoea. Thornton T, O’Donoghue F, Rochford P, Xue C, Trinder J, Jordan A. (Sleep and Biological Rhythms 2013, 11 (Suppl2) 47:148)

Do shift workers fare as badly as obstructive sleep apnoea patients: investigating sleepiness, mood and performance. Westlake J, Kennedy G, Emerson P, Swann P, Howard M. (Sleep and Biological Rhythms 2013, 11 (Suppl2) 53:165)

WORKING TIME SOCIETY (WTS) November 2013, Bahia, Brazil

Thematic

Sleep disorders screening programs in commercial vehicle drivers. Howard M

AMERICAN SOCIETY OF NEPHROLOGY November 2013, Atlanta USA

Poster

Enhanced Phosphorylation of NKCC2 by SPAK/OSR1 in a Murine Model of Diet Induced Obesity. Davies MRP, Katerelos M, Gleich K, Fraser SA, Mount PF, Power DA

INTERNATIONAL SOCIETY OF ORGAN DONATION AND PROCUREMENT (ISODP) CONGRESS November 2013, Sydney, Australia

Oral

Normothermic extracorporeal perfusion of porcine and human liver following donation after cardiac death. Fink M, Bellomo R, Marino B, Strakey G, Wang BZ, Zhu N, Suzuki S, Houston S, Eastwood G, Calzavacca P, Glassford N, Chambers B, Skene A, Schneider AG, Jones D, Hilton A, Opdam H, Warrillow S, Gauthier N, Johnson L, Jones RM.

AUSTIN LIFESCIENCES (ALS) RESEARCH WEEK November 2013, Melbourne, Australia

A model for facilitating participant recruitment in spinal clinical trials in Victoria. Alexander JL, Millard MS, Berlowitz DJ, Graco M, Schembri R, Brown DJ.

Blood monocyte phenotype is not altered in primary lung cancer. Almatroodi AS, McDonald CF, Collins AL, Darby IA, Pouniotis DS.

Patient activity and environmental enrichment in the intensive care unit. Berney S, Rose JW, Bellomo R, Denehy L

The effect of adopting the new GLI reference equations on the interpretation of spirometry. Brazzale DJ, Hall GL, Pretto JJ.

A link between metabolism and renin: renin secretion in mice with mutations of the AMPK/ACC1 pathway. Choy SW, Fraser SA, Davies MRP, Cook N, Katerelos M, Mount PF, Gleich K, Dwyer KM, Hallows KR, Kemp BE, Power DA.

Enhanced phosphorylation of NKCC2 by SPAK/OSR1 in a murine model of diet induced obesity. Davies MRP, Katerelos M, Gleich K, Fraser SA, Mount PF, Power DA.

Impact of arterial blood gas assessment in patients admitted to intensive care following non‐traumatic cardiac arrest. Eastwood GM, Suzuki S, lluch C, Schneider AG, Bellomo R

Intensive care clinicians’ opinion of conservative oxygen therapy (SpO2 90‐92%) for mechanically ventilated patients: a survey. Eastwood GM, Peck L, Young H, Suzuki S, Garcia M, Bellomo R

How recruiting to more than one acute clinical trial in spinal cord injury affects recruitment, withdrawal and other trial processes: the COSAQ experience. Graco M, Schembri R, Brown DJ, Alexander J, Millard M, Berlowitz DJ.

Reliability of the 6‐minute walk test in idiopathic pulmonary fibrosis. Holland AE, Hill CJ, Dowman L, Goh N, Westall G, Symons K, Glaspole I.

Driver awareness of drowsiness and prediction of falling asleep prior to critical driving events during actual motor vehicle driving after actual night shift work. Howard ME, Lee ML, Horrey WJ, Liang Y, Anderson C, Shreeve MS, O'Brien C, Czeisler CA.

Comparison of estimated and measured sleep latency during home polysomnography among patients with suspected obstructive sleep apnoea. Khor YH, Tolson J, Churchward T, Rochford P, Worsnop CJ.

To 3T‐MRI or not to 3T‐MRI? Issues with the use of 3T‐MRI in patients with quadriplegia and obstructive sleep apnoea. Meaklim HJ, Berlowitz DJ, Jackson G, Brown DJ, Connelly A, Farquharson S, Bliston LE, Hatt A, Cistulli PA, Sutherland K, Skordilis C, O'Donoghue F.

Web‐based intervention for women with postpartum depression: feasibility trial results of MumMoodBooster. Milgrom J, Schembri C, Danaher B, Seeley J, Stuart S, Tyler M Ericksen J, Lester W, Gemmill A, Lewinsohn P

A multi‐centre, randomised controlled trial of PEP therapy for inpatients with acute exacerbations of COPD. Osadnik CR, McDonald CF, Miller BR, Hill C, Tarrant B, Steward R, Chao C, Stodden N, Oliveira O, Gagliardi N, Holland AE.

Investigation into periodic limb movements (PLM) muscle activation patterns and the impact of sensor type on PLM detection. Raubenheimer JL, Churchward TJ, Ruehland WR, O'Donoghue F, Tolson J, Rochford PD.

Does change in symptom score reflect change in lung function following 6 months of omalizumab treatment? Rochford S, Rochford P, Sutherland M.

Short term outcomes for obstructive sleep apnoea patients treated with hypoglossal nerve stimulation. Smart KG, O'Donoghue FJ, Worsnop CJ, Collins AL, Barnes M.

Suboptimal management of UFH compared with LMWH in the management of pulmonary embolism. Smith RL, Khor YH, McDonald C.

A pilot before‐and‐after trial of conservative oxygen therapy in mechanically ventilated patients. Suzuki S, Eastwood GM, Peck L, Glassford NJ, Schneider AG, Garcia M, Bellomo R

Oxygen management in mechanically ventilated patients: a prospective observational cohort study. Suzuki S, Eastwood GM, Peck L, Glassford NJ, Bellomo R

An assessment of forearm blood flow by ultrasound Doppler in critically ill patients. Thomson A, Hilton A, Christophi C, Bellomo R

Traditional Chinese Medicine diagnosis of obstructive sleep apnoea. Thornton T, O'Donoghue FJ, Rochford PD, Xue CCL, Trinder J, Jordan AS.

A multicentre randomized double‐blind controlled non‐inferiority multicentre study of Plasmalyte vs. Compound Lactate Solution (Hartmann’s solution) in patients receiving liver resection (Australian New Zealand Clinical Trials Registry No: 12610000147088). Weinberg L, Pearce B, Sullivan R, Siu L, Backstrom M, Scurrah N, Nikfarjam M, McNicol L, Bellomo R, Story D

Do shift workers fare as badly as obstructive sleep apnoea patients: investigating sleepiness, mood and performance. Westlake J, Kennedy G, Emerson P, Swann P, Howard M.

AMYOTROPHIC LATERAL SCLEROSIS / MOTOR NEURONE DISEASE (ALS/MND) INTERNATIONAL SYMPOSIUM December 2013, Milan, Italy

Oral

An ambulatory model of non‐invasive ventilation implementation improves survival in motor neurone disease. Sheers N, Berlowitz DJ, Smith C, Rautela L, Batchelder I, Howard ME.

SOCIETY OF CRITICAL CARE MEDICINE (SCCM) CRITICAL CARE CONGRESS January 2014, San Francisco

Poster

Continuous or intermittent renal replacement therapy in acute kidney injury: an economic perspective. Bagshaw S, Ethgen O, Schneider A, Bellomo R, Kellum J. Critical Care Medicine 2013, 41:12 (Suppl) 1012

INTERNATIONAL SYMPOSIUM ON INTENSIVE CARE AND EMERGENCY MEDICINE (ISICEM) March 2014, Brussels, Belgium

Invited Speaker

The outcome of sepsis has changed over time. Bellomo R

Bicarbonate administration for renal protection: a reappraisal. Bellomo R

Cluster RCTs. Bellomo R

The regional circulation of the kidney. Bellomo R

The hemodynamic effects of furosemide. Bellomo R

Novel biomarkers of AKI. Bellomo R

Oxygen targets in mechanically ventilated patients. Bellomo R

The hemodynamic effect of a fluid bolus. Bellomo R

Consider the MAP gap. Bellomo R

Routine lab tests to identify at risk patients. Bellomo R

Does type of RRT influence renal recovery? Bellomo R

Poster

Effects of perfusion pressure on the splanchnic circulation after cardiopulmonary bypass: a randomized double cross‐over study. McNicol L, Lipcsey M, Bellomo R, Parker F, Poustie S, Liu G, Uchino S, Kattula A. Critical Care 2014, 18 (Suppl1) P186:S67 (doi: 10.1186/cc13376)

Acute kidney injury and cardiac surgery: impact of fl uid balance on AKI classification and prognosis. Moore EM, Tobin A, Reid D, Santamaria J, Bellomo R. Critical Care 2014, 18 (Suppl1) P367:S133 (doi: 10.1186/cc13557)

Fluid accumulation post cardiac surgery and risk for renal replacement therapy. Moore EM, Tobin A, Reid D, Santamaria J, Bellomo R. Critical Care 2014, 18 (Suppl1) P388:S140 (doi: 10.1186/cc13578)

Haemodynamic eff ects of clonidine in an ovine model of severe sepsis with septic acute kidney injury. Calzavacca P, Lankadeva Y, Booth L, Bailey S, Bailey M, Bellomo R, May CN. Critical Care 2014, 18 (Suppl1) P414:S149 (doi: 10.1186/cc13604)

THORACIC SOCIETY OF AUSTRALIA & NEW ZEALAND AND AUSTRALIA & NEW ZEALAND SOCIETY OF RESPIRATORY SCIENCE (TSAANNZZSRS) ANNUAL SCIENTIFIC MEETING April 2014, Adelaide, Australia

Plenary

Physiotherapy in non‐cystic fibrosis bronchiectasis.: Lee A

Oral

Determinants of the 6‐min walk distance in individuals with lung cancer. Granger C, McDonald CF, Denehy L. (Respirology 2014:19(S2) 17)

Be honest and help me prepare for the future: what people with interstitial lung disease want from education in pulmonary rehabilitation. Holland AE, Fiore JF, Goh N, Symons K, Dowman L, Westall G, Glaspole I. (Respirology 2014:19(S2)20)

The sequelae of early life pneumonia and pleurisy on lung function from childhood to middle age. Perret JL, Walters H, Matheson MC, Johns DP, Burgess J, Lowe A, Thompson B, Pretto J, Markos J, Feather I, Morrison S, Thomas P,McDonald CF, Abramson MJ, Dharmage SC. (Respirology 2014:19(S2) 43)

Adherence to the global initiative for chronic obstructive lung disease (GOLD) strategy document for inpatients with an acute exacerbation of chronic obstructive pulmonary disease (COPD). Tang C, Taylor N, McDonald CF, Blackstock F. (Respirology 2014:19(S2) 50)

Poster

Optimal duration of physical activity monitoring in obesity hypoventilation syndrome. Burge A, Holland A, Berlowitz D, Piper A, Howard M, Yee B, Dabscheck E, Mortimer D, Stevens B, Flunt D, Buchan C, Rautela L, Sheers N, Hillman D. (Respirology 2014:19(S2) 133)

Reliability of the hand held dynamometer in measuring muscular strength in people with interstitial lung disease. Dowman L, McDonald CF, Hil CJ , Lee A, Barker K, Boote C, Glaspole I, Goh N, Southcott

A, Burge A, Ndongo R, Martin A, Holland AE. (Respirology 2014:19(S2) 92)

Physical function measured with the Grocery Shelving Task (GST) in patients with chronic obstructive pulmonary disease (COPD). Hill CJ, McDonald CF, Dowman L, Ndongo R, Cox N, Holland AE. (Respirology 2014:19(S2) 60)

Effects of the EverGo portable oxygen concentrator on exertional desaturation in people with interstitial lung disease. Holland AE, Goh N, Hazard A, Symons K, McDonald CF, Westall G, Glaspole I. (Respirology 2014:19(S2) 91)

Retrospective longitudinal study of patients with isolated reduction in single‐breath diffusing capacity. Khor YH, Brazzale D, Minson A, McDonald CF. (Respirology 2014:19(S2) 132)

Interventions to improve physical activity in chronic obstructive pulmonary disease (COPD) ‐ a systematic review. Lahham A, McDonald CF, Holland AE. (Respirology 2014:19(S2) 58)

Field walking tests are reliable and responsive to exercise training in individuals with non‐cystic fibrosis bronchiectasis. Lee AL, Cecins N, Holland AE, Hill C, Burge AT, Rautela L, Thompson PJ, Stirling R, McDonald CF, Jenkins S. (Respirology 2014:19(S2) 91)

Low self‐efficacy is associated with higher levels of dyspnoea and depression in patients with COPD. Lee AL, McDonald CF , Mahal AJ, Hill CJ, Burge A, Moore RP, Ndongo R, Cox N, Lahham A, Nicolson CH, O’Hallaron P, Holland AE. (Respirology 2014:19(S2) 58)

Are two six‐minute walk tests necessary during acute exacerbations Of COPD? Osadnik C, McDonald CF, Holland AE. (Respirology 2014:19(S2) 102)

Anxiety and depression during self‐management for COPD – an exploratory analysis of a multicentre randomized controlled trial (PRSM). Osadnik C, Madrusiak A, Haines T, Nitz J3, Chang A, Yang I, Low‐Choy N, Jackson C, Vicenzino B. (Respirology 2014:19(S2) 101)

SMART ANNUAL SCIENTIFIC MEETING May 2014, Milan, Italy

Invited speaker

Albumin in the critically ill. Bellomo R

Fluid bolus resuscitation in sepsis. Bellomo R

Mild hypoglycemia and outcome. Bellomo R

Fluids and oliguria. Bellomo R

Automatic monitoring of vital signs. Bellomo R

Preventing avoidable arrests in hospitals. Bellomo R

The dangers of chloride. Bellomo R

AMERICAN THORACIC SOCIETY (ATS) ANNUAL SCIENTIFIC MEETING May 2014, San Diego, USA

Plenary

Year in Review: Pulmonary Rehabilitation. Holland AE

Poster

Intensive care patients remain inactive despite receiving rehabilitation. Berney SC, Rose J, Bernhardt J, Denehy L. (American Journal of Respiratory and Critical Care Medicine 189, 2014:A2529)

Determinants of the 6‐min walk distance in individuals with lung cancer. Granger C, McDonald CF, Denehy L. (American Journal of Respiratory and Critical Care Medicine 189, 2014:A4157)

Dyspnoea and comorbidity contribute to anxiety and depression in Interstitial Lung Disease. Holland AE, Fiore JF, Bell E, Westall G, Symons K, Dowman L, Glaspole I. (American Journal of Respiratory and Critical Care Medicine 189, 2014:A1440)

Be honest and help me prepare for the future: what people with Interstitial Lung Disease want from education in pulmonary rehabilitation. Holland AE, Fiore JF, Goh N, Symons K, Dowman L, Westall G, Glaspole I. (American Journal of Respiratory and Critical Care Medicine 189, 2014:A1907)

The sequelae of early life pneumonia and pleurisy on lung function from childhood to middle age. Perret JL, Walters H, Matheson MC, Johns DP, Burgess J, Lowe A, Thompson B, Pretto J, Markos J, Feather I, Morrison S, Thomas P,McDonald CF, Abramson MJ, Dharmage SC, TAHS Investigators. (American Journal of Respiratory and Critical Care Medicine 189, 2014:A4625)

Investigation into periodic limb movements (plm) muscle activation patterns and the impact of sensor type on PLM detection. Rochford PD, Raubenheimer J, Churchward T, Ruehland W, Tolson J, O’Donoghue F. (American Journal of Respiratory and Critical Care Medicine 189, 2014:A5057)

AUSTRALIA AND NEW ZEALAND COLLEGE OF ANAESTHETISTS (ANZCA) ANNUAL SCIENTIFIC MEETING May 2014, Singapore

Poster Sodium bicarbonate infusion does not prevent acute kidney injury in patients undergoing orthotopic liver transplantation: a single‐centre prospective phase 2 blinded randomized controlled trial. Wienberg L, Broad J, Nguyen M, Scurrha N, Pillai P, Story D, Eastwood G, Bellomo R, McNicol L

CHINESE SOCIETY OF CRITICAL CARE MEDICINE ANNUAL SCIENTIFIC MEETING May 2014, Chongqing, China

Invited Speaker

Fluid management and real achievement of dose in renal replacement therapy. Bellomo R

SLEEP 2013 ‐ ANNUAL MEETING OF ASSOCIATED PROFESSIONAL SLEEP SOCIETIES (APSS), LLC May‐June 2014, Minneapolis, USA

Poster

The influence of CO2 in genioglossus muscle activity following arousal in obstructive sleep apnea patients. Cori J, Thornton T, O’Donoghue FJ, Rochford PD, Trinder J, Jordan AS. (SLEEP, Volume 37, Abstract Supplement 2014:A161)

Autobiographical memory bias in patients with obstructive sleep apnea. Jackson ML, Lee V, Kangen S, Pickersgill R, Trinder J. 9SLEEP, Volume 37, Abstract Supplement 2014:A161)

EUROPEAN RENAL ASSOCIATION (ERA) – EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION (EDTA) ANNUAL SCIENTIFIC MEETING May – June 2014, Amsterdam, The Netherlands

Poster

Tubular damage markers linked to iron metabolism or inflammation may improve classical clinical and routine biological risk assessment for major adverse kidney events. Haase‐Fielitz A, Albert C, Westphal S, Hoffmann J, Mertens PR, Michael Plaß M, Westerman M, Bellomo R, Maisel A, Ronco C, Haase M

Predictors of health‐related quality of life in survivors following acute kidney injury: A secondary analysis of post‐renal study outcomes. Wang AY, Bellomo R, Cass A, Myburgh J, Finfer S, Gatta D, Chadban S, Jardine M, Lo S, Barzi F, Gallagher M

Management of acute kidney injury ‐ is there an unmet medical need? Michael Haase M, Robra BP, Hoffmann J, Isermann B, Henkel W, Bellomo R, Ronco C, Haase‐Fielitz A

EUROANAESTHESIA – THE EUROPEAN ANAESTHESIOLOGY CONGRESS May – June 2014, Stockholm, Sweden

Poster

Poor agreement between meta‐analyses and subsequent large randomised controlled trials in peri‐operative medicine. Peyton P, Sivakumar H (European Journal of Anaesthesiology 31, e‐Supp 52)

COLLEGE OF INTENSIVE CARE (CICM) ANNUAL SCIENTIFIC MEETING June 2014, Brisbane, Australia

Invited Speaker

The risk of following guidelines (and how it might be reduced). Bellomo R

The risks of becoming an intensivist. Bellomo R

9. MEDIA AND AWARDS

MEDIA The mainstay of communication in the scientific world is through publication in scientific journals. However, researchers in all fields are becoming more comfortable with engaging with popular media as another way of communicating important findings. In addition, media coverage can inform the public about projects currently recruiting participants.

July 31st 2013: SEN Radio (116AM Melbourne): ‘Fit & Well: Helping you sleep’ A radio interview with David Berlowitz hosted by Paul Coburn and Daniel Harford. http://www.sen.com.au/audioplayer/Audio/Fit‐&‐Well‐Helping‐you‐sleep‐Part‐One/8817

August 2nd 2013: Podcast: ‘Listen to the Lancet’ Amy Jordan discusses sleep apnoea with Richard Lane. http://podcast.thelancet.com/lancet.xml

August 10th 2013: Heidelberg Leader: ‘Austin Hospital music therapist used song to help quadriplegics’ An article by Adrian Bernecich about Jeanette Tamplin’s University of Melbourne Chancellors Prize for her PhD project Singing in Spinal. http://www.heraldsun.com.au/leader/north/austin‐hospital‐music‐therapist‐uses‐song‐to‐help‐quadriplegics/story‐fnglenug‐1226694031965?sv=5f7bd8ec61bbf78c4fa8cedf9c473ff6

August 7th 2013: ABC Radio (774): ‘The Conversation Hour – a discussion about creative therapies’ A radio interview with Jeanette Tamplin hosted by Jon Faine. http://www.abc.net.au/local/audio/2013/08/07/3820586.htm?&section=latest&date=(none)

August 22nd 2013: Body & Soul – Herald Sun: ‘How to be a morning person’ An article by Kimberly Gillan featuring Gerard Kennedy. http://www.bodyandsoul.com.au/sex+relationships/wellbeing/how+to+be+a+morning+person,12491?gclid=COjTg8vD0MECFY8kvQod4aAAzg

September 12th 2013: Casey Weekly (Cranbourne): ‘The bottom line’ An article by Priscilla Moca featuring Gerard Kennedy.

September 13th 2013: Good Food (Fairfax media on‐line): ‘Eat to sleep well?’ An article by Annabel Smith featuring Maree Barnes. http://www.goodfood.com.au/good‐food/food‐news/eat‐to‐sleep‐well‐20130913‐2tox6.html

October 1st 2013: Marie Claire Magazine (on‐line only): ‘Why are you so tired?’ An article by Naomi Jaul featuring Maree Barnes. https://au.lifestyle.yahoo.com/marie‐claire/work‐and‐wellbeing/health‐and‐fitness/a/19530287/why‐are‐you‐so‐tired/

October 5th 2013: Melbourne Festival of Ideas: ‘Healing through art and the power of music’ An interactive session featuring Jeanette Tamplin. http://events.unimelb.edu.au/recordings/94‐festival‐of‐ideas‐healing‐through‐art‐and‐the‐power

October 12th 2013: The Weekend Australian: ‘How art and music therapy help people recover from tragedy and trauma’ An article by Kate Legge featuring regarding Jeanette Tamplin’s University of Melbourne Chancellors Prize and her stroke choir work. www.theaustralian.com.au/news/features/all‐together‐now/story‐e6frg8h6‐1226735620655

October 13th 2013: ABC Radio National: ‘All in the mind’ A radio interview with Jeanette Tamplin hosted by Lynne Malcolm. www.abc.net.au/radionational/programs/allinthemind/the‐power‐of‐music/4994272

October 17th 2013: Channel 9 News: ‘Female insomniacs in early 20’s’ A segment by Gabrielle Rogers featuring Melinda Jackson and Amie Hayley.

October 29th 2013: The Sydney Morning Herald and The Age (Traveller section): ‘Sleeping on planes: why one extra inch makes all the difference’ An article by Robert Upe featuring Maree Barnes. http://www.smh.com.au/travel/sleeping‐on‐planes‐why‐one‐extra‐inch‐makes‐all‐the‐difference‐20131029‐2wdns.html

November 1st 2013: The Melbourne Magazine (The Age): ‘#1 and counting’ An article by Ian Rose related to Cooperative Research Centres. IBAS is one of the two research institutes mentioned.

November 10th 2013: The Sunday Age: ‘Truckie Garry Mitchell’s diary reveals fatigue before fatal crash’ An article by Adam Cooper featuring quotes from Melinda Jackson.

December 5th 2013: ABC Radio (774): ‘Highway hypnosis’ An interview with Gerard Kennedy hosted by Courtney Carthy, Producer of the Drive program.

December 9th 2013: The Conversation: ‘Explainer: What is Music Therapy?’ an article featuring Jeanette Tamplin. http://theconversation.com/explainer‐what‐is‐music‐therapy‐20154

December 12th 2013: ABC Radio NSW: ‘What is Music Therapy?’ An interview with Jeanette Tamplin hosted by Chris Coleman (Statewide Afternoons).

January 28th 2014: Heidelberg Leader: ‘Working on Night Moves ‐ Sleep work seeks disease link’ An article by Laura Armitage featuring Professor Christopher Rowe, seeking participants for a research project.

February 11th 2014: You Tube video clip: ‘Why research matters’ Featuring David Berlowitz and Jack Ross, a video about spinal cord injury research.

May 29th 2014: Herald Sun: ‘Our tiny miracle’ An article by Brigid O’Connell about a premature baby whose mother had severe sleep apnoea and was a participant in an IBAS research project. http://www.heraldsun.com.au/news/victoria/born‐at‐26‐weeks‐weighing‐the‐size‐of‐a‐can‐of‐coke‐baby‐john‐is‐one‐of‐victorias‐smallest‐babies‐to‐survive/story‐fni0fit3‐1226934949946

June 15th 2014: Radio National: ‘Musical Recovery’ All in the Mind with Lynne Malcolm featuring Jeanette Tamplin. http://www.abc.net.au/radionational/programs/allinthemind/musical‐recovery/5512228

AWARDS Awards are one means of acknowledgment of exceptional work. Awards usually reflect a team effort even though the award is often given to one person only. As noted in the introduction to this report, this has been a good year for awards for IBAS personnel, with the following awards having been received this year:

September 2013: Christian Osadnik was awarded a European Respiratory Society Travel Grant at the ERS conference, based on his oral presentation: A multi‐centre, randomised controlled trail of positive expiratory pressure mask therapy for inpatients with acute exacerbations of COPD and sputum expectoration with co‐authors (including IBAS personnel Christine McDonald, Caroline Chao, Cristino Oliveira, Nadia Gagliardi, and Anne Holland).

October 2013: Christian Osadnik was awarded a Cardiorespiratory Physiotherapy (chronic disease) Prize at the APA conference, based on his oral presentation The effect of positive expiratory pressure for airway clearance on ventilation inhomogeneity in individuals with stable COPD and chronic sputum expectoration with co‐authors (including IBAS personnel Christine McDonald, Caroline Chao, Cristino Oliveira, Nadia Gagliardi, and Anne Holland).

November 2013: Anne Holland was awarded a Mid‐career Researcher Excellence Award from La Trobe University, in recognition of her international achievements in pulmonary rehabilitation research.

November 2013: Justine Westlake was awarded the Rob Pierce Memorial Award at Austin Research Week, for her poster titled Shift Do shift workers fare as badly as obstructive sleep apnoea patients: investigating sleepiness, mood and performance with co‐authors Gerard Kennedy, Paul Emerson, Phillip Swann and Mark Howard.

April 2014: Anne Holland was awarded the OLIV (Orphan Lung Disease, Lung Transplantation, Interstitial Lung Disease, Pulmonary Vascular Disease) Special Interest Group award at the TSANZ Scientific conference for her oral presentation Be honest and help me prepare for the future: what people with interstitial lung disease want from education in pulmonary rehabilitation with co‐authors (including IBAS personnel Nicole Goh and Leona Dowman).

10. IBAS PERSONNEL

IBAS personnel are listed by category in surname alphabetical order.

INTERNAL DIRECTORS

Internal Directors are IBAS Board members who also meet criteria for IBAS Fellow status.

Prof Christine McDonald CEO, IBAS Fellow, Director Austin Health Department of Respiratory & Sleep Medicine (DRSM) and Professor of Respiratory Medicine (The University of Melbourne)

Dr Mark Howard IBAS Fellow and Director Austin Health Victorian Respiratory Support Service (VRSS)

FELLOWS

Fellows are those who are engaged in self‐initiated research or education consistent with the aims of IBAS. They are able to take full scientific and ethical responsibility for a project.

Dr Nick Antoniades A/Prof Anne Holland Dr Fergal O’Donoghue

Dr Maree Barnes Dr Natasha Holmes Dr Christian Osadnik

Prof Rinaldo Bellomo Dr Mark Howard A/Prof Philip Peyton

Dr David Berlowitz Dr Melinda Jackson Dr Dodie Pouniotis

Dr Susan Berney Dr Amy Jordan Prof David Power

Prof Michael Christie A/Prof Gerard Kennedy Dr Jeffrey Pretto (dec 8/3/2014)

Dr Kate Crowley Dr Celia Lanteri Mr Peter Rochford

A/Prof Linda Denehy Dr Annemarie Lee Prof Christopher Rowe

Dr Karen Detering Dr Anne Lowell Dr Jo Spong

Dr Scott Fraser Prof Christine McDonald Dr Piyush Srivastava

Dr Nicole Goh Dr Marcus McMahon Dr Michael Sutherland

A/Prof Paul Gow Prof Jeannette Milgrom Dr Jeanette Tamplin

Dr Catherine Granger Dr Peter Mount Dr Christopher Worsnop

Dr Catherine Hill Dr Fergal O’Donoghue

ALUMNI

Alumni are people who have formerly been involved with IBAS and would like to maintain links with,

and support for, IBAS.

A/Prof Bruce Thompson

IBAS ASSOCIATES

IBAS Associates are people either currently involved in IBAS projects within their clinical role or with an interest in research, education or public advocacy.

Dr Naomi Atkins Mr Sandeep Gupta Dr Naghmeh Radhakrishna

Dr Stephen Barnett Ms Amie Hayley Ms Linda Rautela

Mr Danny Brazzale Ms Meredith Henderson Mrs Sue Rochford

Dr Matthew Campbell Mrs Melanie Holmes Mr Adam Rossely

Ms Caroline Chao Mr Rod Hone Ms Nicole Salter

Mr Tom Churchward Dr Megan Howden Ms Nicole Sheers

Ms Emma Clark Dr Angus Husband Ms Sharon Sibenaler

Ms Stephanie Clark Ms Li Jan Ms Kristin Southwell

Mr Simon Conti Dr Barton Jennings Ms Ieesha Sparks

Dr Bassem Dawood Miss Amy Kaplan Dr Phillip Swann

Mr Andrew Dawson Dr Yet Khor Ms Siew Tan

Ms Ann DiStefano Dr Melvin Lim Dr Jibin Thomas

Ms Anne Duncan Dr Simon Luzige Ms Julie Tolson

Ms Alex Ehlert Ms Sue Meade Ms Pavlina Toman

Mr Gavin Fahey Mr Joshua Miles Dr James Trauer

Dr Julio Fiore Ms Suzana Miseski Mrs Bilyana Trenevska

Ms Andrea Fitzgerald Dr Rosemary Moore Dr Amirthan Vinay

Ms Nadia Gagliardi Dr Sanjeevan Muruganandan Dr Peter Wallbridge

Dr John Garvey Mr Gary Nolan Dr James Ward

Dr Andrew Gikas Dr Michael Pallin Mr Jabin Webster

Mr Russell Gilmour Ms Jessica Patti Dr Raymond (Wai Mun) Wong

Ms Maureen Goodwin Dr Reza Pazhang

ADMINISTRATORS

Administrators are those responsible for administration, either for IBAS centrally or for specific projects or programs.

Mr Bruce Abell IBAS Finance Manager

Ms Margaret Bakewell IBAS Administration Officer

Ms Edwige Borg IBAS Finance Officer

Ms Vivienne Pearson Executive Research Officer

Ms Jacqui Wardell Administration Assistant – SHiQ Project

PROJECT STAFF

Project Staff are employed to work within specific IBAS project/s.

Mr Mark Barrett Mrs Sally Dan Ms Jacqueline Ross

Ms Lauren Booker Ms Rebecca Dimovitis Dr Hamna Sahi

Ms Rosie Bourke Mr Paul Emerson Miss Rachel Schembri

Ms Helen Boursinos Ms Marnie Graco Mr Con Skordilis

Ms Anne Buckland Ms Hailey Meaklim Mr Kyle Smart

Ms Angela Burge Ms Rebecca Ndongo Ms Bronwyn Stevens

Ms Allison Collins Mr Cristino Oliveira Miss Justine Westlake

Ms Narelle Cox Ms Jessica Raubenheimer Dr Vanessa Wilkinson

STUDENTS

IBAS Students are those enrolled in a course of study supervised by an IBAS Fellow on an approved project.

Mr Saleh Almatroodi PhD candidate RMIT University

Mrs Therese Thornton PhD candidate University of Melbourne

Ms Leona Dowman PhD candidate University of Melbourne

Mr Paul Emerson Honours student Victoria University

Miss Laura Gainche PhD candidate University of Melbourne

Dr Liam Hannan PhD candidate University of Melbourne

Dr Murad Ibrahim MD candidate University of Melbourne

Miss Aroub Lahham Masters Student La Trobe University

Dr Mariannick Le Guen PhD candidate University of Melbourne

Ms Jennifer Perret PhD candidate University of Melbourne

Mr Warren Ruehland PhD candidate University of Melbourne

Miss Rachel Schembri PhD candidate RMIT University

Ms Danielle Wilson PhD candidate University of Melbourne

Mr Bob Zhang AMS (Advanced Medical Science Student) University of Melbourne

11. FUNDING SOURCES

The Institute acknowledges and appreciates the support provided for its research from the following sources.

Competitive Grants

Austin Medical Research Foundation (AMRF)

Institute for a Broadband‐Enabled Society

National Health and Medical Research Council (NHMRC)

Motor Neurone Disease Research Institute of Australia

Spinal Cord Injury Network

The Eirene Lucas Foundation

The Spinal Research Institute (SRI)

Government and Industry

Biotechnology industry

Institute for Safety, Compensation and Recovery Research (ISCRR)

National Transport Commission

Pharmaceutical industry

preventionXpress

Transport Accident Commission (TAC)

Public Support

Membership Subscriptions o Life membership o Annual membership

Donations o Funds received for Institute research and programs in accordance with the deductible gift

recipient status of IBAS as administered by the Medical & Scientific Research Committee

Deductible Gift Recipient Status

The Institute is endorsed as a Deductible Gift Recipient from the Australian Taxation Office.

DONATIONS

Awareness is increasing about the profound effect that sleep and respiratory disorders have on the lives of many Australians. You may have personal experience of these disorders, know others who are affected or may simply be interested in translating your awareness into positive action.

Although much of the research undertaken by IBAS is funded by grants from various organisations, the Institute welcomes donations from the business community and individuals.

Donations are totally directed to funding initiatives into research, education and public advocacy in respiratory and sleep health.

You have the option of supporting the overall work of IBAS or choosing to support one particular project or specific area of research.

IBAS is a registered charity so all donations of $2.00 and over are fully tax deductible. A receipt will be issued.

Donate Online – go to www.ibas.org.au/how‐you‐can‐help/donations. You can donate online using the free and secure GiveNow donations service. Receipts will be automatically sent to your email address.

Donate by phone Phone 9496 5390 to donate using your credit card over the phone.

Donate by mail/fax Donation forms are available by phoning 9496 5390 or from www.ibas.org.au/how‐you‐can‐help/donations Please send completed forms to: IBAS, Bowen Centre, Austin Hospital, PO Box 5555, Heidelberg, Vic, 3084. Alternatively, you can fax the form to 9496 5124.

Recurring donations ‐ go to www.ibas.org.au/how‐you‐can‐help/donations The free and secure GiveNow online donations service allows you to set up monthly donations for a set period of time.

Donations as gifts ‐ go to www.ibas.org.au/how‐you‐can‐help/donations Donations are becoming a popular way of giving a meaningful gift. Donations can be made in someone else's name using any of the methods listed on this page. If you choose to use the free and secure GiveNow online donations, once you have selected an amount to donate, click on the 'Special Message' section. Whichever method you use, you will receive the receipt and the person you are giving to will receive a note of thanks.

Bequests – go to www.ibas.org.au/how‐you‐can‐help/donations If you or a loved one are considering making a bequest, please see the GiveNow online donations service for options to consider and suggestions for wording.

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