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Copyright Pearson Prentice Hall

12-5 Gene Regulation


Fruit fly chromosome

Fruit fly embryo

Adult fruit fly

Mouse chromosomes

Mouse embryo

Adult mouse


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Gene Regulation: An Example


E. coli provides an example of how gene

expression can be regulated.

An operon is a group of genes that operate

together.

In E. coli, these genes must be turned on so the

bacterium can use lactose as food.

Therefore, they are called the lac operon.

The lac genes are turned off by repressors and turned on by the presence of lactose.


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On one side of the operon's three genes are two regulatory regions.

• In the promoter (P) region, RNA polymerase

binds and then begins transcription.


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• The other region is the operator (O).

When the lac repressor binds to the O region, transcription is not possible.


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When lactose is added, sugar binds to the repressor

proteins.


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The repressor protein changes shape and falls off the

operator and transcription is made possible.


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Many genes are regulated by repressor

proteins.

Some genes use proteins that speed up

transcription.

Sometimes regulation occurs at the level of

protein synthesis.


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Eukaryotic Gene Regulation


Operons are generally not found in

eukaryotes.

Most eukaryotic genes are

controlled individually and have

regulatory sequences that are much

more complex than those of the lac

operon.


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Many eukaryotic genes have a sequence called the

TATA box.

The TATA box seems to help position RNA

polymerase.

Eukaryotic promoters are usually found just before

the TATA box, and consist of short DNA sequences.


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Genes are regulated in a variety of ways by

enhancer sequences.

Many proteins can bind to different enhancer

sequences.

Some DNA-binding proteins enhance

transcription by:

•opening up tightly packed chromatin

•helping to attract RNA polymerase

•blocking access to genes


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Development and Differentiation


As cells grow and divide, they undergo

differentiation, meaning they become specialized in

structure and function.

Hox genes control the differentiation of cells and

tissues in the embryo.

Careful control of expression in hox genes is

essential for normal development.

All hox genes are descended from the genes

of common ancestors.


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Hox Genes

Fruit fly chromosome

Fruit fly embryo

Adult fruit fly

Mouse chromosomes

Mouse embryo

Adult mouse

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12–5

Resources/ch12_sectn05_quiz.qtb






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12–5

Which sequence shows the typical organization

of a single gene site on a DNA strand?

a. start codon, regulatory site, promoter, stop

codon

b. regulatory site, promoter, start codon, stop

codon

c. start codon, promoter, regulatory site, stop

codon

d. promoter, regulatory site, start codon, stop

codon

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12–5

A group of genes that operates together is a(an)

a. promoter.

b. operon.

c. operator.

d. intron.

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12–5

Repressors function to

a. turn genes off.

b. produce lactose.

c. turn genes on.

d. slow cell division.

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12–5

Which of the following is unique to the regulation

of eukaryotic genes?

a. promoter sequences

b. TATA box

c. different start codons

d. regulatory proteins

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12–5

Organs and tissues that develop in various parts

of embryos are controlled by

a. regulation sites.

b. RNA polymerase.

c. hox genes.

d. DNA polymerase.

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Hoxge

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Mutati

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Norma

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Fly

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