NATIONAL UNIVERSITY OF PHARMACY Department of Clinical Laboratory Diagnostic

Пиріг Л.А., Мельман Н.Я., 1982; Пиріг Л.А., 1997, 1999; Забровський Г.И., 1986; Чиж А.С. із співавт., 1990; Radechi S.E. et al., 1989

Мухин Н.А., 1997; Полушин В.И., 1998; Simon P., 1996; Lei H.H. et al., 1998

Neoplasms (kidney,

lymphoma)

Neoplasms (kidney,

lymphoma)

Allergy (anaphylaxis)

Allergy (anaphylaxis)

Metabolic factors (hypercorticoidism, hiprekaltsyemiya)

Metabolic factors (hypercorticoidism, hiprekaltsyemiya)

Injuries to the bladder, ureter, renal

Injuries to the bladder, ureter, renal

Vascular pathology (kidney infarction, congestive heart

failure)

Vascular pathology (kidney infarction, congestive heart

failure)

Iatrogenic factors (anesthesia, cardiac glycosides, NSAIDs, nephrotoxic drugs,

septic shock)

Iatrogenic factors (anesthesia, cardiac glycosides, NSAIDs, nephrotoxic drugs,

septic shock)

Infectious agents (pyelonephritis, leptospirosis,

piroplasmosis)

Ideopatychna and imunoobumovlena pathology (amyloidosis, immune

complexes, hlomerulonefropatiya, interstitsialnyy nephritis)

Ideopatychna and imunoobumovlena pathology (amyloidosis, immune

complexes, hlomerulonefropatiya, interstitsialnyy nephritis)

Chronic Kidney Disease1. The primary glomerular lesions2. Secondary glomerular lesions caused by:a) systemic connective tissue diseasesb) systemic vasculitisc) diabetes of the first or the second-typed) primary or secondary amyloidosise) hepatitis B or C, AIDSe) hypertension of any origing) gestosisg) other causes3. Hereditary nephropathy (glomerular, tubular, cystic)4. Non-communicable Chronic kidney disease tubulointerstytsialni5. Chronic pyelonephritis (complicated, uncomplicated)6. Chronic lesions (disease) kidney transplant

2nd Congress of Nephrology Ukraine, 2005

2. Acute kidney damage1. Acute glomerulonephritis2. Acute pyelonephritis (complicated, uncomplicated)3. Acute nephritis tubulointerstytsialnyy4. Acute renal failurea) prerenalb) renalc) postrenalna5. quickly progressing renal damage1. quickly progressing glomerulonephritis2. Secondary3. Urinary tract infections1. Urinary tract infections without defining topicsa) complicatedb) uncomplicated2. Acute and chronic cystitis (complicated, uncomplicated)3. urethritis, urethral syndrome

2nd Congress of Nephrology Ukraine, 2005

Adrenal Adrenal

The outer shell The outer shell

Pyramid Malpighi Pyramid Malpighi

Renal pelvis Renal pelvis

Renal cup Renal cup

Papilla Papilla

Cortical substance Cortical substance

Medulla Medulla

Ureter Ureter

Renal vein Renal vein

Renal artery Renal artery

Adrenal Adrenal

The right kidney The right kidney

The abdominal aorta The abdominal aorta

Inferior vena cava Inferior vena cava

Urine number ......

"......" ..................... 2015

Last name, first name and patronymic. .....................Age .................................................Medical institution branch ...... ...... .palataPlot ......... medical record № ......... ...

PHYSICAL AND CHEMICAL PROPERTIESNumber ........................... ... ......... .mlColor ................................................... ..Transparency ....................................... ...Relative density ........................ ..Reaction .................................................Protein ............ ..h / L .................. ... ......... ..h%Glucose ......... ..mmol / l ............ ... ......... d%Ketone bodies .......................................Reaction to blood .....................................Bilirubin .............................................Urobilinoyidy ....................................Bile acids .............................. ...Indican ..........................................

The relative density (specific gravity) - characteristic that determines the concentration ability of the kidneys and urine output depends on, the concentration

of dissolved substances in the urine (urea, uric acid, salts, electrolytes, etc.)

Concentration ability of the kidneys evaluated by direct determination of osmotic concentration of urine by krioskopiyi

Zimnitskiy test allows to estimate concentration ability of the kidneys. They carry urine sampling by the rules every 3 hours and got 8 glasses of urine

sent for study:

Zimnitskiy test allows to estimate concentration ability of the kidneys. They carry urine sampling by the rules every 3 hours and got 8 glasses of urine

sent for study:

Daily urine output

Night diuresis

Портативний фотометр

Фізіологічна (аліментарна, після прийому кофеїну,

стресу тощо)

Патологічна (ренальний або цукровий діабет,

гломерулонефрит, гостра ниркова недостатність, нефротичний синдром, хвороба Іценко-Кушинга,

тиреотоксикоз, цироз печінки тощо)

Кількісні реакції на виявлення глюкози у сечі

In violation of the outflow of urine appears fever, symptoms of intoxication, leukocytosis, leukocyte shift to

the left, increasing SHOЭ and anuria

«... The problem of the safety and efficacy of medicinal products is becoming increasingly

important worldwide. This is due to the introduction of the medical practice of a large number of pharmacological agents, irrational

use of medicines, medical errors ... »

World Health Organization, 2006

Humanitarian disasters related to drugs:1937 - Mr. sulfanilamide in diyetylenhlykoli1961 - thalidomide1983 - zomepyrak1983 - osmozyn1982 - benoksaprofen2001 - tseryvastatyn2005 - problem koksybiv2006 - problem antidepressants

Nephrotoxicity drugs or "drug nephropathy" - direct or indirect

(via the immune response) poshkodzhuyacha effect of drugs on urinary system and, above all,

on tubular and glomerular apparatus

Nephrotoxicity drugs or "drug nephropathy" - direct or indirect

(via the immune response) poshkodzhuyacha effect of drugs on urinary system and, above all,

on tubular and glomerular apparatus