0 1 Cigarettes 5 10

0 mg 11mg 55mg 110 mg

Cigarette Smoking Impacts

KGCOE & NTID & ACS Joint Opportunity

Student Opportunities

•MSD 1 & 2 Project delivery of Initial Smoking System May 08 (7) students•Multidisciplinary team•Concept, design and delivery in 22 weeks

•Initial Research Work June- Aug 08 (2) students•FTC / ISO protocol trial conducted•Development of procedures / techniques

•System Enhancement (3) students March, June 09•FTC / ISO protocol work at published standards•Successful satisfaction of AIMs of ACS research grant

•TPM, PAHs, deposition, concentrations

•MSD 1 & 2 Project Delivery of Human Mimic Smoking System (6-8) students•System to mimi human behavior with high fidelity•Continued growth of Bio-Engineering application

KGCOE & NTID & ACS Joint Opportunity

AIMS of ACS GRANT

•AIM #1: Smoking Machine System Based with NTID Analysis•Measure the particle size distribution and relative concentrations of 4 Carcinogens: in mainstream smoke generated from two of the new safer cigarettte brands (Omni and Eclipse) and one of the research cigarettes

•AIM #2 Smoking Machine System Based with NTID Analysis•Perform hollow model deposition measurements for an adult and adolescent (12-15 years old)

•Aim #3•CFD modeling of focal deposition in both adult and adolescent lung models

•AIM #4• CFD modeling of PAH deposition for 12-30 year olds

•AIM #5 Overall, summary of all work•Evaluate the mfg’ claim of safer cigarettes as it pertains to both adult and adolescent smokers based on the dosimetry results for models & experiments.

KGCOE & NTID & ACS Joint Opportunity

Frontiers in Smoking Research

•Recognition that 40 year old FTC / ISO protocol is not satisfactory•2 sec puff every 60 seconds, 35 ml of puff volume•Does not accurately quantify the amounts of particulate matter

•Cigarette design changes to yield lower values per standard test protocol than experienced with real smoking•Behavior changes to compensate for reduced nicotine

•Machine Smoking profiles that more accurately reflect human behavior•Standard protocols with high puff volumes and more frequent puffing•Canada and Mass have more aggressive ( than FTC) profiles / freq

•Machine smoking profiles that can duplicate what any given human is smoking on a puff by puff basis.

•Critical analysis of carcinogen levels generated by these human profiles

•Critical analysis of deposition of these carcinogens in human lung casts

KGCOE & NTID & ACS Joint Opportunity

Lung Volume