Ultrasound Scan Analysis Summary

Courtesy of Dr. Mervyn PattersonWoodford Clinic, Danbury, United Kingdom

Full clinical report available: DermaFrac™ Clinical Trial Report: Ultrasound Analysis DFR-BNA-002 Rev C

BACKGROUND The benefit of including ultrasound as an assessment tool is that it provides quantitative information about what is happening beneath the skin surface which is not always clinically evident.CLINICAL ANALYSIS Nine (9) volunteers between the ages of 42-54 were assessed. Scans were performed prior to treatment (Visit 1) and again at 20 weeks (Visit 2).OBJECTIVES (1) To establish the presence of serum deposited into the upper dermis (Figure 2): Patient M.P; and (2) To establish the effect of the DermaFrac™ treatment on collagen production (Figure 3):; Patient J.D.METHODS A series of six (6) DermaFrac™ Rejuvenate treatments were performed two weeks apart. Only the DermaFrac™ treatments were performed; better results may be achieved when combined with microdermabrasion and LED light therapy, which the DermaFrac™ system offers. RESULTS The difference between Visit 1 to Visit 2 was highly significant, showing a 14.79% increase in collagen.

Figure 1 indicates that the two Zones are clearly different. Zone A is in an area of skin which is highly collagenous and therefore highly reflective to the ultrasound so we see a predominance of yellow pixels. Zone B is in an area of the skin that has noticeably less collagen.

Figure 1:

This scan was taken at the border of the treatment zone so we can see both treated and non-treated areas. Note the region just below the epidermis. In the treated area there is a fluid present which is absent in the non-treated area.

Figure 2: Figure 3:

Visit 1 Visit 2

The results show that the difference between Visit 1 to Visit 2 is highly significant. In this area we see a 14.79% increase in collagen.

15% increase in collagen.DermaFrac™ treatment only;

no microdermabrasion or LEDs.

Serum deposited in the upper dermis

DFR-BNA-003 Rev C: Page 1

60 Year Old Female

6 DermaFrac™ Rejuvenate Treatments

Courtesy of Professor Stephen A. Schendel, MD, DDSPalo Alto, California

Treatment consisted of Crystal-Free Microdermabrasion, DermaFrac™ Micro-Channeling with Rejuvenate Infusion and Red LED Therapy

Before After

Much improved hydration and plumpness.

Significant improvement in fine lines and wrinkles.

DFR-BNA-003 Rev C: Page 2

62 Year Old Female

6 DermaFrac™ Rejuvenate Treatments

Courtesy of Professor Stephen A. Schendel, MD, DDSPalo Alto, California

Treatment consisted of Crystal-Free Microdermabrasion, DermaFrac™ Micro-Channeling with Rejuvenate Infusion and Red LED Therapy

Before After

More even skin tone and texture; improved hydration and plumpness.

Fine lines and pigment changes.

DFR-BNA-005 Rev B

48 Year Old Male

8 DermaFrac™ Treatments(4 Rejuvenate, 4 Lighten)

Courtesy of Dr. Martin KassirDallas, Texas

Treatment consisted of Crystal-Free Microdermabrasion and DermaFrac™ Micro-Channeling with Rejuvenate and Lighten Infusions

Before After

Significant improvement in dark circles under eyes.

DFR-BNA-006 Rev B

41 Year Old Female

8 DermaFrac™ Treatments(4 Rejuvenate, 4 Lighten)

Courtesy of Dr. Martin KassirDallas, Texas

Treatment consisted of DermaFrac™ Micro-Channeling with Rejuvenate and Lighten Infusions

Before After

Significant pigment changes.

DFR-BNA-004 Rev C

59 Year Old Female

Before (UV Photograph) 2 Weeks After Final Treatment (UV Photograph)

5 DermaFrac™ Hydrate Treatments

Courtesy of Dr. Martin KassirDallas, Texas

Treatment consisted of DermaFrac™ Micro-Channeling with Hydrate Infusion. NOTE: UV Photography reveals dehydration with bright blue fluorescence.

Sustained hydration. UV photograph taken 2 weeks after last treatment.

Significant dehydration.