““A Critical Role for AADR in Shaping the A Critical Role for AADR in Shaping the Future of Academic Dental and Craniofacial Future of Academic Dental and Craniofacial

ResearchResearch””

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Nov 10th, 2012

AADR PRESENTATION TO ADEA ‘NEW DEANS’AADR PRESENTATION TO ADEA ‘NEW DEANS’

Rena D’Souza, AADR PresidentChristopher Fox, AADR Executive Director

Topics……Topics……

How Dentistry Evolved- The Discoveries of Dentists that Shaped Health

Care Challenges and Opportunities for Dentistry

- Can we Shape the Future? Translational and Clinical Research

- What ? Why ? How ? Signature Initiatives from NIDCR/NIH What is AADR’s Role?

The Beginnings….The Beginnings…. Barbers and BlacksmithsBarbers and Blacksmiths

Past 150 yrs

Horace WellsWilliam MortonG.V. BlackEdward AngleTruman Brophy WilloughbyWilloughby

Miller (1890)*Miller (1890)*-Bacterial basis for Oral Diseases-Disease Prevention

(JADA: 140, 2009)(JADA: 140, 2009)

The Scientific Evolution of The Scientific Evolution of DentistryDentistry

William J. Gies and the 1926 Carnegie Foundation Report on Dental Education

Dental Schools Incorporated as part of Health Sciences/Medical Centers and Universities

Development of Dental Scientific Journals and Publications in Medical and other Scientific Journals

The role of immigrant dental scientists from Europe

Opening of National Institute of Dental Research in 1948

The Challenges are Great Too !!!The Challenges are Great Too !!!

How to translate discoveries about the DOC complex into better treatment and prevention of diseases and disorders while pushing the frontiers of basic science yet further ?

Those closest to the clinical challenges will Those closest to the clinical challenges will generategenerate the most pertinent and relevant questions.the most pertinent and relevant questions.

Hence a robust body of dental and craniofacial Hence a robust body of dental and craniofacial research findings should be emanating from our research findings should be emanating from our dental institutionsdental institutions

Our Needs Are Great!!!!

Challenges and Opportunities for Dentistry Research is becoming more difficult to support Grants are difficult to obtain Higher % of NIDCR Funding outside dental

schools New schools with minimal infrastructure for

research Lack of formal training in clinical research

methods Need for better diagnostics, point-of-care

therapeutics Several studies available for translation Increase in evidence-based instruction

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Back to the Future…..Back to the Future…..

NIDCR, 2012

Personalized MedicinePredictive, Preventive,

Precision Care Personalized medicine

in the sense of the ‘right treatment for the right patient at the right time”-has been practiced for millennia (Steele, F. Pers. Med. 2009.6,1-5)

Provides the ability to classify individuals into sub populations based on their susceptibility to a disease or response to a specific treatment

NIDCR 2012

NIDCR 2012

NCRR Supports the Continuum of Biomedical Research

Definition of Translational Research

Translational research fosters the multidirectional integration of basic research, patient-oriented research, and population-based research, with the long-term aim of improving the health of the public (Rubio et al., 2010)

Clinical Research. NIH defines human clinical research as (1) Patient-oriented research. Research conducted with human subjects (or on material of human origin) for which an investigator (or colleague) directly interacts with human subjects. Patient-oriented research includes:

(a) mechanisms of human disease,

(b) therapeutic interventions,

(c) clinical trials, and

(d) development of new technologies.

(2) Epidemiologic and behavioral studies.

(3) Outcomes research and health services research.

NIH definitions of clinical research

NIDCR, 2012

Traditional epidemiology studiesMechanistic studies using patient samplesOther studies, such as cohort studies following

subjects to determine outcomes of treatment(s). An example would be a study following individuals with diabetes and dental implants to determine if poor glucose control is associated with shorter implant survival.

Clinical Research

NIDCR, 2012

NIH CTSA program Many translational training programs developed at CTSA institutions, many focused on training clinicians, but others focused on training basic scientists

CTSA institutions working to develop common training standards and best practices--core competencies under development

CTSA consortium creating a repository of programs (on-line and traditional) available at institutions around the country—National CTSA Educational Resource Program

Educational and training opportunities

2010-Building a National CTSA Consortium

55 CTSA sites in 28 states and the District of Columbia

WA

OR

CA

NV

AZNM

MT

UT

WY

CO

SD

ND

NE

KS

OK

TXAK

AR

MO

IA

MN

WI

IL IN

MI

OH

KY

TN

MS AL GA

FL

LA

NC

SC

VAWV

PA

NY

VTNH

ME

MA

DEMD

RI

ID

HI

PRPR

NJ

= IDeA-Eligible State and CTSA Member

= CTSA States

= IDeA-Eligible States

National Dental Practice- Based Research Network

: NDPRN

NIDCR, 2012

NIDCR, 2012

NIDCR 2012

NIDCR, 2012

NIDCR, 2012

NIDCR, 2012

How can AADR Help?

Organize Information Transfer Sessions and Training Workshops at AADR Annual Sessions?? Clinical Research Methodology ? Research Mentoring Teams for Junior Faculty? Practice-Based Research Network Forums ? Meetings with Program Officers from Funding

Agencies ? Year-long AADR- Sponsored Activities ???

Visits of President and Board Members to Schools ? Activation of Local Chapters/Sections?

Dean Participation???

IADR/AADR Global HQ, Alexandria, VA

Rena D’Souza, AADR President, rdsouza@bcd.tamhsc.eduChristopher Fox, AADR Executive Director, cfox@iadr.org