00 k. van liempt faculty of medicine the university of antwerp faculty of medicine university...
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K. Van Liempt
Faculty of Medicine
The University of AntwerpThe University of AntwerpFaculty of MedicineFaculty of Medicine
University Hospital AntwerpUniversity Hospital Antwerp
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The Antwerp Region
• 470.000 people in the City of Antwerp• Most important economic region in Flanders• Strong economic assets:
- Port of Antwerp 2nd largest in Europe; 4th world-wide- Largest cluster of petrochemical industry in the world- Diamond trade- Logistics
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The University of Antwerp
• Founded in 2003 upon the merger of three independent University Institutions
• Roots dating back to 1852
UIA
RUCA UFSIA
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The University of Antwerp in Flanders
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The University of Antwerp in the World
• University Rankings- QS World University ranking : 179
worldwide- ARWU (“Shanghai”) : 201-300 worldwide
• Consistently in the top 250 worldwide
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Facts and Figures
• Main partner in the Antwerp University Association- 1 university (UA)- 4 university colleges
• 30 000 students in total• 400 FTE UA-faculty staff• 1200 UA-research staff• 1100 UA-PhD students
• Around 3500 scientific works published/year- 1500 articles in Web of Science/year
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Organisational Structure
Natural SciencesNatural Sciences
SciencesSciences
Humanities and Social SciencesHumanities and Social Sciences
Applied EconomicsApplied Economics
Arts and PhilosophyArts and Philosophy
LawLaw
Political and Social SciencesPolitical and
Social Sciences
Pharmaceutical, Biomedical and
Veterinary Sciences
Pharmaceutical, Biomedical and
Veterinary Sciences
MedicineMedicine
Life SciencesLife Sciences
7 Faculties7 Faculties
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Front Line Research Domains
Urban History and Contemporary Urban Policy
Urban History and Contemporary Urban Policy
Social Economic Policy and
Organisation
Social Economic Policy and
Organisation
Ecology and Sustainable
Development
Ecology and Sustainable
Development
Materials Characterisation
Materials Characterisation
Drug Discovery and DevelopmentDrug Discovery
and Development
Infectious Diseases
Infectious Diseases
NeurosciencesNeurosciences
ImagingImaging
Harbour, Transport and
Logistics
Harbour, Transport and
Logistics
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Front Line Research Domains
Urban History and Contemporary Urban Policy
Urban History and Contemporary Urban Policy
Social Economic Policy and
Organisation
Social Economic Policy and
Organisation
Ecology and Sustainable
Development
Ecology and Sustainable
Development
Materials Characterisation
Materials Characterisation
Drug Discovery and DevelopmentDrug Discovery
and Development
Infectious Diseases
Infectious Diseases
NeurosciencesNeurosciences
ImagingImaging
Harbour, Transport and
Logistics
Harbour, Transport and
Logistics
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Imaging
• EGAMI: Expert Group Antwerp Molecular Imaging- Network of research labs
• Biomedical Microscopic Imaging• Bioimaging Lab• Molecular Imaging Center Antwerp (MICA)• MicroCT Lab• Vision Lab
- Links with Antwerp University Hospital (UZA)• Radiology• Nuclear Medicine
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Imaging
Molecular and Cellular Imaging
Molecular and Cellular Imaging Small Animal Imaging Small Animal Imaging Clinical Imaging Clinical Imaging
Light MicroscopyLight Microscopy
(Scanning) Electron Microscopy
(Scanning) Electron Microscopy
Fluorescence Microscopy
Fluorescence Microscopy μCTμCT
μMRIμMRI
μPETμPET
In Vivo Biolumi-nescence and Fluorescence
Camera
In Vivo Biolumi-nescence and Fluorescence
Camera
CTCT
MRIMRI
PET/SPECTPET/SPECT
Image Processing
Image Processing
Confocal MicroscopyConfocal Microscopy
Confocal Live Cell Imaging
Confocal Live Cell Imaging
ElectrophysiologyElectrophysiology
Advanced Immuno-histochemistry
Advanced Immuno-histochemistry
Image ProcessingImage Processing
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Imaging
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• Molecular Imaging Center Antwerp (MICA)- Partnership between UA – UZA – Janssen
Pharmaceutica• Cyclotron + μPET/CT: micro-radiotherapy (320 keV),
autoradiography, direct access to FDG, FLT, FET and possibility to produce research tracers, kinetic modeling, multimodal image registration
- Fully operational spring 2011
Imaging - Highlight
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Front Line Research Domains
Urban History and Contemporary Urban Policy
Urban History and Contemporary Urban Policy
Social Economic Policy and
Organisation
Social Economic Policy and
Organisation
Ecology and Sustainable
Development
Ecology and Sustainable
Development
Materials Characterisation
Materials Characterisation
Drug Discovery and DevelopmentDrug Discovery
and Development
Infectious Diseases
Infectious Diseases
NeurosciencesNeurosciences
ImagingImaging
Harbour, Transport and
Logistics
Harbour, Transport and
Logistics
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Neurosciences
Neuronal Degeneration
Neuronal Plasticity
Neuronal Repair/ Replacement
Cognition and Behaviour
Stem CellsStem Cells Stem CellsStem Cells
Neuronal Tissue
Engineering
Neuronal Tissue
Engineering
NeurogeneticsNeurogeneticsNeurogeneticsNeurogenetics
Rodent ModelsRodent Models
NeurobiologyNeurobiology
Neuro-pathology
Neuro-pathology
Biobank/ BiomarkersBiobank/
Biomarkers
Psychiatric Disorders/ Dementia
Psychiatric Disorders/ Dementia
Song BirdsSong Birds
Nano-technology
Nano-technology
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Neurosciences
in vivo
< cell cell tissue organism
ex vivo / in vitro
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Neurosciences - Highlight
• VIB Department of Molecular Genetics (VIB8) (Director: Prof. Dr. Christine Van Broeckhoven)- Genetic analysis of complex neurological and
neuropsychiatric diseases• To identify novel molecular mechanisms for disease causation
and effective drug treatment for these diseases
- 4 research groups• Neurodegenerative Brain Diseases• Peripheral Neuropathies • Neurogenetics• Applied Molecular Genomics
- 2 centralized service facilities • Diagnostic Service Facility• Genetic Service Facility
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Front Line Research Domains
Urban History and Contemporary Urban Policy
Urban History and Contemporary Urban Policy
Social Economic Policy and
Organisation
Social Economic Policy and
Organisation
Ecology and Sustainable
Development
Ecology and Sustainable
Development
Materials Characterisation
Materials Characterisation
Drug Discovery and DevelopmentDrug Discovery
and Development
Infectious Diseases
Infectious Diseases
NeurosciencesNeurosciences
ImagingImaging
Harbour, Transport and
Logistics
Harbour, Transport and
Logistics
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Infectious Diseases
• Multidisciplinary research on infectious diseases and vaccines- Focused on microbiology and immunology, with
contributions of other disciplines• Epidemiology• Statistics/Mathematical modeling• Sociology• Economics
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Infectious Diseases
Basic Research Preclinical Research
Clinical Research
Immune System
Immune System
Disease Mechanisms
Disease Mechanisms
Antibiotic ResistanceAntibiotic
Resistance
BiomarkersBiomarkers
VaccinesVaccines
Injection Devices
Injection Devices PreventionPrevention
Diagnostic Tests
Diagnostic Tests
VaccinesVaccines
EpidemiologyEpidemiology
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Infectious Diseases - Highlights
• Antibiotic use and resistance- European Surveillance of Antimicrobial
Consumption (ESAC)• European project coordinated by Prof. Dr. Herman
Goossens of the UA- Funded by the European Centre for Disease Prevention and
Control (ECDC) - 34 participating countries
• Study of the use of antibiotics, antivirals and antimycotics and occurrence of resistance
• A vaccine against leukemia?- Wilms’ tumor 1 antigen-targeted dendritic cell
vaccination against acute myeloid leukemia • Van Tendeloo et al., PNAS, 2010
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Front Line Research Domains
Urban History and Contemporary Urban Policy
Urban History and Contemporary Urban Policy
Social Economic Policy and
Organisation
Social Economic Policy and
Organisation
Ecology and Sustainable
Development
Ecology and Sustainable
Development
Materials Characterisation
Materials Characterisation
Drug Discovery and DevelopmentDrug Discovery
and Development
Infectious Diseases
Infectious Diseases
NeurosciencesNeurosciences
ImagingImaging
Harbour, Transport and
Logistics
Harbour, Transport and
Logistics
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BiomarkersBiomarkers
ToxicityToxicity
ImagingImaging
Drug Discovery and Development
Target DiscoveryTarget Discovery Drug DiscoveryDrug Discovery Preclinical Drug Development
Preclinical Drug Development
End point: Clinical Trials
End point: Clinical Trials
Disease PathologyDisease
Pathology
Disease Mechanism
Disease Mechanism
Animal ModelsAnimal Models
In vitro ScreensIn vitro Screens
Medicinal ChemistryMedicinal Chemistry
Small Molecules
Small Molecules
Medicinal Plants
Medicinal Plants
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Drug Discovery and Development
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• Major Focus of Disease Areas:- Bone disease
• Osteoporosis
- Cancer- Cardiovascular disease
• Atherosclerosis
- Infectious disease• Bacterial, fungal and parasitic infections
- Kidney disease- Metabolic disease
• Diabetes
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Drug Discovery and Development - Highlight
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• Antwerp Drug Discovery Network- Integrated Platform for early drug discovery from
hit to lead optimisation- Protease Inhibitors
• Urokinase Plasminogen Activator (uPA) inhibitors in Oncology
• Molecular Probes as drug discovery tools
- Infectious Diseases• In vitro screening panels for antifungals and drugs against tropical diseases• Reference Center World Health Organization (WHO)
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Faculty of Medicine
• Overview number of students- Medecine BA-MA 750- Nursing MA 194- Specialisation 250- Doctoral School 210- Physiotherapy 520
- Total 1924
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Faculty of Medicine
• Features of medical education- BA / MA structure- Competence driven and student
oriented teaching- Integration of CANMEDS roles in the
curriculum aimed at transforming students into medical experts
- English semester, Spring, 4th year
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University Hospital Antwerp
• Features of University Hospital- 600 beds- 520.000 consultations and technical
activities- 300 MIO € yearly budget- Legally independent from University,
but connected with several links, especially with the faculty of medicine
- Close collaboration with regional hospitals