11th european congress on epileptology

BE THERE!

2 www.epilepsystockholm2014.org

THE CITY OF STOCKHOLM WELCOMES THE 11TH ECE CONGRESS

Dear Delegates,

Stockholm is one of the world’s most popular cities for meetings of almost all sizes. Not least dueto its proven record of organisation, infrastructure and typical Scandinavian attention to detail,flexibility and efficiency.

Based on innovation and fuelled by high technology, the Stockholm region’s economy boasts oneof the world’s most prominent information and communications technology clusters, one ofEurope’s largest life sciences clusters and fast growing cleantech and fashion industries – to namebut a few. The Capital of Sweden also presents an abundance of culture, attractions and world-renowned entertainment. As a clear recognition of the fact that sustainability is continuing to be atop priority for Stockholm - Stockholm was awarded the “European Green Capital” in 2010.

Reaching Stockholm is swift and simple regardless of where your journey starts. And while here youhave a high speed connection from Stockholm-Arlanda Airport, and one of the most efficient andwell-structured public transport systems in the world at your service - if you don’t just choose towalk around in this compact city.

We hope you will enjoy Stockholm and that coming here will give you a feeling of the city and itsmany advantages as a destination for successful congresses such as the ECE congress.

Yours sincerely,

Henrik von ArnoldDirector Stockholm Convention Bureau

1 1 T H E U R O P E A N C O N G R E S S O N E P I L E P T O L O G Y 2 0 1 4

www.epilepsystockholm2014.org 1

11TH EUROPEAN CONGRESS ON EPILEPTOLOGY29TH JUNE - 3RD JULY 2014



INTERNATIONAL ORGANISING COMMITTEE [IOC]

CO-CHAIRS

Kristina Malmgren (Sweden) Meir Bialer (Israel)

MembersAlla Guekht (Russia)Reetta Kälviäinen (Finland)Ivan Rektor (Czech Republic)Philip Smith (UK)Torbjörn Tomson (Sweden)

SCIENTIFIC ADVISORY COMMITTEE [SAC]CHAIR

Torbjörn Tomson (Sweden)

MembersMeir Bialer (Israel)Milan Brádzil (Czech Republic)Helen Cross (UK)Reetta Kälviäinen (Finland)Merab Kokaia (Sweden)Kristina Malmgren (Sweden)Philippe Ryvlin (France)Simon Shorvon (UK)Federico Vigevano (Italy)



WELCOME LETTER FROM THE CO-CHAIRS OF THE INTERNATIONAL ORGANISING COMMITTEE

Dear Colleagues,

On behalf of the organising committee, we wish to invite you to attend the 11th European Congress onEpileptology (ECE) of the International League Against Epilepsy, in Stockholm on June 29th – July 3rd 2014.The Stockholm 2014 congress promises to be a very interesting and inspiring meeting.

The programme will cover cutting-edge research in the field of epilepsy through presentations from key opinionleaders in the field, including lectures by world-renowned scientists on topics at the interfaces of epilepsy. Theschedule will also feature a coordinated clinical teaching programme with a course on pharmacologicaltreatment of epilepsy as well as a course for epilepsy nurses and EEG technicians.

Four main themes run through the programme: the basic science main session theme has the exciting titleChanging epileptic brain: translational challenges and opportunities.The main theme focusing on epilepsysurgery with the title Who benefits from epilepsy surgery? will be oriented towards patient outcomes; thepaediatric main theme, with the title Epilepsy syndromes: from infancy to adulthood, spans thedevelopment as children grow into adults and, last but not least, the main theme on pharmacological treatmentlooks ahead: Pharmacotherapy of the future: new molecules, new targets, new goals. Parallel sessions,workshops and courses in these and other topics will be held. There will be a strong emphasis on high qualityplatform and poster presentations, and we invite you all to prepare your work for abstract submission.

This promises to be a great congress. The London congress in 2012 gave us Nobel Lectures and the Stockholmcongress will follow up on this with a lecture about the man behind the name – Alfred Nobel. Stockholm is afascinating and beautiful city and the nights are short in summer. We hope that you will enjoy the congressas well as the city and the Nordic summer.

We look forward to welcoming you to Stockholm!

With warm regards,

Kristina Malmgren Meir BialerCo-Chair Co-ChairInternational Organising Committee International Organising Committee

WELCOME FROM THE CHAIR OF THE SCIENTIFIC ADVISORY COMMITTEE

Dear Colleagues,

The Scientific Advisory Committee (SAC) has worked arduously to construct an exceptional programme forthe Stockholm 2014 congress. Our aim has been to offer a programme that provides cutting-edge science aswell as high quality teaching on topics of direct relevance to your everyday clinical practice. Indeed the scientificprogramme is intended to cover all aspects of epileptology, but four main themes have been selectedrepresenting basic science, epilepsy surgery, pharmacotherapy and paediatric epileptology. Each theme will beshowcased in a main session namely “Changing epileptic brain: translational challenges andopportunities”, “Who benefits from epilepsy surgery?”, “Epilepsy syndromes: from infancy toadulthood” and “Pharmacotherapy of the future: new molecules, new targets, new goals”. These fourmain themes are also covered in additional related scientific sessions.

One of the primary goals of the SAC for this congress is to increase the emphasis on high quality platformpresentations by allocating more time to them given that they can often be the source of the latest scientificfindings. Furthermore platform presentations provide an important opportunity for younger researchers tomeet and engage in valuable discussions with their peers. Poster sessions will continue to be a significant partof the programme and we intend to give full attention to the posters with both guided tours and posterhighlight sessions.

Stockholm 2014 will build on the success of its predecessors. Many of the features introduced in London 2012will be carried forward in Stockholm, some with a local twist. The London congress introduced lectures byselected Nobel Prize Laureates. Bringing the 11th ECE to the home town of Alfred Nobel, the Stockholmcongress will follow up on the Nobel theme with a lecture about the man behind the Prize. We are also planningan exhibit of selected items from the Nobel Museum during the Welcome Ceremony. Additionally there willbe a reception in the City Hall, the venue for the Nobel Prize banquet. ECE Forums were a great success inLondon. The Forums will be continued in Stockholm with the ambition to reserve the format for interactivediscussions focusing on new topics or projects of special interest.

However we are also introducing some new features; taking advantage of new technology we invite delegatesto participate in a highly interactive session on the use of the proposed ILAE Classification and organisationof seizures and epilepsies. There will be an exciting joint symposium between the Commission on EuropeanAffairs (CEA) and the European Sleep Research Society entitled “Epileptic and non-epileptic sleep relatedparoxysmal motor events”. Epilepsy Advocacy Europe will present their achievements in a symposium withthe title “A political agenda for supporting epilepsy care and research in Europe”.

Two sessions have a special historical perspective: the session entitled “Unverricht-Lundborg Disease from1891 to 2014” and the “Carbamazepine 50th Year Anniversary Symposium”. The popular Chairs’ Symposiumwill be dedicated to prevention in epileptology in its broadest sense. The meeting will conclude with a CongressHighlights session, where the main session chairs will summarise the most important advancements presentedwithin their themes.

As in London, the last day of the congress will be an ECE teaching day with a full day course on the“Pharmacological treatment of epilepsy” and two separate comprehensive courses targeting epilepsy nursesand EEG technicians.



In addition, teaching sessions will feature three attractive morning series run over three days: “The seizuresemiology smörgåsbord” are didactic video sessions; “Found in translation: basic science explained” targetsclinicians who want to better understand experimental epilepsy research; and lastly the What Not-to-Do series,taking a slightly different perspective than the previous highly appreciated How-to-Do series.

Although we do everything in our power to create an attractive and packed scientific programme, we hopethat you will find some time to enjoy Stockholm. The capital of Sweden has a history spanning more than700 years. Spreading across 14 islands, Stockholm faces the Baltic Sea. June and July, when days are long andnights are bright, is the perfect time to enjoy this beautiful city and its surroundings including the unique andeasily accessible archipelago of 30,000 islands.

On behalf of the Scientific Advisory Committee, we look forward to welcoming you to the 11th EuropeanCongress on Epileptology next June and to the wonderful city of Stockholm.

With best wishes,

Torbjörn TomsonChair Scientific Advisory Committee



SCIENTIFIC PROGRAMME INFORMATION

SESSIONSThe scientific sessions form the main part of the congress. The main topics were chosen by the InternationalOrganising Committee and the sessions were selected from the numerous proposals submitted by ILAEmembers and other experts. These sessions were selected to represent the best European and globalepileptology.

Our programme covers all aspects of epileptology, but four main themes have been selected. Each day hasdifferent themes representing basic science, epilepsy surgery, pharmacotherapy and paediatric epileptology.Each main theme features one plenary main topic session and four additional sessions.

SPECIAL SYMPOSIA Special symposia include the Chairs’ Symposium, which this year is dedicated to Prevention in epileptology.The symposium will explore a number of important aspects of prevention, ranging from prevention of thedevelopment of epilepsy to prevention of the devastating consequences of epilepsy and its treatment. A secondspecial symposium will update delegates on the achievements of the joint ILAE/IBE Task Force – EpilepsyAdvocacy Europe, under the symposium title: A political agenda for supporting epilepsy care and research inEurope. The ILAE Commission on European Affairs (CEA) will also present a special symposium on the Europeanperspective of regulatory issues with antiepileptic drugs.

Another special symposium explores the borderland between epileptology and sleep medicine. This sessionon Epileptic and non-epileptic sleep-related paroxysmal motor events is a collaboration between CEA and theEuropean Sleep Research Society.

TEACHING SESSIONS / COURSES

The seizure semiology smörgåsbord, with didactic video presentations, over 3 mornings.

Found in translation: basic science explained is meant to be truly translational, as the series targetsclinicians who wish to understand and learn more about basic science in epileptology, over 3 mornings.

The What Not-to-Do series is a clinically oriented series of interactive morning seminars presenting redflags in the diagnosis and management of people with seizure disorders, over 3 mornings.

ABC of epilepsy epidemiology will discuss basics in methodologies, for those who want to understand orengage in epidemiological research in one morning teaching session.

Two morning teaching sessions will be dedicated to VIREPA courses.



ECE TEACHING DAYTHURSDAY JULY 3rdWILL FEATURE THREE MAIN COURSES

The course on Pharmacological treatment of epilepsy will run from 08:00 to 15:00. It spans from basicmechanisms of actions of antiepileptic drugs and pharmacokinetics to pharmacological treatment in differentclinical settings. Although the epileptologist delegate is the primary target, the course should also be usefulfor other neurologists and neuropaediatricians who take care of patients with epilepsy and who need an updatefrom experts in the field.

A second course, primarily aimed at epilepsy nurses, will run from 08.00 to 11.00 and a third course, for EEGtechnicians, will run from 11.30 to 13.00.

Day registration will be available for those who wish to register just for these courses. All full registereddelegates for the congress can attend the ECE teaching courses free of charge.

ECE FORUMSThe ECE Forums were an innovation in the scientific programme of the 10th ECE and, following on from theirsuccess, the innovative and popular ECE Forums will again form part of the programme for the 11th ECE.

These Forums are designed to be sessions in which selected topics can be explored and discussed in an informalworkshop or clubroom style. The topics will be selected from proposals submitted by members worldwide andwill focus generally on cutting-edge or controversial aspects of epilepsy work, not least including discussionson new or planned projects of general interest. Priority will be given to new topics rather than the continuationof topics discussed in London.

The sessions are intended to be creative and interactive and are free of charge to all participants of the congress.

AWARDS SESSIONThe symposium of excellence in epileptology will include lectures presented by the recipients of the 2014European Epileptology Award and the CEA Young Investigator Award.

HIGHLIGHTS SESSIONThis concluding session is intended to give delegates an overview of the most important advancements thathave been presented during the congress. Each main topic chair has been charged to summarise what theyconsider to be the highlights from presentations within their theme.

PLATFORM AND POSTER PRESENTATIONSSpecial attention will be given to poster presentations during the 11th ECE. Researchers are invited to submitabstracts that will be reviewed by the Scientific Advisory Committee and considered for platform presentations,special poster sessions or poster tours. Please refer to the congress website for submission instructions.



SPECIAL SYMPOSIA

CHAIRS’ SYMPOSIUM:PREVENTION IN EPILEPTOLOGYPrevention is a priority in health care today and epilepsy should be no exception. The 11th ECE Chairs’Symposium is therefore dedicated to Prevention in epileptology. The symposium will explore prevention in itsbroadest sense. The first lectures will discuss the potential for prevention of epileptogenesis based onexperimental as well as clinical data. The second part of the symposium will focus on aspects of preventionfor people with established epilepsy, including prevention of adverse effects of treatment, prevention of themost devastating consequences of epilepsy, and prevention of adverse effects imposed by society, e.g. stigma.

Co-Chairs: Meir Bialer (Israel), Kristina Malmgren (Sweden)

Prevention of epileptogenesis - a realistic goal? - Astrid Nehlig (France)

Prevention of epileptogenesis - can currently available antiepileptic drugs have a role? - Simon Shorvon(UK)

Prevention of adverse effects of antiepileptic drug treatment - Emilio Perucca (Italy)

Prevention of epilepsy-related mortality - Torbjörn Tomson (Sweden)

Prevention of stigma - Ann Jacoby (UK)

EPILEPSY ADVOCACY EUROPE SYMPOSIUM: A POLITICAL AGENDA FOR SUPPORTING EPILEPSY CARE AND RESEARCH IN EUROPE

Chair: TBC

The ILAE-IBE roadmap in advocating for epilepsy care and research - TBC

A summary of the epilepsy projects financed by Framework Programme 7 - TBC

An update on initiatives at national level - TBC

COMMISSION ON EUROPEAN AFFAIRS (CEA) SYMPOSIUM: REGULATORY ISSUES WITH ANTIEPILEPTIC DRUGS: A EUROPEAN PERSPECTIVE

Chair: Michel Baulac (France)

Challenges with the monotherapy indication - Emilio Perucca (Italy)

Added value of a new AED: are head-to-head, add-on, comparative studies feasible? - Michel Baulac(France)

Extrapolation of efficacy data from adults to children: the paediatric viewpoint - Alexis Arzimanoglou(France)

The EMA and the European regulatory network - TBC



2nd JOINT CEA - ESRS (EUROPEAN SLEEP RESEARCH SOCIETY) SYMPOSIUM: EPILEPTIC AND NON-EPILEPTIC SLEEP-RELATED PAROXYSMAL MOTOR EVENTS

Co-Chairs: Lino Nobili (Italy), Sofia Eriksson (UK)

Pathophysiologic interrelationship between sleep mechanisms and nocturnal focal seizures- Florin Amzica (Canada)

Neural networks in sleep-related complex motor seizures - Philippe Kahane (France)

Non epileptic complex motor behaviours - Claudio Bassetti (Switzerland)

Sleep-related epilepsy and comorbidity with sleep disorders - Raffaele Manni (Italy)

ILAE CLASSIFICATION IN CLINICAL PRACTICE A case based interactive session designed to illustrate the place of classification in day-to-day practice.

Co-Chairs: Helen Cross (UK), Sameer Zuberi (UK)

Overview - where are we now? - Helen Cross (UK)

Epileptic spasms - a clinical dilemma - Christian Korff (Switzerland)

Focal seizures, descriptors and aetiology - Edouard Hirsch (France)

Syndromology: age doesn’t matter - Carla Marini (Italy)

NEUROBIOLOGY SYMPOSIUM The programme of this symposium is currently being prepared by the ILAE Commission on Neurobiology andwill be later announced on the congress website.



MAIN SESSIONS

PHARMACOLOGY

PHARMACOTHERAPY OF THE FUTURE: NEW MOLECULES, NEW TARGETS, NEW GOALS

This main session will be devoted to the pharmacotherapy of the future, with the aim to discuss new moleculartargets and treatment goals, including the far reaching objective of antiepileptogenesis, but also the moreimmediate clinical potential of existing drugs of interest, such as ketamine, bumetamide and serotoninergicagents.

Co-Chairs: Philippe Ryvlin (France), Elinor Ben-Menachem (Sweden)

Novel molecular targets in epileptogenesis - Asla Pitkänen (Finland) Modulating the NMDA receptor with ketamine - Matthew Walker (UK) Modulating serotonin in epilepsy: why and how? - TBC Bumetamide in humans: what is the current evidence? - Eugen Trinka (Austria)

PAEDIATRICS

EPILEPSY SYNDROMES: FROM INFANCY TO ADULTHOOD

The session will focus on the analysis of the similarities and differences between paediatric and adult epilepticsyndromes. Invited speakers will present the clinical and neurophysiological aspects and the prognostic value of severaltypes of seizures associated with idiopathic or symptomatic epileptic syndromes, and their different significance inthe light of the variations they go through between age at onset and adulthood. The influence of genetic mutation,type and frequency of seizures and treatment on long-term cognitive and motor evolution will be stressed.

Co-Chairs: Federico Vigevano (Italy), Thanos Covanis (Greece)

Idiopathic generalized epilepsies: overlap and differences - Paolo Tinuper (Italy) Idiopathic focal epilepsies: overlap and differences - Ulrich Stephani (Germany) Temporal lobe epilepsy: how the age influences the syndrome - Andras Fogarasi (Hungary) Dravet Syndrome: from infancy to adulthood - Ingrid Scheffer (Australia)

BASIC SCIENCE

CHANGING EPILEPTIC BRAIN: TRANSLATIONAL CHALLENGES AND OPPORTUNITIES

Some of the main challenges of current epileptology is to strengthen translational aspects of basic andpreclinical research and to bring discoveries in labs to bedside. This session is an attempt to tackle thesechallenges by first highlighting the critical points that need to be addressed, in order to promote translationalepilepsy research, followed by topics on gene therapy, inflammation and epigenetic approaches, which holdhigh hopes of becoming clinically applicable alternative therapeutics for epilepsy in the future.

Chair: Merab Kokaia (Sweden)

How to make basic research translational - Michele Simonato (Italy) Novel perspectives in gene therapy translation - Dimitri Kullmann (UK) Translating inflammation into therapy - Annamaria Vezzani (Italy) Epigenetics and master regulators in translation - David Henshall (Ireland)





SURGERY

WHO BENEFITS FROM EPILEPSY SURGERY?

Surgical treatment for epilepsy is major brain surgery. As such, it is not a decision to undertake lightly, but oneto be carefully considered. Not everyone with epilepsy can benefit from a surgical procedure. The medicalteam needs to help the patient and their family understand the complications and outcomes of epilepsysurgery in the context of the risk of uncontrolled seizures and high doses of medications. This main sessionoffers a critical overview of risks and benefits of current epilepsy surgery, discusses what is acceptable risk andgives advice for counselling and rehabilitation.

Co-Chairs: Reetta Kälviäinen (Finland), Philippe Kahane (France)

Why do patients risk brain surgery for epilepsy? - Kristina Malmgren (Sweden)What do we know about long-term seizure outcomes in adults and children? - John Duncan (UK) How well can we predict individual risks and benefits? - Arto Immonen (Finland) How can we help patients to a better life after epilepsy surgery? - Sarah Wilson (Australia)

SESSIONS

PHARMACOLOGY

DIFFERENT APPROACHES TO DESIGN AND EARLY ASSESSMENT OF NEW ANTIEPILEPTIC DRUGS

Co-Chairs: Svein I. Johannessen (Norway), Dorothee Kasteleijn-Nolst Trenité (The Netherlands)

Animal model-based design of new antiepileptic drugs - Steve White (USA)

Pharmacokinetic-based design of new antiepileptic drugs that are follow-up compounds to existingdrugs - Meir Bialer (Israel)

Mechanism-based design of new antiepileptic drugs - Wolfgang Löscher (Germany)

Proof of concept studies in assessment of new antiepileptic drugs - Christian E. Elger (Germany)

CARBAMAZEPINE 50TH ANNIVERSARY SYMPOSIUM (1964-2014)

Co-Chairs: Günter Krämer (Switzerland), Dana Craiu (Romania)

How carbamazepine came to dominate the epilepsy world - Simon Shorvon (UK)

How carbamazepine structure and clinical experience affected the design of oxcarbazepine andeslicarbazepine acetate - Meir Bialer (Israel)

Pharmacology and clinical therapeutics of carbamazepine and its progeny - Eugen Trinka (Austria)

How does enzyme induction impact carbamazepine’s current and future position in epilepsy therapy?- Martin Brodie (UK)



WITHDRAWAL OF ANTIEPILEPTIC DRUGS - POSSIBILITIES AND CONSEQUENCES

Co-Chairs: Leif Gjerstad (Norway), Miri Neufeld (Israel)

Risk of relapse and possible predictors for successful withdrawal of antiepileptic drugs - Morten I.Lossius (Norway)

Timing of withdrawal of antiepileptic drugs after surgery - Kees Braun (The Netherlands)

Possible benefits of antiepileptic drugs withdrawal on cognition - Christoph Helmstaedter (Germany)

Refractory seizures after antiepileptic drugs withdrawal - Tony Marson (UK)

CONTROVERSIAL ISSUES IN THE MANAGEMENT OF WOMEN WITH EPILEPSY CONTEMPLATINGPREGNANCY

Co-Chairs: Jana Zarubova (Czech Republic), Anne Sabers (Denmark)

Are there situations where a woman may decide not to become pregnant because of her epilepsy? - LinaNashef (UK)

Treatment alternatives for women with idiopathic generalized epilepsies contemplating pregnancy- Dina Battino (Italy)

Antiepileptic drugs level monitoring during pregnancy: is it useful? - Torbjörn Tomson (Sweden)

Folate supplementation - uncertainties? - Dick Lindhout (The Netherlands)

PAEDIATRICS

TARGETED APPROACHES IN CHILDHOOD EPILEPSY

Co-Chairs: Renzo Guerrini (Italy), Maria Dahlin (Sweden)

Diet treatments - mechanisms of action - Simon Heales (UK)

Ketogenic diet: indications and long-term results - Tove Hallböök (Sweden)

mTOR inhibitors: efficacy on epilepsy in tuberous sclerosis patients - Paolo Curatolo (Italy)

Early treatment with vigabatrin in tuberous sclerosis: do we affect outcome? - Sergiusz Jozwiak (Poland)

NEW INSIGHTS IN EPILEPSY GENETICS

Co-Chairs: Norman Delanty (Ireland), Anna-Elina Lehesjoki (Finland)

Paediatric genetic epilepsies with focal seizures: PRRT2 and infantile convulsions and choreoathetosis- Ingrid Scheffer (Australia)

Genetic epileptic encephalopathies - Rima Nabbout (France)

Genetic variants predisposing to idiopathic generalized epilepsies - Holger Lerche (Germany)

Common variants affecting treatment response in epilepsy - Sanjay Sisodiya (UK)



NEW INSIGHTS IN EPILEPTIC ENCEPHALOPATHIES

Co-Chairs: Solomon Moshé (USA), Alexis Arzimanoglou (France)

Epileptic encephalopathy versus encephalopathy with epilepsy - Nicola Specchio (Italy)

What do animal studies teach us? - Martin Holtkamp (Germany)

The role of epileptiform activity during sleep - Maria Peltola (Finland)

From diagnosis to therapeutic approach - Colin Ferrie (UK)

UNVERRICHT-LUNDBORG DISEASE FROM 1891 TO 2014

Co-Chairs: Sulev Haldre (Estonia), Ruta Mameniškiene (Lithuania)

Herman Lundborg: his research and contributions - Peter Mattsson (Sweden)

Lessons learned from genetic studies of Unverricht-Lundborg disease - Anna-Elina Lehesjoki (Finland)

Unverricht–Lundborg disease: genotype and phenotypes - Reetta Kälviäinen (Finland)

Medical management of Unverricht–Lundborg disease today - Pierre Genton (France)

BASIC SCIENCE

DECIPHERING EPIGENETIC MECHANISMS OF EPILEPTOGENESIS

Co-Chairs: Ingmar Blümke (Germany), Christophe Bernard (France)

Epileptogenesis-related genomic DNA methylation in a rat status epilepticus model - Katja Kobow(Germany)

Epileptogenesis-related genomic DNA methylation in a rat acquired epilepsy model: similar rather thandifferent? - Katarzyna Lukasiuk (Poland)

Analysis of epigenetic factors for excitability in human epileptic tissue - Albert Becker (Germany)

Altered expression of histone deacetylases in a mouse mode of TLE - Günther Sperk (Austria)

TRANSLATIONAL BIOMARKERS AND TARGETS FOR EPILEPTOGENESIS

Co-Chairs: Annamaria Vezzani (Italy), Natalia Gulyaeva (Russia)

MRI biomarkers for post-traumatic epileptogenesis - Asla Pitkänen (Finland)

PET imaging in models of epileptogenesis and chronic epilepsy - Stefanie Dedeurwaerdere (Belgium)

Imaging blood-brain barrier dysfunction as a biomarker for epileptogenesis - Alon Friedman (Israel)

Crosstalk between biomarker and treatment target identification: from experimental models to humanepileptogenesis - Albert Becker (Germany)



ROLE OF GLIA IN EPILEPTOGENESIS

Co-Chairs: Uwe Heinemann (Germany), Erik Taubøll (Norway)

Age-related impairment of neuron-glia interactions in rats with epilepsy - Astrid Nehlig (France)

Astrocytic activity in the age-dependent development of spike-and-wave discharges in genetic absenceepilepsy rats - Filiz Onat (Turkey)

Crucial role of impaired astrocyte gap junction coupling in epilepsy - Christian Steinhäuser (Germany)

Roles of the glial water channel AQP4 and the potassium channel Kir4.1 in epilepsy - Kjell Heuser(Norway)

ILLUMINATING EPILEPTIC BRAIN

Co-Chairs: Dimitri Kullmann (UK), Rüdiger Kohling (Germany)

Optogenetic tools to control brain activity: translational overview - Karl Deisseroth (USA)

Thalamic enlightening controls seizures - John Huguenard (USA)

Optogenetic regulation of epileptoform activity - Matthew Walker (UK)

Disrupting hypersynchronizations by optogenetics: activation of inhibitory interneurons - Merab Kokaia(Sweden)

SURGERY

THE DOWNSIDES OF EPILEPSY SURGERY

Chair: Cigdem Özkara (Turkey)

Surgical and neurological complications of epilepsy surgery - Bertil Rydenhag (Sweden)

Surgically-induced behavioural change - Simon Shorvon (UK)

The consequences to patients of surgically-induced memory disturbance - Sallie Baxendale (UK)

MRI negative neocortical epilepsy - the mythology of a ‘seizure focus’ - Paul Boon (Belgium)

SINGLE PULSE STIMULATION IN PRESURGICAL ASSESSMENT OF EPILEPSY

Co-Chairs: Gonzalo Alarcon (UK), Andrea Rossetti (Switzerland)

Responses to intracranial single pulse electrical stimulation: clinical and pathophysiological significance - Antonio Valentin (UK)

Cortico-cortical evoked potentials: The Cleveland Clinic experience - Rei Enatsu (USA)

Single pulse electrical stimulation and high frequency oscillations - Maryse Von Klooster (TheNetherlands)

Non-invasive alternatives: transcranial magnetic stimulation - Vasilios Kimiskidis (Greece)



EPILEPSY SURGERY IN GENETIC EPILEPSIES: IS IT FEASIBLE?

Co-Chairs: José M. Serratosa (Spain), Petia Dimova (Bulgaria)

Epilepsy surgery in familial temporal lobe epilepsy - Fernando Cendes (Brazil)

Epilepsy surgery in autosomal dominant nocturnal frontal lobe epilepsy - Paolo Tinuper (Italy)

Epilepsy surgery in tuberous sclerosis - Floor E. Jansen (The Netherlands)

Epilepsy surgery in partial forms of GEFS plus - Helen Cross (UK)

CALLOSOTOMY: PAST, PRESENT AND FUTURE

Chair: Eija Gaily (Finland)

Indication for callosotomy and long-term outcome - Ingrid Olsson (Sweden)

Surgical procedures and functional aspects - Bertil Rydenhag (Sweden)

The functional anatomy of fibre crossing - Mojtaba Zarei (Iran)

A reappraisal of the disconnection syndromes - Marco Catani (UK)

OTHER CATEGORIES

WHAT MORE SHOULD WE DO? REHABILITATION IN EPILEPSY

Chair: Sarah Wilson (Australia)

Rehabilitation in epilepsy - too little too late? - Lena Nilsson (Sweden)

Employment and epilepsy - vocational rehabilitation - Ulrich Specht (Germany)

Cognitive deficits in epilepsy - rehabilitation interventions - TBC

Rehabilitation after epilepsy surgery - what is needed and what can be achieved? - Margarete Pfäfflin(Germany)

SUDDEN UNEXPECTED DEATH IN EPILEPSY: FROM NEW INSIGHTS INTO MECHANISMS TOPREVENTION OPPORTUNITIES

Chair: Rainer Surges (Germany)

Neurobiology of Sudden Unexpected Death in Epilepsy - basis for identification of patients at risk andfor interventions - Jeff Noebels (USA)

From unwitnessed fatality to witnessed rescue: non-pharmacological intervention - Lina Nashef (UK)

From unwitnessed fatality to witnessed rescue: pharmacological intervention - Philippe Ryvlin (France)

Epidemiology of Sudden Unexpected Death in Epilepsy prevention: how to test simple population- based interventions - Leone Ridsdale (UK)



SEIZURE DETECTION, SEIZURE COUNTING - METHODS TO IMPROVE ACCURACY

Co-Chairs: Andrea Rossetti (Switzerland), Stevo Lukic (Serbia)

How reliably do patients count seizures: behind the mystery of the patient’s diary? - Christian Hoppe(Germany)

How reliable is surface-EEG? - Christoph Baumgartner (Austria)

Seizure detection and quantification using surface EMG and accelerometry - Sándor Beniczky(Denmark)

Seizure detection and quantification by heart rate variability monitoring - Guido Rubboli (Denmark)

IMPROVING YIELD AND SAFETY IN THE EPILEPSY MONITORING UNIT

Co-Chairs: Kristina Källén (Sweden), Guido Rubboli (Denmark)

General safety issues in the Epilepsy Monitoring Unit - Judith Dobesberger (Austria)

Antiepileptic drugs tapering or withdrawal for seizure provocation: recommendations and safety issues- Stevens Claus (The Netherlands)

Risks with invasive monitoring - can we improve damage control? - Andrew McEvoy (UK)

Epilepsy Monitoring Unit organization, intensity of monitoring and patient management duringseizures: how to improve diagnostic yields - Sándor Beniczky (Denmark)

ADVANCES IN EEG AND IMAGING FOR LOCALIZATION OF EPILEPTOGENIC FOCI

Co-Chairs: Roland Flink (Sweden), Christoph Baumgartner (Austria)

High density EEG source imaging - Margitta Seeck (Switzerland)

High frequency oscillations (HFO) - what does it mean and how useful is it? - Julia Jacobs (Germany)

EEG combined with fMRI - recording in the scanner - clinical application? - TBC

Sophisticated PET-imaging and new tracers in epileptology - TBC

AUTOIMMUNE EPILEPSY

Co-Chairs: Jukka Peltola (Finland), Eva Kumlien (Sweden)

Glutamate receptor antibodies against AMPA and NMDA receptors are present in epilepsy patients,kill neurons and damage the brain - Mia Levite (Israel)

NMDA and GABA(B)-receptor antibodies in encephalitis: occurrence and pathogenic mechanisms- Marteen Titulaer (The Netherlands)

Autoantibodies associated with epilepsy and other CNS disorders: new developments and futurechallenges - Angela Vincent (UK)

Treatment options for autoimmune epilepsy - Christian Bien (Germany)



EPIDEMIOLOGY OF EPILEPSY: FROM FUNDAMENTALS TO FUTURE CONTRIBUTIONS

Co-Chairs: Lars Forsgren (Sweden), Ley Sander (UK)

Epilepsy epidemiology in the era of new ILAE definitions and organizations of seizures and epilepsy- Ettore Beghi (Italy)

What have we learned from epidemiology on etiologies and comorbidities of epilepsy? - DaleHesdorffer (USA)

New insights into the prognosis of epilepsy - Aidan Neligan (UK)

How can the nationwide patient registries be utilized to advance our understanding of epilepsy and itsconsequences? - Jakob Christensen (Denmark)

EMOTION RECOGNITION AND SOCIAL COGNITION IN TEMPORAL LOBE EPILEPSY

Co-Chairs: Petr Marusic (Czech Republic), Hrvoje Hecimovic (Croatia)

Facial emotion recognition in temporal lobe epilepsy patients - Stefano Meletti (Italy)

Social cognition in temporal lobe epilepsy patients - Henric Jokeit (Switzerland)

Social cognition in children with epilepsy - Mary Lou Smith (Canada)

Postoperative changes in emotional recognition and social cognition in temporal lobe epilepsy patients- Jana Amlerova (Czech Republic)

SOMATIC COMORBIDITY IN EPILEPSY

Chair: Dale Hesdorffer (USA)

Concepts, importance and examples of somatic comorbidity in general - Raoul Hennekam (TheNetherlands)

Genetics of somatic comorbidities - Sanjay Sisodiya (UK)

Epilepsy and cancer - Ley Sander (UK)

Obesity: occurrence in epilepsy and treatment implications - Alla Guekht (Russia)

THE MICHAEL DEBATE: FOCAL ICTOGENESIS

Chair: Peter Wolf (Denmark)

Cortical dysplasia is never focal - Ingmar Blümcke (Germany)

Ictogenesis in idiopathic “focal” epilepsies - Matthias Koepp (UK)

The syndrome of temporal lobe epilepsy reflects widespread network dysfunction - Jean Gotman(Canada)

Are there more intelligent invasive treatment options for focal epilepsies beyond resections?- Christian E. Elger (Germany)



TEACHING SESSIONS

WHAT NOT-TO-DO IN EPILEPSY

Are you interested to find out what can go wrong in the management of epilepsy and how to avoid it? Join us in our interactive morning seminars. We know all about mistakes, including our own!

Co-Chairs: Dieter Schmidt (Germany), Christian E. Elger (Germany)

DAY 1

Red flags in the semiology of epileptic seizuresIs it epilepsy? Which type of epilepsy? - Christian E. Elger

Is it a non-epileptic attack? - Dieter Schmidt

DAY 2Red flags for diagnosis of epilepsy

How to miss the diagnosis of epilepsy - Dieter Schmidt

How to mishandle diagnostic tests such as EEG and MRI - Christian E. Elger

DAY 3

Red flags: time for antiepileptic drugs and time for surgeryHow to miss the best time to start or to stop antiepileptic drugs - Dieter Schmidt

How to miss the best time for surgery - Christian E. Elger

FOUND IN TRANSLATION, BASIC SCIENCE EXPLAINED

Coordinator: Merab Kokaia (Sweden)

The main goal of this series of teaching sessions is to provide a common platform for meetings and discussionsof basic scientists and clinical neurologists, where topics of basic research will be addressed from a translationalperspective. The presentations are designed in a more educational format directed towards clinical neurologiststo fill the gap and increase mutual understanding in fundamental concepts for novel treatment strategies thatare currently emerging.

DAY 1Translational models of epileptogenesis

Chair: Wolfgang Löscher (Germany)

Epilepsy developing after status epilepticus - Astrid Nehlig (France)

Epilepsy developing after traumatic brain injury and stroke - Asla Pitkänen (Finland)

Epilepsy developing in genetic models - Antoine Depaulis (France)

DAY 2Understanding epileptogenesis on synaptic levelCo-Chairs: Christine Ekdahl Clementson (Sweden), My Andersson (Sweden)Presynaptic remodeling and epilepsy - Sari Lauri (Finland)Inhibitory synaptic remodeling - Rosa Cossart (France)Plasticity at the axonal initial segment - Hansjürgen Volkmer (Germany)

DAY 3The role of mitochondria and reactive oxygen species in epileptogenesis - from bench to bedsideChair: Matthew Walker (UK)Mitochondria, reactive oxygen species and epilepsy - potential treatment strategies - Stjepana Kovac (UK)Mitochondrial involvement in temporal lobe epilepsy - Wolfram S. Kunz (Germany)Mitochondrial encephalopathies in childhood epilepsy: current and potential drug targets - TBC

SEIZURE SEMIOLOGY SMÖRGÅSBORD

The sessions will be interactive with open discussions following each video-EEG demonstration. The learning goals are that participants should be able to:

correlate seizure-related symptoms to anatomical brain areas and structures analyse localizing and lateralizing signs during seizure evolution identify patients suitable for referral to a tertiary epilepsy centre with a surgical programme

Co-Chairs: Kristina Källén (Sweden), Roland Flink (Sweden) DAY 1

Classification of seizures and their anatomical correlates. What have we learned from functional brainstimulation, SISCOM and fMRI?

DAY 2Analysis of seizure evolution. Localizing and lateralizing signs from focal onset to generalization and duringthe postictal period. How reliable are they?

DAY 3Seizure semiology in surgical candidates. Selected patients from the National Swedish Epilepsy Surgery Registryare demonstrated with reports of outcome from different surgical procedures and histological pathology.

ABC OF EPILEPSY EPIDEMIOLOGY

Coordinators and speakers: Dale Hesdorffer (USA), Ley Sander (UK)

The purpose of the existing standards for the conduct of epidemiological studies and surveillance of epilepsyis to describe epidemiological methodology for new investigators, to provide definitions and to propose newtools that address the broader scope of epidemiological research in epilepsy. These topics will be discussed ina 90-minute teaching session designed for people interested in initiating epidemiological studies of epilepsyas well as for those who want to be able to interpret epidemiological publications. Examples will be providedfor low and middle income countries as well as upper middle and high income countries.





VIREPA AT WORK

It is ten years since ILAE/CEA distance education was introduced, initially under the wings of 'EUREPA', and, since2009, as a formal part of the ILAE educational programme run by the ILAE Virtual Epilepsy Academy 'VIREPA'.

What started as a single course on the genetics of epilepsy has developed into an extensive programme: in2014 VIREPA offers courses on EEG, imaging, clinical therapy, genetics, sleep and psychiatric aspects of epilepsy.New courses are in development.

What remains as constant is an emphasis on small scale group work and a high level of interactive work, bothbetween students and tutors and between students themselves.

The early morning courses in Stockholm will bring together tutors and former pupils of the EEG and imagingcourses and will show, based on case presentations, how the VIREPA format works in practice.

Chair: Walter van Emde Boas (The Netherlands)

DAY 1 EEG in the diagnosis and management of epilepsy

DAY 2 Neuroimaging

TEACHING COURSES

PHARMACOLOGICAL TREATMENT OF EPILEPSY

The target of this course is anyone interested in the pharmacological treatment of epilepsy. The course coversthe spectrum from basic pharmacology and pharmacokinetics to clinical trials and practical use of antiepilepticdrugs in different populations and situations.

Chair: Svein I. Johannessen (Norway)

PART 1: Basic and pharmacokinetic aspects

Mechanisms of action of antiepileptic drugs - Wolfgang Löscher (Germany)

Do mechanisms of action matter for efficacy, tolerability and antiepileptic drugs selection? - GraemeSills (UK)

Clinical pharmacokinetics of antiepileptic drugs - Cecilie Johannessen Landmark (Norway)

Drug interactions and clinical management of pharmacokinetic variabilty - Philip Patsalos (UK)

PART 2: Clinical aspects

Strategies in the development of new antiepileptic drugs - what is in the pipeline? - Meir Bialer (Israel)

Critical reading of clinical trials of antiepileptic drugs - Bernd Schmidt (Germany)

Antiepileptic drugs selection: from evidence-based guidelines to clinical practice: children - Helen Cross (UK)

Antiepileptic drugs selection: from evidence-based guidelines to clinical practice: adults and the elderly - Elinor Ben-Menachem (Sweden)

Predicting, preventing and managing adverse effects of antiepileptic drugs - Piero Perucca (Italy)

Pregnancy and breast-feeding - Torbjörn Tomson (Sweden)

Medical management of difficult-to-treat patients - TBC

Termination of antiepileptic drugs treatment in patients in remission - Morten Lossius (Norway)

Update on the treatment of status epilepticus - Eugen Trinka (Austria)

THE ROLE OF THE EPILEPSY NURSE IN THE MANAGEMENT OF PEOPLE WITH EPILEPSY

Speakers: TBC

The role of the epilepsy specialist nurse in the multidisciplinary epilepsy team

Efficacy of educational programmes for children, adolescents and adults with epilepsy

Structured, nurse-led intervention programme improves quality of life in patients with epilepsy

Implementation of guidelines for epilepsy diagnosis and treatment by the epilepsy nurse

TEACHING COURSE FOR EEG TECHNICIANS: VIDEO EEG MONITORING

The session will discuss more advanced EEG techniques, analysis and monitoring strategies within thediagnostic and preoperative epilepsy programmes. Some basic knowledge about EEG recordings is an advantagefor the participants but anyone with an interest in EEG monitoring is welcome.

Speakers: Florin Amzica (Canada), Sándor Beniczky (Denmark), Roland Flink (Sweden)

Topics that will be addressed: electrodes used for monitoring; sphenoidals vs “low-row”, high density EEG

seizure detection

automatic spike detection

basic source analysis

reporting the findings (semiology and ictal EEG)



Information in this announcement may be subject to change. Please check www.epilepsystockholm2014.org for all updates.



AWARDS

EUROPEAN EPILEPTOLOGY AWARD (EEA) 2014 The Commission on European Affairs (CEA) wishes to invite nominations for the European Epileptology Award2014. The award will be presented to a European epileptologist in recognition of his or her outstandingcontribution to European epileptology at a special symposium during the 11th European Congress onEpileptology in Stockholm in 2014.

The CEA will contribute 10,000 EUR to the award and a committee specially selected by the CEA will judgethe nominations and select the recipient.

Any European individual who has made a substantial lifetime contribution in any aspect of epileptology iseligible for nomination. The major part of the candidate’s work should have taken place in Europe. Nominationswill be accepted from European ILAE Chapters, institutions or individuals. Please note that self-nomination isnot permitted.

EUROPEAN EPILEPSY EDUCATION AWARDThe award carries no monetary value but is given in recognition of outstanding contributions to Europeanepilepsy education.

The award consists of a diploma and will be announced in conjunction with the European Congress onEpileptology to which the awardee will have their registration fees waived.

Awards will be made no more than once every two years and to a maximum of one awardee on each occasion.

Eligible are individuals in Europe of any profession who have made an outstanding contribution to theadvancement of epilepsy education on a European level and who have not received so far an Ambassador forEpilepsy Award or the European Epileptology Award..

Nominations will be accepted from European ILAE Chapters, institutions or individuals. Please note that self-nomination is not permitted.

The CEA will evaluate the nominations and select the awardees.

YOUNG INVESTIGATOR AWARDSThe awards carry no monetary value but are given in recognition of outstanding contributions to epilepsyresearch and in order to stimulate a promising research career in epileptology.

The awards consist of a diploma and will be announced in conjunction with the European Congress onEpileptology to which the awardees will have their registration fees waived.

Awards will be made no more than once every two years and to a maximum of two awardees, one in basicscience and one in clinical science on each occasion.



Eligible are researchers in Europe under the age of 45 who have made a substantial scientific contribution andwith a documented exceptionally promising career in epilepsy research.



EUROPEAN EPILEPSY SERVICE AWARDSThe awards carry no monetary value but are given in recognition of outstanding service contributions toEuropean Epileptology.

The awards consist of a diploma and will be announced in conjunction with the European Congress onEpileptology to which the awardees will have the registration fee waived.

Awards will be made no more than once every two years and to a maximum of two awardees, one in basicscience and one in clinical science on every occasion.



NOMINATION INSTRUCTIONS

Please complete one nomination form for each nominee (the form is available on the congress website). Aperson who received the ILAE-IBE Ambassador for Epilepsy Award cannot be a candidate for any of the abovethree awards.

Completed nomination forms should be accompanied by:

1. A Curriculum Vitae of the nominee (400 - 800 words).

2. An explanatory statement outlining the reasons the proposed nominee has been nominated for theaward. This should include an assessment of the nominee's professional achievements as well as his/hercontribution to European developments in epileptology (max. 400 words).

3. A list of up to 10 publications considered to be particularly representative of the nominee’s contributions.

Nomination forms and other documentation should be returned by December 31st 2013 [email protected]

or posted to:

ILAE Congress Secretariat7 Priory HallBlackrockCo. DublinIreland

GENERAL INFORMATION

TRAVEL BURSARIESIn an effort to further encourage Young Investigators (under 45 years of age) to participate in the 11th EuropeanCongress on Epileptology, the Commission on European Affairs (CEA) will award travel bursaries to a numberof young applicants to assist with registration, travel and accommodation expenses. Members of the BursarySub-Commission will select the successful applicants. Details of how to apply for a travel bursary will beannounced on the congress website at www.epilepsystockholm2014.org

ABSTRACT SUBMISSIONAll abstracts should be submitted via the congress website at www.epilepsystockholm2014.org fromNovember 2013. The abstract submission deadline is currently set for January 2014.

Abstracts must be submitted in English, ready for immediate publication, in keeping with submission guidelines.Authors will receive an e-mail acknowledgement on receipt of their abstract. Authors whose abstracts areaccepted must register following notification of this acceptance.

Late abstracts will not be accepted.

CONTINUING MEDICAL EDUCATION (CME) CREDITS The 11th European Congress on Epileptology has applied to the European Accreditation Council for ContinuingMedical Education (EACCME) for CME accreditation. The EACCME is an institution of the European Union ofMedical Specialists (UEMS). Please visit www.uems.net for further information.

EACCME credits are recognised by the American Medical Association towards the Physician’s Recognition Award(PRA). For further details, please visit www.ama-assn.org.

Please check the congress website for updates on CME accreditation.


26 www.epilepsystockholm2014.org26 www.epilepsystockholm2014.org

VENUE StockholmsmässanMässvägen 1 125 30 ÄLVSJÖ Phone +46 8 749 41 00 Fax +46 8 99 20 44 Website: www.stockholmsmassan.se

CONGRESS DATES 29th June to 3rd July 2014

CONGRESS WEBSITE www.epilepsystockholm2014.orgAll details regarding the congress will be announced on the congress website as they become available. Abstractsubmission, registration and bursary applications will be processed online. Please refer to the website forscientific programme updates.

Details on other ILAE epilepsy congresses worldwide can be accessed through the epilepsy congress portalsite at www.epilepsycongress.org

DATES FOR YOUR DIARY

REGISTRATION Registration is available online at www.epilepsystockholm2014.org



On-line registration available

Abstract submission and travel bursary application available

Abstract submission and travel bursary application deadline

Mid 2013

November 2013

January 2014

Early registration deadline

Late registration deadline

Last minute registration deadline

End March 2014

Mid May 2014

Mid June 2014

Further information regarding registration terms and conditions and cancellation policies may also be found onthe website.


28 www.epilepsystockholm2014.org28 www.epilepsystockholm2014.org

USEFUL CONGRESS INFORMATION

LanguageThe official language of the 11th European Congress on Epileptology will be English.

Congress UpdatesTo receive regular newsletter with updates about the congress please submit your contact details via thecongress website www.epilepsystockholm2014.org or contact [email protected].

VisasEU residents and US, Canadian, Australian, New Zealand and South African citizens do not require a visa andare permitted to enter the country with just a valid passport. Visitors from other countries should contact theSwedish embassy in their respective country for more information. Visitors arriving in Stockholm either by airconnection or at a land border will generally not find customs clearance a complicated or stressful experienceprovided they are in compliance with Swedish customs.

Liability and InsuranceThe congress organisers will not accept liability for personal injury or loss/damage to property/belongings ofparticipants either before, during or following the congress or their stay in Stockholm. It is thereforerecommended that participants arrange their own personal health, accident and travel insurance.

CurrencyThe currency in Sweden is the Swedish krona (crown) - SEK. Credit and debit cards are accepted almosteverywhere in Stockholm.

AccommodationStockholm offers a wide range of excellent hotels in every price category. The accommodation agencyMeetagain has been selected as the official accommodation agency for the 11th European Congress onEpileptology and has secured competitive rates on a selected list of hotels both for individuals and groupsin Stockholm city centre, with easy access to the congress venue Stockholmsmässan by public transport.Please refer to www.epilepsystockholm2014.org for more details.

For accommodation enquiries, please contact:Meetagain Phone: +46 8 664 58 00Cell phone: +46 70 929 85 00E-mail: [email protected]

The 11th ECE Congress Secretariat

• Programme coordinator - Claire Derousseaux Email: [email protected]

• Exhibition & sponsorship - Finola Quinn Email: [email protected]

• Group registration - Gus Egan Email: [email protected]

• Individual registration - Carla Glynn Email: [email protected]

ILAE Congress Secretariat7 Priory HallBlackrockCo. DublinIreland

Phone: +353 1 205 6720Fax: + 353 1 205 6156

Email:[email protected]

www.epilepsystockholm2014.org

www.epilepsystockholm2014.org

WE LOOK FORWARD TO MEETING YOU IN STOCKHOLM!29TH JUNE - 3RD JULY 2014

11th european congress on epileptology

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