Marc D. Malkoff, MD

November 14, 2012

Marc D. Malkoff, M.D.

Professional Address:University of Tennessee Health Science CenterCollege of MedicineNeurosurgery and Neurology847 Monroe Avenue, Suite 427Memphis, TN 38163

Licensure:New Mexico State License MD2008-0381 2008Arizona State License 33667 2005Texas State License K8319 (Inactive) 1998Indiana State Board License 01043760 (Inactive) 1995

Certification:Neuroimaging Unified Council of Neurologic Subspecialties 2009Neurointensive Care Unified Council of Neurologic Subspecialties 2008Vascular Neurology, American Board of Psychiatry and Neurology 2005MRI/CT, American Society of Neuroimaging 1996Neurosonology, American Society of Neuroimaging 1994Neurology, American Board of Psychiatry and Neurology 1989

Educational History: Fellowship, 06/1990, Johns Hopkins University, Baltimore, MD, Neurosciences

Critical Care Unit. Residency, 06/1988, Emory University, Atlanta, GA, Neurology. Transitional Residency, 06/1985, Cleveland Clinic Foundation, Cleveland, OH,

Internal Medicine. Medical Doctor, 05/1984, Northeastern Ohio University College of Medicine,

Rootstown, OH. Bachelor of Science cum laude, 08/1980, Kent State University, Kent, OH, Integrated

Life Sciences

Employment History Professor of Neurosurgery and Neurology, 07/2008-Present, University of New

Mexico, Albuquerque, NM. Director of NSI and Stroke Program, 07/2008-Present, University of New Mexico,

Albuquerque, NM. Hospital Appointment, 07/2008-Present, University of New Mexico, Albuquerque,

NM. Director of Neurocritical and Neurovascular Service, 02/2005-06/2008, Barrow

Neurological Institute, Phoenix, AZ. Hospital Appointment, 02/2005-06/2008, St. Joseph Hospital Medical Center,

Phoenix, AZ. Associate Professor of Neurology and Anesthesiology, 11/1998-01/2005, University

of Texas at Houston Medical School, Houston, TX. Hospital Appointment, 11/1998-01/2005, Hermann Hospital, Houston, TX. Hospital Appointment, 11/1998-01/2005, St. Luke’s Hospital, Houston, TX.

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Marc D. Malkoff, MD

Hospital Appointment, 11/1998-01/2005, Memorial Systems, Houston, TX. Associate Professor of Neurology, 07/1995-10/1998, Indiana University School of

Medicine, Indianapolis, IN. Director, Neuroscience Critical Care Unit, 07/1995-10/1998, Indiana University

School of Medicine, Indianapolis, IN. Associate Professor of Anesthesiology and Neurosurgery (Secondary

Appointments), 07/1995-10/1998, Indiana University School of Medicine, Indianapolis, IN.

Assistant Professor of Anesthesiology (Secondary Appointment),07/1992-06/1995, Saint Louis University School of Medicine, St. Louis, MO.

Assistant Professor of Neurology, 07/1990-06/1995, Saint Louis University School of Medicine, St. Louis, MO.

Director, Neuroscience Critical Care Unit, 07/1990-06/1995, Saint Louis University School of Medicine, St. Louis, MO.

Senior Clinical Fellow, 07/1988-06/1990, Johns Hopkins University, Baltimore, MD.

Professional Recognition, Honors, etc. (teaching, research, service) Fellow, 2001, American Heart Association. Fellow, 1998, American Academy of Neurology. Corresponding Member, 1996, Argentine Society of Cardiology. Fellow, 1994, American Heart Association, Stroke Council. Certificate of Appreciation, Pastoral Care Residents, 1994, Saint Louis University

Health Sciences Center. Pastoral Care Award, 1994, Saint Louis University Health Sciences Center Fellow, Neuroscience, 1988-1990, Charles A. Dana Foundation Outstanding Young Man in America, 1981, National Junior Chamber of Commerce Summer Research Fellow, Neurobiology, 1981, Northeastern Ohio University,

College of Medicine Blue Key National Honor Society, 1980 Mortar Board, 1980 Special Commendation from the Dean, 1979, Kent State University

Other Extramural Professional Activities Society of Critical Care Medicine, Fundamental Critical Care Support Instructor, 2012 Critical Care Medicine Ad Hoc Reviewer 2010-1 2013-4 Society of Critical Care Medicine Abstract reviewer 2011-2 American Stroke Association Abstract Reviewer2011- Journal of Neuroimaging, Ad Hoc Reviewer, 2006-Present American Society of Neuroimaging, Abstract Reviewer, 2004-Present Neuroimaging and Epilepsy, Ad Hoc Reviewer, 2004 Journal of Stroke and Cerebrovascular Disease, Ad Hoc Reviewer, 2001- Present Internet Journal of Emergency and Critical Care, Editorial Board, 2000 Internet Journal of Neurology, Editorial Board, 2000 Annals of Pharmacotherapy, Ad Hoc Reviewer, 1995-2002 Stroke, Ad Hoc Reviewer, 1995-Present American Journal of Obstetrics and Gynecology, Ad Hoc Reviewer, 1995 American Academy of Neurology, Abstract Reviewer, 1995 Headache, Ad Hoc Reviewer, 1994 Journal of Stroke and Cerebrovascular Disease, Ad Hoc Reviewer, 1993-1995 2008-

present

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Marc D. Malkoff, MD

Invited Lectures 2012 Neurocritical Care Society Traumatic Spinal Cord Injury 2012 Subarachnoid Hemorrhage SUNY Stony Brook SICU lecture 2012, Critical Care Issues in Stroke, University of New Mexico School of Medicine,

Neurosciences Grand Rounds 2012, Tele-medicine Stroke Program, The Role of Tele-health in the Management of

Rural Neuro-emergencies Conference, Albuquerque, NM 2012, Update in Critical Care, University of New Mexico School of Medicine Clinical

Neurosciences Symposium 2012 2012, Aggressive Stroke Therapy, University of New Mexico School of Medicine,

Neurosciences Grand Rounds 2011 International Stroke Conference The Economics of Drip and Ship in Stroke

Care 2010, The Changes in Stroke Therapy, University of New Mexico School of

Medicine, Neurosciences Grand Rounds 2010, Regionalization of Stroke Care, Western Neurosurgical Society 2010, Acute Stroke, Gila Regional Medical Center. Grand Rounds 2010, Economics of Drip and Ship, Zahab Quereshi Satellite Conference 2010 ISC

Meeting 2009, Carotid Doppler Stroke Rehab Antiplatelets and Anticoagulation, University of

Minnesota Vascular Neurology Review Course 2009, Stroke Management, EMS Region 3 of New Mexico Preconference 2008, Carotid Doppler Stroke Rehab Antiplatelets and Anticoagulation, University of

Minnesota Vascular Neurology Review Course 2008, Stroke Systems and Acute Treatment, Wellstar Stroke Symposium, Atlanta,

GA 2008, Acute Stroke Update, BNI Symposium 2007, Neurointensive Care, Arizona Neurological Society, Sedona, AZ 2007, Transcranial Doppler, University of New Mexico Neuroscience Grand Rounds 2007, Acute Stroke Care, University of New Mexico Neuroscience Grand Rounds 2007, Multiple Lectures, Bowman Gray TCD Course 2006, ICH, Rapid City Medical Center Grand Rounds 2006, Multiple Lectures, Bowman Gray TCD Course 2006, IAME Course Leader, TCD CME Course 2006, U.S. Health Care System In Response to Neurological Emergencies, Bell

University, Scotland 2006, Stroke Systems, University of Muenster Course, International MBA Course

Phoenix 2006, Hospitalists in Neurology, Banner Baywood Grand Rounds 2006, Acute Stroke Care, Oklahoma Heart Institute Vascular Update, Tulsa, OK 2006, Acute Stroke Care, Tallahassee Memorial Hospital Stroke Update 2005, Acute Hypertension, Tallahassee Memorial Hospital Grand Rounds 2005, Advances in Stroke Care, BNI Nursing Symposium 2005, Advances in Neurocritical Care, BNI Nursing Symposium 2005, SAH, BNI Nursing Symposium 2005, TCD Tutorial, BNI Nursing Symposium 2005, Advanced and Basic TCD, IAME Ultrasound Course 2005, Stroke Systems, University of Muenster Course, International MBA Course

Phoenix

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Marc D. Malkoff, MD

2004, Acute Hypertension, University of Oklahoma Department of Neurology Grand Rounds

2004, IAME TCD Symposium, Las Vegas, NV 2004, NeuroProtection, Baylor University School of Medicine Department of

Anesthesiology 2003, Hypertension in Acute Neurologic Disease, University of California Davis

Department of Neurology 2003, TPA – The Houston Experience, Val’d Hebron Hospital, Barcelona, Spain 2003, Setting up Stroke Centers in the U.S., International Stroke Society Regional

Meeting, Tbilisi, Georgia 2003, Hypertension, International Stroke Society Regional Meeting, Tbilisi, Georgia 2003, Medical Issues in SAH, International Stroke Society Regional Meeting, Tbilisi,

Georgia 2003, Update on Stroke Prevention, St. Luke’s Hospital Neurology Update for

Primary Care 2003, New Developments in Stroke Critical Care, Interventional Stroke Care

Conference, University of Texas at Houston 2003, New Concepts of Cerebral Protection, Baylor University School of Medicine

Department of Anesthesiology 2003, Faculty, Hands-On Workshop in Neurosonology, 26th Society of Neuroimaging

Meeting 2002, Management of Hypertension, Johns Hopkins NCCU Conference 2002, Management of Hypertension, Prince of Wales Hospital, Hong Kong

Neuroscience Conference 2002, Credentialing in Neuroimaging in the U.S., Hong Kong Neurological Society 2002, Faculty, Hands-On Workshop in Neurosonology, 25th Society of Neuroimaging

Meeting 2001, Hypertonic Saline and ICP, Canadian Congress of Neurological Sciences 2001, Ultrasound Assisted Thrombolysis and Recanalization, University of Zagreb

Healthy Lifestyles and Stroke, Dubrovnik, Croatia 2001, Setting Up Acute Stroke Care, University of Zagreb Healthy Lifestyles and

Stroke, Dubrovnik, Croatia 2001, Faculty, Hands-On Workshop in Neurosonology, 24th Society of Neuroimaging

Meeting 2000, Critical Care of Acute Stroke, University of Texas at Houston CME 2000, Acute Stroke Therapy, Florence Nightingale Hospital Special Seminar,

Istanbul, Turkey 2000, Organizing a Rapid Stroke Response Team, Florence Nightingale Hospital

Special Seminar, Istanbul, Turkey 2000, Acute Stroke Therapy, International Stroke Society Regional Meeting, Tbilisi,

Georgia 2000, Organizing a Rapid Stroke Response Team, International Stroke Society

Regional Meeting, Tbilisi, Georgia 2000, Stroke in the New Millennium, Houston Northwest Medical Center Grand

Rounds 2000, Pitfalls in Sedation, Society for Critical Care Medicine Post-Graduate Course 2000, Faculty, Hands-On Workshop in Neurosonology, 23rd Society of Neuroimaging

Meeting 1999, Stroke in the New Millennium, Tombaugh Regional Hospital Grand Rounds 1999, Prehospital Stroke Care, 21st Life Flight Symposium, Houston, TX

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Marc D. Malkoff, MD

1999, New Developments in Stroke Therapy, A Stroke of Courage Program (Co-sponsors American Heart Association and St. Anthony’s Hospital), Oklahoma City, OK

1999, Risk Factors, A Stroke of Courage Program (Co-sponsors American Heart Association and St. Anthony’s Hospital), Oklahoma City, OK

1999, New Developments in Stroke Therapy, St. Anthony’s Hospital Grand Rounds, Oklahoma City, OK

1999, TCD in Critical Care, Institute for Advanced Medical Education, Chicago, IL 1999, Case Studies, Institute for Advanced Medical Education, Chicago, IL 1999, Instructor, Transcranial Doppler Course, Institute for Advanced Medical

Education, Chicago, IL 1999, Faculty, Hands-On Workshop in Neurosonology, 22nd Society of Neuroimaging

Meeting 1998, Intracranial Hypertension, Society of Critical Care Medicine Multidisciplinary

Critical Care Board Review Course, Chicago, IL 1998, Altered Mental Status and Brain Death, Society of Critical Care Medicine

Multidisciplinary Critical Care Board Review Course, Chicago, IL 1998, Faculty, Hands-On Workshop in Neurosonology, 21st Society of Neuroimaging

Meeting 1997, Faculty, American Academy of Neurology Acute Stroke Management

Workshop, Coral Gables, FL 1997, Intracranial Hypertension, Society of Critical Care Medicine Multidisciplinary

Critical Care Board Review Course, Chicago, IL 1997, Altered Mental Status and Brain Death, Society of Critical Care Medicine

Multidisciplinary Critical Care Board Review Course, Chicago, IL 1997, A Critical Care Neurologist Looks at Myasthenic Crisis, Indiana University

Medical Center Continuing Medical Education, Weakness: A Course for the Contemporary Clinician

1997, Neuromuscular Disease in Critical Care Units, Indiana University Medical Center Update in Critical Care

1996, Neuromuscular Respiratory Failure, Indiana University Respiratory Care Symposium

1996, Status Epilepticus, Medical School of the Republic of Uruguay and IMPASA 1996, New Developments in Acute Stroke, Medical School of the Republic of

Uruguay and IMPASA 1996, Neuromonitoring in the ICU, Medical School of the Republic of Uruguay and

IMPASA 1996, Medical Management of Subarachnoid Hemorrhage, Medical School of the

Republic of Uruguay and IMPASA 1996, Neuromuscular Respiratory Failure, University of Campinas (Unicamp)

International Symposium on Neuromonitoring 1996, Minimally Invasive Neuromonitoring in the ICU, University of Campinas

(Unicamp) International Symposium on Neuromonitoring 1996, The Effect of Pre-Renal Azotemia in Acute Strokes, Federal University of Sao

Paolo, Escola Paulsta School of Medicine (UNIFESP) 1996, New Concepts in Stroke Care, Interdisciplinary Council on Strokes of the

Argentinian College of Cardiology 1996, Stroke Delivery Systems, Interdisciplinary Council on Strokes of the

Argentinian College of Cardiology 1996, The Effect of Acute Seizures on Outcome in Cerebrovascular Disease,

Interdisciplinary Council on Strokes of the Argentinian College of Cardiology

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Marc D. Malkoff, MD

1996, Critical Care of Stroke, Federal University of Sao Paolo, Escola Paulsta School of Medicine (UNIFESP)

1996, Medical Complications of Acute Stroke, St. Louis University Woolsey Fest Scientific Program

1996, Medical Complications of Acute Stroke, Indiana University School of Medicine, Neurology for the Primary Care Physician

1996, Advanced Neurological Life Support, American Academy of Neurology Post-Graduate Course Faculty, San Francisco, CA

1995, Pre-Renal Azotemia in Acute Stroke, University of Alabama in Birmingham Neurology Grand Rounds

1995, Cerebellar Infarct: Emergency Management, IX Pan American Congress of Neurology; XIX Annual Reunion, Mexican Academy of Neurology; VII Central American Congress of Neurology, Guatemala

1995, Cost Effective Work-Up of Coma, Indiana University Cost Effectiveness of Neurological Investigations

1995, Stroke, Society for Critical Care Medicine Multidisciplinary Critical Care Board Review

1995, Seizures and Status Epilepticus in the ICU, Society for Critical Care Medicine Multidisciplinary Critical Care Board Review

1995, Altered Mental Status and Brain Death, Society for Critical Care Medicine Multidisciplinary Critical Care Board Review

1995, Subarachnoid Hemorrhage, Society for Critical Care Medicine Multidisciplinary Critical Care Board Review

1995, Head Trauma/Intracranial Hypertension Panel Discussion, Society for Critical Care Medicine Multidisciplinary Critical Care Board Review

1995, Advanced Neurological Life Support, American Academy of Neurology Post Graduate Course Faculty, Seattle, WA

1995, Head and Spine Anatomy and Physiology, St. Louis University Medical Center, Illinois Trauma Nurse Specialist Program

1995, Metabolic Encephalopathies, Society for Critical Care Medicine, Post-Graduate Course in Neuroscience

1995, Critical Care of Subarachnoid Hemorrhage, Indiana University Medical Center Department of Neurology Special Lecture

1994, Treatment of Hypertension in Neurologic Emergencies, St. Louis University Health Sciences Center Anesthesia Grand Rounds

1994, New and Aggressive Concepts in Stroke Therapy, Grady Memorial Hospital, Morehouse University School of Medicine Internal Medicine Grand Rounds

1994, Strategies in Neural Protection, Morehouse University School of Medicine Neuroscience Grand Rounds

1994, New and Aggressive Concepts in Stroke Therapy, Rush Medical School, Chicago, IL

1994, Intracerebral Monitoring and Subarachnoid Hemorrhage, III Interdisciplinary Congress on Stroke, Argentina Society of Cardiology, Buenos Aires, Argentina

1994, Vasospasm and Subarachnoid Hemorrhage, III Interdisciplinary Congress on Stroke, Argentina Society of Cardiology, Buenos Aires, Argentina

1994, Utility of ICU’s and Stroke Units in the Care of Stroke Patients, III Interdisciplinary Congress on Stroke, Argentina Society of Cardiology Round Table, Buenos Aires, Argentina

1994, Myasthenia Gravis and Guillain Barre Syndrome, St. Louis University Health Medical Center Dieticians

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Marc D. Malkoff, MD

1994, Steroids and Other Measures to Control Intracranial Pressure, American Academy of Neurology, Critical Care Neurology Post-Graduate Course

1994, Steroids and Other Measures to Control Intracranial Pressure, Washington University School of Medicine Grand Rounds, St. Louis, MO

1994, Head and Spine Anatomy and Physiology, St. Louis University Medical Center, Illinois Trauma Nurse Specialist Program, St. Louis, MO

1994, New Methods in Cerebral Monitoring, American Association of Critical Care Nurses, St. Louis, MO

1994, Director, American Society of Neuroimaging Symposium on Imaging of Critical Care, Beverly Hills, CA

1993, New Approaches and Aggressive Therapy of Stroke, Missouri Chapter of the American College of Physicians, Lake of the Ozarks, MO

1993, Critical Care Issues in Patients With Ischemic Stroke, St. Louis University Medical Center Symposium on Treating Ischemic Stroke in the 1990’s

1993, Head and Spine Anatomy and Physiology, St. Louis University Medical Center, Illinois Trauma Nurse Specialist Program, St. Louis, MO, September

1993, Head and Spine Anatomy and Physiology, St. Louis University Medical Center, Illinois Trauma Nurse Specialist Program, St. Louis, MO, April

1993, Head and Spine Anatomy and Physiology, St. Louis University Medical Center, Illinois Trauma Nurse Specialist Program, St. Louis, MO, March

1992, Critical Care in Stroke, St. Louis University Medical Center 1992, New Concepts in ICP Management, Christian Northeast Hospital Critical Care

Grand Rounds, St. Louis, MO 1991, Invasive Monitoring of the Head-Injured Patient in the ICU, St. John’s Mercy

Medical Center, St. Louis, MO 1990, New Concepts in Neuro Critical Care, St. Louis University Medical Center,

Eureka, MO

Meeting Sessions Chaired 2009 , Society of Critical Care Medicine 38th Educational and Scientific Symposium

Hemorrhage Session 2005, Neurocritical Care Society, Subarachnoid Hemorrhage Session 1996, Society of Critical Care Medicine 25th Educational and Scientific Symposium,

Neurosurgery, Neuroscience, 1995, American Academy of Neurology 47th Annual Meeting, Session 65, Critical

Care: Cerebral Blood Flow, Metabolism, and Edema. 1995, Society of Critical Care Medicine 24th Educational and Scientific Symposium,

Neuroscience.

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Marc D. Malkoff, MD

Book Chapters Authored or Co-Authored: Miller C, Malkoff M, Cerebral Edema in Handbook of Stroke, Humana Press, Clifton,

NJ, 2008 \\hsc-truchas\departments\surgery Teeple D, Malkoff M, Nutrition in Stroke

Patients in Handbook of Stroke, Humana Press, Clifton, NJ, 2008 Wojner A, Malkoff M, Lumbar Puncture in AACN Procedure Manual, AACN, 2004 Teeple D, Malkoff M, Cerebral Blood Flow and Metabolism in Handbook of

Neurocritical Care, Humana Press, Clifton, NJ, 2004 El-Mitwalli A, Malkoff M, Intracranial Hemorrhage in Conn’s Current Therapy, Rakel

R and Bope E, ed Saunders, 2003 El-Mitwalli A, Malkoff M, Intracranial Hemorrhage in Conn’s Current Therapy, Rakel

R and Bope E, ed Saunders, 2002 Malkoff MD, Selhorst JB, Neurological Examination of the ICU Patient in Principles

and Practice of Neuro Critical Care, Williams and Wilkins, Baltimore, 1998 Malkoff MD, Altered Mental Status and Brain Death in Multidisciplinary Critical Care

Board Review Course, Society of Critical Care Medicine, 65-80, 1998 Malkoff MD, Intracranial Hypertension in Multidisciplinary Critical Care Board

Review Course, Society of Critical Care,15-26, 1998 Malkoff MD, Iatrogenic Neurologic Problems in the Critical Care Unit in Iatrogenic

Neurology. 193-201, 1998 Malkoff MD, Altered Mental Status and Brain Death in Multidisciplinary Critical Care

Board Review Course, Society of Critical Care Medicine, Roberts PR, ed., 575-588,1997

Malkoff MD, Intracranial Hypertension in Multidisciplinary Critical Care Board Review Course, Society of Critical Care, 551-574, 1997

Malkoff MD, Coma in the ICU in Critical Care Pearls II, 171-173, 1997 Gomez C, Malkoff MD, Critical Management of the Acute Stroke: Triage and

Diagnoses in Cerebrovascular Disease, Chicago, 1996 Gomez CR, Malkoff MD, Advanced Neurologic Life Support (ANLS) in American

Academy of Neurology 48th Annual Meeting, Seattle, March 23-30, 1996 Malkoff MD, Gomez CR, Intravascular Ultrasound vs. Angiography in Stroke

Patients in Neurosonology. St. Louis, Mosby, 1996 Malkoff MD, Seizures and Status Epilepticus in the ICU in Multidisciplinary Critical

Care Board Review, Society of Critical Care Medicine, LaJolla, CA, 511-517, 1995 Malkoff MD, Altered Mental Status and Brain Death in Multidisciplinary Critical Care

Board Review, Society of Critical Care Medicine, 497-505, 1995 Malkoff MD, Stroke in Multidisciplinary Critical Care Board Review, Society of

Critical Care Medicine, 489-495, 1995 Gomez CR, Malkoff MD, Advanced Neurologic Life Support (ANLS) in American

Academy of Neurology 47th Annual Meeting, Seattle, May 6-13, 1995 Malkoff MD, Steroids and Other Measures to Control ICP in Critical Care and

Emergency Course, American Academy of Neurology, 1994 May Malkoff MD, The Intensivist’s View of Neuroimaging, Syllabus, Neuroimaging in

Critical Care and Emergency Neurology. 17th Annual Meeting, Amer Assoc of Neuroimag, Beverly Hills, CA, February 1994.

Malkoff MD, Neuromuscular Disease in Pinsky MR ed, The Pathophysiologic Foundations of Critical Care Medicine, Williams and Wilkins, Baltimore, MD, 1993

Borel C, Malkoff MD, Acute Ventilatory Failure in Neuromuscular Disease in Johnson RT ed, Current Therapy in Neurologic Disease-3, BC Decker Inc., Philadelphia, PA, 1990

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Marc D. Malkoff, MD

Original Research or Scholarly Articles in Refereed Journals: Family presence during brain death evaluation: a randomized controlled trial*.

Tawil I, Brown LH, Comfort D, Crandall CS, West SD, Rollstin AD, Dettmer TS, Malkoff MD, Marinaro J.Crit Care Med. 2014 Apr;42(4):934-42. doi: 10.1097/CCM.000000000000010

The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study protocol. Woo D, Rosand J, Kidwell C, McCauley JL, Osborne J, Brown MW, West SE, Rademacher EW, Waddy S, Roberts JN, Koch S, Gonzales NR, Sung G, Kittner SJ, Birnbaum L, Frankel M, Testai FD, Hall CE, Elkind MS, Flaherty M, Coull B, Chong JY, Warwick T, Malkoff M, James ML, Ali LK, Worrall BB, Jones F, Watson T, Leonard A, Martinez R, Sacco RI, Langefeld CD.Stroke. 2013 Oct;44(10):e120-5. doi: 10.1161/STROKEAHA.113.002332. Epub 2013 Sep 10.

Foroud T; FIA Study Investigators, Whole exome sequencing of intracranial aneurysm. Stroke. 2013 Jun;44(6 Suppl 1):S26-8. doi: 10.1161. Review.

Hall CE, Mirski M, Palesch YY, Diringer MN, Qureshi AI, Robertson CS, Wijman CA, Le Roux PD, Suarez JI, First Neurocritical Care Research Conference Investigators; Clinical trial design in the neurocritical care unit; Neurocrit Care; 16(1):6-19; Feb 2012. Review.

Wijman CA, Smirnakis SM, Vespa P, Szigeti K, Ziai WC, Ning MM, Rosand J, Hanley DF, Geocadin R, Hall C; Research and technology in neurocritical care; Neurocrit Care; 16(1):42-54; Feb 2012. Review.

Powers WJ, Clarke WR, Grubb RL Jr, Videen TO, Adams HP, Derdeyn CP, COSS Investigators; Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial; JAMA; 306(18):1983-92, Nov 2011; Erratum Dec 2011.

Tsivgoulis G, Alexandrov AV, Chang J, Sharma VK, Hoover SL, Lao AY, Liu W, Stamboulis E, Alexandrov AW, Malkoff MD, Frey JL; Safety and outcomes of intravenous thrombolysis in stroke mimics: a 6-year, single-care center study and a pooled analysis of reported series. Stroke; 42(6):1771-4; Jun 2011; Epub Apr 2011.

Shi ZS, Loh Y, Walker G, Duckwiler GR, MERCI and Multi-MERCI Investigators; Endovascular thrombectomy for acute ischemic stroke in failed intravenous tissue plasminogen activator versus non-intravenous tissue plasminogen activator patients: revascularization and outcomes stratified by the site of arterial occlusions; Stroke; 41(6),1185-92, Jun 2010, Epub Apr 2010

Shi ZS, Loh Y, Walker G, Duckwiler GR, MERCI and Multi-MERCI Investigators; Clinical outcomes in middle cerebral artery trunk occlusions versus secondary division occlusions after mechanical thrombectomy: pooled analysis of the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi-MERCI trials; Stroke; 41(5), 953-60, May 2010, Epub Apr 2010

Tsivgoulis G, Frey JL, Flaster M, Sharma VK, Lao AY, Hoover SL, Liu W, Stamboulis E, Alexandrov AW, Malkoff MD, Alexandrov AV; Pre-tissue plasminogen activator, blood pressure levels, and risk of symptomatic intracerebral hemorrhage; Stroke; 40(11), 3631-4, Nov 2009

Molina CA, Barreto AD, Tsivgoulis G, Sierzenski P, Malkoff MD, Rubiera M, Gonzales N, Mikulik R, Pate G, Ostrem J, Singleton W, Manvelian G, Unger EC, Grotta JC, Schellinger PD, Alexandrov AV; Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial; Ann Neurol; 66(1), 28-38, Jul 2009

Penumbra Pivotal Stroke Trial Investigators; The penumbra pivotal stroke trial: safety and effectiveness of a new generation of mechanical devices for clot removal

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Marc D. Malkoff, MD

in intracranial large vessel occlusive disease; Stroke; 40(8), 2761-8, Aug 2009, Epub July 2009

Woo D, Hornung R, Sauerbeck L, Brown R, Meissner I, Huston J, Foroud T, Broderick J, FIA Study Investigators; Age at intracranial aneurysm rupture among generations: Familial Intracranial Aneurysm Study; Neurology; 72(8), 695-8, Feb 2009

Broderick JP, Brown R, Sauerbeck L, Hornung R, Huston J, Woo D, Anderson C, Rouleau G, Kleindorfer D, Flaherty ML, Meissner I, Foroud T, Moomaw EC, Connolly ES, FIA Study Investigators; Greater rupture risk for familial as compared to sporadic unruptured intracranial aneurysms; Stroke; 40(6), 1952-7, June 2009, Epub Feb 2009

Murray KO, Baraniuk S, Resnick M, Arafat R, Kilborn C, Shallenberger R, York TL, Martinez D, Malkoff M, Elgawley N, McNeely W, Khuwaja SA; Clinical investigation of hospitalized human cases of west Nile virus infection in Houston, Texas, 2002-2004; Vector Borne Zoonotic Dis; 8(2), 167-74; Summer 2008

Sharma VK, Tsivgoulis G, Lao AY, Malkoff MD, Alexandrov AW, Alexandrov AV; Quantification of microspheres appearance in brain vessels: implications for residual flow velocity measurements dose calculations, and potential drug delivery; Stroke; 39(5), 1476-81, May 2008

Alexandrov AV, Mikulik R, Ribo M, Sharma VK, Lao AY, Tsivgoulis G, Sugg RM, Barreto A, Sierzenski P, Malkoff MD, Grotta JC; A pilot randomized clinical safety study of sonothrombolysis augmentation with ultrasound-activated perflutren-lipid microspheres for acute ischemic stroke; Stroke; 39(5); 1464-9, May 2008

Foroud T, Sauerbeck L, Brown R, Anderson C, Woo D, Kleindorfer D, Flaherty ML, Deka R, Hornung R, Meissner I, Bailey-Wilson JE, Rouleau G, Connolly ES, Lai D, Koller DL, Huston J 3rd, Broderick JP, FIA Study Investigators; Genome screen to detect linkage to intracranial aneurysm susceptibility genes: the Familial Intracranial Aneurysm (FIA) study; Stroke; 39(5), 1434-40, May 2008

Tsivgoulis G, Sharma VK, Hoover SL, Lao AY, Ardelt AA, Malkoff MD, Alexandrov AV; Applications and advantages of power motion-mode Doppler in acute posterior circulation cerebral ischemia; Stroke; 39(4), 1197-204, Apr 2008

Sharma VK, Tsivgoulis G, Lao AY, Malkoff MD, Alexandrov AV; Stroke; 38(12), 3175-81, Dec 2007

Alexandrov AV, Sharma VK, Lao AY, Tsivgoulis G, Malkoff MD, Alexandrov AW; Stroke; 38(11), 3045, Nov 2007

Lao AY, Sharma VK, Tsivgoulis G, Malkoff MD, Alexandrov AV, Frey JL; Effect of body positioning during transcranial Doppler detection of right-to-left shunts; 14(9), 1035-9, Sept 2007

Mikulik R, Ribo M, Hill MD, Grotta JC, Malkoff MD, Molina C, Rubiera M, Delgado-Mederos R, Alvarez-Sabin J, Alexandrov AV, CLOTBUST Investigators; Accuracy of serial National Institutes of Health Stroke Scale scores to identify artery status in acute ischemic stroke; Stroke; 115(20), 2660-5, May 2007, Epub May 2007

Tsivgoulis G, Vijay K, Sharma VK, Lao AY, Malkoff MD, Alexandrov AV; Validation of Transcranial Doppler with CT Angiography in Acute Cerebral Ischemia; Stroke; 38(4), 1245-9, Apr 2007

Sharma VK, Tsivgoulis G, Lao AY, Flaster M, Frey JL, Malkoff MD, Alexandrov AV; Thrombotic occlusion of the common carotid artery (CCA) in acute ischemic stroke treated with intravenous tissue plasminogen activator; Eur J Neurol; 14(2), 237-40, Feb 2007

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Marc D. Malkoff, MD

Lao AY, Sharma VK, Tsivgoulis G, Frey JL, Malkoff MD, Navarro JC, Alexandrov AV; Detection of Right-to-Left Shunts: Comparison between the International Consensus and Spencer Logarithmic Scale Criteria; J Neuroimaging; Jan 2007

Murray K, Baraniuk S, Resnick M, Arafat R, Kilborn C, Cain K, Shallenberger R, York TL, Martinez D, Hellums JS, Hellums D, Malkoff M, Elgawley N, McNeely W, Khuwaja SA, Tesh RB; Risk factors for encephalitis and death from West Nile virus infection; Epidemiol Infect; 1-8, May 2006

Wojner-Alexandrov AW, Malkoff MD; The United States stroke system: credentialing and legislative efforts to improve acute stroke care; Int J Stroke; 1(2), 109-10, May 2006

Choi JY, Pary JK, Alexandrov AV, Molina CA, Garami Z, Malkoff MD, Rubiera M, Shaltoni HM, Moye LA, Grotta JC; Does clinical-CT ‘mismatch’ predict early response to treatment with recombinant tissue plasminogen activator?; Cerebrovasc Dis; 22(5-6), 384-8, 2006, Epub Aug 2006

Chen CI, Iguchi Y, Garami Z, Malkoff MD, Smalling RW, Campbell MS, Alexandrov AV; Analysis of emboli during carotid stenting with distal protection device; Cerebrovasc Dis; 21(4), 223-8, 2006

Sugg RM, Malkoff MD, Noser EA, Shaltoni HM, Weir R, Cacayorin ED, Grotta JC; Endovascular recanalization of internal carotid artery occlusion in acute ischemic stroke; 26(10), 2591-4, Nov-Dec 2005

Song JK, Fisher S, Seifert D, Cacayorin ED, Alexandrov AV, Malkoff MD, Grotta JC, Campbell MS; Postpartum cerebral angiopathy: atypical features and treatment with intracranial balloon angioplasty; 46(12), 1022-6, Dec 2004, Epub Nov 2004

Joseph M, Ziadi S, Nates J, Dannenbaum M, Malkoff M; Increases in cardiac output can reverse flow deficits from vasospasm independent of blood pressure: a study using xenon computed tomographic measurement of cerebral blood flow; Neurosurgery; 53(3), 1044-51 Discussion 1051-2, Nov 2003

Labiche LA, Al-Senani F, Wojner AW, Grotta JC, Malkoff M, Alexandrov AV; Is the benefit of early recanalization sustained at 3 months? A prospective cohort study; Stroke; 34(3), 695-8, Mar 2003

Labiche LA, Malkoff M, Alexandrov AV; Residual flow signals predict complete recanalization in stroke patients treated with tPA; J Neuroimaging; 13(1), 28-33, Jan 2003

Song JK, Cacayorin ED, Campbell MS, Fisher S, Malkoff MD, Alexandrov AV, Grotta JC; Intracranial balloon angioplasty of acute terminal internal carotid artery occlusions; American Journal of Neuroradiology; 23, 1308-1312, Sept 2002

Christou I, Felberg RA, Demchuk AM, Burgin WS, Malkoff M, Grotta JC, Alexandrov AV; Intravenous tissue plasminogen activator and flow improvement in acute ischemic stroke patients with internal carotid artery occlusion; J Neuroimaging; 12(2), 119-23, Apr 2002

Felberg RA, Christou I, Demchuk AM, Malkoff M, Alexandrov AV; Screening for intracranial stenosis with transcranial Doppler: the accuracy of mean flow velocity thresholds; J Neuroimaging; 12(1), 9-14, Jan 2002

El-Mitwalli A, Saad M, Christou I, Malkoff M, Alexandrov AV; Clinical and sonographic patterns of tandem internal carotid artery-middle cerebral artery occlusion in tissue plasminogen activator-treated patients; Stroke; 33(1), 99-102, Jan 2002

Grotta JC, Burgin WS, El-Mitwalli A, Long M, Campbell M, Morgenstern LB, Malkoff M, Alexandrov AV; Intravenous tissue-type plasminogen activator therapy for ischemic stroke: Houston experience 1996 to 2000; Arch Neurol; 58(12), 2009-13, Dec 2001

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El-Mitwalli A, Malkoff MD; Intracerebral Hemorrhage; The Internet Journal of Emergency and Intensive Care Medicine; Vol5N1, 2001

Christou I, Felberg RA, Demchuk AM, Grotta JC, Burgin WS, Malkoff M, Alexandrov AV; A broad diagnostic battery for bedside transcranial Doppler to detect flow changes with internal carotid artery stenosis or occlusion; J Neuroimaging; 11(3), 236-42, July 2001

Briggs DE, Felberg RA, Malkoff MD, Bratina P, Grotta JC; Should Mild or Moderate Stroke Patients Be Admitted to an Intensive Care Unit?; Stroke; 32(4), 871-6, Apr 2001

Alexandrov AV, Felberg RA, Demchuk AM, Christou I, Burgin WS, Malkoff M, Wojner AW, Grotta JC; Deterioration Following Spontaneous Improvement: Sonographic Findings in Patients with Acutely Resolving Symptoms of Cerebral Ischemia; Stroke; 31, 915-9, 2000

Burgin WS, Malkoff M, Felberg RA, Demchuk AM, Christou I, Grotta JC, Alexandrov AV; Transcranial Doppler Ultrasound Criteria for Recanalization After Thrombolysis for Middle Cerebral Artery Stroke; Stroke; 31, 1128-32, 2000

Christou I, Alexandrov AV, Burgin WS, Wojner AW, Felberg RA, Malkoff M, Grotta JC; Timing of Recanalization After Tissue Plasminogen Activator Therapy Determined by Transcranial Doppler Correlates With Clinical Recovery From Ischemic Stroke; Stroke; 31, 1812-6, 2000

Sokol DK, Markand OM, Daly EC, Luerssen T, Malkoff MD; Near Infrared Spectroscopy (NIRS) distinguishes seizure types; Seizure; 9(5), 323-7, Jul 2000

Demchuk A, Christou I, Wein T, Felberg R, Malkoff MD, Grotta J, Alexandrov A; Specific Transcranial Doppler Flow Findings Related to the Presence and Site of Arterial Occlusion; Stroke; 31, 140-6, Jan 2000

Alexandrov AV, Demchuk AM, Felberg RA, Christou I, Barber PA, Burgin WS, Malkoff M, Wojner AW, Grotta JC; High Rate of Complete Recanalization and Dramatic Clinical Recovery During tPA Infusion When Continuously Monitored With 2-MHz Transcranial Doppler Monitoring; 31, 610-4, 2000

Demchuk A, Christou I, Wein T, Felberg R, Malkoff MD, Grotta J, Alexandrov A; The accuracy and criteria for localizing arterial occlusion with transcranial Doppler; J Neuroimaging; 10(1), 1-12, Jan 2000

Latkany P, Ciulla TA, Cacchillo PF, Malkoff MD; Mitochondrial maculopathy: geographic atrophy of the macula in the MELAS associated A to G 3243 mitochondrial DNA point mutation; Am J Ophthalmol; 128(1), 112-4, Jul 1999

Huler KH, Malkoff MD; Central nervous system modulation of respiratory function in the critically ill; Critical Care Clinics of Brazil; 117-136, 1998

Pourmand R, Malkoff MD; Diagnostic approach to neuromuscular respiratory failure; Critical Care Clinics of Brazil; 321-344, 1998

Meschia J, Malkoff MD, Biller J; Reversible segmental cerebral arterial vasospasm and cerebral infarction; Arch Neurol; 55(5), 712-4, 1998

Malkoff MD, Williams LS, Biller J; Advances in the management of carotid atherosclerosis; J Int Care Med; (2), 55-65, 1997

Malkoff MD; Intracranial pressure monitoring in subarachnoid hemorrhage; Revista Argentina de Cardiologia; 64(4), 415-6, 1996

Gomez CR, Cruz-Flores S, Malkoff MD, Sauer CM, Burch CM; Isolated vertigo as a manifestation of vertebrobasilar ischemia; Neurology; 47, 94-7, Jul 1996

Malkoff MD; Vasospasm in subarachnoid hemorrhage: Revista Argentina de Cardiologia; 64(4), 411-3, 1996

Myles GL, Malkoff MD, Perry AG, Bucholz RD, Gomez CR; The utilization of therapeutic intervention scoring system (TISS) levels in the care of patients in

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pentobarbital-induced coma to determine nurse-patient ratios; Am J Crit Care; 5(1), 74-9, Jan 1996

Malkoff MD, Gomez CR, Myles GL, Cruz-Flores S; Cerebrovascular effects of the hemodynamic efficiency of premature ventricular contractions; Angiology; 47(1), 51-6, 1996

Malkoff MD, Ponzillo J, Gomez CR, Myles G, Cruz S; Sinus arrest after administration of intravenous metoclopramide: a case report; Ann Pharmacother; 29(4), 381-4, 1995

Ehsan T, Malkoff MD; Acute isoniazid poisoning simulating meningoencephalitis; Neurology; 45(8), 1627-8, 1995

Myles GL, Perry AG, Malkoff MD, Shatto BJ, Scott-Killmade MC; Quantifying nursing care in barbiturate-induced coma with the therapeutic intervention scoring system; J of Neurosc Nurs; 27(1), 35-42, Feb 1995

Ehsan T, Hayat G, Malkoff MD, Selhorst JB, Martin D, Manepalli A,; Hyperdense basilar artery: an early CT sign of thrombosis; J Neuroimag; 4(4), 200-5, Oct 1994

Gomez CR, Malkoff MD; Attempt to shorten in-hospital therapeutic delays; Stroke; 25(10), 1920-3, 1994

Gomez CR, Cruz-Flores S, Malkoff MD, et al; Preliminary experience using ticlopidine in clinical practice; J Stroke and Cerebrovas Dis; 4(3), 143-7, 1994

Gomez CR, Tulyapronchote R, Malkoff MD; Changing trends in the etiologic diagnosis of ischemic stroke; J Stroke and Cerebrovas Dis; 4(3) 169-73, 1994

Malkoff MD, Borel CO; Central nervous system modulation of respiratory function in the critically ill; New Horizons; 2(4), 419-25, 1994

Tulyapronchote R, Selhorst JB, Malkoff MD, Gomez CR; Delayed sequelae of vertebral artery dissection and occult cervical fractures; Neurology; 44(8), 1397-9, 1994

Ponzillo JJ, Malkoff MD; Focus on felbamate: beginning a new era in the treatment of epilepsy; Hosp Formul; 28(10), 837-47, 1993

Malik MM, Gomez CR, Tulyapronchote R, Malkoff MD, et al; Delay between emergency room arrival and stroke consultation; J Stroke Cerebrovasc Dis; 3(3), 177-80, 1993

Malkoff MD, Borel CO; Weaning the neuromuscular patient from mechanical ventilation; Crit Care Reports I; (1), 100-9, 1989

Other Writings and Scholarly Products Malkoff MD, A Book Review of Neurology of Critical Illness by Eelco F. M. Wijdicks;

F.A. Davis, Philadelphia, c1995; Headache 35(7):435,1995 Malkoff MD, A Book Review of Atlas of Intravascular Ultrasound; John McB.

Hodgson, ed., Helen Sheehan, ed., Raven Press, New York, c1994; J Stroke Cerebrovasc Dis 5(3):185 1995

Malkoff MD, A Book Review of Intravascular Ultrasound Imaging; J. Tobis, P. Yock, ed.; J Stroke Cerebrovasc Dis 5(3):185, 1995

Gomez CR, Malkoff MD, Use of Transcranial Doppler in the assessment of subarachnoid hemorrhage evaluated by Transcranial Doppler sonography; Letter, Neurosurg 34(6):1102-1104, 1994

Malkoff MD, Gomez CR, Tulyapronchote R. Prognostic significance of evoked potential in acute basilar occlusion; Letter, Crit Care Med 22(6):1065-1066, 1994

Gomez CR, Malkoff MD. Cerebral hemodynamics in subarachnoid hemorrhage evaluated by Transcranial Doppler sonography; Letter, Neurosurg 34(6):1102-1104, 1994

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Norris P, Malkoff MD, Hyers T, The Duty to Prolong Life: Determining the Limits; Video, Center for Health Care Ethics, St. Louis University Health Sciences Center, 1993.

Malkoff MD, A Book Review of Cerebral Blood Flow Measurement with Stable Xenon-Enhanced Computed Tomography by Howard Yonas; J Stroke Cerebrovasc Dis 3(1):75, 1993

Tulyapronchote R, Malkoff MD, Selhorst JB, Gomez CR. Treatment of cerebellar infarction by decompression suboccipital craniectomy; Letter, Stroke 24(30):478-479, 1993

Invited or Refereed Abstracts and/or Presentations at Professional Meetings: Molina CA, Barreto AD, Tsivgoulis G, Sierzenski P, Malkoff MD, Rubiera M,

Gonzales N, Mikulik R, Pate G, Ostrem J, Singleton W, Manvelian G, Unger EC, Grotta JC, Schellinger PD, Alexandrov AV for the TUCSON Investigators; Transcranial ultrasound in clinical sonothrombolysis (TUCSON): results of a randomized multi-center safety trial of perflutren lipid microspheres; Am Neurol; 66(1), 28-38, Jul 2009, Epub @ conference website, Key Clinical Trials 2009

El-Mitwalli A, Saad M, Christou I, Malkoff M, Alexandrov AV; Clinical and sonographic patterns of tandem ICA/MCA occlusion in tPA-treated patients; Abstracts of the International Stroke Conference 32: 349, 2009

Al-Senani FM, Piriyawat P, Malkoff M; Does leukoaraiosis have any significance in tPA-treated patients?; Abstracts of the International Stroke Conference 32: 349b, 2009

Malkoff M, Piriyawat P, Al-Senani FM, Hamilton S; ASPECT scores and lesion location: volume and improvement in tPA-treated patients; Abstracts of the International Stroke Conference 32: 369d-370d, 2009

Wojner AW, Persse D, Rodriguez D, Morris G, Malkoff M, Wicklander M, Wells M, Davis L, Morgenstern L, Grotta JC; Prehospital time course of stroke patients: baseline Houston experience; Abstracts of the International Stroke Conference 32: 371a, 2009

Burgin WS, El-Mitwalli A, Malkoff M, Grotta JC, Alexandrov AV; Clinical improvement at 24 hours after MCA occlusion can be predicted from the end of tPA infusion; NIH Stroke Scale Score; Abstracts of the International Stroke Conference 32: 373b, 2009

Grotta JC, Alexandrov AV, Burgin WS, Long M, El-Mitwalli A, Campbell M, Morgenstern LB, Malkoff M; Intravenous tPA for ischemic stroke patients: Houston experience 1996-2000; Abstracts of the International Stroke Conference 32: 323b, 2009

Burgin WS, Wojner AW, Demchuk AM, Felberg RA, Barber PA, Hill MD, Malkoff M, El-Mitwalli A, Piriyawat P, Newcommon N, Button A; Validity and reliability of the thrombolysis in brain infarction (TIBI) flow grades; Abstracts of the International Stroke Conference 32: 324e-325e, 2009

Okon N, El-Mitwalli A, Malkoff M, Alexandrov AV; Optimizing transcranial Doppler screening for vertebra-basilar stenosis; Abstracts of the International Stroke Conference 32: 335d, 2009

Tsivgoulis G, Sharma VK, Ardelt AA, Brenner D, Taylor M, Robinson A, Zhao L, Spengos K, Malkoff MD, Alexandrov AW, Alexandrov AV; Reversed Robin Hood Syndrome: correlation of neurological deterioration with intracerebral steal magnitude; Stroke; 39, 725, 2008

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Tsivgoulis G, Sharma VK, Lao AY, Robinson A, Ngyen HT, Spengos K, Malkoff MD, Alexandrov AW, Alexandrov AV; Microsphere propagation in patent and acutely obstructed proximal intracranial vessels; Stroke; 39, 724, 2008

Tsivgoulis G, Hoover S, Frey JL, Lao AY, Sharma VK, Liu W, Flaster M, Alexandrov AW, Malkoff M, Alexandrov AV; Safety of thrombolysis in stroke mimics; Stroke; 39, 595, 2008

Tsivgoulis G, Frey JL, Sharma VK, Lao AY, Hoover SL, Liu W, Flaster M, Alexandrov AW, Malkoff M, Alexandrov AV; Lack of adherence to guidelines for pre-tPA blood pressure levels is associated with higher risk of symptomatic intracerebral hemorrhage; Stroke; 39, 532, 2008

Lao AY, Sharma VK, Tsivgoulis G, Hoover SL, Frey JL, Malkoff MD, Alexandrov AV; Detection of right-to-left shunts: comparison between the International Consensus and Spencer criteria; Neurology; 68, A393, 2007

Tsivgoulis G, Sharma VK, Lao AY, Hoover SL, Spengos K, Liu W, Malkoff MD, Alexandrov AV; Non-invasive detection of diffuse intracranial disease; Neurology; 68, A322, 2007

Cohn JL, Jahnke H, Tsivgoulis G, Malkoff M, Wojner-Alexandrov A, Alexandrov A, Frey JL; tPA reimbursement under DRG 559; Neurology; 68, A286, 2007

Flaster M, Tsivgoulis G, Lao AY, Sharma VK, Cohn JL, Hoover SL, Frey JL, Malkoff MD, Alexandrov AV; Thrombolysis in stroke patients 80 years or older: a single tertiary care center 10-year experience; Neurology; 68, A285, 2007

Tsivgoulis G, Sharma VK, Lao AY, Hoover SL, Liu W, Flaster M, Malkoff MD, Alexandrov AV; Validation of transcranial Doppler CT angiography in acute cerebral ischemia; Neurology; 68, A64, 2007

Alexandrov AV, Tsivgoulis G, Sharma VK, Hoover SL, Lao AY, Malkoff MD; Multigate Doppler ultrasound criteria for reversed Robin Hood syndrome in acute ischemic stroke patients; Cerebrovasc Dis; 23(suppl 1), 25-6, 2007

Alexandrov AW, Cohn JL, Oliver A, Malkoff MD, Alexandrov AV, Grotta JC; Stroke; The universal-bed concept applied to a stroke unit: cost-effective, safe, seamless nursing care; Stroke; 38, 611, 2007

Sharma VK, Tsivgoulis G, Lao AY, Malkoff MD, Alexandrov AW, Alexandrov AV; Quantification of microbubble appearance in brain vessels: implications for dose calculations and drug delivery; Stroke; 38, 493, 2007

Lao AY, Sharma VK, Tsivgoulis G, Malkoff MD, Alexandrov AV, Frey JL; Safety and feasibility of an expanded contrast TCD protocol for detection of right-to-left shunts; Stroke; 38, 497, 2007

Man CB, Lao AY, Sharma VK, Tsivgoulis G, Malkoff MD, Alexandrov AV; A spectrum of knock-type Doppler signals in the intracranial vessels; Stroke; 38, 600, 2007

Alexandrov AW, Tsivgoulis G, Lao AY, Sharma VK, Cohn JL, Miller C, Flaster, Malkoff MD, Alexandrov AV, Frey JL; Hospitalized Native American stroke patients: a prospective cohort study; Stroke; 38, 533, 2007

Cohn JL, Tsivgoulis G, Sharma VK, Lao AY, Malkoff MD, Alexandrov AV, Alexandrov AW; Weight agreement in tPA (WAIT) treatment: does weight estimation affect outcome?; Stroke; 38, 608, 2007

Frey JL, Jahnke HK, Flaster M, Cohn JL, Tsivgoulis G, Lao AY, Sharman VK, Hoover SL, Oliver A, Miller C, Malkoff MD, Alexandrov AW, Alexandrov AV; Stroke; 38, 505, 2007

Frey JL, Jahnke HK, Flaster M, Cohn JL, Tsivgoulis G, Lao AY, Sharma VK, Hoover SL, Oliver A, Miller C, Malkoff MD, Alexandrov AW, Alexandrov AV; Utility of an

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organized stroke team response and telephone network to increase tPA treatment rate: a 10-year single tertiary care center experience; Stroke; 38, 505, 2007

Tsivgoulis G, Sharma VK, Lao AY, Hoover SL, Malkoff MD, Alexandrov AV; Intracranial collateral pathways in patients with acute common carotid artery thrombotic occlusion; Neuroimaging; 27, 35, 2007

Harma VK, Lao A, Malkoff MD, Frey JL, Alexandrov AV; Diffuse intracranial disease: the other side of the Spencer’s curve; Cerebrovas Dis; 20(suppl. 3), 132, 2006

Alexandrov AV, Alexandrov AW, Malkoff MD; Reversed “Robin Hood” Syndrome: Cyclic Residual Flow Changes in Acute Patients with Fluctuating Neurological Deficits; Stroke; 733, 2006

Shaltoni HM, Sugg RM, Gonzales NM, Choi JY, Cacayorin ED, Weir RU, Alexandrov AV, Malkoff MD, Grotta JC; TIMI flow Grade 2b or higher predicts better outcome after intra-arterial thrombolysis; Stroke; 449, 2005

Mikulik R, Malkoff MD, Kim Y, Garami Z, Fulep E, Alexandrov AV; Recanalization during thrombolytic therapy for MCA stroke; Stroke; 446, 2005

Hall CE, Wojner AW, Noser EA, Shaltoni HM, Cacayorin ED, Campbell III MS, Malkoff MD; Renal Tolerance of Contrast Load Associated with Endovascular Brain Rescue; Stroke; 340, 2004

Wojner AW, Miller WR, Alexandrov AV, Malkoff MD, Hall CE, Shaltoni HM, Ireland JK, Labiche LA, Degioanni J, Choir JY; Feasibility of telemedicine camera-captured brain CT interpretation and treatment decision making; Stroke; 296, 2004

Shaltoni HM, Noser EA, Hall CE, Ireland JK, Wojner AW, Choi JY, Malkoff MD, Song JK, Cacayorin ED, Grotta JC, Campbell III MS; How safe is intra-arterial thrombolysis following full-dose (0.9 mg/kg) intravenous tPA?; Stroke; 294, 2004

Ireland JK, Alexandrov AV, Univ of Texas-Houston, Molina CA, Choi JY, Malkoff MD, Rubiera M, Shaltoni HM; Does clinical-CT “mismatch” predict response to rtPA treatment?; Stroke; 292, 2004

Noser E, Hall CE, Shaltoni HM, Choi JY, Wojner AW, Labiche LA, Malkoff MD, Song JK, Cacayorin ED, Grotta JC, Campbell III MS; Stroke; 292, 2004

Chen CI, Yasuyuki I, Garami Z, Malkoff MD, Smalling RW, Campbell MS, Alexandrov AV; Analysis of emboli in carotid stenting with distal protection device; Stroke; 266, 2004

Garami Z, Chen CI, Uchino K, Yasuyuki I, Chernyshev OY, Hall CE, Noser EA, Choi JY, Song JK, Campbell MS, Malkoff MD; Residual Flow Signals on Pretreatment TCD do not predict recanalization in stroke patients after intra-arterial rescue; Stroke; 263-4, 2004

Wojner AW, Garami Z, Noser EA, Shaw S, Malkoff M, Alexandrov AV; Heads down: lower head position is better in acute ischemic stroke; Stroke; 2003

Garami Z, Calleja S, Labiche LA, Chernyshev O, Campbell MS, Malkoff M, Alexandrov AV; Yield of urgent carotid scanning in acute cerebral ischemia; Stroke; 2003

Labiche LA, Al-Senani F, Grotta JC, Wojner AW, Malkoff M, Alexandrov AV; Is the benefit of early recanalization sustained at 3 months? A prospective cohort study; Stroke; 2003

Christou I, Burgin WS, Wojner AW, Felberg RF, Grotta JC, Malkoff M, Alexandrov AV; Timing of recanalization after tPA therapy determined by transcranial Doppler correlated with clinical recovery after ischemic stroke; J Neuroimaging; 10, 59, 2000

Christou I, Felberg RA, Dubey N, Grotta JC, Burgin WS, Malkoff M, Alexandrov AV; Predictive value of transcranial Doppler screening for severe carotid stenosis revisited; Stroke; 31, 331, 2000

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Burgin WS, Christou I, Malkoff M, Dubey N, Alexandrov AV; Ultrasound criteria for intracranial recanalization: an angiographic correlation; Stroke; 31, 329, 2000

Felberg RF, Burgin WS, Shaw W, Alexandrov AV, Malkoff M; Patients who received thrombolysis for acute stroke and required mechanical ventilation: outcome and analysis; Stroke; 31, 324, 2000

Alexandrov AV, Demchuk AM, Felberg RF, Christou I, Barber PA, Burgin WS, Malkoff M, Wojner AW, Grotta JC; Dramatic improvement during tPA infusion combined with TCD monitoring is associated with complete recanalization; Stroke; 31, 284, 2000

Demchuk AM, Felberg RF, Christou I, Wein TH, Barber PA, Malkoff M, Grotta JC; Combined intravenous and intra-arterial thrombolytic therapy for severe stroke; Stroke; 31, 275, 2000

Demchuk AM, Christou I, Felberg RF, Barber PA, Malkoff M, Alexandrov AV; Thrombolysis in brain ischemia (TIBI) flow grades predict likelihood of recanalization and recovery in intravenous tPA-treated patients; Stroke; 31, 275, 2000

Nates JL, Joseph M, Zaidi S, Malkoff M, Kim D; Increased cardiac output or mean arterial pressure, but not hypervolemia, reverses the deficits in cerebral blood flow from vasospasm following subarachnoid hemorrhage; Critical Care Medicine; 27(12), 1999

Briggs D, Felberg R, Malkoff M, Bratina P, Grotta J; Should mild or moderate strokes be admitted to an intensive care unit? Ann Neurol; 46, 3, 508, 1999

Christou I, Hickey J, Felberg R, Demchuk A, Bratina P, Malkoff M, Grotta J; Admission to the stroke unit: outcomes and costs; Ann Neurol; 46, 3, 508, 1999

Graffagnino C, Gomez C, Mayer SA, Bernardini GL, Malkoff MD; Induced controlled extended hypothermia improves outcomes in malignant stroke; Neurology; 50 (Suppl 4): A412, 1998

Sokol DH, Markand ON, Luerssen TT, Daly E, Malkoff MD; Near infrared spectroscopy (NIRS) during seizures; Neurology; 50 (Suppl 4): A286, 1998

Nievera CC, Biller J, Malkoff MD; Methylglutaconic aciduria in young adults; Neurology; 50 (Suppl 4): A16, 1998

Malkoff MD, Razumovsky AY, Williams MA, Diringer MN, Borel CO, Hanley DF; Sleep associated arterial oxygen desaturation in patients with hydrocephalus; May 1997; 10th International Symposium on Intracranial Pressure and Neuromonitoring in Brain Injury, Williamsburg, VA

Eichholz K, Malkoff MD, Gomez CR, Burch CM; The effect of hyponatremia upon the outcome of strokes admitted to a neurointensive care unit; Neurology; 48(3), Suppl A306, 1997

Malkoff MD, Schulz C, Orencia A; The effect of delay in neurological consultation on outcome in the intensive care unit; Crit Care Med; 25(1), Suppl 1:A72, 1997

Diringer MD, Malkoff MD; Survey of neuro critical care training programs in the United States; Am Academy Neurol; 46(2), 228, 1996; poster presentation

Eichholz K, Malkoff MD; Significance of acute seizures in stroke admitted to the ICU; Am Academy Neurol; 46(2), 228, 1996

Chang YJ, Malkoff MD, Gomez CR, Burch CM, Myles GL, Banet GA; Impact of dehydration on outcome of acute ischemic stroke; Annals of Neurology; 38(2), 321, 1995

Burch CM, Gomez CR, Malkoff MD, Kuseliauskas C; Impact of the extent of evaluation on stroke management; Annals of Neurology; 38(2), 321, 1995

Gomez CR, Banet GA, Tulyapronchote R, Malkoff MD, Malik CM, et al; Impact of consulting with stroke specialists in ambulatory clinical practice; Annals of Neurology; 38(2), 320, 1995

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Burch CM, Malkoff MD, Gomez CR, et al; Does the “pulsatility index” truly indicate cerebral arterial pulsatility?; Neurology; 45 (Suppl 4):A468, 1995; American Academy of Neurology, 47th Annual Meeting, Seattle WA, May 1995, Poster presentation

Malkoff MD, Burch CM, Gomez CR, Chang Y-J, et al; Quantification of dynamic changes in cerebral arterial diameter in man; Neurology; 45 (Suppl 4):A173, 1995; American Academy of Neurology, 47th Annual Meeting, Seattle WA, May 1995, Poster presentation

Stadlin NY, Gomez CR, Malkoff MD, Chang Y-J; Feasibility of angioscopic assessment of the intracranial vasculature; J Neuroimaging; 82, 327, 1995; Annual Meeting of the American Association of Neurological Surgeons, Orlando FL, Apr 1995, Presented

Malkoff MD, Keller CA, Gomez CR, Shalan GA; Preliminary experience in the detection of extracardiac right-to-left shunts in chronic pulmonary hypertension using transcranial Doppler; J Neuroimag; 5(1), 65, 1995; 18th Annual Meeting of the American Society of Neuroimaging, San Juan PR, Mar 1995, Poster presentation

Gomez CR, Kern MJ, Moore JA, Malkoff MD, Burch C; Cineangiography in the invasive evaluation of cerebral vasculature; J Neuroimag; 5(1), 68, 1995; 18th Annual Meeting of the American Society of Neuroimaging, San Juan PR, Mar 1995, Poster presentation

Gomez CR, Stadlin N, Malkoff MD; Cerebral angioscopy: the next frontier in vascular neuroimaging; J Neuroimag; 5(1), 68, 1995; 18th Annual Meeting of the American Society of Neuroimaging, San Juan PR, Mar 1995

Cruz-Flores S, Gomez CR, Sauer C, Malkoff MD, et al; Isolated vertigo as the presentation of severe basilar artery occlusive disease; Amer Acad of Neurol, Washington DC, May 1994

Malkoff MD, Bucholz R, Gomez CR, Myles GL; Barbiturate coma as salvage therapy in aneurysmal subarachnoid hemorrhage; J Neurosurg; 80(2), 367, 1994; Annual Meeting of the American Association of Neurological Surgeons, San Diego CA, Apr 1994; Poster presentation

Perry AG, Jones I, Myles G, Malkoff MD, et al; Development and reliability of testing of a surveillance instrument to detect ventilator-associated pneumonia; Midwest Nursing Research Society, Milwaukee, WI; Apr 1994; Poster presentation

Malkoff MD, Awwad E, Gomez CR; Value of sequential imaging in thrombolytic treatment of acute ischemic stroke; J Neuroimag; 4(1), 65, 1994; American Society of Neuroimaging, Beverly Hills CA, Feb 1994; Poster presentation

Malkoff MD, Gomez CR; Application of ultrasound techniques in the neurocritical care unit; J Neuroimag; 4(1), 63, 1994; American Society of Neuroimaging, Beverly Hills CA, Feb 1994; Poster presentation

Gomez CR, Malkoff MD, Bucholz RD; Life-threatening cerebral edema following biopsy for idiopathic hypertrophic cranial pachymeningitis; J Neuroimaging; 4(1) 5-66, 1994; American Society of Neuroimaging, Beverly Hills CA, Feb 1994; Poster presentation

Malkoff MD, Gomez CR, Tulyapronchote R, et al; Incidence and significance of dehydration in patients with ischemic stroke; 19th Annual Joint Conference on Stroke and Cerebral Circulation, San Diego CA, Feb 1994; Presented

Cruz-Flores S, Gomez CR, Malkoff MD, Tulyapronchote R, Malik MM, Bandalamudi R; Preliminary experience using ticlopidine in clinical practice; Neurology; 43 (Suppl 2):A264; 45th Annual Meeting of the American Academy of Neurologists, New York NY, Apr 1993; Presented

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Malkoff MD, Gomez CR, Njemanze PC; Hemodynamic effects of premature ventricular contractions on the cerebral circulation; Annals of Neurology; 30(2), 246, 1991; 116th Annual Meeting of American Neurologists Association, Seattle WA

Njemanze PC, Gomez CR, Wade JB, Malkoff MD; Cerebrovascular resistance and distensibility in systemic hypertension; J Neuroimag; 1(1), 54, 1991; 14th Annual Meeting of the American Society of Neuroimaging, Orlando FL, Feb 1991; Presented

Mirza W, Rosenfeld WE, Njemanze PC, Gomez CR, Malkoff MD, et al; Synchronized TCD and video EEG II: utilization in the epilepsy unit; J Neuroimag 1(1), 54, 1991; 14th Annual Meeting of the American Society of Neuroimaging, Orlando FL, Feb 1991; Presented

Njemanze PC, Gomez CR, Rosenfeld WE, Mirza W, Malkoff MD; Synchronized TCD and video EEG I: rationale and methodology; J Neuroimag 1(1), 60, 1991; 14th Annual Meeting of the American Society of Neuroimaging, Orlando FL, Feb 1991; Presented

Malkoff MD, Diringer M, Borel C, Kirsch J, Hanley D; Arterial hemoglobin desaturation accompanies nocturnal elevation of intracranial pressure and hydrocephalus; Ann of Neurol; 26(1), 133, 1989

Malkoff MD, Watts RL, Schatten S, Hopkins LC, Perlmutter J; Hemichorea and lupus anticoagulant as the presenting features of systemic lupus erythematosis; Neurology, 39(3), Suppl 1, 333, 1988

Hendricks CT, Teyler TJ, Malkoff MD; Electrophysiological characterization of rat claustroentorhinal connections; Soc of Neurosc; A89.8, 1982

Contributed (Unrefereed) Abstracts and/or Oral Presentations at Professional Meetings: Perry AG, Jones I, Myles G, Malkoff MD, et al; Development and reliability testing of

a surveillance instrument to detect ventilator-associated pneumonia; Oct 1993; Research Day, Sigma Theta Tau, Delta Lambda Chapter, St. Louis MO

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Marc D. Malkoff, MD

Current Grant and Contract Funding: Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH)

o Project PI: Daniel Woo, MD, University of Cincinnatio Site PI: Marc Malkoff, MDo LOE 10%o Funding Organization: NIH, University of Cincinnatio August 1, 2010 – July 31, 2015o Period 1

August 1, 2010 – July 31, 2011 $105,902 Direct + $50,963 F&A = $156,865 Total

Membrane-Activated Chelator Stroke Intervention (MACSI)o Project PI: Gilad Rosenberg, MD, MSco Site PI: Marc Malkoff, MDo LOE 5%o Funding Organization: CATO, (d-Pharm, Ltd)o May 12, 2010 – May 11, 2012o Period 1

May 12, 2010 – May 11, 2011 $56,958 Direct + $17,087 F&A = $74,045 Total

Past Grant and Contract Funding Allon Physionics

o Site PI, Marc Malkoff, MDo University of Washington / National Institutes of Healtho 2006-2008o $20,000

Imarxo Site PI, Marc Malkoff, MDo 2006-2007o $100,000

CASG West Nile Virus #210 and #211, LOE 10% Familial Aneurysm Study, LOE 1.2% CASG Herpes Encephalitis Study, PI 2001, LOE 5% Comparison of Non-Invasive Body Electrical Bioimpedance Cardiac Output and

Invasive Thermodilution Output, Adult Populationo Site PI, Marc Malkoff, MDo Siemens Medical Systemso March 10, 1997 – September 30, 1997o $3,000

Stroke Councilo Student Preceptor Summer Fellowshipo Site PI, Marc Malkoff, MDo American Heart Associationo 1995o $2,000

Nutrition in Subarachnoid Hemorrhageo Site PI, Marc Malkoff, MDo Sandoz Nutrition Corporationo 1994o $15,855

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Marc D. Malkoff, MD

A Clinical Evaluation of Two Fiberoptic Jugular Bulb Catheterso Site PI, Marc Malkoff, MDo Abbott Laboratorieso 1994o $3,560

Double-Blind Multicenter Study to Assess the Efficacy and Safety of D.H.E. 45 (Dihydroergotamine Mesylate) Nasal Spray 2.0 and 3.0 Doses in Comparison with Placebo for the Acute Treatment of Migraine

o Site PI, Marc Malkoff, MDo Sandoz Pharmaceuticals Corporationo 1993-1994o $12,054

Charles A. Dana Foundation Fellowo 1988-1990o $50,000

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Marc D. Malkoff, MD

Mentoring of Other Faculty in Research or Scholarship Dr. Chamisa MacIndoe, 2010-Present, Assistant Professor of Critical Care,

Departments of Surgery and Neurosurgery, University of New Mexico Dr. Steven Hoover, 2006-2007, Fellow, Cerebrovascular Diseases, Dr. Christiana Hall, 2003-2005, Fellow, Neurocritical Care Dr. Gregg Shalan, 1994-1995, Fellow, Neurocritical Care Dr. Roekchai Tulyapronchote, 1993-1994, Fellow, Stroke and Critical Care

Teaching / Education 2008-Present, University of New Mexico Health Sciences Center Phase II Medical

Students and/or Neurology Residents; Coma, Intracranial Hemorrhage, Internal Medicine and Current Treatment in Stroke, Stroke, Neuronal Cell Death, Nonaneurysmal Intracranial Hemorrhage, Brain Death, Increased Intracranial Pressure, The Evidence Behind UNM Stroke Protocol, Stroke Protocol and System at UNM, Imaging Perfusion, Changes in Stroke Therapy

Dr. Yao-Jen Chang, 1994-1994, Medical Student Preceptor, American Heart Association Summer Fellowship, Cerebrovascular Disease

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Marc D. Malkoff, MD

Service Present Patient Care Activities

Medical Director, University of New Mexico Hospital Stroke Program Medical Director, NeuroSciences Intensive Care Unit University of New Mexico Hospital Critical Care Committee

Past Patient Care Activities Medical Director, Neuroscience Critical Care Unit, St. Louis University Hospital,

1990-1995

Local, State, Regional, National Committees 2010, New Mexico State Stroke Advisory Board, Chairman 2009-Present, American Heart Association, South Central Stroke Advisory

Committee, Member 2009-Present, American Society of Neuroimaging, Secretary 2008-Present, New Mexico State Stroke Advisory Board, Member 2007-Present, United Council of Neurologic Subspecialties Neuroimaging

Examination Committee 2004-Present, American Society of Neuroimaging, Executive Board 2003-2009, American Society of Neuroimaging, Board of Directors 2003-2006, Neurocritical Society, Executive Board 2002-2004, Society of Critical Care Medicine, Neuroscience Section, President 2000-2006, American Society of Neuroimaging, CT/MRI Exam Committee Chair 2000-2002, Society of Critical Care Medicine, Neuroscience Section, President-Elect 1999-Present, American Society of Neuroimaging, Program Committee 1999-2003, Texas Medical Association, Stroke Action Committee, Executive

Committee 1998-Present, American Society of Neuroimaging, CT/MRI Exam Committee 1995-1997, American Academy of Neurology, Section of Critical Care and

Emergency Neurology, Secretary 1995-2004, American Academy of Neurology, Section of Critical Care and

Emergency Neurology, Executive Committee 1994-Present, American Society of Neuroimaging, Neurosonology Exam Committee 1994-1995, American Society of Neuroimaging, Membership Committee 1993-2003, American Board of Psychiatry and Neurology, Associate Examiner 1993-1994, Society of Critical Care Medicine, Project IMPACT, Monitoring

Subcommittee

Mentoring of Other Faculty Members in Clinical or Other Service Activities Dr. Steven Hoover, 2006-2007, Assistant Professor, University of Oklahoma Health

Sciences Center, Oklahoma City, Oklahoma Dr. Christiana Hall, 2003-2005, Assistant Professor of Neurology and Neurosurgery,

Director of Neurocritical Care Fellowship, Southwestern Medical Center, Dallas, Texas

Dr. Gregg Shalan, 1994-1995, Private Practice, Dallas, Texas Dr. Roekchai Tulyapronchote, 1993-1994, Leading Stroke Neurologist, Thailand

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