…………. aydan kansu, md ankara university school of medicine, department of pediatric...
TRANSCRIPT
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………….
Aydan Kansu, MDAnkara University School of Medicine, Department of Pediatric Gastroenterology andHepatology, Turkey
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Building National Task ForceBuilding National Task Force
National representative
Ministry of Health(Head of non-infectious diseases and chronic diseases)
Turkish Society of Pediatric Gastroenterology and Hepatology
Celiac Society (Ankara)
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Training and Dissemination at National Level – 1Training and Dissemination at National Level – 1
Universities, School of Medicine
Pediatrics residency training programmecurriculum 20/01/2011– Chronic abdominal pain– Chronic constipation– GER– Chronic liver diseases – liver failure– Malabsorption – Celiac disease– Malnutrition
Pediatric gastroenterology fellowship training programme
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Training and Dissemination at National Level - 2Training and Dissemination at National Level - 2
Family doctors (GP)– Distant Training (Celiac module)
(Ministry of Health)– Regional Seminars (proposed)
(Turkish Society of Pediatric Gastroenterology and Hepatology)
Pediatricians– Regional Seminars (proposed)
(Turkish Society of Pediatric Gastroenterology and Hepatology)
– Congress – Meetings– Distant Training (proposed)
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Training and Dissemination at National Level – 3Training and Dissemination at National Level – 3
For the society
– Radio-TV (proposed)(Turkish Society of Pediatric Gastroenterology and Hepatology)(Celiac Society)
– Parenthood Education (proposed)(Ankara University School of Medicine, Department of Pediatrics)
– Elementary Schoolscurriculum (3rd and 5th grade) 09/2010
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Diagnostic GuidelinesDiagnostic Guidelines
Transglutaminase
HLA (not widely available)
Endoscopic bx (managed)
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Retrospective StudyRetrospective Study
tg levels – bx: correlated
HLA: 26/50 DQ2
3/50 DQ8
3/50 DQ2 + DQ8
3/50 no DQ2 / DQ8
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AJG-10-1661.R2
PREVALENCE OF CELIAC DISEASE IN HEALTHY TURKISH SCHOOL CHILDREN
Dear Dr. Sari
Thank you for submitting your revised manuscript. Your revised manuscript has been reviewed, and the Editors and Editorial Board are pleased to accept it for publication in a future issue of the Journal.
Yours sincerely,
Dr. Joseph MurrayAssociate Editor
William Chey, MDPaul Moayyedi, MDEditors-in-Chief
01.02.2011
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Turkish Celiac Study Group - 1Turkish Celiac Study Group - 1
20.190 children from 139 schools in 62 cities
489 ab+ IgA tTG +: 270IgA tTG + IgA EMA +: 215IgG tTG +: 4
215 bx 95 CDHistology IgA tTGMarsh O 43.3 (28.6-81.6)Marsh I (n:18) 115.2 (59.3-198)Marsh II (n:6) 120.6 (26.8-220)Marsh III (n:71) 220 (199.2-220)
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Turkish Celiac Study Group - 2Turkish Celiac Study Group - 2
Histopathological grade was correlated with IgA tTG titer (p<0.0001)
IgA EMA (+) patients had higher IgA tTG titer
The best PPV (88.73%) for IgA tTG was found when cutt off: 180 RU/ml (9xULN)
bx proven prevalence of CD 1:212
estimated prevalence of CD 1:58(bx + already diagnosed + tTG + EMA)
serologic positivity 1:41
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Pilot StudyPilot Study
URFA
State Hospital
Pediatric gastroenterologist (obligatory work)
Very big family size (10-12 children/family)
Very high rate of gluten consuming
tg available
bx will be referred
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Risk FactorsRisk Factors
Genetic
Biological samples
DNA
PROBLEMPROBLEM
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Celiac AssociationCeliac Association
~ 12.000 celiac patients in Turkey
CA– Ankara (400) – very active
– İstanbul
– Bursa
– Konya
– Kayseri
– Diyarbakır
– Gaziantep
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Gluten Free DietGluten Free Diet
01.03.2011
0-5 y: 52.50 TL (28 €)
5-15 y: 80 TL (36 €)
15 y : 72.50 TL (33 €)
flour : 7.6 €/kgpasta : 13.2 €/kg