1 coordinating and financing r&d in developing countries-moving beyond pdp's the andi...
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Coordinating and Financing R&D in Developing Countries-moving beyond PDP's
The ANDI Experience
Solomon Nwaka
CEWG on R&D Financing & Coordination, April 6, 2011
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ANDI Vision
"Creating a sustainable platform for R&D innovation in Africa to address Africa’s own health needs"
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ANDI touches 8 elements of the GSPOA
1. prioritizing research and development needs;
2. promoting research and development;
3. building and improving innovative capacity;
4. transfer of technology;
5. application and management of intellectual property;
6. improving delivery and access;
7. ensuring sustainable financing mechanisms;
8. establishing monitoring and reporting systems.
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Evolution of ANDI
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>500 people at ANDI Meeting Nairobi 2010
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Mapping & priority setting exercise supports ANDI establishment
Exploratory Research
Natural product / TM
Clinical
Marketing
Medicinal Chemistry
IP management
Regulatory
Manufacturing
Pre-clinical toxicology
Safety / pharmacology
API production
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SOURCE: Thomson Web of Science
Cities with 30 or more articles published in the 2004 - 08 period
Total of 90 cities in 27 countries
16,647 biomedical articles led by African authors included in analysis
Note: Only top 40 cities by research output labeled
Competency research centers exist
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R&D collaborations biased externally e.g. HIV/AIDS
SOURCE: Thomson Web of Science, UCINET
Institut PasteurWHO
Univ Washington Univ AmsterdamJohns Hopkins Univ
Univ Witwatersrand
CDCUniv Alabama
Univ North Carolina
UCSF
London Sch Hyg & Trop Med
Makerere UnivUniv Nairobi
Univ London
Columbia Univ
Harvard Univ
Univ KwaZulu
Univ Oxford
Univ Zimbabwe
UCL
Muhimbili Univ
Natl Inst Communicable Dis
Univ Cape Town
Size equivalent to no. of article with lead authorSize equivalent to no. of article with lead author
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SOURCE: Delphion, VantagePoint, UCINET
Patent activity also biased externally
US
UruguaySouth Africa
Madagascar
Kenya
Benin
Guinea
Morocco
Egypt
Tunisia
UK
France
Belgium Netherlands
Japan
Canada
US
UruguaySouth Africa
Madagascar
Kenya
Benin
Guinea
Morocco
Egypt
Tunisia
UK
France
Belgium Netherlands
Japan
Canada
1 -2
3 - 4
5 - 8
9 - 11
> 11
Patent #
Total: 164
1 -2
3 - 4
5 - 8
9 - 11
> 11
Patent #
Total: 164
Note: Patents published in the period 2004-2009 by WIPO or the US and European patent offices with at least one assignee from Africa (under under International Patent Codes A61K or A61P)
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WHA62.16, 2009: "ANDI is a key initiative aimed at supporting and promoting African led health product
innovation…."
AMCOST, 2010: "AMCOST welcomes…African Network for Drugs and Diagnostics Innovation (ANDI) and its anticipated contribution to the
science, technology and innovation……''
ANDI approach has received political recognition
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Governance
Hosting Agency– UNECA
Board– Co-Chaired by:
Minister Mugo of Kenya (Health)
Minister Pandor of South Africa (S&T)
– 12 members with >75% from Africa
– WHO, AfDB, UNECA
Secretariat– Operates through regional hubs
North hub
Central hub
South hub
East hubWest hub
ANDI Office
Advocacy
IP/technology transfer
R&D coordination
STAC
African InnovationFund
Board
Executive committee (EC) Finance
Committee (FC)
Board
Fund
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ANDI business model – network-based projects
Function
Infrastructure improved
Competence/excellence centers developed
R&D capability built
Scope
Example: Drug for
TB/Malaria
Example: Schisto
diagnostic
Example: TM1 project
Core R&D activities
▪ Project/portfolio management▪ Funding▪ IP management
Brokerage▪ Advocacy▪ Public/private partnerships
Network support
▪ Research equipment▪ Research facilities▪ Knowledge/IT management
Project 1 Project 2 Project 3Function
Infrastructure improved
Competence/excellence centers developed
R&D capability built
Scope
Example: Drug for
TB/Malaria
Example: Schisto
diagnostic
Example: TM1 project
Core R&D activities
▪ Project/portfolio management▪ Funding▪ IP management
Core R&D activities
▪ Project/portfolio management▪ Funding▪ IP management
Brokerage▪ Advocacy▪ Public/private partnershipsBrokerage▪ Advocacy▪ Public/private partnerships
Network support
▪ Research equipment▪ Research facilities▪ Knowledge/IT management
Network supportNetwork support
▪ Research equipment▪ Research facilities▪ Knowledge/IT management
Project 1 Project 2 Project 3
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ANDI's IT platform - open access and secure components
ANDI database
BasicResearch
ProductDiscovery
ProductDevelopment
& Clinical
Regulation/Manufacturing
Networking & Knowledge Management Space
African &ANDI R&D
ProfessionalNetwork
Protocols,SOP &
ReportingProcesses
Researchlibrary, tools &
InformationSystem
Research &ANDI
policies
Op
en
Acc
ess
Se
arc
h E
ngin
eS
ecure
Ba
ckbo
ne ANDI PPP1 management tool
ANDI database
BasicResearch
ProductDiscovery
ProductDevelopment
& Clinical
Regulation/Manufacturing
Networking & Knowledge Management Space
African &ANDI R&D
ProfessionalNetwork
Protocols,SOP &
ReportingProcesses
Researchlibrary, tools &
InformationSystem
Research &ANDI
policies
Op
en
Acc
ess
Se
arc
h E
ngin
eS
ecure
Ba
ckbo
ne ANDI PPP1 management tool
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Technical progress & challenges
– Centres of Excellence for health innovation in Africa being identified (public & private)
• Call resulted in 130 applications being reviewed
– Call for projects resulted in 207 project applications • Projects being reviewed & prioritized for funding
– Key challenge is: $$$$$$$• EU have provided seed funds
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Financing options
Trust Fund at UNECA– Seeking to grow to $30M p.a. in regular contributions in 5 years– Actively fund raising
Exploring – Additional Trust Funds with other partners– Endowment Fund
Potential to leverage financing for projects / infrastructure– National Resources (public and private) – Governments and development agencies– Development and trade banks– Foundations and others …….
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One measure of success in 5 - 10yrs
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Lessons learned through ANDI
Desire for regionally coordinated / facilitated approach– Support at technical, business and political levels important
Address interface between research and market access early – Local product manufacture, regulatory and IP issues
Need for alignment between public and private sectors– Interest from governments, development and private banks
Link to Regional Science, Technology and Innovation policies– Support for SMEs, manufacture and commercialization
R&D financing should consider ALL these opportunities and the potential power of catalytic financing and leverage at local level
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Future coordinating role may be required