1. thalidomide
TRANSCRIPT
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Thalidomide
UJIAN TENGAH SEMESTER
TOKSIKOLOGI LINGKUNGAN
OlehPUTRY APRIYANI
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Rumus Kimia : C13H10N2O4 Massa molar: 2!"23 #$mol Nama sis%&ma%i' (IU)AC*: (RS* +2 + (2",+-io.o/i/&ri-i+
3+il*+1H+isoi-ol&+1" 3 (2H*+-io
)ro%&i m&#i'a% masi#+masi# -a ,, u%u'(*+R -a (+*+&asiom&r S
Thalidomide
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Tali-omi-& m&ru/a'a sua%u oa% s&-a%i5&i/o%i' 6a# -i'&ma#'a -i J&rma 7ara%
s&'i%ar %au 184 u%u' m&#a%asiisomia9 Namu -alam /&ralaa6a oa%ii a6a' -isalar&s&/'a /a-a iu amilu%u' m&#a%asi #&ala mual -a mu%a9
Kar&a /o/ulari%as6a" -alam ;a'%u 3 %aus&%&la -i/asar'a oa% %&rs&u% %&la-i'osumsi s&
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7a6i+a6i 6a# -ilair'a ol& iu 6a# /a-a saa%amil m&#'osumsi %ali-omi-& -i%&mu'a
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)a-a /&r%&#aa
%au 18,2" Tali-omi-&-i6a%a'a -i%ari'
-ari /&r&-ara -is&luru -uia9 >a#/ali# %ra#is" u%u'm&#&%i'a
%ra#&-i oa% ii-i/&rlu'a ;a'%u6a# ama% /aa#"
6ai%u ! %au
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Tali-omi-& -i'&ma#'a ol& /&rusaaa=armasi J&rma Gr@&%al -i S%ol&r# -&'a%Aa
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Tali-omi-&" -ilu
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8/16/2019 1. Thalidomide
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o'%&r 'a-u#a Aus%ralia Billiam M
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)a-a %au 18,2" Ko#r&s Am&ri'a S&ri'a%m&m&rla'u'a /&ra%ura 6a#m&#arus'a ui '&amaa oa% 6a#-i#ua'a s&lama '&amila9 )a-a %au ii"
Tali-omi-& -ilara# -ir&s&/'a a%au -iuals&lama &&ra/a -&'a-&9
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Emrio#&&sis a-ala /ros&s 6a# rumi% 6a#-a/a% -&#a mu-a %&r#a##u -&#a
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M&'aism& -i ali'
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S&%&la %ali-omi-& m&#i-ar sis%&m%ras/or%asi /&#aisa" ia mam/um&#i-u'si s%r&s o'si-a%i= /a-a s/&si&so'si#& r&a'%i= (ROS* alur %&r#a%u# si6al
-i /u##u#a a/i'al &
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M&'aism& %&ra%o#&i
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Kolo
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i# o.i-a%i5& s%r&ss
&
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Kar&a &%u' mol&'ul%ali-omi-&" i%u mam/um&#i'a% -a '&rusa'a NA-a m&#a
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Penyebab Keaatan
E=&' 'liis 6a# %&ra-i /a-a iu amil 6a#m&#'osumsi Tali-omi-& u'a la m&ru/a'a&=&' sam/i# -ari oa%9 Hal ii %&ra-i 'ar&as&6a;a Tali-omi-& m&mili'i -ua &a%iom&r6ai%u (R*+Tali-omi-& 6a# m&mili'i &=&' 'liiss&a#ai oa% /&&a# -a (S*+Tai-omi-& 6a#m&mili'i &=&' 'liis m&##a##u /&r%umua
ai9
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alam &&ra/a %au %&ra'ir %&la -i%&mu'aa;a i-i5i-u o+amil isa m&-a/a%'a'&u%u#a -ari oa% %&rs&u%9 Sala sa%u a/li'asim&-is -ari %ali-omi-& m&lia%'a '&mam/ua6a
u%u' m&ma%u -alam /&#oa%a mul%i/l&m6&loma" -a i%u -is&%uui u%u' -i#ua'a ii ol&AS oo- a- ru# A-miis%ra%io /a-a %au 200,9Hal ii -i6a'ii a;a %ali-omi-& m&
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)a-a %i#'a% mol&'ul&r" %ali-omi-&m&#ama% a#io#&&sis ol& %&ri%&r'alasia%au m&masu''a -iri6a '& -alam #uai+si%osi (GC* -a&ra 'a6a NA9 &#a
i%&r'alasi ii" %ali-omi-& m&r&/r&si -a&ra/romo%or /&r%umua isuli =a'%or+1 (IG+1*-a =a'%or /&r%umua rolas%+2 (G2*"ai' 6a# &r%a##u# a;a u%u'
m&ra#sa# a#io#&&sis9 I%&r'alasi u#a-i%&rima s&a#ai i/o%&sis 6a# masu' a'alm&#a/a %uas a##o%a %uu &mrio &r&%i=ormulir9 Hal ii 'ar&a /&m&%u'a a##o%a
%uu u- s&lama /&r'&ma#a &mrio
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Gil&r%" S