146256 2 merged 1449157353-1 - cancer discovery€¦ · ri wkh wxpru vxssuhvvru 37(1 zklfk lv d...
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![Page 1: 146256 2 merged 1449157353-1 - Cancer Discovery€¦ · ri wkh wxpru vxssuhvvru 37(1 zklfk lv d olslg skrvskdwdvh wkdw gdpshqv wkh dfwlylw\ ri 3, . vljqdolqj /rvv ri 37(1 fruuhvsrqgv](https://reader035.vdocuments.site/reader035/viewer/2022070720/5ee0c40aad6a402d666be17e/html5/thumbnails/1.jpg)
Research. on June 8, 2020. © 2015 American Association for Cancercancerdiscovery.aacrjournals.org Downloaded from
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on December 8, 2015; DOI: 10.1158/2159-8290.CD-15-0283
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Research. on June 8, 2020. © 2015 American Association for Cancercancerdiscovery.aacrjournals.org Downloaded from
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on December 8, 2015; DOI: 10.1158/2159-8290.CD-15-0283
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Research. on June 8, 2020. © 2015 American Association for Cancercancerdiscovery.aacrjournals.org Downloaded from
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on December 8, 2015; DOI: 10.1158/2159-8290.CD-15-0283
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Research. on June 8, 2020. © 2015 American Association for Cancercancerdiscovery.aacrjournals.org Downloaded from
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on December 8, 2015; DOI: 10.1158/2159-8290.CD-15-0283
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BRAF,
BRAF α β
β
Research. on June 8, 2020. © 2015 American Association for Cancercancerdiscovery.aacrjournals.org Downloaded from
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BRAF
BRAF
BRAF
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in
vitro in vivo.
BRAF
BRAF
in vitro
in vivo
in vivo
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in vitro in vivo
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BRAF NRAS BRAF BRAF/NRAS
PTEN
PTEN
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γ PTEN
PTEN
PTEN
CTNNB1 β
PTEN
PTEN β
β
χ
β
Research. on June 8, 2020. © 2015 American Association for Cancercancerdiscovery.aacrjournals.org Downloaded from
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in vitro
in vivo
in vivo
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TNFRSF10C PDGFRB, TILR3,
MASP2 CLU
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ATG16L
ATG16L
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MAP1LC3B
MAP1LC3B
MAP1LC3B
MAP1LC3B MAP1LC3B
MAP1LC3B
MAP1LC3B
β
β
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β
In vitro β
β
β
β
β
β
β
β
BRAF
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in vivo β
β
β
β β
β
β
in vivo
BRAF
β
β
β
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β
BRAF,
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BRAF
BRAF
BRAF-
BRAF/NRAS-
PTEN
PTEN
β
β
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in vivo
in vitro, in vivo
γ
in vivo
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in vitro
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in vitro
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β
in vitro in vivo
in vitro in vivo
β
β
β
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BRAF
in vitro in vivo
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in vivo
in vivo
μ
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in vivo
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Published OnlineFirst December 8, 2015.Cancer Discov Weiyi Peng, Jie Qing Chen, Chengwen Liu, et al. immunotherapyLoss of PTEN promotes resistance to T cell-mediated
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