yesterday, today, tomorrow - /// yesterday, today, tomorrow in karlovac, the companies isis (zagreb)

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  • YESTERDAY, TODAY, TOMORROW

  • PLIVA ANNUALLY

    MANUFACTURES

    5.5

    30

    10

    billion tablets

    million injections

    million tubes of creams and ointments

  • There are only a few companies in Croatia or worldwide which can take pride in the long tradition that PLIVA can. Its history dates back to as early as 1921 when the Kaštel factory in Karlovac started to manufacture domestic herb extracts. In its history which spans over more than 90 years PLIVA has manufactured hundreds of different high quality medicines and made an exceptional contribution to the treatment of patients in Croatia and globally. Its experts, researchers and scientists have also greatly contributed to scientific and technological developments.

    After decades of intensive development, PLIVA is today the largest pharmaceutical company in Croatia and one of the leading companies in Southeast Europe. With about 2000 employees, PLIVA is also among the major economic entities in Croatia and one of the country’s leading exporters. Since 2008 PLIVA has operated as a member of Teva, one of the largest pharmaceutical companies in the world, and PLIVA’s site in Zagreb has become one of the strategic production and research and development sites for the Teva Group.

    PLIVA has state-of-the-art development and manufacturing capacities and offers a broad portfolio of high-quality generic medicines with superior therapeutic solutions for a large number of European and international markets. In addition to finished dosage forms, PLIVA also manufactures a large number of active pharmaceutical ingredients and is the only pharmaceutical company in Croatia and one of the few in the region with vertically integrated production.

    Over the last several years PLIVA has doubled its production of finished dosage forms. With more than 90 different molecules, PLIVA manufactures about 1000 various products for the USA, the European Union and other markets all around the world.

    A new investment cycle, worth about USD 200 million and one of the biggest in the company’s history, is underway. The investment is earmarked for the new production facility for active pharmaceutical ingredients at PLIVA’s site in Savski Marof and the construction of environmental facilities compliant with the IPPC Directive. The expansion of production capacities for finished dosage forms is underway at the Prilaz baruna Filipovića site in Zagreb. These investments will also result in new jobs and the employment of various experts.

    Through both its current and future efforts PLIVA wants to be available to an even greater number of patients and a high- quality and reliable partner to healthcare systems in Croatia and Southeast Europe.

    Sincerely yours,

    Tihomir Orešković PLIVA CROATIA Ltd. Management Board President

    WELCOME TO PLIVA!

    Since 2008 PLIVA has operated as a member of Teva, one of the largest

    pharmaceutical companies in the world, and PLIVA’s site in Zagreb has become one of

    the strategic production and research and development

    sites for the Teva Group

  • PLIVA MILESTONES

    1921 1923 1927

    PLIVA’S OXYTETRACYCLINE PRODUCTION PLANT RECEIVES APPROVAL BY THE US FOOD AND DRUG ADMINISTRATION (FDA), THE FIRST OF MORE THAN 30 DMF SUBMISSIONS APPROVED BY THE FDA

    PRODUCTION IN THE NEW FACILITY FOR FINISHED DOSAGE FORMS STARTS. ONE HUNDRED AND THIRTY TWO NEW MEDICINES ARE MANUFACTURED, 58 OF WHICH ARE BASED ON ORIGINAL FORMULATIONS

    PLIVA’S ORIGINAL MACROLIDE ANTIBIOTIC AZITHROMYCIN IS PATENTED

    AZITHROMYCIN IS LAUNCHED UNDER PLIVA’S BRAND NAME SUMAMED

    AZITHROMYCIN IS LAUNCHED UNDER PFIZER’S BRAND NAME ZITHROMAX ON AMERICAN AND WESTERN EUROPEAN MARKETS

    19801965 19881971 1991

    PAGE 04

    /// YESTERDAY,

    TODAY, TOMORROW

    IN KARLOVAC, THE COMPANIES ISIS (ZAGREB) AND CHINOIN (BUDAPEST)

    FOUND THE COMPANY KAŠTEL D.D., PLIVA’S PREDECESSOR. THE

    PRODUCTION OF DOMESTIC HERB EXTRACTS BEGINS

    THE PRODUCTION OF INJECTIONS, SYRUPS AND TABLETS BEGINS

    PRODUCTION MOVES TO THE CURRENT SITE IN ZAGREB, WHICH EMPLOYS ABOUT 60 PEOPLE, OF WHOM TEN ARE TERTIARY QUALIFIED

  • VLADIMIR PRELOG, PHD, NOBEL PRIZE WINNER FOR CHEMISTRY IN 1975, JOINS THE COMPANY AND BEGINS A RESEARCH ROLE IN KAŠTEL D.D.

    KAŠTEL D.D. BECOMES ONE OF THE FIRST SULPHONAMIDE PRODUCERS IN THE WORLD. STREPTAZOL IS PATENTED UNDER NUMBER 13726. SINCE THEN, PLIVA HAS FILED MORE THAN 400 PATENT APPLICATIONS IN OVER 40 COUNTRIES WORLDWIDE

    STREPTAZOL TABLETS AND INJECTION ACHIEVE A HUGE MARKET SUCCESS

    THE PLIVA RESEARCH INSTITUTE IS FOUNDED

    THE PRODUCTION OF VITAMIN C, BASED ON IN-HOUSE PATENTED TECHNOLOGY, BEGINS

    OXYTETRACYCLINE AND VITAMIN B6 PRODUCTION STARTS

    1935 1936 1937

    PLIVA GETS ITS CURRENT NAME (THE STATE INSTITUTE FOR PRODUCTION OF MEDICINES AND VACCINES) AFTER 1945 PRODUCTION INCREASES, THE NUMBER OF EMPLOYEES INCREASES, AND THE CONTROL- ANALYTICAL SECTOR IS FOUNDED

    1941 1952 1953 1959

    THE NEW RESEARCH INSTITUTE OPENS

    A NEW INVESTMENT CYCLE, ONE OF THE BIGGEST IN THE COMPANY’S HISTORY

    OVER THE NEXT SEVERAL YEARS, A NEW PRODUCTION FACILITY FOR ACTIVE PHARMACEUTICAL INGREDIENTS WILL BE BUILT AT PLIVA’S SITE IN SAVSKI MAROF. THE EXPANSION OF PRODUCTION CAPACITIES FOR ORAL SOLID FORMS AND INJECTIONS, AND THE INTRODUCTION OF NEW TECHNOLOGIES TO THE PRODUCTION AND PACKAGING OF FINISHED DOSAGE FORMS, GETS UNDERWAY AT THE ZAGREB SITE

    THE FINANCIAL SHARED SERVICE CENTRE ZAGREB FOR TEVA’S EUROPEAN SITES OPENS WITHIN PLIVA

    PRODUCTION IN THE NEW FACILITY FOR ORAL SOLID FORMS STARTS

    NUMEROUS RECONSTRUCTION ACTIVITIES TAKE PLACE AT THE INJECTIONS AND CREAMS PRODUCTION FACILITIES

    2001 2001 - 2010 2002 2011 2012

    PLIVA BECOMES A MEMBER OF THE TEVA GROUP, ONE OF THE WORLD’S LARGEST GENERIC PHARMACEUTICAL COMPANIES

    2008

  • Although PLIVA’s history starts with the establishment

    of the joint-stock company and factory Kaštel in Karlo-

    vac in 1921, manufacturing at PLIVA’s current site in Savs-

    ki Marof dates back to as early as 1878, when the baron

    Dumreicher opened a factory and refinery for spirits and

    baker’s yeast. This factory was recognised as a pioneer

    in the industrialisation and economic development of

    Croatia for that time, and was subsequently renamed

    Žumberak, and in 1967 its name changed to PLIVA, Savs-

    ki Marof site.

    The first president of the Board of the Joint-Stock Com-

    pany Kaštel was Prof. Gustav Janaček, Ph.D. who, in co-

    operation with Eugen Ladany, Ph.D., started the produc-

    tion of pharmaceutical and galenical preparations thus

    paving the way for the modern production of medicinal

    products in this region.

    A team of enthusiasts, guided by a passion for science

    and its values, started with researching and developing

    new medicines soon after the establishment of Kaštel.

    Organised research work at PLIVA started in 1936 in co-

    operation with Prof. Vladimir Prelog from the University

    of Zagreb, later a Nobel Prize Laureate for chemistry. In

    1936 Kaštel launched and patented sulphanilamide, an

    active substance with bacteriostatic effects, under the

    name Streptazol and thus became one of the first sul-

    phonamide manufacturers in the world.

    The production of vitamin C started in 1953 and it was

    based on the in-house patented technology. The produc-

    tion of oxytetracycline and vitamin B6 started soon after.

    A LOOK INTO THE PAST Over 90 years of successful pharmaceutical operations

    IN 1936 KAŠTEL LAUNCHED AND PATENTED

    SULFANILAMIDE, AN ACTIVE SUBSTANCE WITH

    BACTERIOSTATIC EFFECTS, UNDER THE NAME STREPTAZOL.

    KAŠTEL BECAME ONE OF THE FIRST SULPHONAMIDE

    MANUFACTURERS IN THE WORLD

    PAGE 06

    /// YESTERDAY,

    TODAY, TOMORROW

  • PLIVA MAINTAINED ITS R&D FOCUS AND FOUNDED ITS OWN RESEARCH INSTITUTE IN 1952 WHERE IT DEVELOPED IN-HOUSE LABORATORY AND TECHNOLOGICAL PROCEDURES FOR MANY PHARMACEUTICAL PRODUCTS.

    In the middle of the fifties PLIVA had galenical, tablet and

    injection departments, and in 1952 it founded its own Re-

    search Institute. The department for the preparation of

    production worked on granulation, granulate drying and

    tabletting. Although it had modest equipment, some tab-

    lets were sugar coated, even back then. In addition to fin-

    ished dosage forms, PLIVA currently also manufactures a

    large number of active pharmaceutical ingredients.

    The discovery of azithromycin, the first azalide antibiotic,

    was a landmark in both PLIVA’s history and the history of

    the entire Croatian pharmaceutical industry. This discov-

    ery made PLIVA one of the few pharmaceutical compa-

    nies with an in-house developed original medicine and

    Croatia one of only nine countries with its own antibiotic.

    Thanks to its outstanding therapeutic properties, Suma-

    med has become and remained one of the most success-

    ful blockbuster medicines worldwide.

    Until about twenty years ago PLIVA was a typical local

    company, generating about 75% of its reve