12th international symposium, exhibit and workshops on...
TRANSCRIPT
1
12th International Symposium, Exhibit and Workshops on
Preparative / Process Chromatography,
Ion Exchange,
Adsorption / Desorption Processes
& Related Separation Techniques
May 23 – 26, 1999 Holiday Inn Golden Gateway
San Francisco, CA, USA
Final Program
2
1999 PREP SYMPOSIUM & EXHIBIT
SYMPOSIUM CHAIRMEN
DR. GEORGES GUIOCHON DR. JOHN FRENZ
University of Tennessee and Genentech
Oak Ridge National Laboratory
ORGANIZING COMMITTEE
Firoz Antia, Merck & Company
Giorgio Carta, University of Virginia
John Frenz, Genentech
Georges Guiochon, Univ. of Tennessee and Oak Ridge National Laboratory
Jana Jacobson, Lygra-mura
Anita Katti, Engineering and Process Chromatography Solutions
Klaus Lohse, BTR-Separations
Joan Newburger, R.W. Johnson Pharmaceutical Research Institute
SPONSORS
We would like to acknowledge the following organizations for their support:
NovaSep, Prochrom, TechniKrom, and Waters
SYMPOSIUM MANAGER
Ms. Janet Cunningham
Barr Enterprises
P. O. Box 279
Walkersville, MD 21793 USA
Phone 301-898-3772 Fax 301-898-5596 E-mail [email protected]
3
GENERAL INFORMATION
BADGES A name badge must be worn by each registered participant and
accompanying persons in order to gain admittance to the meeting, exhibits,
posters, and social gatherings.
REGISTRATION If you need assistance, please come to the Symposium Registration
Desk located outside the Emerald Room on the lobby level. The
Registration Desk will be open throughout the Symposium.
PROGRAM Lectures will be held in the Emerald Room. On the lower level, posters
will be displayed in the Pacific Suite Rooms, Exhibits will be held in the
Gold Rush Ballroom, and receptions and coffee breaks will be located
near the Exhibit area.
POSTER — Poster boards are labeled with the number corresponding to the
SESSIONS abstract number in the Final Program Book.
— Authors presenting posters are requested to be in attendance at their
posters during the times indicated in the program.
— Posters with program numbers in the 100 series will be presented on
Monday, and posters with program numbers in the 200 series will be
presented on Tuesday.
— Poster Sessions will take place in the Pacific Suite
— All posters should be mounted on Monday between 8AM and 1PM,
and will remain on display all day Monday and Tuesday so attendees
have opportunities to view all posters throughout both days.
— Posters must be removed by 6PM on Tuesday (anything remaining
after that time will be discarded).
AUTHOR INDEX Author Index is located at the end of the Final Program Book
“L” preceding abstract number = lecture
“P” preceding abstract number = poster
EXHIBITS The exhibition is an important component of the meeting, so please
take time to thank all the exhibitors for their support of the program.
Exhibits will be held in the Gold Rush Ballroom located on the lower level
of the hotel. Exhibit hours are Monday and Tuesday, 8:30 am – 7:00 pm.
Exhibit-only guest passes are available on Tuesday, May 25, from 9:00 am
to 7:00 pm.
SPEAKER For those who will give lecture presentations and wish to
PREVIEW ROOM preview their slides, they may do so in the Executive
Conference Room, located across from the Emerald Room.
SPONSORS Monday 6-7PM Reception sponsored by TECHNIKROM
Tuesday 6-7PM Reception sponsored by PROCHROM
Monday coffee break sponsored by NOVASEP
4
CORPORATE SPONSORS
We would like to acknowledge the following organizations for their support:
TECHNIKROM
PROCHROM
WATERS
NOVASEP
5
FREE VENDOR WORKSHOPS
• To attend, Symposium registrants MUST PRE-REGISTER (see details below)
• Booths are located in the Gold Rush Ballroom located on the lower level of the hotel
• Space is limited and pre-registration is required
MONDAY, MAY 24
12:30 – 1:45 pm Workshop on Practical Issues in the Ion Exchange
Chromatography of Proteins at Production Scale
Sponsored by Whatman — complimentary lunch provided
Location: Emerald Room (lobby level of hotel)
Pre-registration at Whatman’s booth is required
TUESDAY, MAY 25
7:15 – 8:30 am Workshop on BioProcessing Equipment Design Considerations
Sponsored by TechniKrom — complimentary continental breakfast provided
Location: Emerald Room (lobby level of hotel)
Pre-registration at TechniKrom’s booth is required
— OR —
7:15 – 8:30 am Workshop on BioPharmaceutical Purification Processes
Sponsored by Sepragen — complimentary continental breakfast provided
Location: Monterey/Carmel Room (lower level of hotel)
Pre-registration at Symposium Registration Desk is required
TUESDAY, MAY 25
12:30 – 1:45 pm Workshop on Gradiflow—A Revolution in Protein Purification
Sponsored by Gradipore — complimentary lunch provided
Location: Emerald Room (lobby level of hotel)
Pre-registration at Gradipore’s booth is required
— OR —
12:30 – 1:45 pm Workshop on Recent Advances in Recycling Preparative HPLC
Sponsored by DyChrom — complimentary lunch provided
Location: Monterey/Carmel Room (lower level of hotel)
Pre-registration at Symposium Registration Desk is required
WEDNESDAY, MAY 26
7:15 – 8:30 am Workshop on An Introduction to EasyPack and Geltech
Industrial Chromatography Columns – easy to use, sanitary design
columns for pilot and production scale biotherapeutic manufacturing
Sponsored by PE Biosystems — complimentary continental breakfast provided
Location: Emerald Room (lobby level of hotel)
Pre-registration at PE Biosystems’ booth is required
— OR —
7:15 – 8:30 am Workshop on Optimization in Industrial HPLC
Sponsored by EKA Nobel — complimentary continental breakfast provided
Location: Crystal Room (lobby level of hotel)
Pre-registration at BTR-Separations’ booth is required
6
MONDAY, MAY 24
— Meeting Location: Emerald Room —
8:00 am Registration
8:30 am Exhibits Open in Gold Rush Ballroom (location of coffee breaks)
8:55 am Opening Remarks
CHAIR: DR. JOHN FRENZ
9:00 am (L-101) The Challenge for HPLC Separations in the Post-Genome Era
—William S. Hancock, J. Chakel, A. Apffel, K. Hahnenberger,
G. Choudhray, Hewlett-Packard, Palo Alto, CA, USA; E. Lehmberg,
E. Pungor, Jr., Berlex Biosciences, Richmond, CA, USA;
Cs. Horvath, Yale University, New Haven, CT, USA
9:20 am (L-102) Optimization of the Extraction and Purification of a
Recombinant Protein Pharmaceutical—Raymond Arnold,
J. Cacia, J. Frenz, Genentech, S. San Francisco, CA, USA
9:40 am (L-103) Purification of Recombinant Proteins From Yeast Broth
Containing a High Percentage of Solids Using Expanded Bed
Chromatography—Shiaw-Lin (Billy) Wu, R. Caren, I. Vassilieva,
F. Leung, P. Stathis, S. Chamow, Scios, Mountain View, CA, USA
10:00 am (L-104) Process Validation in the Development of the Recombinant
Protein Pharmaceutical Lenercept—Marjorie E. Winkler,
M. Field, Z. Shahrokh, M. Vanderlaan, Genentech, S. San
Francisco, CA, USA
10:20 am BREAK sponsored by NOVASEP
Location: Gold Rush Ballroom on lower level of hotel
7
MONDAY, MAY 24
— Meeting Location: Emerald Room —
CHAIR: PROF. GIORGIO CARTA
10:50 am (L-105) Preparative Purification and Quality Control of Biologically
Active Proteins From Human Plasma—Djuro Josic, H. Schwinn,
A. Buchacher, P. Schulz, G. Gruber, K. Pock, Octapharma
Pharmazeutika Produktionsges. m.b.h., Vienna, AUSTRIA
11:10 am (L-106) Integrating Maldi-TOF and Preparative-LC as a Tool in the
Identification of Recombinant Proteins as Vaccine Candidates—
Michael Meys*, A. Sultana†, R.G. Ulrich†, P. Lynch*, T. Nadler*,
D. Whitney*, and D. Patterson*, PE Biosystems, Framingham, MA,
USA; †USAMRIID, 1425 Porter St., Fort Detrick, Frederick, MD,
USA
11:30 am (L-107) Semi-Preparative Scale Purification of Monoclonal
Antibodies—Gerald Bell, N. Fuschetto, T. John, and S. Mische,
Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, USA
11:50 am (L-108) The Development and Optimization of Non-Affinity and
Non-Traditional Affinity Methods for Monoclonal Antibody
Purification—Natalie Fuschetto, G. Bell, T. John, S. Mische,
Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, USA
12:10-3:30 pm BREAK / EXHIBITS / POSTERS
12:30-1:45 pm WORKSHOP on Practical Issues in the Ion Exchange
Chromatography of Proteins at Production Scale
Sponsored by Whatman—complimentary lunch provided
Location: Emerald Room (lobby level of hotel)
Pre-registration at Whatman’s booth is required
2:00-3:15 pm POSTER SESSION
Location: Pacific Suite (lower level of hotel)
8
MONDAY, MAY 24
— Meeting Location: Emerald Room —
CHAIR: PROF. ATHANASIOS I. LIAPIS
3:30 pm (L-109-new) SMB Design for Chiral Separation: Optimal Particle Size of the
(moved from L-302) Stationary Phase—O. Ludemann-Hombourger, Roger M. Nicoud,
NovaSep SA, Vandoeuvre l’Nancy, FRANCE
3:50 pm (L-110) Highly-Productive Preparative Enantiomeric Separations Using
Carbon Dioxide Chromatography—F. Geiser, Mohamed
Shaima, J. K. Lee, Chiral Technologies, Exton, PA, USA
4:10 pm (L-111) Optimization of Chiral Separations Using Laser-Based
Polarmetric Detection—Gary W. Yanik*, D.R. Bobbitt, *PDR-
Chiral, Palm Beach Gardens, FL, USA; University of Arkansas,
Fayetteville, AR, USA
4:30 pm (L-112) The Preparative Separation of Racemic Mixtures:
A Comparison of the Conventional Recycling and Steady State
Recycling Techniques—Charles M. Grill*, L.A. Dolak, E.P.
Seest, *R&S Technology, Wakefield, RI, USA; Pharmacia &
Upjohn, Kalamazoo, MI, USA
4:50 pm PAUSE
5:10 pm GENERAL DISCUSSION
6:00-7:00 pm RECEPTION sponsored by TECHNIKROM
Location: Gold Rush Ballroom on lower level of hotel
Visit the TechniKrom booth to receive complimentary drink tickets
9
TUESDAY, MAY 25
— Meeting Location: Emerald Room —
7:15-8:30 am WORKSHOP on BioProcessing Equipment Design Considerations
Sponsored by TechniKrom—complimentary continental breakfast provided
Location: Emerald Room (lobby level of hotel)
Pre-registration at TechniKrom’s booth is required
7:15 – 8:30 am WORKSHOP on BioPharmaceutical Purification Processes
Sponsored by Sepragen — complimentary continental breakfast provided
Location: Monterey/Carmel Room (lower level of hotel)
Pre-registration at Symposium Registration Desk is required
8:30 am Exhibits Open in Gold Rush Ballroom (location of coffee breaks)
CHAIR: DR. ANDREAS SEIDEL-MORGENSTERN
9:00 am (L-201) Flow Distribution in Chromatographic Column—
Q. Sarah Yuan, J.S. Moscariello, M.A. Teeters, T.W. Root,
E.N. Lightfoot, University of Wisconsin, Madison, WI, USA
9:20 am (L-202) Evidence of Wall Friction in the Consolidation of Beds of
Packing Materials in Chromatographic Columns—
Georges Guiochon, E. Drumm, B.G. Yew, D. Cherrak, University
of Tennessee, Knoxville, TN, USA and Oak Ridge National
Laboratory, Oak Ridge, TN, USA
9:40 am (L-203) Network Modeling and Simulation of the Performance of
Continuous Bed Chromatography—J.J. Meyers,
Athanasios I. Liapis, University of Missouri, Rolla, MO, USA
10:00 am (L-204) Expanded-Bed Chromatography in Primary Protein
Purfication—F. Birger Anspach, GBF-Gesellschaft fuer
Biotechnologische Forschung mbH, Braunschweig, GERMANY
10:20 am BREAK
Location: Gold Rush Ballroom on lower level of hotel
10
TUESDAY, MAY 25
— Meeting Location: Emerald Room —
CHAIR: DR. ANTIA M. KATTI
10:50 am (L-205) Preparative Chromatography in Synthesis for Pharmaceutical
Market Registration: Regulatory Implications and Control
Strategies—Joan Newburger, R.W. Johnson Pharmaceutical
Research Institute, Spring House, PA, USA
11:10 am (L-206) Quantification of Single Solute and Competitive Adsorption
Isotherms Using a Closed-Loop Perturbation Method—
C. Bluemel¹, P. Hugo2, Andreas Seidel-Morgenstern3,
¹Wissenschaftlicher Gerätebau H. Knauer GmbH, Berlin,
GERMANY; 2Technische Universität Berlin, Berlin, GERMANY; 3Otto-von-Guericke Universität Magdeburg, Magdeburg,
GERMANY
11:30 am (L-207) An Investigation of Hydrophobic Interaction Chromatography
Using Flow Microcalorimetry—M. Esquibel-King, A.C. D.
Cabral*, J.A.S.R. Queiroz*, Neville G. Pinto, University of
Cincinnati, Cincinnati, OH, USA; *Universidade da Beira Interior,
Covilha, PORTUGAL
11:50 am (L-208) Protein Diffusion in Charged Polyacrylamide Gels:
Visualization and Modeling—R.K. Lewus, Giorgio Carta,
University of Virginia, Charlottesville, VA, USA
12:10-3:30 pm BREAK / EXHIBITS / POSTERS
Location: Gold Rush Ballroom and Pacific Suite on lower level of hotel
12:30-1:45 pm WORKSHOP on Gradiflow—A Revolution in Protein Purification
Sponsored by Gradipore—complimentary lunch provided
Location: Emerald Room (lobby level of hotel)
Pre-registration at Gradipore’s booth is required
12:30 – 1:45 pm WORKSHOP on Recent Advances in Recycling Preparative HPLC
Sponsored by DyChrom — complimentary lunch provided
Location: Monterey/Carmel Room (lower level of hotel)
Pre-registration at Symposium Registration Desk is required
2:00-3:15 pm POSTER SESSION
Location: Pacific Suite (lower level of hotel)
11
TUESDAY, MAY 25
— Meeting Location: Emerald Room —
CHAIR: DR. JANA JACOBSON
3:30 pm (L-209) The Cost of Not Optimizing the Design and Operating
Parameters in Process Chromatography—Anita M. Katti,
Engineering and Process Chromatography Solutions, Boulder,
CO, USA
3:50 pm (L-210) Titanium Dioxide - Unique Selectivity for Preparative Liquid
Chromatography—B. Hirthe, Jochen Winkler, G. Benkner,
R. Wittenberg, S. Marmé, Sachtleben, Duisburg, and Ulrich
Trüdinger Consulting, Wiesbaden, GERMANY
4:10 pm (L-211) Preparation and Characterization of a New High Capture, High
Capacity Process Media—Jia Li Liao, H. Chen, L. Cummings, S.
Franklin, R. Frost, W.-K. Lam, L. Olech, C. Ordunez, K. Talmadge,
T. Tisch, Bio-Rad Laboratories, Hercules, CA, USA
4:30 pm (L-212) Hydrophobic Displacement Chromatography (HDC):
Applications for Bioprocessing—Kkhurram M. Sunasara,
A.A. Shukla, S.M. Cramer, Rensselaer Polytechnic Institute,
Troy, NY, USA
4:50 pm PAUSE
5:10 pm GENERAL DISCUSSION
6:00-7:00 pm RECEPTION sponsored by NOVASEP
Location: Gold Rush Ballroom on lower level of hotel
7:00 pm EXHIBIT CLOSES
12
WEDNESDAY, MAY 26
— Meeting Location: Emerald Room —
7:15-8:30 am WORKSHOP on An Introduction to EasyPack and Geltech Industrial
Chromatography Columns – easy to use, sanitary design columns for
pilot and production scale biotherapeutic manufacturing
Sponsored by PE Biosystems—complimentary continental
breakfast provided
Location: Emerald Room (lobby level of hotel)
Pre-registration at PE Biosystems’ booth is required
7:15-8:30 am WORKSHOP on Optimization in Industrial HPLC
Sponsored by EKA Chemicals—complimentary continental
breakfast provided
Location: Crystal Room (lobby level of hotel)
Pre-registration at BTR-Separations’ booth is required
CHAIR: DR. FIROZ ANTIA
9:00 am (L-301) An Overall Mass Transfer Design Method for SMB
Chromatography for Amino Acids Separation—Y. Xie, D.J. Wu,
Z. Ma*, N.-H.L. Wang, Purdue University, W. Lafayette, IN, USA;
*Bioanalytical Systems, W. Lafayette, IN, USA
(presented by Ben Hritzko)
9:20 am (L-302-new) SF-SMB (Supercritical Fluid Simulated Moving Bed) Application to
Chiral Separations—Olivier Ludemann-Hombourger, F. Denet,
M. Bailly, R.M. Nicoud, NovaSep SA, 15 Rue du Bois de la
Champelle, BP 50, 54502 Vandoeuvre , FRANCE
9:40 am (L-303) Separation of Phytol-Stereoisomers in a SFC-SMB Plant—
A. Depta, T. Giese, Monika Johannsen, G. Brunner, Technische
Universität Hamburg-Harburg, Hamburg, GERMANY
10:00 am (L-304) Enantiomer Separation by SMB Chromatography: The Case of
Non-Instantaneous Equilibrium at the Solid-Fluid Interface—
Diana C.S. Azevedo, M. Li and A.E. Rodrigues, LSRE, University
of Porto, Porto Codex, PORTUGAL
10:20 am BREAK
13
WEDNESDAY, MAY 26
— Meeting Location: Emerald Room —
CHAIR: DR. JOAN NEWBURGER
10:50 am (L-305) A Novel SMB-Method for Further Reduced Solvent
Consumption—Thomas B. Jensen, T. Reijns, H.A.H. Billiet,
L.A.M. van der Wielen, Delft University of Technology, THE
NETHERLANDS
11:10 am (L-306) Preparative Continuous Annular Chromatography (P-CAC) as
a Continuous Downstream Process for Biotechnology—
Juergen Wolfgang, A. Prior, Prior Technologie Ges.m.b.H, Götzis,
AUSTRIA
11:30 am (L-307) Applying Preparative Centrifugal Counter-Current
Chromatography as Purification Tool for Fermentation
Products—W.W. Fan, Ernst Küsters, C.P. Mak, NOVARTIS
Pharma AG, Basel, SWITZERLAND
11:50 pm (L-308) Preparative Continuous Annular Biochromatography—
R. Giovannini, Ruth Freitag, ETH Lausanne, Ecublens,
SWITZERLAND
12:10 pm (L-309) A Nine Zone SMB for the Recovery of Glucose and Xylose From
Biomass Hydrolyzate—Z. Ma, N.-H.L. Wang, R. Wooley*,
*National Renewable Energy Laboratory; Purdue University, W.
Lafayette, IN, USA
12:30 pm BREAK
14
WEDNESDAY, MAY 26
— Meeting Location: Emerald Room —
CHAIR: PROF. GYULA VIGH
2:00 pm (L-310) Assessing the Use of Process Liquid Chromatography in
Production of Drug Substances—Gregor Mann, Schering, Berlin,
GERMANY
2:20 pm (L-311) Monolithic Macroporous Poly(Styrene-CO-Divinylbenzene)
Columns for Rapid or High Throughput Reversed Phase
Separation of Proteins—Shaofeng Xie, R. Allington, B. Allington,
J. Algaier, V. Pakhye, A.G. Craske, F. Svec*, J.M.J. Fréchet*,
ISCO, Lincoln, NE, USA; *University of California, Berkeley, CA,
USA
2:40 pm (L-312) Development, Optimization, and Scale-Up of a
Chromatographic Purification for a Synthetic Oligonucleotide—
Robert A. Picciotti, Jr., J.R. Fisher, J.K. O’Donnell, R.E. Rosen,
J.J. Maikner*, M.K. Kraus**, S.J. Iuliano, A.E. Pressley, TosoHaas,
Montgomeryville, PA, USA; *Rohm and Haas Company, Spring
House, PA, USA; **TosoHaas GmbH, Stuttgart, GERMANY
3:00 pm (L-313) Influence of Column Design on Process-Scale Ion-Exchange
Chromatography—Peter R. Levison, A.K. Hopkins, P. Hathi,
Whatman International Ltd., Kent, UK
3:20 pm (L-314) Pharmaceutical Purification Facility Design and Considerations
—Lou Bellafiore, K. Henretta, TechniKrom, Evanston, IL, USA
3:40 pm MEETING ADJOURNS
15
— POSTER PRESENTATIONS — MONDAY, MAY 24
Location: Pacific Suite Rooms / Session Times: 2:00 – 3:15 p.m.
P-113 Aqueous Coefficient Calculations for Alkanes, Acetaminophenes and
Barbiturates—F. Torrens, J. Sánchez-Marín, I. Nebot-Gil, Universitat de València,
Burjassot, SPAIN
P-114 Preparative Chromatographic Resolution of Enantiomers Using Polar Organic
Solvents with Polysaccharide Chiral Stationary Phases—L. Miller, R. Fronek,
C. Orihuela, Searle, Skokie, IL, USA
P-115 Predictable, Reproducible Scaling of Microbore, Analytical, and Preparative
Liquid Chromatography—D. Lee, S. Liao, Hamilton Company, Reno, NV, USA
P-116 Packing Procedures and Properties of VYDAC Media in the Axial Compression
Column—M.K. Li, P. Kostel, Vydac, The Separation Group, Hesperia, CA, USA
(withdrawn)
P-117 SF-SMB (Supercritical Fluid Simulated Moving Bed) Application to Chiral
Separations—F. Denet, W. Hauck, R.M. Nicoud, NovaSep SA, Vandoeuvre
l’Nancy, FRANCE
P-118 How To Choose A Simulation Model to Represent the SMB Process?—
O. Ludemann-Hombourger, R.M. Nicoud, M. Bailly*, * LSGC CNRS-ENSIC,
Nancy, Cedex, FRANCE; NovaSep SA, Vandoeuvre l’Nancy, FRANCE
P-119 Modeling the Steady State Recycling Process Comparison of Theory and
Experiment—I. Quinones-Garcia, G.Guiochon†, C.M. Grill*, L. Miller**,
University of Tennessee, Knoxville, TN, USA and †Oak Ridge National
Laboratory, Oak Ridge, TN, USA; *R&S Technology, Wakefield, RI, USA;
**Searle, Skokie, IL, USA
P-120 Development of a Preparative Chiral Separation for Racemic Thalidomide in
Normal Phase—D.-R. Wu, K. Lohse, BTR Separations, Wilmington, DE, USA
P-121 High-Concentration Band Profiles and System Peaks in a Ternary Solute
System—I. Quiñones, J.C. Ford*, G. Guiochon, University of Tennessee,
Knoxville, TN, USA and Oak Ridge National Laboratory, Oak Ridge, TN, USA;
*Indiana University of Pennsylvania, Indiana, PA, USA
P-122 Analytical and Preparative-Scale Isoelectric Focusing Separation of
Enantiomers—P.V. Glukhovskiy, G. Vigh, Texas A&M University, College
Station, TX, USA
16
— POSTER PRESENTATIONS — MONDAY, MAY 24
Location: Pacific Suite Rooms / Session Times: 2:00 – 3:15 p.m.
P-123 Effect of Column to Column Differences on the Performance of Simulated
Moving Bed Separators—J. Frickea, K. Mihlbachlera,b, T. Yuna,b, J. Strubec,
H. Schmidt-Traubc, G. Guiochona,b; aUniversity of Tennessee, Knoxville, TN,
USA; bOak Ridge National Laboratory, Oak Ridge, TN, USA; cUniversity of
Dortmund, GERMANY
P-124 Enantiomer GC Separation of -Ionone Using Cyclodextrin Derivatives—
F. Quattrini, G. Biressi, M. Juza, M. Mazzotti, C. Fugantiš, M. Morbidelli, ETH
Zentrum, Zürich, SWITZERLAND; Politecnico di Milano, Milano, ITALY
P-125 Characterization of Ionic Binding on Base Degraded Size Exclusion Chromato-
graphy Resin—S. Ramachandran, E. Ford, Genentech, S. San Francisco, CA, USA
P-126 Preparative Chiral Purification of Enantiomers Using Covalently-Bonded Chiral
Stationary Phases—D.-R. Wu, K. Lohse, L. Lin*, BTR Separations, Wilmington,
DE, USA; MediChem Research, Lemont, IL, USA
P-127 Separation of 1-Phenyl-1-Propanol Enantiomers Using Simulated Moving Bed—
S. Khattabi*, D.E. Cherrak*†, J. Fischer#, K. Mihlbachler*†, G. Guiochon*†; *University of Tennessee, Knoxville, TN, USA; †Oak Ridge National Laboratory,
Oak Ridge, TN, USA; #University of Pardubice, Pardubice, CZECH REPUBLIC
P-128 Characterization and Scale-up of a New Weak Cation Exchanger CM Sepharose™
High Performance—B. Forsberg, J. Gustavsson, I. Langerlund, E. Larsson,
L. Lundh, Amersham Pharmacia Biotech, Uppsala, SWEDEN
P-129 Design of a Simulated Moving Bed for Sucrose-Betaine Separation—
S. Giacobello, G. Storti, G. Tola, University of Cagliari, Cagliari, ITALY
P-130 Calibration Considerations for Determination of On Column Concentration
Distributions Using Photographic Detection—S. Broyles, A. Shalliker,
G. Guiochon, University of Tennessee, Knoxville, TN, USA and Oak Ridge
National Laboratory, Oak Ridge, TN, USA
P-131 Strategies for High Throughput HPLC Purification for Combinatorial Chemistry
—J. Carmody, U. Neue, R. Crowley, C. Andrews, Waters, Milford, MA, USA
P-132 Titanium Dioxide – Properties and Applications in LC—J. Winkler, S. Marmé,
B. Hirthe, G. Benkner, R. Wittenberg, Sachtleben, Duisburg, GERMANY;
U. Trüdinger, Consulting, Wiesbaden, GERMANY
17
— POSTER PRESENTATIONS — MONDAY, MAY 24
Location: Pacific Suite Rooms / Session Times: 2:00 – 3:15 p.m.
P-133 Evaluation of Commercial Simulated Moving Bed Units Through A Binary Test
Separation—M. Juza, CarboGen Laboratories, Aarau, SWITZERLAND
P-134 Kromaguide: A Tool for Simulation and Optimization of Industrial HPLC—
L. Torstensson, P. Jageland, EKA Chemicals, Bohus, SWEDEN
P-135 Determination of the Thermodynamic Contribution to Peak Asymmetry of Basic
Solutes in Reversed-Phase Liquid Chromatography—B.J. Stanley, California State
University, San Bernardino, CA, USA
P-136 Advances in Large Scale Chromatography Packing—G. Purdom, N. Dickson,
P. O’Neil, F. Mann, Millipore, Gloucester, ENGLAND
P-137 Comparison Between Experimental and Calculated Band Profiles of 3-Chloro-1-
Phenyl-1-Propanol Enantiomers on Chiral Stationary Phase. Influence of Mass
Transfer Kinetic—D.J. Cherrak*, S. Khattabi*, G. Guiochon*+, *University of
Tennessee, Knoxville, TN, USA; +Oak Ridge National Lab., Oak Ridge, TN, USA
P-138 Generating Trace Impurity Samples From Omeprazole by Semi-Preparative
PCSFC—I. Bhoir, S. Patil, S. Dhuri, M. Sundaresan, C.B. Patel Research Centre
for Chemistry and Biological Sciences, Mumbai, INDIA (withdrawn)
P-139 Preparation by PCSFC of Zopiclone Oxides From Zopiclone on a Semi-Preparative
Scale by Modifier Programming—V. Bari, I.C. Bhoir, V. Mudliyar, M.
Sundaresan, C.B. Patel Research Centre for Chemistry and Biological Sciences,
Mumbai, INDIA (withdrawn)
P-140 Design of a Carousel Process for Removing Cesium From SRS Wastes Using
Crystalline Silicotitanate Ion Exchanger—B.J. Hritzko, N.-H.L. Wang, D.D.
Walker*, Purdue University, W. Lafayette, IN, USA; *Westinghouse Savannah
River Co., Aiken, SC, USA
P-141 Reduced Costs and Increased Revenues of Biopharmaceutical Purification
Process—S. Saxena, C. Boomla (Sepragen Corporation, Asia), Sepragen
Corporation, 30689 Huntwood Ave., Hayward, CA, USA
P-142 Preparative Electrochromatography—J.-R. Chen, R.N. Zare, Stanford University,
Stanford, CA, USA
18
— POSTER PRESENTATIONS — TUESDAY, MAY 25
Location: Pacific Suite Rooms / Session Times: 2:00 – 3:15 p.m.
P-213 Charcoal De-Colorization Using Pre-Packed Disposable Cartridges—
S. Ghassemi, P.C. Rahn, Biotage, Charlottesville, VA, USA
P-214 Purification of Peptides by Flash Technique—S. Ghassemi, P.C. Rahn, Biotage,
Charlottesville, VA, USA
P-215 Purification and Characterization of the Vascular Endothelial Growth Factor
Receptor Kinase Domain—W.D. Holmes, W.-J. Chen, R. Davis, A. Edison,
C. Hoffman, E. Horne, S. Kadwell, B. Ellis, Glaxo Wellcome, Research Triangle
Park, NC, USA
P-216 Phytic Acid as an Efficient Low-Molecular-Weight Displacer for Anion
Exchange Displacement Chromatography of Proteins—Q. Luo, J.D. Andrade,
University of Utah, Salt Lake City, UT, USA
P-217 Polycations as Displacer in High-Performance Bioseparation—B. Schmid,
C. Wandrey, R. Freitag, ETH Lausanne, Ecublens, SWITZERLAND
P-218 Hydroxyapatite Chromatography - A Solution for Large Scale Plasmid DNA
Purification?—J. Wright, J. van Adrichem, F. Wurm, R. Freitag, ETH Lausanne,
Ecublens, SWITZERLAND
P-219 Increasing Efficiency in Purification Using Automated LC/SPE Coupling
Techniques and Parallel Chromatography—R. God, C. Heuer, AnalytiCon AG,
Potsdam, GERMANY
P-220 Specific Capture of Antibodies Using Hydrophobic Charge Induction
Chromatography—M. Taylor, L. Guerrier, E. Boschetti, BioSepra, Marlborough,
MA, USA
P-221 Chromatographic Assay of Pharmaceutical Compounds Under Column-
Overloading With Dual Wavelength Detection—J. Zhu, C. Coscolluella, J. Rosen,
Schering-Plough Corp., Kenilworth, NJ, USA
P-222 Studies on Chromatographic Fractionation of Trichoderma Reesei Cellulases by
Hydrophobic Interaction—C.T. Tomaz, J.A. Queirox, Universidade da Beira
Interior, Covilhã, PORTUGAL
19
— POSTER PRESENTATIONS — TUESDAY, MAY 25
Location: Pacific Suite Rooms / Session Times: 2:00 – 3:15 p.m.
P-223 Adsorption of Proteins on Porous, High-Capacity Acrylamido-Based Ion-
Exchange Media—A.K. Hunter, G. Carta, University of Virginia, Charlottesville,
VA, USA
P-224 Preparative Electrophoresis: Strategies for Optimization of Protein Purification—
D.B. Rylatt, M.D. Napoli, D. Ogle, A. Gilbert, L. Lim*, C.H. Nair, Gradipore Ltd.,
Sydney, AUSTRALIA; *Macquarie University Center for Analytical
Biotechnology, Sydney, AUSTRALIA
P-225 Synthesis of Recombinant Human -Amyloid Peptides 1-42 and 1-40 in E. coli—
E.B. Neuhaus, N.K. Menon, R.A. Makula, A.E. Przybyla, University of Georgia,
Athens, GA, USA
P-226 Anion Exchange Chromatography to Remove Contaminants from Albumin
Preparations—S. Trukawinski, R. Sharma, H.-I. Paul, Bayer Corporation, Clayton,
NC, USA
P-227 A Survey of Selectivity Differences Between Fractogel® EMD Anion Exchange
Chromatography Resins for Plasmid DNA—T.L. Chao, B.R. Cabrera, L. Britsch*,
EM Industries, Gibbstown, NJ, USA; *Merck, Darmstadt, GERMANY
P-228 Chromatography Simulation as a Process Development Tool—J.S. Bowers,
P.M. Gioioso, D.C. Wylie, M. Voloch, Schering-Plough Research Institute,
Union, NJ, USA
P-229 Process Economics Aspects of RPC Peptide Purifications—K.C. Deissler,
M.K. Kinzey, R.E. Rosen, J.F. Fisher*, M. Kraus*, J.J. Maikner, Rohm and Haas
Company, Springhouse, PA, USA; *TosoHaas, Montgomeryville, PA, USA
P-230 On-Line Substrate Analysis with Selective Biocart Enzyme Cartridges—
J.D. MacFarlane, W. Schaefer*, H.-R. Howind*, JM Science, Grand Island, NY,
USA; *Anasyscon Instrumentelle Analysentechnik GmbH, Hannover, GERMANY
P-231 Very Fast Separation of Synthetic Oligonucleotides by Ion-Exchange
Chromatography on CIM Ultra-Short Columns—A. Strancar1, M. Prhavc2,
S. Jaksa2, M. Barut1, J. Jancar1, A. Podgornik3, J. MacFarlane4, 1BIA Separations
d.o.o., Ljubljana, SLOVENIA; 2National Institute of Chemistry, Ljubljana,
SLOVENIA; 3BIA d.o.o., Ljubljana, SLOVENIA; 4JM Science, Grand Island, NY,
USA
20
— POSTER PRESENTATIONS — TUESDAY, MAY 25
Location: Pacific Suite Rooms / Session Times: 2:00 – 3:15 p.m.
P-232 Ultra-Fast Purification of Human Plasma Proteins Using Ultra-Short CIM
Columns—M. Barut1, A. Strancar1, A. Podgornik2, A. Buchacher3, D. Josic3,
J.D. MacFarlane4, 1BIA Separations d.o.o., Ljubljana, SLOVENIA; 2BIA d.o.o.,
Ljubljana, SLOVENIA; 3Octapharma ProdmbH, Wien, AUSTRIA; 4JM Science,
Grand Island, NY, USA
P-233 Ultra-Fast HPLC Prep-Scale Purification of Endoxylanases Using CIM DEAE
Columns—R.M. Logar1, M. Barut2, F.V. Nekrep1, A. Strancar2, J.D. MacFarlane3, 1University of Ljubljana, Domzale, SLOVENIA; 2BIA Separations, d.o.o.,
Ljubljana, SLOVENIA; 3JM Science, Grand Island, NY, USA
P-234 The Study of Atrazine Detection by ELISAs—G. Coman, M. Pop, C. Draghici,
Transilvania University of Brasov, Brasov, ROMANIA
P-235 TLC Resolution of DL Amino Acids and Their Derivatives on Chrial Stationary
Phases—C. Draghici, G. Coman, G. Roman, M. Pop, Transilvania University of
Brasov, Brasov, ROMANIA
P-236 Environmental Analysis by Ion Chromatography—M.L. Gupta, V.B. Apale,
P.K. Shrivastave, N. Upadhyay, M. P. Pollution Control Board, Bhopal, INDIA
P-237 The Effect of NaOH Sanitization of Gel Capacity, Column Lifetime and
Inactivation of Viruses and Microorganisms—E. Shane, D. Vu, C. Oliver,
MedImmune, Gaithersburg, MD, USA
P-238 A New Hydrophobic Interaction Chromatography Resin for the Purification of
Biomolecules—R.E. Rosen, J.K. O’Donnell, J.R. Fisher, M.K. Kraus*, S.J. Iuliano,
R.A. Picciotti, A.E. Pressley, TosoHaas, Montgomeryville, PA, USA; *TosoHaas
GmbH, Stuttgart, GERMANY
P-239 Fast Flow and Linear Scalability of Chromatography in Production at Low Costs—
S. Saxena, Marcel Raedts (Sepragen Corporation, Europe), Sepragen Corporation,
30689 Huntwood Ave., Haywood, CA, USA
P-240 Fast Direct Capture From Crude Feed Streams—S. Saxena, Sepragen Corporation,
30689 Huntwood Ave., Hayward, CA, USA
21
E X H I B I T O R S
AMERSHAM PHARMACIA BIOTECH
800 Centennial Ave., P.O. Box 1327, Piscataway, NJ 08855-1327
phone: 800-526-3593 / fax: 800-FAX-3593
Exhibiting: Amersham Pharmacia Biotech is a supplier of equipment and chemicals to the
biopharmaceutical industry. The Separations unit provides chromatography resin and equipment
for the production of biopharmaceuticals.
ANALYTICON AG
Box 5926, Kingwood, TX 77325
phone: 281-361-7393 / fax: 281-361-6885
Exhibiting: SEPBOX chromatography systems for purification of drug substances and
fractionation of natural products. Automated on-line coupling of preparative HPLC and Solid
Phase Extraction that leads to easy access of pure compounds in a buffer free organic
environment. Multi-Parallel HPLC for automated high throughput purification.
BIOSEPRA
111 Locke Drive, Marlborough, MA 01752
phone: 800-752-5277 / fax: 508-357-7595
Exhibiting: Biochromatography Media.
BIO-RAD LABORATORIES
2000 Alfred Nobel Drive, Hercules, CA 94547
phone: 510-741-1000 / fax: 510-234-2642
Exhibiting: Discover Bio-Rad. We are presenting our full line of process chromatography
supports, including the Macro-Prep ion exchangers and ceramic hydroxyapatite. Learn more about
our new size exclusion supports and our UNO continuous bed columns. Inquire about our custom
manufacturing services, including specialty buffers and custom chromatography supports.
BTR-SEPARATIONS
3521 Silverside Road, Concord Plaza-Quillen Bldg., Wilmington, DE 19810
phone: 800-766-6141 / fax: 302-695-5026
Exhibiting: BTR-Separations supplies innovative solutions to purification problems. The company
is a preferred source of products and technical support for chromatographers in the pharmaceutical
and biotechnology industries. BTR-Separations will feature new Chiral Media and Chiral
Development Services, in addition to our other process development and process media products -
ZORBAX®Classic, ZORBAX LP, Kromasil® and IMPAQ®. These products are considered
benchmarks for excellence in performance worldwide and are available in columns for process
development, prep-columns and bulk media.
22
E X H I B I T O R S
CHIRAL TECHNOLOGIES, INC.
730 Springdale Drive, P.O. Box 564, Exton, PA 19341
phone: 800-624-4725 or 610-594-2100 / fax: 610-594-2325
Exhibiting: Chiral Technologies, Inc. specializes in enantiomeric separation products and services
for the pharmaceutical and related industries. Visit our booth to discuss recent advances in bulk
chiral stationary phases that lead to increased productivity and improved economics for SMB
processes. Separation service arrangements available for gram to metric ton quantities.
DYCHROM
473 Sapena Court, Suite 8, Santa Clara, CA 95054
phone: 408-988-7611 / fax: 408-988-4536
Exhibiting: DyChrom is a leading supplier of specialty liquid chromatography products. We
introduced this year Model LC-918 Recycling Preparative HPLC; a cost effective system for
purification of complex samples. DyChrom is also a dealer for two types of countercurrent
chromatographs; droplet countercurrent and rotation locular countercurrent.
GRADIPORE
Riverside Corporate Park, 35-105 Delhi Road, North Ryde, Sydney NSW 2113, AUSTRALIA
phone: 011-61-2-98782777 / fax: 011-61-2-98050624
Exhibiting: Gradipore Ltd. will be exhibiting their Gradiflow protein purification technology.
Gradiflow is a novel scaleable technology for separation of proteins and other charged
macromolecules. This system is the first to harness the resolution of polyacrylamide
electrophoresis at a preparative scale. The unique tangential flow membrane configuration allows
the separations of macromolecules by either size and or charge. The system also has the capacity
to concentrate and desalt.
HAMILTON COMPANY
4970 Energy Way, Reno, NV 89502
phone: 775-858-3000 / fax: 775-856-7259
Exhibiting: Hamilton manufactures 16 polymeric HPLC packings for a wide variety of
applications. Column diameters from 1.0 to 101.6 mm. Bulk material is available in particle sizes
of 10, 12-20, 20-30, 30-50 and 50-75 ums. Custom synthesis and modification services are
available as we manufacture all our HPLC supports.
HITACHI INSTRUMENTS, INC.
3100 North 1st Street, San Jose, CA 95134
phone: 408-432-0520 / fax: 408-432-8258
Exhibiting: NovaPrep semi-preparative HPLC systems. Nova Prep 200 features a flow rate
range of 1-200 ml/min while Nova Prep 800 ranges from 8-800 ml/min; both systems are totally
inert. Isocratic, step gradient, low pressure gradient and high pressure gradient configurations are
available. A wide range of columns and sorbents are available.
23
E X H I B I T O R S
JM SCIENCE, INC.
P.O. Box 250, 355 Lang Blvd., Grand Island, NY 14072
phone: 716-774-8706 / fax: 716-774-8708
Exhibiting: New Convective Interaction Media (CIM) semi-prep and preparative tubes for very
fast separations of proteins, oligonucleotides and other biomolecules. Also new HPLC pump for
pilot and production scale separations. Shodex preparative columns up to 30cm diameter for all
scales of separation. New automated bioprocessing system for monitoring key metabolites for
days or weeks.
KNAUER (Dr. Ing. Herbert Knauer GmbH)
Hegauer Weg 38, 14163 Berlin, GERMANY
phone: 011 49 30 80 97 27 50 / fax: 011 49 30 8 01 50 10
Exhibiting: KNAUER introduces the high performance preparative HPLC pump K-1800. It is the
smallest HPLC pump in its performance class with flow rates up to 1,000mL/min. KNAUER
offers a wide range of photometric detectors and easy to handle software for individual needs.
MALLINCKRODT BAKER, INC.
222 Red School Lane, Phillipsburg, NJ 08865
phone: 908-859-2151 / fax: 908-859-9318
Exhibiting: BAKERBOND Chromatography Columns and Packings will be featured with
products for biochromatography and synthetic peptide purification, and our new line of spherical
products for small molecule separations. Detailed information on the CYCLE-TAINER Dispense
system and a complete listing of high purity solvents and reagents for scale-up will also be
presented.
MODcol CORPORATION
845 Stewart Drive, Sunnyvale, CA 94068-4514
phone: 408-530-0010 / fax: 408-530-0011
Exhibiting: MODcol has recently developed "Axial Compression Spring Loaded" (Patents
Pending) preparative HPLC columns. Designed for on-site, efficient self-slurry packing with the
aid of the pneumatic "MultiPacker" (Patents Pending)--products are unique since several
preparative HPLC columns may be packed sequentially. Also offering Patented Fixed bed
modular stainless steel columns for preparative HPLC, Pilot Plat and Industrial large-scale LC at
various lengths, I.D. and ASME Coded by request. MODcol is renown worldwide for slurry
packing of various microparticulates in its modular columns using proprietary procedures, and
guarantees efficient slurry packing, as a paid service, with excellent resolution and low pressure
drop. Various MODadapters are available to extend the length of the modular columns.
24
E X H I B I T O R S
NOVASEP, INC.
480 S. Democrat Road, Gibbstown, NJ 08027
phone: 609-423-6718 / fax: 609-423-1720
Exhibiting: Conception of turn-key solutions for industrial chromatographic separations: • SMB or
HPLC systems (with liquid, gas or supercritical eluents, low and high pressure operations), with
fully integrated solvent recycling and storage units. • Complete services for all applications
requiring large-scale purification (pharmaceuticals, food additives, fine chemicals), from
feasibility study to process development, optimization and validation, and custom purification
under GMP.
PDR-CHIRAL
3 Old Meadow Way, Palm Beach Gardens, FL 33418
phone: 561-625-2645 / fax: 561-625-2646
Exhibiting: PDR-Chiral Inc presents its new Advanced Laser Polarimeter for the measurement of
optically active compounds. The diode laser-based detector provides information about
enantiomeric ratio, in real-time, even without complete resolution of the enantiomers. The low
noise, opto-electronic design results in a detection limit of 25-microdegrees with the capability of
determining better than 1% enantiomeric excess for most enantiomers. The instrument can be used
in conjunction with LC, LC-MS, FIA and SFC. It can also be used as a monitor for preparative-
scale chromatography and process control.
PE BIOSYSTEMS
500 Old Connecticut Path, Framingham, MA 01701
phone: 508-383-7482 / fax: 508-383-7885
Exhibiting: PE Biosystems introduces a new line of process scale chromatography columns. These
columns, manufactured under a 5 year agreement with Verdot Industries of Riom, France, are
designed for ease of use and reliability, and are accompanied by full regulatory support
documentation. Available in glass, stainless steel, or acrylic, these columns all feature a center
screw mechanism and inflatable seal which allows for the simplest and most efficiently packed
columns. A consistent and sanitary design is used in all columns from 90mmID to 2000mmID for
the best scale-up results. Please come by our booth, and attend our workshop where we will
introduce the unique features of these products.
PHENOMENEX
2320 West 205th Street, Torrance, CA 90501
phone: 310-212-0555 / fax: 310-328-7768
Exhibiting: Offering a complete line of HPLC colulmns and bulk materials for preparative and
process chromatography utilizing revolutionary new silica and bonding technology. LUNA 100A
and Jupiter 300A (proteins/peptides) materials provide ultra-high performance characteristics such
as: 1.5-10.0 pH stability, exceptional peak shape, increased loadability, and superior mechanical
strength for maximum efficiencies. Available world-wide in economical 10 and 15 particles in
packed columns, or 1-1000 Kg bulk quantities.
25
E X H I B I T O R S
SEPRAGEN CORPORATION
30689 Huntwood Avenue, Hayward, CA 94544
phone: 510-476-0650 / fax: 510-476-0655
Exhibiting: Sepragen Corp. is a leading provider of Automated Scale-Up Instruments, Columns
and Media to the biopharmaceutical Industry, “from lab to manufacturing”. Sepragen also
develops and sells processes and products using its proprietary technology for the dairy, juice and
nutraceutical markets.
TECHNIKROM, INC.
1801 Maple Avenue, Evanston, IL 60201
phone: 800-865-4100 / fax: 800-293-5059
Exhibiting: TechniKrom provides cGMP industrial bioprocessing equipment for LPLC, HPLC,
automated buffer preparation, UF, MF, expanded bed/capture, SMB, fermentation and peptide
synthesis. Walk away automation capability is permitted through the innovative use of precise
feedback and control available on all equipment. Our staff of engineers and chemists provide
services including equipment customization, facility layouts, process method development, scale-
up and contract GLP/GMP purifications.
TOSOHAAS
156 Keystone Drive, Montgomeryville, PA 18936
phone: 215-283-5000 / fax: 215-283-5035
Exhibiting: TosoHaas features a wide range of liquid chromatography products for the analysis
and purification of proteins, peptides, enzymes, oligonucleotides, antibodies and small molecules.
Our line of Amberchrom, Toyopearl and TSK-GEL pre-packed columns and bulk media are
designed to provide seamless scale-up from laboratory to process scale.
VARIAN ASSOCIATES
3045 Hanover Street H-111, Palo Alto, CA 94304
phone: 650-424-5848 / fax: 650-858-0480
Exhibiting: A full line of Preparative HPLC products will be displayed: The state-of-the-art SD-1
solvent delivery system can repetitively separate mg to gram quantities of material in automated,
unattended fashion, increasing lab throughput and reducing costs. The RamPak Axial
Compression Packing Station can be used to pack 41 or 77 mm ID preparative columns.
VYDAC/THE SEPARATIONS GROUP
17434 Mojave Street, Hesperia, CA 92345
phone: 800-247-0924 / fax: 888-244-6107
Exhibiting: VYDAC offers preparative HPLC columns and bulk reversed phase silicas providing
simple, high performance solutions to purification problems. These materials, part of the family of
materials used in the research laboratory, offer simple scale-up of laboratory procedures and give
production laboratories the same level of performance, purity and recovery available to the
research scientist. Packed columns are available in I.D.s up to 100 mm; bulk materials are
available for process scale separations in 100-kilogram lots.
26
E X H I B I T O R S
WATERS CORPORATION
34 Maple Street, Milford, MA 01757
phone: 508-478-2000 / fax: 508-482-2674
Exhibiting: Waters continues to advance HPLC instrumentation, software and chemistries. Waters
Delta 600 PrepLC System provides powerful, yet flexible analytical to semi-prep capabilities.
Waters DeltaPrep 4000 System extends the analytical to prep capability into true preparative scale
with programmable flow rates. Waters PrepLC 2000 is a dedicated high throughput preparative
LC system. Waters has a full line of Preparative Chromatography Columns.
WHATMAN, INC.
401 West Morgan Road, Ann Arbor, MI 48108
phone: 800-343-5853 / fax: 734-665-3516
Exhibiting: The Whatman chromatography portfolio includes the Express-Ion range of high flow
rate media, including the Express-Ion Mini-Columns. This media is versatile, easy to use, and cost
effective in industrial scale purification processes. Express-Ion products are ideal where
processing times of large volume feedstocks are to be minimized.
YMC CORPORATION
Exhibiting: For full selection of YMC products, see Waters Corporation booths.