Training program in Assisted Reproductive Technology (ART)Started in 2003, we offer a unique opportunity to learn the latest techniques in this rapidly changing subspecialty at one of the world’s premier ART centers:

• World-class faculty• ART centers through: training facilities• Personalized hands-on training• Multiple comprehensive training modules• Tremendous satisfaction rates• Trained over 175 alumni from 32 countries since 2003• Certificate of Training awarded at the end of training

This intensive, 320-hour course is available exclusively to scientists and physicians with specific interest in gynecology, andrology or embryology as well as other health professionals such as embryologists, reproductive biologists and technologists.The course covers: • In vitro fertilization (IVF) • Intracytoplasmic sperm injection (ICSI) • Gamete cryopreservation • Routine and advanced tests in andrology

Referral to a Human IVF Clinic may be available to select candidates looking for clinical observation in the following areas:

• Logistics of running an IVF Lab

• Observe IVF/ICSI procedures

• Oocyte retrieval

• Oocyte assessment

• Fertilization check

• Embryo assessment

• Intrauterine insemination

Learn from the LeadersThe American Center for Reproductive MedicineCleveland Clinic’s American Center for Reproductive Medicine was established 24 years ago in 1993 with a three-fold mission: to conduct cutting-edge research into the causes of human reproductive pathologies, develop new fertility biomarkers and treatment modalities, and train physicians and scientists with a commitment to advancing the understanding of human reproduction, infertility, and fertility preservation.

Course ContentHands on Assisted Reproduction (IVF/ICSI) - Module 5A - 5C (160 hours)Learn basic and advanced techniques in:IVF Techniques• Module 5A • ICSI: Intracytoplasmic sperm injection • Classical IVF • Oocyte handling and scoring • Embryo handling and scoring • Catheter loading for embryo transfer

• Module 5B • Preparation of ICSI dishes • ICSI: injection of the spermatozoon into the oocyte • Oocyte handling (using fresh mouse oocytes)

Laboratory Training• Equipments • Micromanipulators: components and mechanics • Installing and aligning ICSI instruments

• Supplies & Culture Medium • Preparation of culture medium and dishes for IVF/ IVF-ICSI cases • Embryo culture • Extended embryo culture

Advanced ART Techniques• Assisted hatching (laser and chemical [acidified Tyrode’s] method)• Embryo biopsy (laser and chemical methods)

Pre-Implantation Genetic Diagnosis• Blastomere biopsy• Micromanipulator set-up• Biopsy of mouse/hamster 8-cell stage embryos• Use of laser and acid Tyrode’s solution for zona drilling• Blastomere and polar body aspiration and fixation techniques• Cell spreading• Fixation techniques

Cryopreservation• Embryo cryopreservation (mouse embryos)• Vitrification

Andrology• Sperm preparation for IVF/ICSI

Virtual Tour of Facilities

MODULE 5

Module 5A:IVF/ICSI/Micromanipulation (80 hours)

Module 5B:ICSI/Micromanipulation (40 hours)

Module 5C:Advanced ART Techniques (40 hours)

Module 5D*:Customizable ART Training (40 - 320 hours)

*How Module 5D Works:1) Candidates select a) the techniques they wish to learn (Modules 1-8); and b) the duration of their training (1- 8 weeks).

2) Candidates consult with the Course Director regarding their training needs and choices, and together, they will decide on the appropriate modules and duration required by the candidate

3) A personalized training schedule is created specifically for the candidate

4) Training is provided at a pace established by the candidate and is geared towards fulfilling the candidates personal needs.

ART Trainee

taking Module 5

will receive a

FREE copy of

an ART Book

and more...

Amer

ican

Center for Reproductive Medicine

Centrum Excellentiae Est.

1993

Ranked One of America’s Top 5 Hospitals

American Center for Reproductive Medicine

ART Training Hands on Training in

Assisted Reproductive Technology

1 | Cleveland Clinic American Center for Reproductive Medicine Learn more about our ART Training Program

2 | Cleveland Clinic American Center for Reproductive Medicine Learn more about our ART Training Program

Edmund Sabanegh, MDChairman, Department of UrologyHead, Section of Male InfertilityProfessor, Lerner College of Medicine

Sajal Gupta, MS, MD, TS (ABB) (MS in Clinical Embryology, Jones Institute)Reproductive SpecialistSupervisor, Andrology CenterAssistant Professor, Lerner College of Medicine

Rakesh Sharma, PhDResearch Coordinator,American Center for Reproductive MedicineAssociate Professor, Lerner College of Medicine

Ashok Agarwal, PhD, HCLDDirector, Andrology CenterDirector, American Center forReproductive MedicineProfessor, Lerner College of Medicine

Christina Anagnostopoulou, MSDirector and Clinical EmbryologistIVF Clinic “Embryo ART”Athens, GreeceTestimonial

Israel Maldonado Rosas, MScDirector and Clinical EmbryologistCitmer IVF ClinicMexico City, MexicoTestimonial

Semenology - Modules 1A (8 hours) and 1B (16 hours)Gain proficiency in:

Module 1A: • Collection and delivery of semen sample • Routine semen analysis • Computer assisted semen analysis (CASA) • Review quality control methods for semen analysis • Proficiency survey for semen analysis

Module 1B: • Sperm morphology assessments by WHO and Kruger’s strict criteria (WHO 4th and 5th Ed.) • Differences between the two morphology classification systems • Semen smear preparation and practice staining techniques • Quality control measures

ART Sperm Preparation - Module 3 (16 hours)Develop skills in sperm preparation for ART: • Preparation of ejaculated sperm for ART: Sperm wash Double density gradient technique Swim-up protocol • Method of retrieval of sperm from retrograde ejaculate (demonstration only) • Sperm retrieval and preparation of testicular biopsy specimens (using rat or mouse specimens)

Advanced Andrology Techniques - Module 2A (40 hours) and 2B (80 Hours)Gain proficiency in these advanced techniques:

Module 2A (40 hours) • Measurement of sperm DNA fragmentation by TUNEL assay using FACS* Flow Cytometry • Measurement of Oxidation Reduction Potential (ORP) in semen samples • Measurement of Reactive Oxygen Species (ROS) levels in semen samples • Measurement of lipid peroxidation in semen samples • Measurement of Total Antioxidant Capacity (TAC) in seminal plasma • Selection of non-apoptotic spermatozoa using MACS** technique

Module 2B (80 hours) • Measurement of sperm DNA fragmentation by TUNEL assay using FACS* BD Accuri C6 Benchtop Flow Cytometer • Measurement of Oxidation Reduction Potential (ORP) in semen samples • Measurement of Reactive Oxygen Species (ROS) levels in semen samples • Measurement of lipid peroxidation in semen samples • Measurement of Total Antioxidant Capacity (TAC) in seminal plasma • Selection of non-apoptotic spermatozoa using MACS** technique

*Fluorescence-activated cell sorting**Magnetic-activated cell sorting

Cryopreservation - Module 4 (8 hours)Learn the proper procedures for freezing human spermatozoa: • Freezing of ejaculated human spermatozoa • Cryopreservation of epididymal and vas deferens aspirates* • Isolation and cryopreservation of sperm from testicular biopsy specimens* • Protocol for cryopreservation of ovarian tissue from cancer patients**demonstration only

Management of IVF and Andrology Laboratories - Module 7 (16 hours)Gain proficiency in: • Implementation of a Total Quality Management Program • Regulation, licensing and accreditation • Quality Control and Quality Assurance • Proficiency Testing • Quality management tools • Troubleshooting

Vitrification - Module 6 (8 hours)Acquire competency and knowledge of vitrification: • Fundamentals of vitrification • Vitrification for routine use in an embryology laboratory • Hands on training in set-up vitrification of oocytes and embryos using techniques such as: open and closed vitrification system, warming of cryopreserved oocytes and embryos, oocyte and blastocyst vitrification, cleavage stage embryo vitrification

Preparing for CAP Accreditation and FDA Inspection - Module 8 (16 hours)Learn how to prepare your laboratory or tissue bank for accreditation by the Collegeof American Pathologists (CAP) Reproductive Laboratory Inspection Program • Learn how to prepare your laboratory for the College of American Pathologists (CAP) inspection program accreditation or you tissue bank for the United States: Food and Drug Administration (FDA) inspection. • What to do: Pre-inspection, during inspection and post inspection • Inspection Techniques • Quality Management (pre-analytic, analytic, and post-analytic processes) • Critical indicators for all three processes • Laboratory General Checklist • Reproductive Laboratory Checklist (Embryology and Andrology) • Team Leader assessment • FDA Compliance

Training Faculty

AccreditationAccredited for 320 AMA PRA Category 1 CreditsTM

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association Council on Continuing Medical Education for Category 2 credit.Accredited by the American College of Embryology

Learn MoreFor complete information, application instructions and course fees, visit www.clevelandclinic/org/reproductiveresearchcenter/arttraining.html

Virtual tour of the American Center for Reproductive Medicine

Training Methodology:1. Training provided by 2 certified, practicing Clinical Embryologists

2. Trainers include Andrologists, Reproductive Endocrinologists and other experts in ART

3. Fully hands-on, one-on-one laboratory training sessions under the direct guidance of Clinical Embryologists • Training is done using animal models (frozen hamster oocyte and mouse embryos) (Module 5)

4. Each training session is customized to the trainee’s • Professional background • Level of skill and competence • Specific training needs • Desired outcomes from attending the ART training course

5. Interactive discussion and teaching sessions

6. Live lectures and multimedia presentations in small group sessions

7. Four state-of-the-art micromanipulators dedicated solely for training purposes (IVF/ICSI)

Note:• Training is offered in a dedicated ART training suite inside a non-clinical research laboratory• There is no patient contact

Trainee Evaluations:Each Trainee is tested at the end of their training for:

1. Knowledge/Theoretical Component (30%): Multiple choice questions on lab techniques linked to each course module

2. Practical Skills (50%): Tested on specific lab techniques taught during the training

3. Verbal Communication & Comprehension Skills/Integrative Component (20%):

• The performance of the candidate throughout the course will be reflected in a Grading Report.

• Candidates who meet the training requirements and successfully complete the course work will be awarded a Training Certificate

Registered Trainees Will Receive…1. Course Syllabus with Reading Material and Lab Protocols

2. Free Access to the Cleveland Clinic Alumni Library

3. Free Text Book on “Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices” edited by Dr. Peter Nagy et al, Springer (only for Modules 5A-5D)4. Free E-Book titled “Andrological Evaluation of Male Infertility: A Laboratory Guide” edited by Dr. Ashok Agarwal et al, Springer (only for Modules 1-4) (on Flash Drive)

5. WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction: Fifth Edition (on Flash Drive)

6. Certificate of Training (issued upon successful assessment by the instructor)

7. Daily Meal Tickets

This certificate is presented to:

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Scholarship in Teaching AwardTraining Program in Advanced Reproductive Techniques

The Case Western Reserve School of Medicine Scholarship in Teaching Awards is an annual program designed to recognize faculty contribution to education from the preceding year and promote undergraduate, graduate, and continuing medical education teaching as a scholarly activity.

Teaching approaches considered scholarly are characterized by 1) purposeful planning 2) systematic implementation and 3) reflection and assessment for improvement. The result should be an academic product that is actively shared and that will support the development of a community of teaching scholars.

This award was given out at the Case Medical School Education Retreat on March 12, 2015. ACRM’s hands-on ART training program has previously been twice-recognized with this prestigious Scholarship in Teaching Award, in 2013 and again in 2014.

Certificate of Training Awarded Upon the Successful Completion

of the Hands on ART Training

This certificate is presented to:

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Grading Report

Grading Scale: A+ (>96%), A (91-95%), A- (86-90%), B+ (81-85%), B (76-80%), B- (71-75%), C (<70% is Fail)

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Program Director

ART Training Certificate Presentation Ceremony, ACRM, September 2013

2016 Summer Mentorship in Reproductive Medicine, July 2016

Meet Our 2016 ART Trainees

Read Additional Evaluations

4 | Cleveland Clinic American Center for Reproductive Medicine Learn more about our ART Training Program

Read Additional Evaluations

“I have gained multiple new skills from the training, such as how to read morphology and how to read vitality.”

“The program was truly a one-on-one experience, which was very effective. It was hands-on training and the supplementation

of sperm analysis with sperm preparation was a very effective aspect of the program.”

“The trainers were extremely knowledgeable and attentive throughout

the entire course. I feel like most of what makes a good embryologist is

trouble shooting when things go wrong. They gave a lot of very helpful tips/

techniques for oocyte/embryo handling and micromanipulator troubleshooting.”

“The trainers put in a great deal of effort in helping us

learn the basics, and overall, it was great one-on-one and

hands-on teaching.”

“The training provided me with good knowledge, various skills,

and it was more than what I was expecting. The trainers were great and helped me throughout the program.”

“My trainers were excellent. I have been training in courses around the world, but never have I met such patient, caring, and diligent trainers. Not only do they teach you the skills, but they want to make sure that you have gained enough expertise to be a pro. The training for me was an amazing experience. It was an open candid environment, where you can easily learn and absorb what is the latest up to date technology.

“The training was extremely hands on in every aspect and was truly one-on-one training from world renowned, experienced embryologists.”

“The program was run with effective time management, and the course curriculum covered every topic I hoped to learn in detail. The trainers made sure to have a personal focus on each member. Things could be taken at your own pace. I enjoyed the morning

meetings because they shared an insight into recent world scientific topics.”

“The training was run by qualified and nice staff, had a friendly environment, and it was well organized. The hands on experience was excellent.”

“The training was definitely hands-on training. There were helpful clinical discussions and many helpful handouts as study material. The instructors were very well trained embryologists, who

were comfortable with dealing with various embryology procedures and troubleshooting instruments.”

Mohamed Abouhalawa, BSc | Doha, Qatar

Gilbertha Alexander, MD, FRCOG | Cayman Islands

Joshua Allen Pecenica, MS | Indiana, USA

Harshita Ramamurthy, MBBS, MS | Bangalore, India

Thais Walverde Siqueira, MSc | Sao Paulo, Brazil

Sara Tanwir Ahmed, MSc | Lahore, Pakistan

Annapoorani Chockalingam, DVM, PhD | Florida, USA

Shweta Gupta, MBBS, MS, MRCOG | Missouri, USA

Farid Keyvanifard, MSc | Doha, Qatar Ahmed Mansour, MD | New York, USA

Amer

ican

Center for Reproductive Medicine

Centrum Excellentiae Est.

1993

ACRM Staff, Fellows and Students,Lerner Research Institute, July 2016

Efiok Eyo Efiok, MBBCh, FWACSCross River State, Nigeria“Excellent hands-on training.”

Rian SalasinPennsylvania, USA“The highlight of my experience would have to be receiving my certificate – it was a lot of work but I am proud that I was able to complete the training requirements. I am taking away a lot from the experience.”

Bindu Garg, MD, DGO, FICMCHGurgaon, India“We experienced a homely environment and received unrivaled hospitality from the Senior Staff. The course is run very well and it meets the demands and expectation of the candidates.”

Shweta Patki, MBBSKolhapur, India“This is the most wholesome course on embryology that I have ever come across. The difficult aspects like trouble-shooting of ICSI or recent advances like vitrification were made clear to us.”

Godwin Akhabhoa, FMCOG, FWACSLagos, Nigeria“The Director and other Departmental Personnel showed personal interest. Excellent teachers in a beautiful learning environment.”

Abdullah Al Najmi, MDJazan, Saudi Arabia“I gained so much theoretical and technical know-how from the comprehensive teaching in all the 6 modules that I was training in.”

Abdullahi Abdulwahab-Ahmed, MDSokoto State, Nigeria“The hands-on nature of the course made it a standout way of learning the techniques of ART from experienced and seasoned Trainers and Organizers.”

Jason Krumholtz, MDNew York, USA“The working environment was very comfortable and the hands-on training coupled with the didactic lectures were very effective.”

Arun Muthuvel, MDChennai, India“Each Trainee gets an individual Trainer. The Course was completely custom-made, I could choose the areas where I needed more help. Trainers were very patient and were willing to teach us all the time. This is the only program that gives real hands-on training. This program is the best I could think of in any part of the world. Real spoon feeding!”

Oziga Dada Vincent, MBBS, FWACSDelta State, Nigeria“Excellent relationship between Trainers and Trainees. Good practical demonstration sessions.”

Zainab Shilbayeh, MDTexas, USA“The way the Trainers taught was very efficient. It was such an excellent experience here that I think I can’t find it anywhere else.”

Zahraa Alyahaei, DPhilAl Ain, UAE“There was plenty of time to practise the techniques and discuss different topics related to the IVF lab with the Course Instructors. Excellent knowledge sharing and transfer.”

Shazia Magray, MD, MRCOGDubai, UAE“Techniques such as ICSI, vitrification, and embryo transfer were practiced so many times that in the end, you feel as if you have been performing them for a long time.”

Mai Jawad Abdullah Al-Qattan, MBAKuwait City, Kuwait“Learning the most recent techniques and sharing of different knowledge with different co-workers was aneffective aspect of this course.”

Priya Mehta, MBBS, DGOFaridabad, India“The module has the scope to give more time in areas which the trainee finds tough, so the course is flexible according to one’s needs. The complete hands on experience is like no place else.”

Dharmaraj Palanisamy, MS, DNBTamil Nadu, India“Step by step procedure in ICSI and hands-on training that can never be forgotten. All teaching staff had the patience to teach head to toe within the stipulated period.”

Read Additional Evaluations

Beatriz Jimenez Vanegas, MScTexas, USA“For me to switch from animal to human ICSI was an important step. Also the use of vitrification, as animal IVF uses more slow freezing. This course is a plus for me in this learning process and will help me in the future for my PhD.”

2014

2015 2013

Feedback by our ART Training Alumni

Satya Baalasundaram, MVSc India, 2013“I liked the one to one, hands on experience and having been given more time to learn better. Also the lectures/presentations prior to training were very helpful.”

Johnkennedy Anyanwu, PhDTexas, USA, 2013“The one-on-one training was excellent and knowledgeable – I never felt hurried.”

Sreedhar Kammela, MDIndia, 2013“There was strict punctuality throughout the course. I received a thorough update of scientific knowledge and an orientation to research.”

Cleveland Clinic American Center for Reproductive Medicine | 5Learn more about our ART Training Program

Sridevi Kammela, MDIndia, 2013“Trainers gave personalized commitment that benefited each candidate. Attention was also given to every detail.”

Krishnan Kanniah, BSc Malaysia, 2013“There is a systematic training program for each day. The review process every morning about what we learnt the day before – brings about good explanation and discussion. Trainers were willing to answer questions and provide excellent explanation.”

Rizwan Malik, MDIndiana, USA, 2013“Lectures are excellentand informative. Great course, superb experience. Faculty and staff are very caring. Course was very well organized.”

Lillian Parzianello, BScBrazil, 2013“I had exclusive attention from the trainers; they were able to explain the procedures because they have many years of experience in their own labs. Training is provided by experts in IVF/Andrology that have published in the best journals. It was great to receive the best and complete textbook on ART, i.e. the ART-Practical Manual of IVF.”

Kannappan Palaniappan, MDMalaysia, 2013“Personalized guidance in teaching and in lab preparation. A well-structured course; very

comprehensive.”

Kristina Staab, BScPennsylvania, USA, 2013“I was able to ask questions at any time and get immediate feedback.”

Gözde Köksal, MScTurkey, 2012“Excellent training with lots of opportunity for hands on work.”

Swetha Thumula, MDIndia, 2013“The hands on and one-to-one training is unique. The course is well organized and caters to what you want to learn. The feedback session everyday is excellent and gives you more confidence.”

Mahipal Singh, PhDAtlanta, USA, 2013“I commend the personal commitment of the staff and I enjoyed the home-like environment in the lab.”

Malathy Shanmugam, MBBS, DGOIndia, 2013“I was taught all about the basics of handling a microscope, micromanipulators, laser optical system etc. I also learnt to do ICSI confidently.”

Reem Taha, BScJordan, 2012“The hands on experience for me was the most effective because it provided me with practice and taught new techniques that I had never seen before.”

Sweta Tiwari, MDIndia, 2012“The one on one training for ART was excellent. The trainer taught the steps patiently and provided me with complete understanding of the protocols.”

Liliana-Aura Chitu, PhDRomania, 2012“As a result of the training provided at Cleveland Clinic, I was able to masterthe skills and achievedexterity in ART techniques.”

2013

2012

2011Raffaele DinardoItaly, 2011“Everything was amazing, especially the skills and patience of the trainers.”

Marisabel Hernandez, BScVenezuela, 2011“The most effective part for me was the hands on training. The equipment was in perfect condition, the lectures are in tune with the practices and the staff are very helpful. I think I improved exponentially and was able to see my own this progress.”

Bianca Kreuscher, MSBrazil, 2011“The course was extremely important, because Ilearned new things that I can use immediately. The best of all was having the opportunity to relate to important people and make new contacts. It was more than I expected.”

Feedback by our ART Training Alumni

Helena Malvezzi, MSBrazil, 2011“I learned many new things and had the chance to meet and work with interesting people from all over the world.”

ACRM Staff and Fellows with the ART Trainer and Trainees, ACRM, Sept 2012

Kelly J Porter, HTL (ASCP)New Jersey, USA, 2010“Overall this was a great course with a tremendous amount of material. After spending a week at Cleveland Clinic, I have a much greater understanding of semen analysis and feel confident I will be able to introduce this testing to my facility. This week has also given me a greater sense of appreciation for Andrology in general.”

Canan Aslan, MScTurkey, 2010“Adequate hands on practice helped me master the techniques.”

2010

Christopher Danga, BSNigeria, 2009“Hands on training - I was given the opportunity to participate in cell biopsy and fixation, and advanced sperm function tests - everything was NEW!”

Carolina Sellito, PhDItaly, 2010“I would recommend the ART Training at the Cleveland Clinic to anyone who is looking to receive world class, hands on training in ART. The knowledge and friendships that I have brought back to Italy will be of immense significance to me for many years to come.”

2009

Romil Stanislavov, PhDBulgaria, 2009“The presentation and demonstration of the methods (are) in detail. Appropriate time (given) for discussion and questions.”

Gulnara Utepova, MDKazakhstan, 2009“Friendly staff. New information. Excellent overall course management and facility (is) conducive to learning.”

6 | Cleveland Clinic American Center for Reproductive Medicine Learn more about our ART Training Program

Read Additional Evaluations

Saranda Murtezaj, BScKosovo, 2013“I enjoyed the many different ways of learning techniques from the trainers - this is different from what I am used to.”

Rifat Morina, PhDKosovo, 2013“The equipment and the possibility to learn new techniques were good. The possibility to get answers for every question regarding the course was perfect.”

Mary Robert, MBBS, MD, DGOUnited Arab Emirates, 2004“The impossible being made possible! I benefited immensely from the precise manner by which the techniques were made simple. I am now able to perform the technique independently and with confidence.”

Troy Anhalt, BSWisconsin, USA, 2005“I enjoyed my time here. The staff were wonderful and I am exited to take this information back to my lab.”

Andrea Mustata, MDRomania, 2007“Hands-on-training techniques were very well organized. Very dedicated trainers who were patient and helpful. Excellent ART training.”

Lina Garcia, MTCPPuerto Rico, 2008“The experience was great. Everybody was very professional and willing to help me at all moments. I felt very happy about choosing this program and I will come back if I decide to expand.”

Pratima Sekhar, MDIndia, 2006 “It was a great experience being in such a huge IVF lab with the best of the infrastructure and technical personnel.”

Desta Gelagay, BS (ASCP)California, USA, 2008“The course has met every expectation that I had made for the class. The class was a ton of fun, but very intellectually challenging at the same time. I was able to learn a great deal of information that will help in my current job. The experience has motivated me to work harder.”

Luis A Murrain Jr, DONew York, USA, 2008“The one to one interaction with the instructors allowed the trainee to focus on the areas they feel they need to work on the most while meeting the course objectives. Helpful critique of technique and common pitfalls to avoid. This is an excellent training course for those seeking to learn new skills or refine their technique. The strong emphasis on research ensures the trainee will be up to date on current literature and treatment protocol.”

Amanda Setti, BSBrazil, 2007“I have learned everything I wanted to mainly because of the trainer’s knowledge and patience in teaching.”

Harry Beauvais, MDHaiti, 2007“The accessibility of the trainers to provide assistance and share their great experience was very valuable.”

Karuna Sharma, MDSaudi Arabia, 2006“The faculty members are very encouraging and they were boosting your morale all the time.”

Samina Naeem Khalid, MDPakistan, 2006“I liked the collaboration of researchers from all over the world – it gave me the opportunity to learn more.”

Chris Agboghoroma, MDNigeria, 2007“Very conducive atmosphere to learning.”

Pamela Herbst, MTFlorida, USA, 2005“This was a refresher course for me, so the hands on time was very valuable.”

Feedback by our ART Training Alumni

2008 2006

2005

2004

2007

Cleveland Clinic’s American Center for Reproductive MedicineHands on Training in Assisted Reproductive TechnologyFor more info, contact Dr. Ashok AgarwalDirector of ART Trainingagarwaa@ccf.org, +1.216.444.9485http://www.clevelandclinic.org/reproductiveresearchcenter/artmain.html

ACRM Staff and Fellows with ART Trainer and Trainees, Andrology Clinical Laboratory, Sept 2011

Cleveland Clinic American Center for Reproductive Medicine | 7Learn more about our ART Training Program

Read Additional Evaluations

Training in Scientific Writing - Module 9 (120 hours)

Develop fundamental skills set necessary for you to write high quality scientific articles from start to completion:

• Conduct a systematic literature search and scientific review of identified articles

• Select the relevant articles and present significant findings from these reviewed articles

• Develop an outline of the proposed article

• Develop a strategy for scientific writing

• Edit, revise and finalize the manuscript for submission to a journal

Training in Bench Research - Module 10 (160 hours)

Develop fundamental skills necessary to conduct high quality scientific experiments in your laboratory:

• Design and develop a bench research project

• Conduct research by application of the relevant experimental techniques

• Acquire skills necessary for data analysis

• Develop the ability to present and write the research data in a methodical, scientifically and statistically sound manner

• Acquire skills to write a scientific report based on the outcomes of the research conducted

NEW in 2017Other Training Modules at ACRM

For more information, please contact

The Cleveland Clinic’s American Center Center for Reproductive Medicine gives you a unique opportunity to:• Receive mentoring by world-renowned faculty in medicine and health sciences• Participate in meaningful, real-time bench research experience• Engage in intensive training in scientific writing• Publish research articles in prestigious medical journals• Listen to captivating lectures delivered by a team of reputed scientists and physicians

To learn more about our Summer Internship Course, including program faculty, internship syllabus, daily schedule, complete project listing, internship awards, pictures of interns’ presentations, reception banquet, multimedia feedback, and accommodation options, please visit our 2016 Summer Mentorship webpage.

Gain priceless research experience under the guidance of world-renowned experts in

reproductive medicine, male fertility, and women’s health

at the Cleveland Clinic

Faculty

Program Director Coordinators Consultants

Ashok Agarwal, PhDProfessor, Lerner College of MedicineDirector, American Center for Reproductive MedicineDirector, Andrology CenterDepartment of UrologyCleveland Clinic

Rakesh Sharma, PhDAssociate Professor,Department of UrologyResearch Coordinator, American Center for Reproductive MedicineCleveland Clinic

Sajal Gupta, MDAssistant Professor,Department of UrologyAssistant Research Coordinator, American Center for Reproductive MedicineCleveland Clinic

Sijo Parekattil, MDCo-Director of Personalized Urology and Robotics ClinicSouth Lake Hospital and Orlando HealthClermont, Florida

Botros Rizk, MDProfessor of Ob-Gyn Reprod Endocrinol & InfertilityUniversity of South AlabamaMobile, Alabama

The American Center for Reproductive MedicineThe American Center for Reproductive Medicine (ACRM) is a part of the Glickman Urological and Kidney Institute of the Cleveland Clinic. The Department of Urology is ranked as the No. 2 Urology program in the nation by U.S.News & World Report.

The American Center for Reproductive Medicine enjoys an international reputation for excellence and innovation in cutting edge research in human infertility. It is being ranked as #1 Research Program in the world due to the largest number of peer reviewed high quality publications, citations and international collaboration. Research papers from the Center staff are selected regularly for publication in distinguished medical journals. The Center’s website has been ranked No. 1 for research in reproductive medicine and andrology since 2001 by all top five international search engines, including Google, Bing, Yahoo! and Ask.com. It has attracted over 968,000 visitors from all over the world.

More than 1,000 physicians and scientists from more than 55 countries have received their training at the American Center for Reproductive Medicine during the past 24 years. Nearly 200 students in majors ranging from biology to English to the musical arts have participated in summer internships at our Center.

For additional information on internship staff, please visit our faculty page.

For more information, please contact

· Ce

nter

for R

eproductive Medicine ·

Cleveland Clinic

Be a part of theCleveland Clinic’s American Center

for Reproductive Medicine2017 Summer Internship

June 12 to July 28, 2017The 10th Annual Summer Mentorship Course in

“Reproductive Medicine and Research”

Ralf Henkel, PhDProfessor

University of Western Cape, South Africa

Suresh Sikka, PhD, HCLDProfessor of Urology

Tulane University, New Orleans, LA

Hassan Sallam, MD, PhDProfessor of Ob-Gyn

Alexandria University, Egypt

Dolores Lamb, PHD, HCLDProfessor

Baylor College of Medicine, Houston, TX

Sijo Parekattil, MDCo-Director of PUR Clinic

Clermont, FL

Ramadan Saleh, MDProfessor, Faculty of Medicine

Sohag University, Egypt

Cleveland ClinicAmerican Center for Reproductive MedicineMail Code X-1110681 Carnegie AvenueCleveland, OH 44195, USPhone: 216.444.9485Fax: 216.445.6049Email: crm@ccf.org

Amer

ican

Center for Reproductive Medicine

Centrum Excellentiae Est.

1993

Amer

ican

Center for Reproductive Medicine

Centrum Excellentiae Est.

1993

Amer

ican

Center for Reproductive Medicine

Centrum Excellentiae Est.

1993

2017Make this a summer to remember! 10 Celebrating a decade

of EXCELLENCE! YEARS

Research Fellowship in

Human Reproduction and Male Infertility

Our Research Fellowship and training opportunities represent one of the most active, state-of-the-art and comprehensive programs in human reproduction and infertility in the United States.

Our Fellows gain priceless research experience under the strong mentorship of world-renowned experts in reproductive medicine and biology at our Center in the Cleveland Clinic.

Amer

ican

Center for Reproductive Medicine

Centrum Excellentiae Est.

1993

Scientific Presentation Day, 2016 Summer Internship, Lerner Research Institute

For more information, please contact:

American Center for Reproductive Medicine and the Andrology CenterCleveland Clinic, X-1110681 Carnegie AvenueCleveland OH 44195, United StatesTel: +1.216.444.9485Toll-Free: 1.800.CCF.CARE (ext. 4-9485)Fax: +1.216.445.6049Email: CRM@CCF.ORGhttp://www.ClevelandClinic.org/ReproductiveResearchCenter

Table of ContentsOur Mission 2Testimonials 3 – 4Application 3Who We Are 4Books Published 5Research Collaborators 6, 9, 10Research Overview 7 – 15Publications 9 – 15Recent Research Alumni 16 – 17Fulbright Research Scholars 18About Our Center 19 – 20Research Alumni 21 – 22 About ACRM 23About Cleveland 24

American Center for Reproductive Medicine

Amer

ican

Center for Reproductive Medicine

Centrum Excellentiae Est.

1993

Ranked One of America’s Top 4 Hospitals

Hands on Training in Assisted Reproductive Technology

ART Trainees 2004 - 2016

American Center for Reproductive Medicine

Abu Dhabi

Austria

Bahrain

Brazil

Canada

Cayman Islands

Chile

China

Colombia

Croatia

Czech Republic

Egypt

Greece

Guyana

Hong Kong

India

Iraq

Israel

Italy

Jamaica

Japan

Jordan

Kazakhstan

Korea

Kosovo

Kuwait

Lebanon

Malaysia

Mexico

Nigeria

Pakistan

Peru

Philippines

Qatar

Romania

Saudi Arabia

Serbia

Slovak Republic

South Africa

Spain

Syria

Turkey

UAE

USA

Venezuela

20042005

2008

2009

2006

2007

Eman Geneidi

Amanda Setti

Aline Souza

Anwar Al Harban

Gita Khanna

Carmen Mirzan

Betty John

Lina Garcia

Asifa Ehsani

Fu Nan Wang

Lidia de Oliveira

Anna Frusch

Mary Roberts

Xueyu Xiang

Harry Beauvais

Daniel de Matos Darlaine Dorval Gabriela Parise

Madhuma ShilaharLuis Murrain Jr.

Rizwan Malik

Christopher Danga

Harjot Kaur Chahlal

Andreea Mustata

Luciana Lopes

Desta Gelagay

Nilofer Poonawala

Gulnara Utepova

Pamela Herbst

Angelica Zuccolotto

Nirmala Agarwal

Franciele Lunardi

Nitin Lad

Leila Chalova

Arozia Moazzam

Ayodele Benson

Preethi Abraham

Heloisa Lavorato

Shital Punjabi

Karuna Sharma

Barbara Scheetz

Vaishali Kale

Israel Maldonado

SunithaSoundarapandian

Madhu Singh

Bruna Barros

Wirla Munhoz

Jaime Mendiola-Olivares

Surveen Sindhu

Pratima Sekhar

Carla Silva

Pallavi Khanna

Hullamani Puttapa

Jessica Torres

Wirla Munhoz

Sameera Madan

Chris Agoboghoroma

Amit Gupta

Kiran Bijlani

Samina Khalid

ChristinaAnagnostopoulou

Ana Paula Porto

Lakshmi Prasuna

Amanda Alvarez Eva Hernandez Mohamed Hajjo

Ahmed Mansour Anna Chockalingam

Farid Keyvanifarid

Gilbertha Angela Alexander

Harshita Ramamurthy

Israel Maldonado Rosas

Joshua Allen Pecenica

Maria Juliana Salamanca Ortiz

Mohamed Abouhalawa

Sara Tanwir Ahmed

2016

2012

2013

2014

2015

Caroline Lapa

Krishnan Kanniah

Arun Muthuvel David Guerra

Vincent Oziga

Amani Shaman

Kannappan Palaniappan

Zahraa Alyahaei

Sezgin Gunes

DamaDurairajanayagam Gozde Koksal Mariana De Mello

Kristina Staab Lilian Parzianello

Rifat Morina

Abdullahi Ahmed

Zainab Shilbayeh Avraham Harlev

Julian Trejos

Mahipal Singh

Ashlie Sadler

Simon du Plessis

Priya Mehta

Liliana-Aura Chitu

Malathy Shan-mugam

Beatriz Vanegas

Rian Salasin

Jason Krumholtz Aimee Parker

Reem Taha

Rizwan Malik

Dharmaraj Palanisamy

Abdullah Najmi

Osama Abdalmageed

Shubhadeep Roychoudhury

Rogerio de Souza

Saranda Murtezaj

Efiok Efiok

Bindu Garg

Sarat Sajja

Saad Alshahrani

SatyaBaalasundaram

Godwin Akhabhoa

Gulfam Ahmad

Stella Antinori

Sreedhar Kammela

Heidi Price

Shweta Patki

Jeanne Ricci

Sridevi Kammela

Ini Etukudo

Ibrahim Alogaili

Addeli Angulski

Johnkennedy Anyanwu

Swetha Thumula

Mai Al-Qattan

Shazia Magray

2011

Carolina Sellitto Janis Roman

Kelly Porter Lisa Fradl Midna Torres Shilla Chakrabarty Susana CordobaMarilia Pieretti Ana Nogueira Ashish Kale

Bruna Selbach

Bianca Kreuscher

Debora Rangel Helena Malvezzi Laura Vellez MarisabelHernandez Raffaele Dinardo Saad Al-DujailyMoisa Pedrosa

2010

Canan AslanAijaz AnjumNataliya

Savateyeva Rajul Tyagi Romil Stanislavov Sarita Oberoi Vessela Nikolova

Thais Walverde SiqueiraShweta Gupta

Academic Activities

Antioxidants in Male Infertility: A Guide for Clinicians and Researchers

Sijo Parekattil, Ashok Agarwal (Editors)Publication Date: November 2013

Table of Contents

Andrological Evaluation of Male Infertility: A Laboratory Guide

Ashok Agarwal, Sajal Gupta, Rakesh Sharma (Editors)Publication Date: 2016

Table of Contents

Unexplained InfertilityGlenn L. Schattman, Sandro C. Esteves,

Ashok Agarwal (Editors)Publication Date: 2015

Table of Contents

Exercise and Human Reproduction: Induced Fertility Disorders and Possible Therapies

Diana Vaamonde, Stefan S. du Plessis, Ashok Agarwal

Publication Date: 2016Table of Contents

Non-Invasive Sperm Selection for In Vitro Fertilization: Novel Concepts and Methods

Ashok Agarwal, Edson Borges Jr., Amanda S. Setti (Editors)Publication Date: 2015

Table of Contents

Puberty: Physiology and AbnormalitiesPhilip Kumanov, Ashok Agarwal (Editors)

Publication Date: 2016Table of Contents

Male Infertility: A Complete Guide to Lifestyle and Environmental Factors

Stefan S. du Plessis, Ashok Agarwal, Edmund S. Sabanegh Jr. (Editors)

Publication Date: 2014Table of Contents

Recurrent Pregnancy Loss: Evidence-Based Evaluation, Diagnosis and Treatment

Asher Bashiri, Avi Harlev, Ashok Agarwal (Editors)Publication Date: 2016

Table of Contents

Strategies to Ameliorate Oxidative Stress During Assisted Reproduction

Ashok Agarwal, Damayanthi Durairajanayagam,Gurpriya Virk, G., Stefan Du Plessis (Editors)

Publication Date: 2015Table of Contents

Understanding Male Infertility Global Practices and Indian Perspective

Sonia Malik, Ashok Agarwal (Editors)Publication Date: 2014

Table of Contents

Building and Managing an IVFLaboratory: A Practical Guide

Zsolt Peter Nagy,Alex C. Varghese, Ashok Agarwal (Editors)

Publication Date: October 2013Table of Contents

Clinical Embryology: A Practical GuideZsolt Peter Nagy,

Alex C. Varghese, Ashok Agarwal (Editors)Publication Date: October 2013

Table of Contents

Gamete Assessment, Selection and Micromanipulation in ART

Zsolt Peter Nagy,Alex C. Varghese, Ashok Agarwal (Editors)

Publication Date: October 2013Table of Contents

Male Infertility for the Clinician:A Practical Guide

Sijo J. Parekattil, Ashok Agarwal (Editors)Publication Date: August 2013

Table of Contents

Medical and Surgical Managementof Male Infertility

Botros RMB Rizk, Nabil Aziz, Ashok Agarwal, Edmund Sabanegh (Editors)

Publication Date: September 2013 Table of Contents

Sperm Chromatin for the Researcher: A Practical Guide

Armand Zini, Ashok Agarwal (Editors)Publication Date: September 2013

Table of Contents

Male Infertility: Contemporary Clinical Approaches, Andrology, ART

& AntioxidantsSijo J. Parekattil, Ashok Agarwal (Editors)

Publication Date: June 7, 2012Table of Contents

Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices

Zsolt Peter Nagy, Alex C. Varghese,Ashok Agarwal (Editors)

Publication Date: April 24, 2012Table of Contents

Studies on Men’s Health and Fertility (Oxidative Stress in Applied Basic Research and Clinical Practice)

Ashok Agarwal, Robert John Aitken,Juan G. Alvarez (Editors)

Publication Date: March 17, 2012Table of Contents

A Workbook on Human Spermatozoa and Assisted Conception

Sonia Malik, Ashok Agarwal (Editors)Publication Date: February 2012

Table of Contents

Fertility Preservation: Emerging Technologies and Clinical Applications

Emre Seli, Ashok Agarwal (Editors)Publication Date: September 23, 2011

Table of Contents

Sperm Chromatin: Biological and Clinical Applications in Male Infertility

and Assisted ReproductionArmand Zini, Ashok Agarwal (Editors)

Publication Date: August 4, 2011Table of Contents

Andrology Laboratory ManualKamini A. Rao, Ashok Agarwal,

MS Srinivas (Editors)Publication Date: February 10, 2010

Table of Contents

Fertility Preservation in Males: Emerging Technologies and

Clinical ApplicationsEmre Seli, Ashok Agarwal (Editors)Publication Date: October 5, 2012

Table of Contents

Fertility Preservation in Females: Emerging Technologies and

Clinical ApplicationsEmre Seli, Ashok Agarwal (Editors)Publication Date: October 5, 2012

Table of Contents

Varicocele and Male Infertility: Current Concepts, Controversies and ConsensusAlaa Hamada, Sandro C. Esteves, Ashok Agarwal

Publication Date: 2016Table of Contents

Studies on Women’s Health(Oxidative Stress in Applied Basic Research and Clinical Practice)

Ashok Agarwal, Nabil Aziz, Botros Rizk (Editors)

Publication Date: August 1, 2012Table of Contents

Endometriosis: A Comprehensive UpdateSajal Gupta, Avi Harlev, Ashok Agarwal

Publication Date: 2015Table of Contents

Quality Management in ART Clinics: A Practical Guide

Fabiola Bento, Sandro Esteves,Ashok Agarwal (Editors)

Publication Date: November 13, 2012Table of Contents

Sperm Chromatin for the Clinician: A Practical Guide

Armand Zini, Ashok Agarwal (Editors)Publication Date: August 2013

Table of Contents

BOOKS PUBLISHED

Cleveland Clinic American Center for Reproductive Medicine | 11Learn more about our ART Training Program

12 | Cleveland Clinic American Center for Reproductive Medicine Learn more about our ART Training Program

” ” ”

”The spermatozoa and oocyte represent the personalized,

hands-on ART training course offered annually since 2003

and the opportunity to learn the latest techniques in the fast

changing subspecialty of Assisted Reproduction at

one of the world’s premier ART Training Centers.

175 candidates from more than 32 countries

have participated in this course.

The open book and beaker represent the

Summer Internship program, offered annually

since 2008. Nearly 200 interns have experienced

bench research and scientific writing under the

personalized mentorship of scientists/physicians and

reproductive biologists worldwide.

The DNA strand represents the essence of the research

fellowship in human reproduction, andrology and male

infertility, offered at the ACRM since 1993. More than 500

scientists/physicians from over 50 countries have

trained at the ACRM. The Center is currently focusing

on the use of proteomics and bioinformatics to

elucidate biomarkers of male infertility.

The microscope and a hand holding the test tube represent the routine and advanced

diagnostic testing offered to infertility patients

at the Andrology Center and Reproductive Tissue

Bank, one of the largest state-of-the-art facilities in

the country. Our staff has more than 3 decades of experience

in assisting patients with male infertility.

American Center for Reproductive Medicine(ACRM)

Our Story

our vision our mission our values

“

“

“ “Am

eric

an Center for Reproductive Medicine

Centrum Excellentiae Est.

1993

To be a premier center for researchers interested in human reproduction, providing them individualized mentoring and high quality training opportunities that lead to technical, analytical, and intellectual expertise in the field.

We believe in integrity, excellence, innovation, accountability, commitment, perseverance, teamwork and collaboration.

To conduct cutting-edge research in human reproduction, as well as the causes of infertility, and to train physicians and scientists to advance the understanding of reproductive sciences.

Founded in 1993, the ACRM offers research fellowships, hands-on training in human assisted reproduction, and summer mentorship opportunities. We also offer diagnostic & therapeutic services for infertile couples and cancer patients. In the past 24 years, more than 1,000 scientists, physicians, researchers, reproductive medicine professionals and students from all over the world have trained at our Center.

About

Cleveland Clinic’s Glickman Urological and Kidney Institute is recognized worldwide for excellence in patient care, teaching and research. It merges Cleveland Clinic’s urology and nephrology programs. Urology and nephrology physicians and scientists at Cleveland Clinic are recognized worldwide for excellence in patient care, teaching and research. This year, U.S. News & World Report ranked our urology program No. 2 and our kidney disease program No. 2 in the nation.Please visit us at: clevelandclinic.org/services/urology-kidney/about-urology-nephrology

About Cleveland ClinicCleveland Clinic is ranked as one of America’s Top 2 Hospitals by U.S. News & World Report. Located in Cleveland, Ohio, Cleveland Clinic is a nonprofit, multispecialty academic medical center that integrates clinical and hospital care with research and education. Founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation, it is the second largest group practice in the world with 3,432 physicians and scientists practicing and researching in more than 130 medical specialities. Today with more than 1400 beds on the Cleveland Clinic main campus and 4,450 beds system-wide, Cleveland Clinic is one of the largest and most respected hospitals in the country.

In addition, the main hospital campus, located near downtown Cleveland, occupies 167 acres and 44 buildings. It includes a hospital, an outpatient clinic, a children’s hospital, cancer institute, eye institute, research institute, a medical school and supporting labs and facilities. The Cleveland Clinic operates nine regional hospitals, a children’s hospital, and 18 full-service family health centers in Ohio, as well as hospitals in Florida, Las Vegas, Canada, and Abu Dhabi, employing more than 49,000 individuals and providing global world class medical care. Last year alone, 6.62 million patients from 150 countries and all 50 states received their care at the Cleveland Clinic.

Our locations are linked by health information technology and critical care transport, getting patients to the right facility, at the right time, for the right care. Cleveland Clinic is organized into patient-centered institutes based on single diseases or organ systems. Each institute combines medical and surgical services at the same location under the same leadership to improve patient care and experience. Each institute is required to establish benchmarks and measure and improve quality. Institutes are also required to publish annual outcomes books showing volumes, results, innovations, publications and other information relevant to patients and referring physicians. Cleveland Clinic integrates its far-flung system with an extensive electronic medical records system. This system includes participating community physicians and patients, who are able to access test results and portions of their medical record remotely via the Internet. Cleveland Clinic’s model of medicine has made it possible for us to achieve cost savings on a vast scale over the past several years. Our mantra is “Patients First.” Our motto is “To Act as a Unit.” Our goal is to give every patient the best outcome and experience. That’s the Cleveland Clinic way.Visit: clevelandclinic.org

Cleveland Clinic American Center for Reproductive Medicine | 13Learn more about our ART Training Program

Andrology Center StaffDr. Ashok Agarwal, Ph.D., HCLD | Director

Dr. Ashok Agarwal, PhD, HCLD, is the Director of the Andrology Center and Reproductive Tissue Bank and the Director of Research at the American Center for Reproductive Medicine. He is a Staff member in the Glickman Urological and Kidney Institute, Obstetrics-Gynecology and Women’s Health Institute, Anatomic Pathology, and Immunology. Dr. Agarwal is also on the faculty of the Cleveland State University.

Dr. Agarwal is a board-certified Clinical Laboratory Director in Andrology by the American Board of Bioanalysisand an Inspector for the College of American Pathologists “Reproductive Laboratory Program” for accreditationof Andrology & IVF Laboratories. He served as the Chairman of the Board of the American College of Embryology from 2009 to 2012. He was the recipient of a 2011 Innovator Award for the development of “Remote Sperm Banking Kits” from Cleveland Clinic Innovations and a recipient of 2011 to 2016 Star Awards from the American Society for Reproductive Medicine. Dr. Agarwal received the 2011 and 2013 “Scholarship in Teaching Award” for his innovative Summer Internship Course and the 2013 Teaching Award for the Training Program in Advanced Reproductive Techniques from the Case Western Reserve University School of Medicine. Dr. Agarwal has published over 550 scientific papers and review articles in peer-reviewed scientific journals, authored over 150 book chapters, and presented over 750 papers at both national and international scientific meetings. Dr. Agarwal is the recipient of about 100 research grants. His current research interests are in identifying biological markers of oxidative stress, DNA damage and apoptosis using proteomic research tools and bioinformatics analysis as well as preserving fertility in patients with cancer. Dr. Agarwal is actively involved in laboratory and clinical studies assessing the efficacy of certain antioxidants in improving the fertility of male patients.

Dr. Rakesh Sharma, Ph.D. | Coordinator

Dr. Sharma is an Associate Professor at the Lerner College of Medicine of Case Western Reserve University andserves as the Coordinator of the Andrology Center and the American Center Center for Reproductive Medicine.

Dr. Sharma received his Ph.D. degree from Panjab University, Chandigarh, India. He completed his postdoctoral training at the Cleveland Clinic. Dr. Sharma has published over 200 scientific papers and 25 reviews in peer-reviewed scientific journals, authored two dozen book chapters and presented 400 abstracts at both national and international scientific meetings. He is a member of several professional societies. Dr. Sharma is an investigator on 60 research grants. He is the recipient of the Cleveland Clinic Innovator Award, the 2011 and 2013 Scholarship in Teaching (SIT) Award from the CASE Medical School for his innovative Summer Internship Course and the 2012-2016 Star Award from the American Society for Reproductive Medicine.

His current research interests include the role of free radicals in the pathophysiology of male and femaleinfertility, oxidative stress and DNA integrity, alterations in oxidative stress-related proteins, sperm proteomicsapoptosis, and fertility preservation.

Dr. Sajal Gupta, MD | Supervisor

Dr. Gupta holds the position of Assistant Professor at the Lerner College of Medicine of Case Western ReserveUniversity and Project Staff in the Glickman Urological Institute and has served as the Assistant Coordinator ofResearch at the American Center for Reproductive Medicine since 2006. Dr. Gupta is the Technical Supervisor of the Andrology Center since 2008. She has done her residency in Obstetrics and Gynecology from University of Delhi. Sajal has received “Dr. Tommaso Falcone Award for Excellence in Female Infertility and Women’s Health Research” and the 2011 and 2013 Scholarship in Teaching Award from the Case Western Reserve Medical School.

Dr. Gupta has published over 50 articles in peer-reviewed scientific journals, authored a dozen book chapters, and has presented over 50 abstracts at both national and international scientific meetings. She is a member of several professional societies. Dr. Gupta is an investigator on over 18 research grants. Her current research interests include the role of free radicals in male and female infertility, endometriosis, assisted reproductive techniques and gamete cryobiology.

14 | Cleveland Clinic American Center for Reproductive Medicine Learn more about our ART Training Program

For more information about Cleveland, visit these resources:About Cleveland, Cleveland.com, Cleveland, The New American City, Positively Cleveland, Travel Cleveland, and Discover Ohio.

Cleveland is the second largest city in the state of Ohio, after Cincinnati. Located on the southern shores of Lake Erie, Cleveland lies at the outflow of the Cuyahoga River into Lake Erie. The main campus of Cleveland Clinic is situated 5 miles east of downtown Cleveland. Case Western Reserve University and University Hospitals are within one mile of Cleveland Clinic. Cleveland State University and John Carroll University are also within a short distance of the Cleveland Clinic main campus. Nearby the Cleveland Clinic is University Circle, which serves as the cultural, medical and education center of Cleveland and Northeast Ohio. Medical research in the University Circle institutions places Cleveland as one of the major medical research environments in the country.

University Circle is also the home to the Cleveland Museum of Art, the Cleveland Institute of Music, the Cleveland Institute of Art, and the Museum of Natural History. The Cleveland Museum of Art houses one of the country’s most highly acclaimed art collections. The world-famous Cleveland Orchestra, performs regularly in the elegant Severance Hall. Playhouse Square is the home to several large theaters that host traveling Broadway plays and various other performances.

The University Circle area is walking distance from Cleveland’s historic Little Italy with its brick streets, a quaint and charming area of intimate Italian restaurants, antique and craft shops, and art galleries. The Coventry Village area is close to the Clinic’s main campus and popular with its shops and restaurants.

Cleveland hosts the Rock and Roll Hall of Fame and Museum, and the Great Lakes Science Center. Outdoor enthusiasts of all ages enjoy the ‘Emerald Necklace’, the Cleveland Metroparks network of parks that encircles the city, which offer a variety of recreational opportunities. When it comes to professional sports, Cleveland is the proud home to the Browns football, Cavaliers basketball, Indians baseball and Lake Erie Monsters hockey teams respectively. As the Great Lakes city on America’s North Coast, Cleveland offers abundant lakeshore for different activities.

Cleveland and its surrounding suburbs are home to nearly 3 million residents. A vibrant and versatile metropolitan area, Cleveland has nearly 80 residential communities. Fine residential areas are located within minutes of the Cleveland Clinic campus. Recognized as one of the best places to live and visit, Cleveland and North-East Ohio is bustling with exciting things to do for people of all ages.

Art Museum Duck Pond in Spring Cleveland skyline in Summer Autumn in the Park Lake Erie in Winter

Cleveland — a great place to call HOME!

Rock and Roll Hall of Fame

State Theater Playhouse Square Beachwood Place Mall

Cuyahoga Valley National Park Edgewater Park

Browns Stadium

Cleveland Clinic American Center for Reproductive Medicine | 15Learn more about our ART Training Program

This state-of-the-art laboratory manual contains protocols that can be used daily in the investigation of male infertility. In its 24 chapters, the book covers most of the common routine and advanced testing that is available at the present time. This text is unique in its emphasis in presenting test protocols in detail that allow immediate use in a clinical laboratory setting. It has a number of hand-drawn, artistic presentations of key equipment and procedures which add to the clarity. At the beginning of the text, information is presented to place clinical aspects of male infertility in context of the role of semen testing.

Drs Agarwal, Gupta, and Sharma combine their over 50 years of experience in running a state-of-the-art clinical andrology laboratory to provide an indispensable resource for thousands of clinicians, reproductive professionals (andrologists, embryologists), laboratory technicians, as well as other students of andrology lab testing. This experienced team has authored dozens of texts related to all aspects of male fertility. Their current book is a one of a kind work—a must-read for all with an interest in providing the highest quality and most accurate andrology testing for their patients.

Edmund Sabanegh, Jr., MD Chairman, Department of Urology | The Cleveland Clinic | USA

This state-of-the-art laboratory manual includes 20 clinical protocols used daily for the investigation of the infertile male, presented with easy to understand, step-by-step methodology. The protocols are arranged from routine to advanced laboratory procedures common to clinical practice, including computer-assisted semen analysis, sperm preparation for IUI by density gradient and swim-up, sperm cryopreservation, and sperm DNA fragmentation test by TUNEL method, among others. The methodology in each protocol follows best practice guidelines made clearer by professionally hand-drawn illustrations covering most of the important steps and equipment. The authors, hailing from the world-renowned Andrology Center at Cleveland Clinic, have over 50 years of combined first-hand experience in managing very busy diagnostic and research facilities in male infertility and andrology. The book will be an indispensable resource for thousands of laboratory technologists, clinicians and reproductive professionals (andrologists, embryologist, etc.) engaged in the diagnosis and management of infertile men around the world.

Foreword

16 | Cleveland Clinic American Center for Reproductive Medicine Learn more about our ART Training Program

CopyrightAndrology Center, Cleveland Clinic, 10681 Carnegie Avenue, Cleveland, Ohio 44106, USA; CRM@CCF.ORG

Editor: Ashok Agarwal | Graphics/Design: Bernastine BuchananFirst edition: Jun 3, 2014

Second edition: Jan 3, 2017