1. kinase inhibitors · synthetic derivative of geldanamycin, which is one of the ansamycin...

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1. Kinase InhibitorsProduct Name

Wako Cat. No. Pkg. Size CAS No. Soluble in IC50 Storage Condition

Summary

A-83-01 【TGF-β R I Kinase Inhibitor IV】

018-22521 2 mgfor Cellbiology 909910-43-6 DMSO - Keep at -20℃.

014-22523 10 mg

<Protein kinase inhibitor>Selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7. Inhibits Smad2/3 phosphorylation and TGF-β-induced epithelial-to-mesenchymal transition. This product has little or no effect on bone morphogenetic protein type I receptors, p38 MAP kinases, and extracellular-regulated kinases.

17-AAG, 97.0+ % (HPLC)

012-20101 1 mg for Cellbiology 75747-14-7 DMSO, methanol EC50 of HSP90 = 7.2 μM Keep at -20℃.

<Protein kinase inhibitor/ protein tyrosine kinase (PTK) inhibitor>Synthetic derivative of geldanamycin, which is one of the ansamycin antibiotics. 17-AAG inhibits the function of HSP90 by binding to the ATP binding site of HSP90. HSP90 inhibitors dephosphorylate Akt resulting in inactivation of Akt and apoptosis.

AG 490, 95+% (TLC)

013-17181 5 mg for Biochemistry 134036-52-5DMSO, DMF,

methanol

IC50 of Dephosphorylation of EGF receptor tyrosine kinase: 1.2 μmol; EGF dependent cell proliferation: 6 μmol

Keep at -20℃.

<PTK inhibitor>Specific and potent JAK-2 protein tyrosine kinase inhibitor. Also inhibits EGF receptor autophosphorylation.

AG 1296

016-20121 5 mg for Cellbiology 146535-11-7 DMSO - Keep at -20℃.

<PTK inhibitor>It inhibits signaling in human PDGF (platelet-derived growth factor) α receptor, PDGF β receptor, stem cell stimulating factor c-kit and FGF (fibroblast growth factor) receptor.

AG 1478


<PTK inhibitor>Potent and selective inhibitor of EGF receptor kinase. Decrease in EGF-stimulating DNA synthesis and inhibition of activation of EGF-dependent src family kinase have been reported.

ALK5 Inhibitor, 96.0+ % (HPLC)

012-23021 1 mg for Cellbiology 446859-33-2 methanol - Keep at -20℃.

<Protein kinase inhibitor>Potent and selective ATP-competitive inhibitor of TGF-β RI kinase/ALK5. Can be used as substitute of Sox2 or c-Myc (Yamanaka 4 factors) in induction of murine iPS cells.

Aminogenistein, 90.0+ % (HPLC)

017-15901 1 mg for Biochemistry 132018-32-7 Ethanol, DMSO IC50 of lck = 1.2 μM Keep at -20℃.

<PTK inhibitor>Inhibitor of PTK, especially p56lck. The product, even among other flavons, is able to specifically inhibit lck activity at a low dose and is therefore employed as an useful tool for clarification of the mechanism of immune response activation.

Apigenin, 95+ % (TLC)

010-18914 5 mg

for Biochemistry 520-36-5 Methanol - Keep at 2-10℃.016-18911 10 mg

012-18913 50 mg

<MAP kinase inhibitor>Plant flavonoid. It changes phenotypes of many ras transformed cells to the original form. This is achieved by inhibition of signal transduction route mediating MAP (Miogen Activated Protein) kinase (MAPK). In case of NIH3T3 cells transformed by v-H-ras, treatment with apigenin (12.5 μM) induces dephosphorylation of p44 MAPK resulting in a decrease in MAP kinase activity.

AS 604850, 98.0+ % (HPLC)

015-23131 5 mg for Cellbiology 648449-76-7 DMSOIC50 of PI3Kα: 4.5 μM; PI3Kγ: 250 nM;

PI3Kβ, PI3Kδ: 250 nMKeep at 2 - 10℃

<Protein kinase inhibitor>Thiazolidine-dione compound, which is a potent, cell permeable and ATP-competitive inhibitor of PI3K γ. It exhibits highly selectivity.

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Product Name


Summary

AS 605240, 95.0+ % (HPLC)

012-23141 5 mg for Cellbiology 648450-29-7 DMSOIC50 of PI3Kα: 60 nM; PI3Kγ: 270 nM;

PI3Kβ: 8 nM; PI3Kδ: 300 nMKeep at 2 - 10℃

<Protein kinase inhibitor>Thiazolidine-dione compound, which is a potent, cell permeable and ATP-competitive inhibitor of PI3K γ (Ki = 180 nM). It exhibits highly selectivity.

ATM Kinase Inhibitor, 97.0+ % (HPLC)

015-22911 2 mg for Cellbiology 587871-26-9 Ethanol ATM: IC50 = 13 nM; Ki = 2.2 nM Keep at -20℃.

<Cyclin-Dependent Kinase (CDK) Inhibitor>Cell-permeable, ATP-competitive inhibitor of ATM kinase. Shows high ATM kinase selectivity for PIKK and PI3K family kinases.

6-Bromoindirubin-3'-oxime 【BIO】【GSK-3 Inhibitor IX】, 95.0+ % (HPLC)

029-16241 1 mg for Cellbiology 667463-62-9 - - Keep at 2 - 10℃

<Protein kinase inhibitor>Potent and reversible ATP-competitive inhibitor. It shows to activate the Wnt signaling pathway and maintain pluripotencies in human and murine ES cells and also promotes cardiomyocyte proliferation and acts as a GSK-3 inhibitor.

Butein, 98.0+ % (HPLC)

027-14461 10 mg for Biochemistry 487-52-5 Methanol, DMSO - Keep at -20℃.

<Protein tyrosine kinase (PTK) inhibitor>Tyrosine kinase inhibitor isolated from plant polyphenols. Reported to activate SIrt1 (Class III HDAC).

Calphostin C, 95.0+ % (HPLC)

030-15133 50 μgfor Cellbiology 121263-19-2 DMSO, DMF

IC50 of PKC: 50 nM; HeLa S3: 0.23 μg/mL; MCF-7: 0.18 μg/mL

Keep at 2-10℃.034-15131 100 μg

<Protein kinase C (PKC) inhibitor>Specific protein kinase C (PKC) inhibitor. Shows strong anticellular activity against a variety of cultured cells.

Carbonyl Cyanide m-Chlorophenylhydrazone, 97+% (TLC)

034-16993 100 mgfor Biochemistry 99534-03-9 Ethanol, acetone - Keep at -20℃.

038-16991 1 g

<Protein kinase inhibitor>Potent uncoupler of oxidative phosphorylation that inhibits mitochondrial function.

CKI-7 Dihydrochloride, 97.0+ % (HPLC)

034-21501 5 mg for Cellbiology - Water - Keep at -20℃.

<Protein kinase inhibitor>Casein kinase (CK1) inhibitor. Use with SB431542 and Y-27632 induces differentiation of human ES cells and human iPS cells into retinal progenitor cells in serum- and feeder cell-free culture medium.

Compound 15e, 98.0+ % (HPLC)

031-21491 5 mg for Cellbiology 371943-05-4 EthanolIC50 of PI3Kα: 2 nM; PI3Kβ: 16 nM;

PI3Kγ: 660 nM; PI3KC2β: 220 nMKeep at 2 - 10℃

<Protein kinase inhibitor>Permeable morpholino pyrimidine compound. A highly selective PI3Kα inhibitor.

Compound 401, 98.0+ % (HPLC)

033-21951 1 mgfor Cellbiology 168425-64-7 Methanol

IC50 of DNA-PK: 0.28 μM; mTOR: 5.3 μM; ATM, ATR ＞ 100 μM

Keep at -20℃.039-21953 5 mg

<Protein kinase inhibitor>Reversible and selective DNA-PK and mTOR inhibitor. It exhibits negligible affinity to PI3K, ATM and ATR. It has been known to inhibit mTOR-dependent proliferation and induce apoptosis in TSC1-/- mouse embryo fibroblasts.

Deguelin

047-29211 5 mg for Cellbiology 522-17-8Acetone,

dichloromethane, acetonitrile, DMSO

- Keep at 2-10℃.

<Akt inhibitor>Akt (Protein Kinase B; PKB) inhibitor. It inhibits proliferation of cells in the GM-2 stage of cell cycle. It induces apoptosis in the precancerous and cancerated cell lines.

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Summary

Dibucaine Hydrochloride, 98.0+ % (after drying)(Titration)

049-20011 1 g for Biochemistry 61-12-1Water, glacial acetic

acid, ethanol, acetone and chloroform.

- Keep at RT.

<Protein kinase inhibitor>Lipophilic PKC inhibitor. Inhibits Na+ and K+-ATPase activities, too.

Dorsomorphin, 99.6% (HPLC, the initiall lot)

045-31221 1 mgfor Cellbiology 866405-64-3 Methanol - Keep at 2 - 10℃

041-31223 5 mg

<Protein kinase inhibitor>Permeable pyrazolopyrimidine compound, which is potent, selective and reversible ATP-competitive inhibitor of AMPK (AMP-activated protein kinasse). It has been shown to inhibit BMP signal strongly by inhibition of BMP type I receptors (ALK-2, ALK-3 and ALK- 6).

Dorsomorphin Dihydrochloride, 98.0+ % (HPLC)

047-31801 1 mgfor Cellbiology 1219168-18-9 Water - Keep at 2 - 10℃

043-31803 5 mg

<Protein kinase inhibitor>This substance inhibits bone morphogenic factor (BMP) type I receptors (ALK2, ALK3 and ALK6). It has been shown to inhibit BMP signal necessary for embryogenesis and accelerates important nerve differentiation from human pluripotential stem cells. It also functions as a potent, selective and reversible ATP-competitive inhibitor of AMP-activating protein kinase (AMP-K).

Geldanamycin, from Streptomyces hygroscopicus, 95.0+ % (HPLC)

077-04571 100 μg for Biochemistry 30562-34-6 Methanol - Keep at -20℃.

<Protein kinase inhibitor>This product is an antitumor agent that has a benzoquinoid skeleton and has a pp60src tyrosine kynase inhibitory potency. Its pharmacological action is more potent than that of herbimycin, which has a similar structure.

Genistein, 98.0+ % (HPLC)

073-05531 20 mgfor Cellbiology 446-72-0 Ethanol - Keep at -20℃.

079-05533 100 mg

<Protein tyrosine kinase (PTK) inhibitor>Isoflavone compound. Tyrosine kinase inhibitor by antagonizing against ATP. Known to inhibit the proliferation of various solid tumor cells and induce the differentiation of the tumor cells.

Genistin, from Soybean; 98.0+ % (HPLC)

070-04681 10 mgfor Biochemistry 529-59-9 Hot methanol - Keep at 2-10℃.

076-04683 100 mg

<Protein tyrosine kinase (PTK) inhibitor>Soy extract isoflavone, or glucoside. Cancer-suppressing effects, antioxidant effects, and osteoporosis preventive effects have been reported.

GF 109203X, 90.0+ % (HPLC)

079-03811 1 mg for Cellbiology 133052-90-1 DMSO IC50 of PKC: 10 nM Keep at 2 - 10℃

<Protein kinase inhibitor / protein kinase C (PKC) inhibitor>Potent and selective PKC inhibitor among bisindolylmaleimides, which have an inhibatory action on PKC. The structure is similar to that of staurosporine.

Gö 6983

070-05801 1 mg for Cellbiology 133053-19-7 DMSOIC50 of PKCα: 7 nM; PKCβ: 7 nM; PKCγ: 6 nM; PKCδ: 10 nM; PKCζ: 60 nM; PKCμ: 20μM

Keep at -20℃.

<Protein kinase C (PKC) inhibitor>Cell-permeable PKC inhibitor

GSK 269962A, 97.0+ % (HPLC)

070-05921 2 mg for Cellbiology 850664-21-0 DMSO, acetonitrile IC50 of ROCK-I: 1.6 nM; ROCK-II: 6 nM Keep at 2 - 10℃

<Protein kinase inhibitor>ROCK Inhibitor. Not available for sale in the USA due to patent.

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GSK 429286A, 97.0+ % (HPLC)

073-05911 2 mg for Cellbiology 850664-21-0Ethanol, DMSO,

waterIC50 of ROCK: 14 nM Keep at 2 - 10℃

<Protein kinase inhibitor>ROCK inhibitor. It cancels out adrenaline-induced contraction of the aortic valve in rats and lowers the mean blood pressure in the arteries of hypertensive rats.

H-1152 Dihydrochloride

088-09281 1 mg for Cellbiology 871543-07-6 Water IC50 of ROCK-II: 12 nM Keep at -20℃.

<Protein kinase inhibitor>ROCK inhibitor. Its inhibitory activity is more potent than that of Y-27632. It exhibits weak affinity to other serine/threonine kinases.

Herbimycin A, 98.0+ % (HPLC)

085-06491 1 mg for Biochemistry 70563-58-5 Methanol, DMSO - Keep at 2-10℃.

<Protein tyrosine kinase (PTK) inhibitor>Tyrosine kinase inhibitor by binding to the SH group of cysteine in oncogene src. It also inhibits transformation activity of oncogenes (src, yes, fps, ros, abl, erbB) that have tyrosine kinase activity. It also has the unique ability to restore RSVts-NRK cells to their normal form.

Hypericin, from Hypericum perforatum

086-07761 1 mgfor Biochemistry 548-04-9 Water-THF - Keep at 2 - 10℃

082-07763 5 mg

<Protein kinase inhibitor / PKC inhibitor>Inhibitor of PKC, insulin receptor, EGF receptor, casein kinase II, and thyrosine kinase activity of MAPK. It also exhibits antivirus and antiretrovirus activities.

IPA-3, 97.0+ % (HPLC)

093-06231 5 mg for Cellbiology 42521-82-4 DMSO, acetonitrile PAK1: IC50 = 2.5 μM Keep at 2 - 10℃

<Protein kinase inhibitor>p21 activation kinase (PAK) inhibitor, which binds to the regulatory domain of PAK and accelerates inactivation of PAKs structure. Shows high selectivity to PAK1 in particular. PAK1 involves in tumor formation and metastasis.

K-252a

113-00561 50 μg

for Biochemistry 97161-97-2 Ethyl acetate - Keep at -20℃.119-00563 100 μg

117-00564 250 μg

<Protein kinase inhibitor / PKC inhibitor>Selective inhibitor of PKA (cyclic AMP-dependent protein kinase), PKC (phospholipid-dependent protein kinase) and PKG (cyclic GMP-dependent protein kinase).

K-252b

110-00571 50 μgfor Biochemistry 99570-78-2 Methanol - Keep at -20℃.

114-00574 250 μg

<Protein kinase inhibitor / PKC inhibitor>Selective inhibitor of PKA (cyclic AMP-dependent protein kinase), PKC (phospholipid-dependent protein kinase) and PKG (cyclic GMP-dependent protein kinase).

Kenpaullone


116-00833 5 mg

<CDK Inhibitor>Potent GSK-3β and CDK inhibitor. Inhibits antagonistically ATP binding. Reported to be substitutable for Klf4, one of the 4 Yamanaka factors (Oct3/4, Klf4, Sox2, c-Myc), in iPS cell production. Also reported to improve reprogramming efficiency if added upon the introduction of 4 Yamanaka factors.

Ki 8751, 96.0+ % (HPLC)

112-00891 5 mg for Cellbiology 228559-41-9 DMSO IC50 = 0.9 nM Keep at -20℃.

<Protein kinase inhibitor>Potent and selective VEGFR-2 tyrosine kinase inhibito.

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KN-62

118-00631 1 mgfor Biochemistry 127191-97-3 Methanol, DMSO

Ca2+ / calmodulin-dependent protein kinase II (in rat brain): IC50 = 0.3 μM

Keep at 2-10℃.114-00633 5 mg

<Kinase inhibitor / Calmodulin antagonist>Selective inhibitor of Ca calmodulin-dependent protein kinase II in the rat brain. It inhibits the proliferation of K562 cells (1 μM).

KN-93

115-00641 1 mgfor Biochemistry 139298-40-1 Methanol

Ca2+ / calmodulin-dependent protein kinase II (in rat brain): IC50 = 2.0 μM

Keep at 2-10℃.111-00643 5 mg

<PKC inhibitor / Calmodulin antagonist>Selective inhibitor of Ca calmodulin-dependent protein kinase II in the rat brain. Inhibits insulin release from isolated islands of Langerhans caused by glucose induction and forskolin stimulation. It induces stoppage of the cell cycle in theG1 phase and apoptosis in NIH3T3 cells.

KN-93, Water-Soluble

114-00731 1 mg for Cellbiology - Water - Keep at -20℃.

<PKC inhibitor>Selective inhibitor of Ca calmodulin-dependent protein kinase II in the rat brain. Inhibits insulin release from isolated islands of Langerhans caused by glucose induction and forskolin stimulation. It induces stoppage of the cell cycle in theG1 phase and apoptosis in NIH3T3 cells.

KT 5720

117-00581 50 μg

for Biochemistry 108068-98-0 Methanol - Keep at -20℃.113-00583 100 μg

111-00584 250 μg

<Protein kinase inhibitor>K252a derivative and membrane permeable PKA (cyclic AMP-dependent protein kinase) inhibitor

KT 5823

114-00591 50 μg

for Biochemistry 126643-37-6Ethyl acetate,

methanol- Keep at -20℃.110-00593 100 μg

118-00594 250 μg

<PKC inhibitor>Cell-permeable PKC inhibitor

KU 0063794, 98.0+ % (HPLC)

115-00881 5 mg for Cellbiology 938440-64-3Acetone,

dichloromethane, acetonitrile, DMSO

IC50 of mTOR1: 10 nM; mTOR2: 10 nM. Keep at 2-10℃.

<Akt inhibitor>Selective mTOR (mammalian target of rapamycin) inhibitor. Shows no inhibitory activity against 76 types of protein kinases including PI3K even at 1,000-fold concentration.

LDN 193189 Hydrochloride, 98.0+ % (HPLC)

124-06011 2 mg for Cellbiology 1062368-62-0 Water IC50 of ALK2: 5 nM; ALK3: 30 nM. Keep at 2 - 10℃

<Protein kinase inhibitor>This product inhibits ALK2 and ALK3, which are BMP type I receptors, and consequently inhibits phosphorylation of Smad1, Smad5 and Smad8.

LY 294002, 97.0+%（HPLC)

129-04861 5 mg

for Biochemistry 154447-36-6 Ethanol, acetoneIC50 of PI3-kinase: 1.4 μM;Histamine secretion by PBL-2H3: 5 μM.

Keep at 2-10℃.125-04863 10 mg

123-04864 25 mg

<Akt inhibitor>Highly cell-permeable, specific phosphatidylinositol 3-kinase (PI3-kinase) inhibitor. It inhibits the proliferation of rabbit aorta smooth muscle cells without inducing apoptosis. It is also reported to inhibit histamine secretion by RBL-2H3 cells.

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Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Tyr

331-43741 0.5 mgPeptide Institute

(4374-v)- Water IC50 = 4.1 nM Keep at -20℃.

<Protein kinase inhibitor>Inhibitor of calmodulin-dependent protein kinase II.

3-Methyladenine

131-17671 100 mgfor Biochemistry 5142-23-4 　- - Keep at -20℃.

137-17673 1 g

<PI3 kinase inhibitor>This product prevents downstream mTOR kinase activity degradation by inhibition of PI3-kinase , which in turn suppresses autophagy.

NSC 693868, 98.0+ % (HPLC)

140-08891 5 mg for Cellbiology 40254-90-8 DMSO - Keep at 2 - 10℃

<Protein kinase inhibitor>Selective inhibitor of GSK-3β and CDK5.

NU 7026, 97.0+ %

145-08841 5 mg for Cellbiology 154447-35-5 DMSOIC50 of DNA-PK: 0.23 μM; PI3K: 13.0 μM;

ATM, ATR ＞100 μMKeep at 2 - 10℃

<Protein kinase inhibitor>ATP-competitive inhibitor of the protein kinase DNA-PK (DNA-dependent protein kinase).

NU 7441, 98.0+ % (HPLC)

143-09001 1 mgfor Cellbiology 503468-95-9 Methanol

IC50 of DNA-PK: 14 μM; mTOR: 1.7 μM; PI3K: 13.0 μM; ATM, ATR ＞100 μM

Keep at -20℃.149-09003 5 mg

<Protein kinase inhibitor>Potent, reversible and selective inhibitor of DNA-PK (DNA-dependent protein kinase) and mTOR. Has little affinity with PI3K, ATM, and ATR. Known to inhibit mTOR-dependent proliferation and induce apoptosis in TSC1-/- mouse embryonic fibroblasts.

Olomoucine, 97+ % (TLC)

157-01901 5 mg for Biochemistry 101622-51-9 DMSO - Keep at -20℃.

<CDK Inhibitor / MAPK inhibitor>It inhibits p34cdc/cyclin B, p33cdk2/cyclin A, p33cdk2/cyclin E, cerebral p33cdk5/p35 and erk1/MAPK, and it has been reported to inhibit in vitro the transition of the G2/M phase in the oocytes of starfish, and the transition of the G1/S phase in the mesophyll protoplasts of petunia.

PD-98059, 95+ % (TLC)

169-19211 5 mg for Biochemistry 167869-21-8 Ethanol, acetone - Keep at -20℃.

<Protein kinase inhibitor/ MAPK inhibitor>MAPK-1 inhibitor. This product has been reported to inhibit MAPK activation by insulin and block completely the increase in cell growth and MAP activity induced by leptin (obesity regulating hormone). The resting cell pretreated with PD-98059 has been demonstrated to inhibit a great deal the expression of the advance early genes c-fos and eggr-1 induced by a peroxisome proliferative agent.

PD 173074

166-24351 5 mg for Cellbiology 219580-11-7 Methanol -　 Keep at 2-10℃.

<PTK inhibitor>ATP competitive type FGF receptor inhibitor. The FGF signaling pathway is associated with spontaneous proliferation of stem cells in a host of systems.

PD 184352, 98.0+ % (HPLC)

169-25181 5 mg for Cellbiology 212631-79-3 Methanol, DMSO - Keep at 2-10℃.

<MAPK Inhibitor>Poteent and selective inhibitor of MEK1. Recent studies showed that culturing ES cells in a medium containing CHIR99021, SU5402, PD184352 allows for highly-efficient suppression of differentiation.

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PD 0325901

162-25291 5 mgfor Cellbiology 391210-10-9 Methanol, DMSO IC50 of MEK: 0.33 nM Keep at -20℃.

168-25293 25 mg

<MAPK Inhibitor>MAPK inhibitor with potent antitumor activity. It induces phosphorylation of MAPK, inhibition of its activation and inhibition of tumor cell proliferation. PD0325901 inhibits MAPK activity without adverse reactions. Addition of this product and CHIR99021 to a culture medium results in efficient culture of mouse ES cells.

Phloretin, 98.0+ % (HPLC)

160-17781 250 mg for Biochemistry 60-82-2 Methanol IC50 = 16 μM Keep at 2 - 10℃

<PKC inhibitor>The aglycone moiety of phlorizin, a specific inhibitor of the sugar active transport system, which is actually responsible for the inhibitory action of phlorizin. When used alone, phloretin has been reported to be less effective for the active transport system while it is known to be more inhibitory than phlorizin to the carrier transport system, suggesting a difference in the mode of action according to structure. It is also useful as means for the study of the kinetics and regulatory mechanisms of PKC as a non-specific inhibitor of PKC.

PI-103, 98.0+ % (HPLC)


169-24243 10 mg

<Akt inhibitor>Potent, cell-permeable and ATP-competitive inhibitor of DNA-PK, PI-3K, and mTOR with selectivity for a wide range of lipids and protein kinases. Reported to inhibit PIP3 production, insulin signal transduction, and Akt phosphorylation, suppress cell proliferation, and induce cell death.

Piceatannol

169-21661 10 mg for Cellbiology 10083-24-6 Ethanol - Keep at 2 - 10℃

<Protein kinase inhibitor / PTK inhibitor>Selective inhibitor of non-reception type tyrosine kinase Syk. An activator of human deacetylase class III (SIrt1).

PIK-75 Hydrochloride, 98.0+ % (HPLC)

162-24451 5 mg for Cellbiology - Water-methanolIC50 of PI3Kα: 0.3 nM; PI3Kβ: 850 nM;

PI3Kγ: 40 nM; PI3K C2β: 100 nMKeep at 2 - 10℃

<Protein kinase inhibitor>Cell-permeable imidazopyridine compound, which is a selective inhibitor of PI3Kα.

PKC 412, 96.0+ % (HPLC)

164-25751 1 mgfor Cellbiology 120685-11-2 - - Keep at -20℃.

160-25753 10 mg

<Protein kinase inhibitor>Wide range of kinase inhibitor. Inhibits PKC, PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1,EGFR, etc.

PP 2, 94.0+ % (HPLC) 　

166-20331 1 mg for Biochemistry 172889-27-9 Methanol, DMSO - Keep at -20℃.

<PTK inhibitor>Src family tyrosine kinase inhibitor.

PP 3, 94.0+ % (HPLC)

163-20341 1 mg for Biochemistry 5334-30-5 Methanol - Keep at -20℃.

<PTK inhibitor>EGF receptor type tyrosine kinase inhibitor

PP 242, 98.0+ % (HPLC)

165-24441 5 mg for Cellbiology 1092351-67-1 DMSOIC50 of mTOR: 8 nM; PI3Kα: 2 μM; PI3Kβ: 2.2 μM; PI3Kγ: 1.3 μM; PI3Kδ: 0.1 μM

Keep at 2-10℃.

<Akt inhibitor>Potent and selective mTOR (mammalian target of rapamycin) inhibitor

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Quercetin Dihydrate

171-00404 100 mg

Practical Grade 6151-25-3 Ethanol, acetone - Keep at RT.177-00401 1 g

173-00403 10 g

<Akt inhibitor>Yellow flavonoid. Has antioxidant and anti-tumor effects. Its fat absorption inhibitory effect is particularly strong compared with other polyphenols, and it aids in eliminating the body fat. Boosts the fat metabolism in the liver, increases fat combustion, and inhibits fat absorption by binding to fat in the digestive tract. Also said to reduce the inflammation in pollinosis.

Rac1 Inhibitor, 98.0+ % (HPLC)

180-02491 5 mg for Cellbiology - Water - Keep at 2-10℃.

<MAPK Inhibitor>Selective inhibitor of Rac1-GEF interaction. Specifically inhibits Rac1 activity by inhibiting the interactions between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors), TrioN and Tiam1.

Radicicol, 97.0+ % (HPLC)

183-01901 1 mg for Cellbiology 12772-57-5Ethanol, methanol,

DMSO- Keep at -20℃.

<PTK inhibitor>Macrocyclic lactone antifungal antibiotic with antimalarial activity. It inhibits a heat shock protein 90 (HSP90) and protein tyrosine kinase.

Rapamycin (mixture of isomers)

184-02531 1 mg

for Cellbiology 53123-88-9 - - Keep at -20℃.180-02533 10 mg

188-02534 50 mg

<Protein kinase inhibitor>Macrolide immunosuppressive agent. A structural analog of FK506 that binds to FK506 binding proteins (FKBPs) but does not inhibit calcineurin activity. The rapamycin-FKBP complex inhibits the signal from IL-2 by inhibiting the kinase activity of mTOR. Inhibits G1-to-S phase transition of the cell cycle.

RG-14620

188-02811 10 mgfor Cellbiology 136831-49-7 - IC50 = 3μM Keep at -20℃.

184-02813 50 mg

<Protein kinase inhibitor>EGFR tyrosine kinase inhibitor

Ro 31-8220 Methanesulfonate

186-02591 1 mg for Cellbiology 138489-18-6 EthanolIC50 of PKCα: 5 nM; PKCβI: 24 nM; PKCβII: 14 nM; PKCγ: 27 nM; PKCε: 24 nM; PKA: 0.9 μM; CaM kinase II: 17 μM

Keep at 2-10℃.

<PKC inhibitor>A structural analog of staurosporine. Potent, cell-permeable PKC inhibitor. Its selectivity for PKAs and CaM kinase II is low, and it also has inhibiting effects on glycogen synthase kinase 3 (GSK3) and voltage-dependent Na channels.

Roscovitine, 98.0+ % (HPLC)

182-01591 1 mgfor Biochemistry 186692-46-6

DMSO, ethanol, acetone

- Keep at -20℃.188-01593 10 mg

<CDK inhibitor>Olomoucine analog and CDK2 and CDK5 inhibitor. In Alzheimer's disease, it is believed to be associated with hyperphosphorylated tau.

SB 202190

193-13531 1 mg for Cellbiology 152121-30-7 Methanol - Keep at -20℃.

<MAPK Inhibitor>Potent and selective inhibitor of the p38α and β isoforms of p38 MAPK family. Shows membrane permeability. It has no effect on ERK and JNK MAPK.

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SB 203580, 98.0+ % (HPLC)

199-16551 1 mgfor Cellbiology 152121-47-6 DMSO, methanol

IC50 of SAPK2a / p38: 50 nM; SAPK2b / p38β2: 50 nM

Keep at -20℃.195-16553 10 mg

<Protein kinase inhibitor / MAPK inhibitor>Specific MAPK p38α and p38β inhibitor. Also used to separate and maintain embryonic stem cells (ES cells).

SB 203580 Hydrochloride, 98.0+ % (HPLC)

198-16761 1 mg for Cellbiology 869185-85-3 WaterIC50 of p38α (in vitro): 34 nM;

(in vivo): 600 nMKeep at -20℃.

<MAPK Inhibitor>Specific MAPK p38α and p38β inhibitor. Also used to separate and maintain embryonic stem cells (ES cells).

SB 415286, 98.0+ % (HPLC)


<Protein kinase inhibitor>Potent, cell-permeable, and selective GSK-3 inhibitor. GSK-3β inhibitors are used in a variety of stem cell research including ES cells and iPS cells. Reduces the cell death of cerebellar granule neurons in vivo. Also increases cytoplasmic β-catenin concentration and inhibits GSK-3-dependent tau phosphorylation. Also reported to stimulate glycogen synthesis and gene transcription and have protective effects on the heart and nerves.

SB 431542, 98.0+ % (HPLC)

192-16541 5 mgfor Cell Culture 331752-47-7 DMSO IC50 of ALK = 7 nM Keep at -20℃.

198-16543 25 mg

<Protein kinase inhibitor>Selective inhibitor of activin receptor-like kinase (ALK) 4, 5 and 7 (the TGF-β type I receptor). Promotes proliferation, differentiation and sheet formation of endothelial cells of ES cell origin. Can be able to grow dramatically efficiency reprogramming to Human iPS Cells when used with Thiazovivin and PD0325901. It also promotes the speed.

SP 600125, 98.0+ % (HPLC)

197-16591 5 mgfor Cellbiology 129-56-6 Acetone, DMSO

IC50 of JNK1: 40 nM; JNK2: 40 nM; JNK3: 90 nM

Keep at -20℃.193-16593 25 mg

<MAP kinase inhibitor>MAPK inhibitor and potent ATP-competitive inhibitor of the c-Jun N-terminal kinase (JNK) subfamily.Its selectivity to JNK exceeds 20 times that of ERK and p38 MAPK. It inhibits c-Jun phosphorylation and the expression of inflammatory genes such as COX-2, LI-2, IFN-γ, and TNF-α. It is neuroprotective in vivo.

D-erythro-Sphingosine, 99+% (TLC)

192-11161 25 mg for Biochemistry 123-78-4Methanol-

chloroform mixtureIC50 of PKC: 1 - 3 μM Keep at -20℃.

<Protein kinase inhibitor / PTK inhibitor>Selective PKC inhibitot.　It exhibit inhibitory action competitively to diacylglycerol, phorbol dibutyrate and Ca2+. It does not affect the activities of MLCK and PKA. It has also been reported to induce apoptosis in human myelocytic leukemia cells, HL-60.

SR 3677 Hydrochloride, 98.0+ % (HPLC)

195-16151 2 mg for Cellbiology 1072959-67-1 Water, DMSO IC50 of ROCK-I: 56 nM, ROCK-II: 3 nM Keep at RT.

<Protein kinase inhibitor>Potent ROCK inhibitor

Staurosporine, 95.0+ % (HPLC)

197-10251 100 μgfor Biochemistry 62996-74-1 DMSO

IC50 of PKC: 2.7 nM; PKA: 8.2 nM; p60v-src tyrosine kinase: 6.4 nM

Keep at -20℃.193-10253 500 μg

<PKC inhibitor / CDK inhibitor>A microbial alkaloid and extremely potent inhibitor of protein kinase Cs (PKCs). Also has comparable inhibitory actions on cAMP-dependent protein kinases (PKAs) and p60v-src tyrosine kinase, the product of an oncogene src.

Stellettamide A Trifluoroacetate, 95.0+ % (HPLC)

193-11831 100 μg for Biochemistry 129744-24-7 Methanol - Keep at -20℃.

<PKC inhibitor>Substance isolated and extracted from sponge (Stelletta sponge). It inhibits calmodulin.

Grade

1. Kin

ase Inh

ibito

rs


Product Name


Summary

SU 4312, 97.0+ % (HPLC)

190-15861 5 mg for Cellbiology - EthanolKi: unactivated form: 0.04 μM;

activated form: 4 μMKeep at -20℃.

<Protein kinase inhibitor / Akt inhibitor>VEGFR2 tyrosine kinase inhibitor. Also Inhibits angiogenesis in tumors.

SU 5402, 95.0+ % (HPLC)


<PTK inhibitor>Tyrosine kinase inhibitor in fibroblast growth factor receptor 1 (FGFR1). It also inhibits phosphorylation of ERK1 and ERK2 induced by aFGF. A recent study has demonstrated inhibition of differentiation at a high efficiency by incubating ES cells in a medium containing CHIR99021, SU5402 and PD184352.

SU 5416, 97.0+ % (HPLC)

196-15841 5 mg for Cellbiology 204005-46-9 EthanolIC50 of VEGFR2: 1.3 μM; FGFR1: 4.2 μM;

PDGFRβ: 37.9 μMKeep at -20℃.

<Protein kinase inhibitor / Akt inhibitor>VEGFR2 tyrosine kinase inhibitor. Also Inhibits angiogenesis in tumors.

SU 6668, 98.0+ % (HPLC)

193-15851 5 mg for Cellbiology 252916-29-3 EthanolIC50 of VEGFR2: 3.9 μM; FGFR1: 3.8 μM;

PDGFRβ: 0.10 μMKeep at 2 - 10℃

<Protein kinase inhibitor>VEGFR2 tyrosine kinase inhibitor

SU 11274, 95.0+ % (HPLC)

198-17121 5 mgfor Cellbiology 658084-23-2 -

IC50 of c-MET tyrosine kinase: 10 nM; VEGFR1/2 tyrosine kinase: 0.8 mM; PDGFR: 19.4 mM

Keep at -20℃.194-17123 25 mg

<Protein kinase inhibitor>Selective inhibitor of c-MET tyrosine kinase.

Tamoxifen Citrate, 98.0+ % (Ti)

209-14361 250 mg

for Biochemistry 54965-24-1 EthanolIC50 of PKC: 2.7 nM; PKA: 8.2 nM;

p60v-src tyrosine kinase: 6.4 nMKeep at 2-10℃.

205-14363 1 g

203-14364 5 g

207-14362 25 g

<PKC inhibitor>Estrogen analog, which is used as a drug used for prophylactic therapy of breast cancer, is known to selectively bind to estrogen receptors and is also called SERM (selective estrogen receptor modifier). It is considered to be deeply associated with diseases such as breast cancer and osteoporosis.

Triciribine, 95.0+ % (HPLC)

206-19371 5 mg for Cellbiology 35943-35-2 - IC50 of AKT kinase: 150 nM Keep at -20℃.

<Protein kinase inhibitor>Triciribine is inhibitor of AKT1/2/3 kinase and DNA synthesis inhibitor.

TWS 119, 90.0+ % (HPLC)

206-17671 1 mgfor Cellbiology 601514-19-6 Methanol - Keep at 2 - 10℃

202-17673 5 mg

<Protein kinase inhibitor>Acts as a potent and selective inhibitor of GSK-3β. Also reported to selectively induce neuronal differentiation in murine embryonic stem cells.

Tyrphostin A25, 95.0+ % (HPLC)

204-19311 10 mgfor Cellbiology 118409-58-8 - IC50: 3 μM Keep at -20℃.

200-19313 50 mg

<Protein kinase inhibitor>EGFR tyrosine kinase inhibitor

Grade

1. K

inas

e In

hib

ito

rs

11

Product Name


Summary

U 0126 (mixture of isomers), 95.0+ % (HPLC)

211-01051 5 mg for Biochemistry 109511-58-2 Acetonitrile, ethanol - Keep at -20℃.

<MAP kinase inhibitor>MAPK inhibitor used for signal transduction studies.

W-5 Hydrochloride

236-01721 5 mgfor Biochemistry 61714-25-8 Methanol, water IC50 of PDE: 240 μM; MLCK: 230 μM Keep at -20℃.

232-01723 25 mg

<PKC inhibitor / Calmodulin antagonist>A naphthalenesulfonate amide calmodulin antagonist to inhibit Ca2+/calmodulin-dependent phosphodiesterase (PDE) and myosin light chain kinase (MLCK). However, compared to W-7, its action as a calmodulin antagonist is low, and the product is mainly used as a negative control of W-7.

W-7 Hydrochloride

233-01731 5 mg

for Biochemistry 61714-27-0 Methanol, water IC50 of PDE: 28 μM; MLCK: 51 μM Keep at -20℃.239-01733 50 mg

237-01734 250 mg

<Protein kinase inhibitor / Calmodulin antagonist>A naphthalenesulfonate amide calmodulin antagonist to inhibit Ca2+/calmodulin-dependent phosphodiesterase and myosin light chain kinase.

(+)-Wortmannin, 97.0+ % (HPLC)


236-02343 10 mg

<Akt inhibitor>Has selective and irreversible inhibitory actions on myosin light chain kinases, a type of protein kinase that regulates smooth muscle contraction etc., and concentration-dependent and irreversible inhibitory actions on phosphatidylinositol 3-kinases, which are involved in phosphatidylinositol metabolism, one of the intracellular signal transduction mechanisms.

Y-27632, 98.0+ % (HPLC)

257-00511 1 mg

for Cellbiology 146986-50-7 Water p160ROCK (Ki = 140 nM) Keep at -20℃.253-00513 5 mg

251-00514 25 mg

<Protein kinase inhibitor>Selective and potent ROCK inhibitor. It inhibits contraction of the vascular smooth muscle, infiltration of cancer cells, and regulation of cell differentiation caused by a signal transduction system of ROCK. Enhances survival rate after cryopreservation and cloning efficiency of human ES and iPS cells.

5 mmol/L Y-27632 Solution

253-00591 300 μL for Cell Culture 331752-47-7 - - Keep at -20℃.

<Protein kinase inhibitor>5 mmol/L Y-27632 in aqueous soution.

Grade

1. Kin

ase Inh

ibito

rs


2. Protein Phosphatase InhibitorsProduct Name


Summary

Calyculin A, 95.0+ % (HPLC)

038-14453 10 μgfor Biochemistry 101932-71-2

Methanol, ethanol, DMSO

IC of PP2A: 3 nM; smooth muscle: 5 nM;smooth muscle endogenous: 1 nM

Keep at -20℃.032-14451 100 μg

Contracts the smooth muscle regardless of the presence of external calcium, with its effects being approximately 100 times more potent than okadaic acid. A variety of actions have been confirmed, such as equally-potent inhibition of type 1 and 2A phosphatase activities and promotion of protein phosphorylation.

Cantharidin

036-20461 25 mg

for Cellbiology 56-25-7 Acetone IC50 of PP2A: 40 nM; PPA: 473 nM Keep at 2-10℃.032-20463 100 mg

030-20464 500 mg

Potent and selective protein phosphatase 2A inhibitor. Also inhibits protein phosphatase 1 at high concentrations.

Cyclosporin A, 97.0+ % (HPLC)

031-18963 50 mgfor Cellbiology 59865-13-3

Methanol, ethanol, acetone, ether,

chloroform- Keep at 2-10℃.

035-18961 200 mg

It is a representative immunosuppressant used for prevention of rejection reaction at the time of organ transplantation and it binds to the intracellular receptor in T lymphocytes inhibiting IL-2 and IFN-γ transcription (calcineurin inhibition). Consequently, it inhibits activation and proliferation of helper T cells contributing to immune reaction.

Fostriecin Sodium Salt

065-05051 10 μg for Cellbiology 87860-39-7 Ethanol, water IC50 of PP1: 131 nM; PP2A: 3.2 nM Keep at -20℃.

An antibiotic with anti-tumor activity isolated from Streptomyces pulveraceous (subspecies fostreus). Binds near the active center of the catalytic subunit of PP2A and inhibits substrate dephosphorylation. Does not affect PP2B enzyme activity but shows inhibitory action on PP1 as well at high concentrations.

RK-682, 95.0+ % (HPLC)

185-01341 1 mg for Biochemistry - Ethanol, acetone IC50 of CD45: 54 μM; VHR: 2.0 μM Keep at RT.

Specific tyrosine phosphatase inhibitor, which inhibits dephosphorylation of CD45 or VHR, protein-tyrosine phosphatase (PTPase), and regulates the cell cycle from G1 to S period.

Tautomycin

209-12041 100 μg for Biochemistry 109946-35-2Chloroform,

ethanol, methanol

IC50 of PP2A, PP1 (smooth muscle): 32 nM; PP1 (skeletal muscle): 22 nM; Smooth muscle endofenous: 6 nM

Keep at -20℃.

Protein phosphatase inhibitor and antifungal antibiotic produced from Streptomyces spiroverticillatus.

Disodium β-Glycerophosphate Pentahydrate, 95.0+ % (Titration)

046-31251 50 gfor Cellbiology 13408-09-8 Water: 1 g/20 mL - Keep at 2-10℃.

042-31253 250 g

Has a structure of phosphorylated glycerol and in animal tissues is released into the blood with the breakdown of triglycerides in the liver. Also produced as a glycolytic intermediate.

Levamisole Hydrochloride, 98.0+ % (Titration)

123-04641 10 g for Biochemistry 16595-80-5Water: 210 g/L

(20℃)- Keep at RT.

Powder type of alkaline phosphatase inhibitor. It promotes the maturation of T lymphocytes and increases cellular immune responses.

Grade

2. P

rote

in P

hosp

hata

se

Inhi

bito

rs

13

3. Inhibitor Cocktail SetsProduct Name


Summary

Phosphatase Inhibitor Cocktail Solution I (×100)

167-24381 1 mL for Cellbiology - - - Keep at 2-10℃.

5 phosphatase inhibitor mixture [Inhibition Target] serine/threonine phosphatases, tyrosine phosphatases, and dual-specificity phosphatases [Composition] sodium fluoride, sodium orthovanadate, sodium pyrophosphate, β-glycerophosphate, and sodium molybdate

Phosphatase Inhibitor Cocktail Solution II (×100)

160-24371 1 mL for Cellbiology - - - Keep at 2-10℃.

5 phosphatase inhibitor mixture [Inhibition Target] acid phosphatases; alkaline phosphatases; tyrosine phosphatases [Composition] sodium fluoride, sodium tartrate, sodium orthovanadate, imidazole, and sodium molybdate

Protease Inhibitor Cocktail Set I, Animal-derived-free (for general use) (x 100), Lyophilized

165-26021 for 1 mLfor Cellbiology - - - Keep at -20℃.

161-26023 for 1 mL x 5

5 inhibitor mixture solution. It replaces aprotinin from bovine lung with recombinant aprotinin produced with no animal by-products. [Inhibition Target] a wide variety of proteases and esterases.

Protease Inhibitor Cocktail Set III, DMSO Solution (EDTA free) (x 100)

163-26061 1 mLfor Cellbiology - - - Keep at -20℃.

169-26063 1 mL x 5

6 inhibitor mixture solution being suitable for experiments targeted on metal-binding proteins in mammalian cells, tissue extracts, and bacterial extracts. It does not contain EDTA or other metalloproteinase inhibitors. [Inhibition Target] a wide range of proteases including aminopeptidases.

Protease Inhibitor Cocktail Set III, DMSO Solution, Animal-derived-free (EDTA free) (×100)


166-26073 1 mL x 5

6 inhibitor mixture solution being suitable for experiments targeted on metal-binding proteins in mammalian cells, tissue extracts, and bacterial extracts. It inhibits a wide range of proteases including aminopeptidases. It does not contain EDTA or other metalloproteinase inhibitors. It replaces aprotinin from bovine lung with recombinant aprotinin produced with no animal by-products.

Protease Inhibitor Cocktail Set IV, DMSO Solution (for Fungal and Yeast) (×100)


163-26083 1 mL x 5

4 inhibitor mixture DMSO solution, being suitable for use in mold and yeast extracts. [Inhibition Target] serin proteases, cystein proteases, metalloproteases, asparatic proteases.

Protease Inhibitor Cocktail Set V (EDTA free) (×100), Lyophilized

162-26031 for 1 mLfor Cellbiology - - - Keep at -20℃.

168-26033 for 1 mL x 5

4 inhibitor mixture solution, being suitable for experiments targeted on metal-binding proteins and recombinant proteins. In addition, also useful for metal-affinity column chromatography.[Inhibition Target] serin proteases, cystein proteases, metalloproteases, asparatic proteases.

Protease Inhibitor Cocktail Set VI, DMSO Solution (for Plant) (×100)


160-26093 1 mL x 5

6 inhibitor mixture solution, being suitable for plant extracts. [Inhibition Target] serin proteases, cystein proteases, trypsin-like proteases, aminopeptidase B, leucine aminopeptidase, asparatic proteases, metalloproteases.

Protease Inhibitor Cocktail Set VII, DMSO Solution (for Histidine-tagged Protein) (× 100)


163-26103 1 mL x 5

EDTA-free 5 inhibitor mixture solution, being suitable for purification of histidine-tagged proteins.[Inhibition Target] serin proteases, cystein proteases, aminopeptidase B, leucine aminopeptidase, asparatic proteases, metalloproteases.

Grade

3. Inhibitor Cocktail Sets


4. Calcium Signaling related InhibitorsProduct Name


Summary

Alendronate Sodium Salt Trihydrate, 97.0+ % (HPLC)

012-22661 100 mg for Pharmacology Research

121268-17-5 Water IC50 = 10 μM Keep at -20℃.018-22663 500 mg

<Calcium metabolism regulator>This product is a bisphosphonate compound that is selectively distributed in the calcified bone surface to which the osteoclasts are attached. It is released under an acid environment created by the osteoclasts, taken in the cells, and inhibits the bone resorption activity. The inhibition of the bone resorption is considered to be caused by apoptosis induction effect of the osteoclasts and direct suppression of bone resorption of the osteoclasts.

(-)-Blebbistatin, 98.0+ % (HPLC)

021-17041 1 mgfor Cellbiology 856925-71-8 DMSO (5 mg/mL) - Keep at -20℃.

027-17043 5 mg

<Calcium ATPase Inhibitors>Specific inhibitor of myosin II. It inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly in the vertebrate cell divisions. It has been reported to block blebbing and apoptosis and increases the colony forming rate when human ES cells are dispersed to single cells from a colony.

Calpain Inhibitor 2, 95.0+ % (HPLC)

038-19811 10 mg for Cellbiology 110115-07-6 Ethanol, methanol - Keep at -20℃.

<Calpain inhibitors>This product inhibits neutral cysteine proteinases such as calpain 1, calpain 2, cathepsin B and cathepsin L. It is also a weak inhibitor of proteasomes.

Chlorpromazine Hydrochloride, 99.0+ % (Titration)

033-10581 10 g for Biochemistry 69-09-0 Water, ethanol IC50 = 25 μM Keep below 25℃.

<Calmodulin antagonists>Chlorpromazine Hydrochloride is a phenothiazine neuroleptic which induces tranquilization, analgesia, lowering of body temperature by inhibiting the hypothalamic thermoregulatory mechanism, antiemesis by inhibiting CTZ of the medulla oblongata, inhibition of conditioned avoidance response, and hypnosis, as well as an antidopaminergic. This reagent potently blocks α-adrenergic receptors. Its mode of action in the biogenic system is inhibition of calmodulin, similar to trifluoperazine.

Cyclopiazonic Acid, 98.0+ % (HPLC)

030-17171 5 mg for Biochemistry 18172-33-3 Methanol IC50 of Ca2+: 0.2 μM; ATPase: 0.35 μM Keep at -20℃.

<Calcium ATPase Inhibitors>Mycotoxin (fungal toxin). It is a specific inhibitor of Ca2+-ATPase.

2,5-Di-t-butylhydroquinone, 99.0+ % (Capillary GC)

040-24681 100 mgfor Biochemistry 88-58-4

Benzene， ethanol，acetone，

carbon bisulfideIC50 = 66.7 ± 2.1 μM Keep at RT.

046-24683 1 g

<Calcium ATPase Inhibitors>This product inhibits the Ca2+ ATPase of the sarcoplasmic reticulum and does not act on the plasma membrane Ca2+ pump.

E-64d, 97.0+ % (HPLC)

054-08021 1 mgfor Cellbiology 88321-09-9 Methanol IC50 = 0.5 μM Keep at -20℃.

050-08023 5 mg

<Calpain inhibitors>Membrane-permeable cysteine protease inhibitor which is an analog of E-64, a cysteine protease inhibitor isolated from Aspergillus japonicas. Esters are hydrolyzed when permeated through the membrane and E-64d is considered to change to an activated form, E-64c. This reagent inhibits calpain and cathepsin. It is used in combination with pepstatin A in order to prevent degradation of LC3-II in the autophagosome inner membrane during autophagy.

Fluphenazine Dimaleate, 98.0+ % (Titration)

061-01751 1 g for Biochemistry 3093-66-1Dilute hydrochloric

acid- Keep at 2-10℃.

<Calmodulin antagonists>Phenothiazine neuroleptic. It is a calmodulin inhibitor, similar to chlorpromazine.

Grade

4. C

alci

um

Sig

nal

ing

re

late

d In

hib

ito

rs

15

5. Ion Channel-related Blockers(1) Calcium Channel Blockers

Product Name


Summary

Mastoparan

139-16511 1 mg for Cellbiology 72093-21-1 Water IC50 = 15 μM Keep at -20℃.

<Calmodulin antagonists>Amphiphilic peptide isolated as an ingredient of hornet poison. It activated directly pertussis toxin-sensitive G protein (Gi, G0) by a mechanism resembling G protein-conjugate type receptors. It also acts as a calmodulin antagonist.

MG-132, 80.0+ % (HPLC)

139-16251 1 mgfor Cellbiology 133407-82-6 Methanol IC50 = 1.25 μM Keep at -20℃.

135-16253 5 mg

<Calpain inhibitors>Membrane-permeable peptide aldehyde protease inhibitor which reversibly inhibits the chymotrypsin-like activity of 26S proteasome.

Quinacrine Dihydrochloride Dihydrate, 95.0+ % (HPLC)

171-00502 25 g for Biochemistry 69-05-6 Water, ethanol IC50 = 4.4 μM Keep below 25℃.

<Calmodulin antagonists>Antimalarial; calmodulin inhibitor; phospholipase inhibitor

Suramin Sodium, 98.0+ % (HPLC)

199-10613 100 mgfor Biochemistry 129-46-4 Water IC50 = 4.9 ± 1.2 μM Keep at RT.

193-10611 200 mg

<Calcium ATPase Inhibitors>This product inhibits Ca2+ ATPase of the sarcoplasmic reticulum. It also blocks growth factors, including EGF from binding to the cell envelope.

Thapsigargin

209-17281 1 mgfor Cellbiology 67526-95-8 Acetonitrile IC50 = 0.13 ± 0.02 μM Keep at -20℃.

205-17283 5 mg

<Calcium ATPase Inhibitors>Thapsigargin is an endoplasmic reticulum Ca2+-ATPase(SERCA) inhibitor which inhibits all SERCA isoforms. The endoplasmic reticulum uptake of calcium ion is blocked causing releasing of calcium ions from the endoplasmic reticulum to the cytoplasm, by irreversible inhibition of SERCA activity.

Grade

Product Name


Summary

ω-Agatoxin IVA (P-type Blocker), from Funnel Web Spider, Agelenopsis aperta

339-42561 0.1 mgPeptide Institute, Inc.

(4256-s)145017-83-0 - - Keep at -20℃.

Channel selective blockers with Cys-Cys binding. Peptidic ion channel blockers.

ω-Agatoxin TK (P-type Blocker)


(4294-s)145017-83-0 - - Keep at -20℃.


Agelenin, from Spider, Agelena opulenta


(4247-s)- - - Keep at -20℃.


Manufacturer

4. Calciu

m S

ign

aling

related

Inh

ibito

rs5. Ion C

hannel-related B

lockers


Product Name


Summary

Amlodipine, 98.0+ % (HPLC)

011-24951 100 mgfor Cellbiology 88150-42-9 - - Keep at RT.

017-24953 1 g

L-type calcium channel blocker with a hypotensive action. It acts on cardiovascular system, including facilitation of NO production, inhibition of oxidative stress, and inhibition of adhesion of monocytes to the endothelium. In addition, it acts for a prolonged period compared to other similar calcium channel blockers.

2,3-Butanedione Oxime

045-00652 25 gWako Special Grade 57-71-6 Water, ethanol IC50 = 15.3 mM Keep at RT.

047-00651 100 g

2,3-Butanedione Oxime has phosphatase activity and inhibits contraction of skeletal muscles and cardiac muscles.

Calcicludine (L-type Blocker), 99.0+ % (HPLC), from Green Mamba, Dendroaspis angusticeps


(4310-s)178037-96-2 - - Keep at -20℃.

Neuronal L-type Ca2+ Channel Blocker. Peptidic ion channel blockers.

Calciseptine (L-type Blocker), from Black mamba, Dendroaspis polylepis polylepis


(4255-s)- - - Keep at -20℃.

L-type Ca2+ Channel Blocker. Peptidic ion channel blockers.

Cinnarizine, 98.0+ % (Titration)

030-13592 25 g for Biochemistry 298-57-7Acetone, ether,

chloroform, benzene

IC50 = 0.75 μM Keep at RT.

Cinnarizine has antihistaminic and vasodilatory activities, improves cerebral blood flow impairment, and exerts Ca2+ channel inhibitory activity.

ω-Conotoxin GVIA (N-type Blocker), from Marine Snail, Conus geographus


(4161-v)106375-28-4 - - Keep at -20℃.

N-type Ca2+ Channel Blocker. Peptidic ion channel blockers.

ω-Conotoxin MVIIA (N-type Blocker), 99.0+ % (HPLC) from Marine snail, Conus magus


(4289-v)107452-89-1 - - Keep at -20℃.

Reversible N-type Ca2+ Channel Blocker. Peptidic ion channel blockers.

ω-Conotoxin MVIIC (P/Q-type Blocker), 99.0+ % (HPLC), from Marine Snail, Conus magus


(4283-v)147794-23-8 - - Keep at -20℃.


(4283-s)

P/Q-type Ca2+ Channel Blocker. Peptidic ion channel blockers.

ω-Conotoxin SVIB (N-type Blocker), 99.0+ % (HPLC), from Marine Snail, Conus striatus


(4284-v)150433-82-2 - - Keep at -20℃.

N-type Ca2+ Channel Blocker. Peptidic ion channel blockers.

Diltiazem Hydrochloride, 98.0+ % (Titration)

047-20311 1 gfor Biochemistry 33286-22-5

Formic acid, water, ethanol, chloroform

IC50 = 4.5 μM Keep at 2-10℃.043-20313 5 g

Therapeutic substance for circulatory diseases such as hypertension, angina and arrhythmia. It inhibits voltage-dependent calcium channels and reduces the inflow of Ca2+ from extracellular to intracellular parts. Specific calcium antagonists include nifedipine, verapamil and diltiazem.

Grade/Manufacturer

5. Io

n C

hann

el-r

elat

ed

Blo

cker

s

17

(2) Potassium Channel Blockers

Product Name


Summary

Kurtoxin, 98.0+ % (HPLC), from Scorpion, Parabuthus transvaalicus


(4375-s)- - - Keep at -20℃.

T-type Ca2+ channel blocker. Peptidic ion channel blockers.

Nicardipine Hydrochloride, 99.0+ % (HPLC)


Methanol, chloroform

IC50 = 2.56 μM Keep at RT.141-06383 5 g

It inhibits voltage-dependent calcium channels and reduces the inflow of Ca2+ from extracellular to intracellular parts.

Nitrendipine, 98.0+ % (HPLC)

142-06411 200 mg for Biochemistry 39562-70-4Chloroform, acetonitrile

IC50 = 23 μM Keep at RT.

It inhibits voltage-dependent calcium channels and reduces the inflow of Ca2+ from extracellular to intracellular parts. It dilates peripheral vessels and coronary arteries and has hypotensive and anti-angina actions. Its hypotensive action is comparable to nifedipine, and the action lasts longer than nifedipine.

PLTX-II, 99.0+ % (HPLC), from Spide, Plectreurys tristes


(4300-s)- - - Keep at -20℃.

Presynaptic Ca2+ Channel Blocker

ProTx-1, 97.0+ % (HPLC), from Tarantula, Thrixopelma pruriens


(4409-s)- - - Keep at -20℃.

T-Type Ca2+ Channel / Na+ Channel / K+ Channel Blocker (Gating Modifier)

Ryanodine

185-02821 1 mg for Cellbiology 15662-33-6 Methanol - Keep at -20℃.

Signal transduction Ca2+ channel Inhibitor Ryanodine is an alkaloid isolated from Ryania speciosa Vahl. It acts to increase calcium permeability by binding to the arcoplasmic reticulum calcium channel.

SNX-482, 99.0+ % (HPLC), from Tarantula, Hysterocrates gigas


(4363-s)203460-30-4 - - Keep at -20℃.

Class E (R-type) Ca2+ Channel Blocker

Verapamil Hydrochloride, 98.0+ % (Titration)

222-00781 1 gfor Biochemistry 152-11-4 Ethanol IC50 = 0.3 μM Keep at RT.

228-00783 10 g

Verapamil HCl directly affects the smooth muscle of blood vessels and the heart and is a Ca2+ antagonist. It also promotes effects of tumoricidal drugs and is used in research concerning the mechanism of calcium antagonists.

Grade/Manufacturer

Product Name


Summary

Apamin, 99.0+ % (HPLC), from Honeybee, Apis mellifera


(4257-v)24345-16-2 - - Keep at -20℃.

Small conductance Ca2+-activated K+ channel blocker

Charybdotoxin, 99.0+ % (HPLC), from Scorpion, Leiurus quinquestriatus var. hebraeus


(4227-s)95751-30-7 - - Keep at -20℃.

Ca2+-activated K+ channel blocker

Manufacturer

5. Ion Channel-related

Blockers


Product Name


Summary

Dendrotoxin 1, 99.0+ % (HPLC), from black mamba, Dednroaspis polylepis polylepis


(4330-s)107950-33-4 - - Keep at -20℃.

Voltage-dependent K+ channel blocker

E-4031 n-Hydrate, 98.0+ % (HPLC)

059-08451 10 mgfor Cellbiology - Water

Native guinea pig HERG channel: IC50 = 397 nM

Keep at -20℃.055-08453 50 mg

E-4031 is a HERG potassium channel blocker with antiarrhythmic action (class III ). It selectively inhibits Ikr, a rapid component of the delayed rectifier K current, during repolarization after muscle cells are depolarized.

Glibenclamide, 98.0+ % (Titration)

078-03881 5 gfor Biochemistry 10238-21-8 DMF IC50 = 0.1 μM Keep at RT.

076-03882 25 g

<Potassium Channel Blockers>Sulfonylurea hypoglycemic substance. It blocks ATP-dependent K+ channel of the pancreas to increase intracellular Ca2+, thus increasing insulin secretion. It pharmacologically antagonizes the action of K+ channel-opening agents in the heart and blood vessels.

Guangxitoxin-1E, 97.0+ % (HPLC), from Tarantula, Plesiophrictus guangxiensis sp. nov.


(4433-s)- - - Keep at -20℃.

Kv2.1/Kv2.2 channel blocker / Enhancer of glucose-dependent insulin secretion

Iberiotoxin, 99.0+ % (HPLC), from Scorpion, Buthus tamulus


(4235-s)129203-60-7 - - Keep at -20℃.

Highly selective and potent high conductance Ca2+-activated K+ channel blocker

Kaliotoxin (1-37), 99.0+ % (HPLC), from Scorpion, Androctonus mauretanicus mauretanicus


(4259-s)145199-73-1 - - Keep at -20℃.

High conductance Ca2+-activated K+ channel blocker

Margatoxin 【MgTX】, 99.0+ % (HPLC)


(4290-s)145808-47-5 - - Keep at -20℃.

Voltage-dependent K+ channel blocker (specific for Kv1.3 channel )

MCD-Peptide, 99.0+ % (HPLC), from Honeybee, Apis mellifera


(4258-v)32908-73-9 - - Keep at -20℃.

Voltage-dependent K+ channel blocker

Scyllatoxin, 99.0+ % (HPLC), from Scorpion, Leiurus quinquestriatus hebraeus


(4260-s)116235-63-3 - - Keep at -20℃.

Small conductance Ca2+-activated K+ channel blocker

Stichodactyla Toxin, 99.0+ % (HPLC), from Sea Anemone, Stichodactyla helianthus


(4287-s)- - - Keep at -20℃.

Voltage-dependent K+ channel (A channel) blocker

Tertiapin, 99.0+ % (HPLC), from Apis mellifera


(4364-s)58694-52-3 - - Keep at -20℃.

Potent blocker of inward-rectifier K+ channels such as ROMK1 and GIRK1/4 at 2.5-10 nM.

Grade/Manufacturer

5. Io

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19

(3) Sodium Channel Blockers

(4) Transient Receptor Potential (TRP) Channel Blockers

Product Name


Summary

Tityustoxin Kα, 99.0+ % (HPLC), from Scorpion, Tityus serrulatus


(4313-s)39465-37-7 - - Keep at -20℃.

Voltage-dependent K+ channel (A channel) blocker

Manufacturer

Product Name


Summary

Clotrimazole, 98.0+ % (HPLC)


Ethanol, chloroform, carbon tetrachloride

IC50 = 1.8 μM Keep at RT.033-16022 25 g

It exhibits bactericidal action by destroying cytoplasmic membranes of fungi.

μ-Conotoxin G3B, 99.0+ % (HPLC), from Marine Snail, Conus geographus


(4217-v)140678-12-2 - - Keep at -20℃.

Na+ channel blocker: Specific for skeletal muscle

μ-Conotoxin GS, 95.0+ % (HPLC), from Marine Snail, Conus geographus


(4263-v)171358-00-2 - - Keep at -20℃.

Selective blocker of Na+ channels of skeletal muscles.

μ-Conotoxin SIIIA, 99.0+ % (HPLC), from Marine Snail, Conus striatus


(4440-v)877860-32-7 - - Keep at -20℃.

Tetrodotoxin-resistant Na+ channel blocker with analgesic activity

Huwentoxin-IV, 97.0+ % (HPLC), from Chinese Bird Spider, Ornithoctonus huwena


(4455-s)- - - Keep at -20℃.

Neuronal tetrodotoxin-sensitive Na+-channel blocker

Omeprazole, 98.0+ % (HPLC)


Dichloromethane, methanol

IC50 = 4.2 μM Keep at -20℃.158-02092 25 g

Eradicating agent for Helicobacter pylori (HP).Selective inhibitor of gastric H+, K+ ATPase (proton pump), and used as a marker to test the susceptibility of HP to this product in vitro.

ProTx-II, 99.0+ % (HPLC)


4450-s- - - Keep at -20℃.

Na+ channel (especially Nav1.7) / Ca2+ channel blocker (gating modifier)

Grade/Manufacturer

Product Name


Summary

AMG 9810, 98.0+ % (HPLC)

015-25071 10 mgfor Cellbiology 545395-94-6 Ethanol - Keep at 2-10℃.

011-25073 50 mg

Antagonist of transient receptor potential vanilloid 1 (TRPV1). TRPV1 is one of the TRP channels cloned as a capsaicin receptor, functions as a pain receptor, and is activated by capsaicin, heat, and protons. It also inhibits the activation of TRPV1 by heat and protons, besides capsaicin.

Grade


Blockers


Product Name


Summary

AP 18, 98.0+ % (HPLC)


Ethanol (10 mg/2 mL)

- Keep at -20℃.010-25163 50 mg

Selective TRPA1 (transient receptor potential ankyrin 1) inhibitor. TRPA1 is involved in pain transmission, and its involvement in respiratory depression has also been reported.

2-APB, 98.0+ % (HPLC)


019-24913 500 mg

Inhibitor of inositol triphosphate (IP3) receptors. It can also block TRP channels TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2. At high concentrations, it can activate TRPV1, TRPV2 and TRPV3.

BCTC, 98.0+ % (HPLC)


023-18243 50 mg

TRPV1 antagonist. It inhibits the activation of TRPV1 by capsaicin and acids.

Capsazepine, 98.0+ % (HPLC)

037-23171 10 mgfor Cellbiology 138977-28-3 Ethanol - Keep at 2-10℃.

033-23173 50 mg

TRPV1 antagonist. Capsaicin analog.

HC-030031, 98.0+ % (HPLC)

086-09961 10 mgfor Cellbiology 349085-38-7 DMSO - Keep at RT.

082-09963 50 mg

Selective TRPA1 (transient receptor potential ankyrin 1) inhibitor.

Olvanil, 98.0+ % (HPLC)


150-03233 50 mg

It demonstrated to block intracellular accumulation of Anandamide through interaction with the anandamide transporter at concentrations similar to those needed for TRPV1 activation. Also inhibits FAAH (fatty acid amide hydrolase). It also acts as a potent TRPV1 angonist and a CB1 agonist.

RN-1747, 98.0+ % (HPLC)

183-02981 10 mgfor Cellbiology 1024448-59-6 DMSO - Keep at 2-10℃.

189-02983 50 mg

TRPM8 antagonist. It also acts as a TRPV4 (transient receptor potential vanilloid 4)-selective agonist.

Ruthenium Red

184-00331 100 mgWako Special Grade 11103-72-3 Water - Keep at RT.

180-00333 1 g

TRPA1 antagonist.

SB-366791, 98.0+ % (HPLC)


199-17433 50 mg

TRPV1 antagonist, which inhibits the activation of TRPV1 by capsaicin and heat. It has been reported that it does not inhibit activation by protons.

Grade

5. Io

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(5) Acid-Sensing Ion Channel Blockers

(6) Nicotinic Acetylcholine Receptor Blockers

(7) Other Blockers

Product Name


Summary

APETx2, 99.0+ % (HPLC)


(4472-s)713544-47-9 - - Keep at -20℃.

Selective blocker of acid-sensing ion channel blocker, ASIC3

Psalmotoxin 1, 97.0+ % (HPLC), from South American Tarantula, Psalmopoeus cambridgei (Trifluoroacetate Form)


(4435-s)- - - Keep at -20℃.

Selective blocker of ASIC1a

Manufacturer

Product Name


Summary

α-Conotoxin G1, 97.0+ % (HPLC), from Marine Snail, Conus geographus (Hydrochloride Form)


(4126-v)76862-65-2 - - Keep at -20℃.

Nicotinic acetylcholine receptor blocker

α-Conotoxin ImI, 99.0+ % (HPLC), from Marine Snail, Conus imperialis


(4311-v)156467-85-5 - - Keep at -20℃.

Nicotinic acetylcholine receptor blocker in central nervous system

α-Conotoxin M1, 99.0+ % (HPLC), from Marine Snail, Conus magus


(4140-v)88217-10-1 - - Keep at -20℃.


α-Conotoxin SI, 99.0+ % (HPLC), from Marine Snail, Conus striatus


(4228-v)133605-58-0 - - Keep at -20℃.


Manufacturer

Product Name


Summary

Chlorotoxin, 99.0+ % (HPLC), from Scorpion, Leiurus quinquestriatus


(4282-v)163515-35-3 - - Keep at -20℃.

Small-conductance Cl- channel blocker

GsMTx-4, 99.0+ % (HPLC)


(4393-s)- - - Keep at -20℃.

Inhibitor for cation-selective stretch-activated channels / Atrial fibrillation inhibiting peptide

Purotoxin-1, 99.0+ % (HPLC)


(4457-s)- - - Keep at -20℃.

P2X3 purinoreceptor inhibitor

Manufacturer


Blockers


6.G-protein Signaling and Second Messenger-related InhibitorsProduct Name


Summary

Andrographolide, 98.0+ % (HPLC)

014-15271 500 mg for Biochemistry 5508-58-7 Methanol, acetone IC50 = 5.6 ± 0.7 μM Keep at 2-10℃.

<Guanylate Cyclase Inhibitors>It is reported to suppress the decrease of glutathion and to counteract toxic liver damage caused by substances such as carbontetrachloride and t-butylhydroperoxide.

BAY 11-7085, 98+ % (NMR)

020-14331 10 mgfor Biochemistry 196309-76-9 Ethanol, acetone IC50 = 10 μM Keep at -20℃.

026-14333 25 mg

<NFκB Inhibitors>Inhibitor of cytokine-induced IκBα phosphorylation and decreases expression of NFκB and adhesion molecule. It also exhibits strong antiinflammatory activity.

8-(4-Chlorophenylthio)adenosine 3',5'-(Cyclic)monophosphate Sodium Salt, 98.0+ % (HPLC)

039-18121 10 mgfor Biochemistry 93882-12-3 Water IC50 of PKA: 900 nM; PKG: 25 μM Keep at -20℃.

035-18123 100 mg

<Adenylate Cyclase Inhibitors>Cell permeable cAMP analog, used as an activator of cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG).

Curcumin

038-04921 1 gWako Special Grade 458-37-7 Ethanol, acetic acid

IC50 of 5-Lipoxygenase: 5 - 10 μM, COX ≦ 100 μM

Keep at RT.036-04922 25 g

<Guanylate Cyclase Inhibitors>Inhibitor of 5-lipoxygenase and cyclooxygenase.

Isotetrandrine

306-01771 25 mgKaken Shoyaku Co.,

Ltd.477-57-6 - - Keep at 2-10℃.

<G-protein Signaling Inhibitor>A biscoclaurine alkaloid inhibitor of G protein activation of PLA2

LY-83583, 94+ % (TLC)

128-04691 5 mg for Biochemistry 91300-60-6 Ethanol, acetoneIC50 of soluble Guanylate cyclase in human platelets: 2 μM; leukotriene synthesis in guinea pig lung and rat celiac cells: 1.8 μM

Keep at -20℃.

<Guanylate Cyclase Inhibitors>It decreases the concentration of cellular cGMP through the inhibition of guanylate cyclase.

NS2028, 98.0+ % (HPLC)

149-06921 5 mg for Biochemistry 204326-43-2 Water, ethanol - Keep at -20℃.

<Guanylate Cyclase Inhibitors>Selective inhibitor of soluble guanylate cyclase (sGC) that is sensitive to NO. It does not inhibit sGC activity enhanced by YC-1 or CO.

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one 【ODQ】, 97.0+ % (HPLC)

153-01981 10 mgfor Biochemistry 41443-28-1 Ethanol, acetone - Keep at 2-10℃.

159-01983 25 mg

<Guanylate Cyclase Inhibitors>It inhibits the guanylate cyclase activity of NO produced by NOS rather than NO synthase (NOS), and controls the increase in cGMP.

Pentoxifylline, 98.0+ % (Titration)

160-18761 10 g for Biochemistry 6493-05-6Methanol, ethanol,

acetone, waterTNFα: IC50 = 100 μM Keep at RT.

<Guanylate Cyclase Inhibitors>TNF-α synthesis inhibior and phosphodiesterase inhibitor

Grade/Manufacturer

6. G

-prote

in Sig

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Mess

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23

7.Neurotransmitter Inhibitors(1) Glutamate Receptor Antagonists

Product Name


Summary

Rolipram, 98+ % (TLC)

180-01411 10 mg for Biochemistry 61413-54-5 Ethanol IC50 = 20 μM Keep at 2-10℃.

<NFκB Inhibitors>This cAMP diphosphodiesterase inhibitor selectively inhibits phosphodiesterase IV, a type of isozyme. Improvement of arthritis (in rats with collagen II induced arthritis) has been reported.

Grade

Product Name


Summary

DL-2-Amino-4-phosphonobutyric Acid, 98.0+ % (HPLC)

013-22071 100 mg for Cellbiology 6323-99-5Hydrochloric acid,

water- Keep at 2-10℃.

NMDA-type glutamate receptor antagonists.

L-2-Amino-4-phosphonobutyric Acid, 98.0+ % (HPLC)

016-22083 10 mg for Cellbiology 23052-81-5 Water EC50 = 16.0 μM Keep at 2-10℃.

Selective agonist for group III metabotropic glutamate receptors ( mgluR4, mgluR6).

D(-)-2-Amino-5-phosphonovaleric Acid 【D-AP5】

015-18481 10 mg for Biochemistry 79055-68-8 Hydrochloric acid IC50 = 3.7 ± 0.32 μM Keep at RT.

A neural amino acid. It is a potent antagonist of the NMDA-type receptor, which is one of the ion-channel glutamine receptors.

DL-2-Amino-5-phosphonovaleric Acid 【DL-AP5】

018-18471 10 mg for Biochemistry 76326-31-3 Water IC50 = 90 μM Keep at RT.


(R)-CPP

031-22091 1 mgfor Cellbiology 126453-07-4 Water (10 mg/mL) - Keep at RT.

037-22093 5 mg

Highly potent glutaminergic NMDA receptor antagonist. It exhibits a higher activity than racemic CPP. It is selective to NR2A in NMDA receptor.

Dextromethorphan Hydrobromide Monohydrate, 98.0+ % (Titration)


Methanol, acetic acid, ethanol

- Keep below 25℃.049-21552 25 g

NMDA receptor antagonist.

Diazoxide, 99.0+ % (HPLC)

047-23133 250 mgfor Biochemistry 364-98-7 DMSO - Keep at RT.

041-23131 1 g

Desensitization blocker of AMPA receptor.

DL-AP7, 98.0+ % (1H- NMR)

041-31941 5 mg for Cellbiology 85797-13-3 NaOH soln. IC50 = 11.1 ± 2.1 μM Keep at RT.


DNQX, 95+ % (TLC)

044-26301 50 mg for Biochemistry 2379-57-9 Methanol - Keep at -20℃.

AMPA/Kainate receptor antagonist

Grade

6. G-protein Signaling and Second Messenger-related Inhibitors

7. Neu

rotran

smitter

Inh

ibito

rs


Product Name


Summary

Evans Blue

056-04061 5 gPractical Grade 314-13-6 Water IC50 = 87 nM Keep at RT.

054-04062 25 g

AMPA/Kainate receptor antagonist.

Felbamate, 98.0+ % (HPLC)

060-05861 10 mgfor Cellbiology 25451-15-4 DMSO, ethanol IC50 = 0.78 ± 0.07 mM Keep at -20℃.

066-05863 50 mg

Allosteric antagonist of NR2B subunit of glutaminergic NMDA receptor and exhibits strong anticonvulsant action. It also has a property as a γ-aminobutyric acid (GABA) receptor agonist.

Joro Spider Toxin JSTX-3, 98.0+ % (HPLC)

104-00051 0.1 mg for Biochemistry 112163-33-4 Water IC50 = 1.7 μM Keep at 2-10℃.

Toxin isolated from Joro Spider poison gland, paralyzes the movement of arthropods (insects, crustaceans, etc.). It irreversibly blocks excitatory transmissions of neurons and muscles by glutamate released from the synaptic terminal of motor neurons. It acts selectively on quisqualate glutamate receptor.

Loperamide Hydrochloride

129-05721 5 g for Pharmacology Research

34552-83-5 Methanol, ethanol IC50 = 0.9 ± 0.2 μM Keep at RT.127-05722 25 g

NMDA receptor antagonist. It reduces Ca2+ flow. Loperamide Hydrochloride is a NMDA receptor antagonist that reduces the flow of Ca2+. It is an antidiarrheal agent that inhibits both peristaltic movement of the intestinal tract and secretion, and enhances absorption, via opioid receptor in the intestinal tract.

(+)-MCPG, 99.0+ % (HPLC)

135-16111 2 mgfor Cellbiology 150145-89-4 0.1M NaOH IC50 = 272 μM Keep at 2-10℃.

131-16113 10 mg

Competitive antagonist for group 1 (mGluR1, mGluR5) and group 2 (mGluR2, mGluR3) metabotropic glutamate receptors. It is an active enantiomer of (±)-MCPG.

Memantine Hydrochloride

132-16981 25 mgfor Cellbiology 41100-52-1 Water IC50 = 1.2 ± 0.2 μM Keep at RT.

138-16983 100 mg

This is a glutaminergic NMDA receptor antagonist and stimulates dopamine release by binding to the ion channel site. It is used in researches on Parkinson's disease, spasms, Alzheimer's disease and so on.

(+)-MK 801 Maleate, 98.0+ % (HPLC)

130-17381 10 mgfor Cellbiology 77086-22-7 Methanol Ki = 30.5 ± 1.5 nM Keep at 2-10℃.

136-17383 50 mg

Selective antagonist of NMDA glutamate receptor. It inhibits calcium ion influx across cell membranes by binding mainly to the pore of the ion channel opened upon the ligand binding. It is known as an anti-ischemic agent.

NBQX Disodium Salt, 98.0+ % (HPLC)

147-08661 10 mg for Cellbiology 479347-86-9 Water - Keep at 2-10℃.

Water-soluble NBQX. NBQX is a potent and competitive AMPA/kainate receptor antagonist.

NBQX, 99+ % (TLC)

148-06751 10 mg for Biochemistry 118876-58-7 Acetone IC50 = 0.90 μM Keep at 2-10℃.

Antagonist of the AMPA/kainate receptor.

Pentamidine Isethionate, 98.0+ % (HPLC)

166-25191 50 mg for Cellbiology 140-64-7 Water IC50 = 2 - 18 μM Keep at -20℃.

This substance exhibits nerve protection activity and inhibits homeostatic NO synthase in the brain. It is an antagonist to NMDA glutamate receptor. It inhibits glucose metabolism and protein synthesis in Pneumocystis carinii.

Grade

7. N

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25

(2) Inhibitors of Angiotensin Conversion Enzyme

(3) Cannabinoid Receptor Antagonists

Product Name


Summary

Spermine, 95.0+ % (Titration)

198-09811 250 mgfor Biochemistry 71-44-3 Water, chloroform IC50 = 170 μM Keep at 2-10℃.

194-09813 1 g

Agonist during depolarization and antagonist during hyperpolarization.

Product Name


Summary

Benazepril Hydrochloride, 97.0+ % (HPLC)

024-14091 1 gfor Biochemistry 86541-74-4 Ethanol - Keep at RT.

020-14093 5 g

ACE inhibitor used clinically as a therapeutic for hypertension.

Captopril, 96.0+ % (Titration)

039-20951 1 gfor Pharmacology

Research62571-86-2

Methanol, acetone, water

IC50 = 9 nM Keep below 25℃.035-20953 5 g

037-20952 25 g

Angiotensin converting enzyme (ACE) inhibitor that blocks ACE and inhibits the pressor system while enhancing the depressor system. It is a crude drug for essential and renal hypertensions.

Enalaprilat Dihydrate, 98.0+ % (HPLC)

055-06851 1 g for Biochemistry 84680-54-6 Methanol IC50 = 4.8 nM Keep at RT.

This is an active form of enalapril, which is an angiotensin converting enzyme (ACE) inhibitor. One of the percutaneous vasodilators.

Enalapril Maleate, 98.0+ % (HPLC)

051-06711 1 gfor Biochemistry 76095-16-4 Methanol, ethanol IC50 = 1 - 10 nM Keep at RT.

057-06713 5 g

It inhibits angiotensin II synthesis by inhibiting angiotensin converting enzyme.

Lisinopril Dihydrate, 98.0+ % (HPLC)

128-04711 1 gfor Biochemistry 76547-98-3 Water IC50 = 1.2 nM Keep at RT.

124-04713 5 g

It inhibits angiotensin II production by blocking angiotensin converting enzyme, and has antihypertensive effects. It is a crude drug for treating hypertension, chronic heart failure, etc.

Grade

Product Name


Summary

AACOCF3

011-18461 10 mg for Biochemistry 149301-79-1 Ethanol IC50 = 15 μM Keep at -20℃.

Selective inhibitor of cellular phospholipase A2 (cPLA2) and Ca2+ independent phospholipase A2 (iPLA2) (IC50 = 15 μM).

Grade

Grade

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rotran

smitter

Inh

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(4) GABA Receptor Antagonists

Product Name


Summary

AM 251, 95.0+ % (HPLC)

011-24191 2 mg

for Cellbiology 183232-66-8 DMSO, DMF IC50 = 8.9 μM Keep at -20℃.017-24193 10 mg

015-24194 50 mg

Potent CB1 receptor antagonist/inverse agonist. Ki = 7.5 nM. It is an analog of a cannabinoid receptor antagonist, SR141716A.

AM 281, 97.0+ % (HPLC)

012-22161 2 mgfor Cellbiology 202463-68-1 Methanol IC50 = 6 nM Keep at 2-10℃.

018-22163 10 mg

Potent CB1 receptor antagonist/inverse agonist. Ki = 14 nM. It is an analog of a cannabinoid receptor antagonist, SR141716A.

AM 630

019-22551 2 mgfor Cellbiology 164178-33-0 DMSO IC50 = 6.3 μM Keep at 2-10℃.

015-22553 10 mg

Antagonist/inverse agonist of cannabinoid receptor subtype CB2 (Ki = 31.2 nM).

Grade

Product Name


Summary

(+)-Bicuculline, 98.0+ % (HPLC)


Methanol, chloroform

IC50 = 4.5 μM Keep at -20℃.022-16133 250 mg

Lactone of bixin, known for its use as a proconvulsant. It is a selective antagonist of GABA(A) receptor, a GABA receptor subtype that exists in the central and peripheral nervous systems. Because this reagent binds to GABA binding site, it competitively blocks GABA and muscimol actions.

(-)-Bicuculline Methobromide

026-14291 100 mg for Biochemistry 73604-30-5 Water IC50 = 15 nM Keep at 2-10℃.

GABAA receptor antagonist.

(-)-Bicuculline Methochloride, 93.0+ % (HPLC)

026-17611 10 mgfor Biochemistry 53552-05-9 - IC50 = 0.8 ± 0.2 μM Keep at -20℃.

022-17613 50 mg

Water-soluble methochloride salt of (+)-bicuculline

Picrotoxin, 97.0+ % (HPLC)

168-17961 1 gWako 1st Grade 124-87-8 Ethanol IC50 = 2.6 ± 0.4 μM Keep at RT.

164-17963 5 g

GABAA receptor antagonist.

Picrotoxinin, 95.0+ % (HPLC)

165-17351 500 mg for Biochemistry 17617-45-7 Ethanol, Chloroform IC50 = 25 ± 0.4 μM Keep at 2-10℃.

A bitter component isolated from a plant of family Menispermaceae (Anamirta cocculus). The toxic moiety of picrotoxin (central nerve excitation agent), which blocks the Cl- channel in an allosterical manner that forms a molecular complex with GABA receptors.

Grade

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(5) Serotonin-related Inhibitors

Product Name


Summary

Amitriptyline Hydrochloride, 99.0+ % (Titration)

013-12882 25 g for Biochemistry 549-18-8Water, chloroform,

ethanol5-HT: IC50 = 39 nMNA: IC50 = 21 nM

Keep at RT.

Tricyclic antidepressant substance, anxiolytic substance. It inhibits reuptake of noradrenaline and serotonin in the brain and exerts an antidepressant action.

Amoxapine, 98.0+ % (HPLC)


14028-44-5Acetic acid,

glacial, chloroform, dichloroethane

- Keep at RT.011-23633 5 g

This is a tricyclic antidepressant. It inhibits reuptake of serotonin (5-HT) and noradrenaline in nerve terminals in the brain.

Azasetron Hydrochloride, 90.0+ % (HPLC)

014-24441 50 mgfor Biochemistry 123040-16-4 Water - 　

010-24443 200 mg

5-HT3 Receptor Antagonist

Blonanserin, 98.0+ % (HPLC)


132810-10-7Acetonitrile, acetic

acid, methanol, ethanol

Ki = 0.812 nM (5-HT2A); 0.142 nM (Dopamine D2); 0.494 nM (Dopamine D3)

Keep at RT.028-17453 50 mg

This substance binds selectively to dopamine D2 receptor and serotonin 5-HT2 receptor and exhibits antagonistic activities.

DL-p-Chlorophenylalanine, 99.0+ % (Titration)

037-10741 1 g

Wako Special Grade 7424-00-2Dilute hydrochloric

acid- Keep at RT.033-10743 5 g

035-10742 25 g

It irreversibly binds to tryptophan hydroxylase and decreases intracerebral serotonin (serotonin synthetic inhibitor).

Citalopram Hydrobromide, 98.0+ % (HPLC)


59729-32-7 Water, ethanol IC50 = 1.8 nM Keep at 2-10℃.037-22233 100 mg

Citalopram Hydrobromide is a selective serotonin reuptake inhibitor (SSRI). This reagent blocks the reuptake of intracerebral serotonin and exhibits antidepressive effects by increasing serotonin in the synaptic cleft. It is considered to have almost no affinity for other neurotransmitter receptors.

Clomipramine Hydrochloride, 98.0+ % (volumetric analysis), 98.0+ % (HPLC)


17321-77-6Water, acetic

acid, methanol, chloroform

IC50 of 5-HT: 1.5 nM; NA: 24 nM Keep at RT.032-21943 5 g

Clomipramine Hydrochloride is a derivative of imipramine and has tricyclic antidepressant effects. This reagent blocks the uptake of intracerebral serotonin (5-HT) and noradrenaline into the nerve terminal. It potently blocks serotonin uptake.

Desipramine Hydrochloride, 99.0+ % (Titration); 99+ % (TLC)


Chloroform, water, ethanol

IC50 of 5-HT: 382 nM; NA: 1.26 nM Keep at RT.040-23123 5 g

Tricyclic antidepressant. It binds to amine transporter and blocks reuptake of intracerebral serotonin (5-HT) and noradrenaline into the nerve terminal. It is an active metabolite of imipramine.

Doxepin Hydrochloride (mixture of isomers), 98.0+ % (HPLC)


1229-29-4 Water IC50 of 5-HT: 280 nM; NA: 40 nM Keep at RT.049-32003 5 g

Tricyclic antidepressant. It blocks the reuptake of serotonin and noradrenaline. It is a potent H1 histamine receptor antagonist.

Grade

7. Neu

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Inh

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Product Name


Summary

Duloxetine Hydrochloride, 98.0+ % (HPLC)


136434-34-9 Methanol, DMSO IC50 of 5-HT: 6.3 nM; NA: 5.8 nM Keep at RT.047-32043 100 mg

Tricyclic antidepressant. It blocks the reuptake of serotonin and noradrenaline. It is a potent H1 histamine receptor antagonist.

(±)-Fluoxetine Hydrochloride, 98.0+ % (HPLC)

068-04321 10 mg

for Biochemistry 56296-78-7

Methanol, ethanol, acetonitrile, chloroform,

acetone

IC50 = 6.8 nM Keep below 25℃.064-04323 50 mg

068-04326 1 g

Selective serotonin reuptake inhibitor (SSRI). It inhibits serotonin reuptake and consequently elevates serotonin concentration in synaptic gaps exhibiting antidepressive effect.

Fluvoxamine Maleate


61718-82-9 Ethanol IC50 = 0.29 nM Keep at 2-10℃.061-05173 100 g

Selective serotonin reuptake inhibitor (SSRI). It is used for treating melancholia, depression, obsessive compulsive disorder, and social anxiety disorder.

Granisetron Hydrochloride, 98.0+ % (HPLC)


107007-99-8 Water IC50 = 0.20 nM Keep at 2-10℃.079-06133 50 mg

Highly selective serotonin receptor 5-HT3 antagonist. It is an antiemetic.

Milnacipran Hydrochloride, 98.0+ % (HPLC)


101152-94-7 Water IC50 of 5-HT: 28.0 nM; NA: 29.6 nM Keep at -20℃.139-17013 100 mg

Serotonin-noradrenaline reuptake inhibitor (SNRI). It selectively binds to the reuptake site of serotonin and noradrenaline at nerve terminals thus inhibiting uptake of monoamine and increasing extracellular concentrations of serotonin and noradrenaline in the brain.

Olanzapine, 98.0+ % (HPLC)

150-03071 50 mgfor Pharmacology

Research132539-06-1 Acetonitrile

Ki of 5-HT2A: 2.5 nM; 5-HT2B: 11.8 nM; 5-HT2C: 28.6 nM; 5-HT6: 2.5 nM; Dopamine D2: 11 nM; Dopamine D3: 16 nM; Dopamine D4: 27 nM; α1-adrenaline: 19 nM; Histamine H1: 7 nM

Keep at RT.

156-03073 500 mg

Olanzapine antagonizes various neuronal receptors including serotonin 5-HT2A, 2B, 2C, 5-HT6, dopamine D2, D3, D4, α1-adrenaline, histamine H1 receptors.

Paroxetine Hydrochloride, 98.0+ % (HPLC)


Research78246-49-8 Water IC50 = 0.29 nM Keep below 25℃.

Potent and selective serotonin reuptake inhibitor (SSRI) in the serotonin neuron system in brain

Perospirone Hydrochloride Dihydrate, 98.0+ % (HPLC)


192052-81-6Methanol, ethanol, acetonitrile, water

5-HT2: Ki=0.61 nM; Dopamine D2: 1.4 nM Keep at RT.163-25243 50 mg

It binds selectively to dopamine D2 receptor and serotonin 5-HT2 receptor and exhibits antagonistic activities.

Quetiapine Fumarate, 98.0+ % (HPLC)


111974-72-2N,N-

Dimethylformamide

IC50 of 5-HT2: 148 nM; Dopamine D2: 329 nM; adrenaline α1: 94 nM; Histamine H1: 30 nM

Keep at RT.178-00693 10 g

Dibenzothiazepine compound. It inhibits dopamine D2 receptor and serotonin 5HT2 receptor. It shows affinity to a number of receptors other than dopamine D2 and serotonin 5HT2. It shows higher affinity to serotonin 5HT2 receptor than dopamine D2 receptor.

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(6) Dopamine Receptor Antagonists

Product Name


Summary

Risperidone


106266-06-2 Methanol - Keep at RT.184-02313 250 mg

It binds selectively to dopamine D2 receptor and serotonin 5-HT2A receptor and exhibits antagonistic activities.

Sertraline Hydrochloride, 98+ % (HPLC)


79559-97-0 Methanol IC50 = 0.058 μM Keep at RT.199-16193 1 g

Selective serotonin reuptake inhibitor (SSRI). It exhibits antidepressant activity by the inhibition of serotonin reuptake in the brain and increase in the amount of serotonin in synaptic gaps.

Trazodone Hydrochrolide, 98.0+ % (HPLC)

209-14964 500 mg for Biochemistry 25332-39-2 WaterIC50 of 5-HT uptake: 580 nM;

NA uptake: 11 μMKeep at 2-10℃.

Triazolopyridine antidepressant, which acts more selectively on serotonin than on noradrenaline in its inhibition of monoamine reuptake and exerts antidepressant activity. It has almost no anti-cholinergic effects and hardly inhibits reuptake of noradrenalin in the heart.

Venlafaxine Hydrochloride, 98.0+ % (HPLC)


Research99300-78-4 Water Ki = 41.0 ± 9.1 μM Keep at RT.

Serotonin-noradrenaline reuptake inhibitor (SNRI). It selectively binds to the reuptake site of serotonin and noradrenaline at nerve terminals thus inhibiting uptake of monoamine and increasing extracellular concentrations of serotonin and noradrenaline in the brain.

Grade

Product Name


Summary

Aripiprazole, 98.0+ % (HPLC)


129722-12-9Benzyl alcohol,

acetic acidIC50 = 37 nM (with 100 nM Dopamine) Keep at RT.

013-23833 1 g

Quinoline derivative antagonist of dopamine D2 receptor when dopamine is insufficient. It also acts as partial agonist of serotonin 5-HT1A receptor and dopamine D2 receptor and antagonist of serotonin 5-HT2A receptor.

Bupropion Hydrochloride, 98.0+ % (HPLC)


21535-47-7 MethanolIC50 of NA transporter: 1.4 μM;

DA transporter: 2.8 μMKeep at RT.

024-17313 1 g

Noradrenaline-dopamine reuptake inhibitors (DNRIs).It inhibits the reuptake of noradrenalin and dopamine into the nerve terminals in the brain, thereby increasing the extracellular serotonin concentrations of noradrenaline and dopamin in the brain.

Clozapine, 98.0+ % (HPLC)


5786-21-0 EthanolIC50 of D4: 9 nM; 5-HT2A: 12 nM;

5-HT2C: 8 nMKeep at RT.

034-22743 50 mg

Subtype D4 selective dopamine receptor antagonist. It also antagonizes serotonin receptors (5-HT2A, 5-HT2C, 5-HT3, 5-HT6, 5-HT7).

Haloperidol, 98.0+ % (Titration)

084-04261 1 g

Wako Special Grade 52-86-8Acetic acid, glacial,

chloroform- Keep at RT.080-04263 5 g

082-04262 25 g

Haloperidol antagonizes especially dopamines at the dopamine receptor and blocks their action.

(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC)

191-15531 10 mgfor Cellbiology 125941-87-9 DMF IC50 of D1: 0.2 nM; D5: 0.3 nM Keep at 2-10℃.

197-15533 50 mg

Potent dopamine D1 receptor antagonist. It also potently agonizes 5-HT1C/2C receptors.

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(7) Noradrenaline-related Inhibitors

(8) Alzheimer's Disease Research

Product Name


Summary

(±)-Sulpiride, 98.0+ % (Titration)

190-12061 1 g

for Biochemistry 15676-16-1 Acetic acid, glacial D2: IC50 = 4 nM Keep at 2-10℃.198-12062 25 g

196-12063 100 g

This product blocks dopamin D2 receptors, thereby increasing the extracellular dopamine levels in the brain. It exhibits little antagonist action on the receptors of monoamine such as adrenaline and serotonin.

Grade

Product Name


Summary

Maprotiline Hydrochloride, 98.0+ % (HPLC)


10347-81-6Methanol, chloroform

IC50 = 8.4 nM Keep at RT.135-17093 5 g

Tetracyclic antidepressant. It increases noradrenaline concentrations by inhibiting the reuptake of noradrenaline into the nerve terminals.

Mianserin Hydrochloride


21535-47-7 MethanolIC50 of α2 adrenaline receptor: 12 nM;

α adrenaline receptor: 300 nM; 5-HT receptor: 22 nM

Keep at RT.138-16863 500 mg

Tetracyclic antidepressant. It blocks presynaptic α2 adrenaline autoreceptor, thereby accelerates noradrenaline release into synaptic gaps. Acceleration of metabolic turnover of noradrenaline in the brain has also been reported. It exhibits 5-HT receptor blocking activity.

Mirtazapine, 98.0+ % (HPLC)


85650-52-8Ethanol, methanol,

chloroform

pKi = 6.9 - 7.0 (α2); 5.2 (5-HTA1); 7.88 (5-HT2); 6.8, 8.1 (5-HT3); 5.5 - 5.8 (NA uptake); ＜5.0 (5-HT uptake)

Keep at RT.130-16823 50 mg

Noradrenergic and specific serotonergic antidepressant. Mirtazapine acts as an antagonist on presynaptic α2-adrenergic autoreceptors and heteroreceptors and enhances noradrenaline and serotonin (5-HT) releases and adrenergic and serotonergic neurotransmission in the brain. It also blocks 5-HT2 and 5-HT3 receptors and selectively activates 5-HT1A receptors.

Grade

Product Name


Summary

BMS 299897, 97.0+ % (HPLC)

021-17781 5 mgfor Cellbiology 290315-45-6 - - Keep at -20℃.

027-17783 25 mg

Potent γ-secretase inhibitor that inhibits the formation of the amyloids Aβ40 and Aβ42 in vitro. It is also known not to inhibit Notch signaling. It has oral activity.

DAPT, 97.0+ % (HPLC)

045-30981 5 mgfor Cellbiology 208255-80-5 Methanol - Keep at -20℃.

041-30983 25 mg

γ-secretase inhibitor.

Donepezil Hudrochloride, 90.0+ % (HPLC)

045-32321 50 mgfor Biochemistry 120011-70-3 Water (1 mg/mL) - Keep at 2-10℃.

041-32323 250 mg

Reversible acetylcholinesterase (AChE) inhibitor. Donepezil-induced downregulation of AChE leads to increased levels of acetylcholine in the brain, which in turn stimulates cholinergic nerve system in the brain.

L-685, 458, 98.0+ % (HPLC)

121-06141 1 mg for Cellbnioloty 292632-98-5 DMSO (>10 mg/mL) - Keep at -20℃.

Potent and selective γ-secretase inhibitor. It also inhibits with equal potency to Aβ40 and Aβ42 peptides.

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IndexProduct Name PAGE

AA-83-01 ················································· 1AACOCF3 ············································ 2517-AAG ·················································· 1AG 1296 ················································ 1AG 1478 ················································ 1AG 490 ·················································· 1ω-Agatoxin IVA ···································· 15ω-Agatoxin TK ····································· 15Agelenin ··············································· 15Alendronate Sodium Salt Trihydrate ···· 14ALK5 Inhibitor ········································ 1AM 251 ················································ 26AM 281 ················································ 26AM 630 ················································ 26AMG 9810 ··········································· 19DL-2-Amino-4-phosphonobutyric Acid ··· 23L-2-Amino-4-phosphonobutyric Acid ··· 23D(-)-2-Amino-5-phosphonovaleric Acid ··· 23DL-2-Amino-5-phosphonovaleric Acid ··· 23Aminogenistein ······································ 1Amitriptyline Hydrochloride ················· 27Amlodipine ·········································· 16Amoxapine ·········································· 27Andrographolide ·································· 22AP 18 ··················································· 20Apamin ················································ 172-APB ·················································· 20APETx2 ················································ 21Apigenin ················································ 1Aripiprazole ········································· 29AS 604850 ············································· 1AS 605240 ············································· 2ATM Kinase Inhibitor ····························· 2Azasetron Hydrochloride ····················· 27

BBAY 11-7085 ······································· 22BCTC ··················································· 20Benazepril Hydrochloride ···················· 25(+)-Bicuculline ······································ 26(-)-Bicuculline Methobromide ·············· 26(-)-Bicuculline Methochloride ·············· 26Bio ························································· 2(-)-Blebbistatin ····································· 14Blonanserin ·········································· 27BMS 299897 ········································ 306-Bromoindirubin-3'-oxime ··················· 2Bupropion Hydrochloride ···················· 292,3-Butanedione Oxime ······················ 16Butein ···················································· 2

CCalcicludine ········································· 16Calciseptine ········································· 16Calpain Inhibitor 2 ······························· 14Calphostin C ·········································· 2Calyculin A ··········································· 12Cantharidin ·········································· 12

Capsazepine ········································ 20Captopril ·············································· 25C arbonyl Cyanide

m-Chlorophenylhydrazone ················· 2Charybdotoxin ····································· 17DL-p-Chlorophenylalanine ·················· 278 -(4-Chlorophenylthio)adenosine 3,5-(Cyclic)

monophosphate Sodium Salt ················· 22Chlorotoxin ·········································· 21Chlorpromazine Hydrochloride ············ 14Cinnarizine ··········································· 16Citalopram Hydrobromide ··················· 27CKI-7 Dihydrochloride ··························· 2Clomipramine Hydrochloride ··············· 27Clotrimazole ········································ 19Clozapine ············································· 29Compound 15e ······································ 2Compound 401 ····································· 2α-Conotoxin G1 ··································· 21μ-Conotoxin G3B ································ 19μ-Conotoxin GS ·································· 19ω-Conotoxin GVIA ······························· 16α-Conotoxin ImI ··································· 21α-Conotoxin M1 ·································· 21ω-Conotoxin MVIIA ······························ 16ω-Conotoxin MVIIC ····························· 16α-Conotoxin S1 ··································· 21μ-Conotoxin SIIIA ································ 19ω-Conotoxin SVIB ······························· 16(R)-CPP ················································ 23Curcumin ············································· 22Cyclopiazonic Acid ······························ 14Cyclosporin A ······································ 12

DD-AP5 ·················································· 23DL-AP5 ················································ 23DAPT ··················································· 30Deguelin ················································ 2Dendrotoxin 1 ······································ 18Desipramine Hydrochloride ················· 27D extromethorphan Hydrobromide

Monohydrate ······································ 23Diazoxide ············································· 23Dibucaine Hydrochloride ······················· 3Diltiazem Hydrochloride ······················ 16D isodium β-Glycerophosphate

Pentahydrate ····································· 122,5-Di-t-butylhydroquinone ················· 14DL-AP7 ················································ 23DNQX ·················································· 23Donepezil Hudrochloride ····················· 30Dorsomorphin ········································ 3Dorsomorphin Dihydrochloride ············· 3Doxepin Hydrochloride ························ 27Duloxetine Hydrochloride ···················· 28

EE-4031 n-Hydrate ································ 18

E-64d ··················································· 14Enalaprilat Dihydrate ··························· 25Enalapril Maleate ································· 25Evans Blue ··········································· 24

FFelbamate ············································ 24(±)-Fluoxetine Hydrochloride ·············· 28Fluphenazine Dimaleate ······················ 14Fluvoxamine Maleate ·························· 28Fostriecin Sodium Salt ························ 12

GGeldanamycin ······································· 3Genistein ··············································· 3Genistin ················································· 3GF 109203X ··········································· 3Glibenclamide ······································ 18Gö 6983 ················································· 3Granisetron Hydrochloride ·················· 28GSK-3 Inhibitor IX ································· 2GSK 269962A ········································ 3GSK 429286A ········································ 4GsMTx-4 ·············································· 21Guangxitoxin-1E ·································· 18

HH-1152 Dihydrochloride ························ 4Haloperidol ·········································· 29HC-030031 ·········································· 20Herbimycin A ········································· 4Huwentoxin-IV ····································· 19Hypericin ··············································· 4

IIberiotoxin ············································ 18IPA-3 ······················································ 4Isotetrandrine ······································ 22

JJoro Spider Toxin JSTX-3 ···················· 24

KK-252a ··················································· 4K-252b ··················································· 4Kaliotoxin (1-37) ·································· 18Kenpaullone ··········································· 4Ki 8751 ·················································· 4KN-62 ···················································· 5KN-93 ···················································· 5KN-93, Water-Soluble ··························· 5KT 5720 ················································· 5KT 5823 ················································· 5KU 0063794 ··········································· 5Kurtoxin ··············································· 17

LL-685, 458 ··········································· 30LDN 193189 Hydrochloride ··················· 5


IndexProduct Name PAGE

Levamisole Hydrochloride ··················· 12Lisinopril Dihydrate ······························ 25Loperamide Hydrochloride ·················· 24LY-83583 ·············································· 22LY 294002 ·············································· 5L ys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Tyr ·································· 6

MMaprotiline Hydrochloride ··················· 30Margatoxin ··········································· 18Mastoparan ········································· 15MCD-Peptide ······································ 18(+)-MCPG ············································ 24Memantine Hydrochloride ··················· 243-Methyladenine ···································· 6MG-132 ··············································· 15MgTX ··················································· 18Mianserin Hydrochloride ····················· 30Milnacipran Hydrochloride ·················· 28Mirtazapine ·········································· 30(+)-MK 801 Maleate ····························· 24

NNBQX ··················································· 24NBQX Disodium Salt ··························· 24Nicardipine Hydrochloride ··················· 17Nitrendipine ········································· 17NS2028 ················································ 22NSC 693868 ·········································· 6NU 7026 ················································ 6NU 7441 ················································ 6

OODQ ····················································· 22Olanzapine ··········································· 28Olomoucine ··········································· 6Olvanil ·················································· 20Omeprazole ········································· 191 H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin- 1-one ················································· 22

PParoxetine Hydrochloride ···················· 28PD-98059 ·············································· 6PD 173074 ············································· 6PD 184352 ············································· 6PD 0325901 ··········································· 7Pentamidine Isethionate ······················ 24Pentoxifylline ······································· 22Perospirone Hydrochloride Dihydrate ··· 28Phloretin ················································ 7Phosphatase Inhibitor Cocktail Solution I ··· 13Phosphatase Inhibitor Cocktail Solution II ··· 13PI-103 ···················································· 7Piceatannol ············································ 7Picrotoxin ············································ 26Picrotoxinin ·········································· 26PIK-75 Hydrochloride ···························· 7

PKC 412 ················································ 7PLTX-II ················································· 17PP 2 ······················································ 7PP 3 ······················································ 7PP 242 ··················································· 7Protease Inhibitor Cocktail Set I ·········· 13Protease Inhibitor Cocktail Set III ········ 13Protease Inhibitor Cocktail Set IV ········ 13Protease Inhibitor Cocktail Set V ········· 13Protease Inhibitor Cocktail Set VI ········ 13Protease Inhibitor Cocktail Set VII ······· 13ProTx-1 ················································ 17ProTx-II ················································ 19Psalmotoxin 1 ······································ 21Purotoxin-1 ·········································· 21

QQuercetin Dihydrate ······························ 8Quetiapine Fumarate ··························· 28Quinacrine Dihydrochloride Dihydrate 15

RRac1 Inhibitor ········································ 8Radicicol ················································ 8Rapamycin ············································ 8RG-14620 ·············································· 8Risperidone ········································· 29RK-682 ················································ 12RN-1747 ·············································· 20Ro 31-8220 Methanesulfonate ·············· 8Rolipram ·············································· 23Roscovitine ············································ 8Ruthenium Red ···································· 20Ryanodine ··········································· 17

SSB 202190 ············································· 8SB 203580 ············································· 9SB 203580 Hydrochloride ····················· 9SB-366791 ·········································· 20SB 415286 ············································· 9SB 431542 ············································· 9(+)-SCH23390 Hydrochloride ·············· 29Scyllatoxin ··········································· 18Sertraline Hydrochloride ······················ 29SNX-482 ·············································· 17SP 600125 ············································· 9Spermine ············································· 25D-erythro-Sphingosine ·························· 9SR 3677 Hydrochloride ························· 9Staurosporine ········································ 9Stellettamide A Trifluoroacetate ············ 9Stichodactyla Toxin ····························· 18SU 4312 ··············································· 10SU 5402 ··············································· 10SU 5416 ··············································· 10SU 6668 ··············································· 10SU 11274 ············································· 10(±)-Sulpiride ········································ 30

Suramin Sodium ·································· 15

TTamoxifen Citrate ································ 10Tautomycin ·········································· 12Tertiapin ··············································· 18TGF-β R I Kinase Inhibitor IV ················· 1Thapsigargin ········································ 15Tityustoxin Kα ······································ 19Trazodone Hydrochrolide ···················· 29Triciribine ············································· 10TWS 119 ·············································· 10Tyrphostin A25 ····································· 10

UU 0126 ················································· 11

VVenlafaxine Hydrochloride ··················· 29Verapamil Hydrochloride ····················· 17

WW-5 Hydrochloride ······························ 11W-7 Hydrochloride ······························ 11(+)-Wortmannin ···································· 11

YY-27632 ··············································· 115 mmol/L Y-27632 Solution ················· 11

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1. kinase inhibitors · synthetic derivative of geldanamycin, which is one of the ansamycin...

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