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XI NATIONAL CONGRESS OF THE ITALIAN SOCIETY OF IMMUNOLOGY,

CLINICAL IMMUNOLOGY AND ALLERGOLOGY

B A R I 28-31 M A Y 2 0 1 7

SCIENTIFICPROGRAM

Congress PresidentsAngela Santoni

Angelo Vacca

Scientific Committee

Francesco Annunziato

Flavia Bazzoni

Ennio Carbone

Raffaele De Palma

Francesca Di Rosa

Cecilia Garlanda

Francesca Granucci

Vito Pistoia

Angela Santoni

Angelo Vacca

Local Organizing Committee Sebastiano Cicco

Maria Antonia Frassanito

Gianfranco Lauletta

Marcella Prete

Vito Racanelli

Roberto Ria

Antonio Solimando

Angelo Vacca

8

Room Nicolaus (Floor -1)

14.45-15.15 OPENING CEREMONY

15.15-16.00 OPENING LECTURE

16.00-18.00Symposium - Joint SIICA-AINI

IMMUNE-MEDIATED NEUROLOGICAL DISEASES

18.00-18.45 EFIS LECTURE

18.45 WELCOME COCKTAIL

SUNDAY, 28 MAY 2017

Room Nicolaus (Floor -1) Room Cassiopea (Floor 1) Room Unicorno (Floor -1)

09.00-11.00

Symposium IMMUNOREGULATION

(9.00-10.45) Workshop - Joint SIICA-SIAAIC

SEVERE ASTHMA. FROM MECHANISMS TO

TREATMENT (part I)

11.00-11.10 Break

11.10-13.30 Workshop 1*AUTOIMMUNITY

Workshop - Joint SIICA-SIAAIC SEVERE ASTHMA.

FROM MECHANISMS TO TREATMENT (part II)

Workshop 2*INNATE IMMUNITY AND

INFLAMMATION I

13.30-14.30 Sponsored SessionBecton Dickinson Italia

Sponsored SessionGlaxoSmithKline

14.30-16.30Symposium

IMMUNE CHECK POINTS AND CANCER IMMUNOTHERAPY

Workshop AUTOIMMUNE MECHANISMS

AND DISEASES

16.30-18.00 Break & Poster Session I - (P1.1-P7.18) - Poster Area

18.00-18.45 SIICA President Lecture

18.45-20.00 SIICA ASSEMBLY

MONDAY, 29 MAY 2017

TIME TABLE

9




09.00-11.00

Symposium IMMUNOREGULATION

(9.00-10.45) Workshop - Joint SIICA-SIAAIC

SEVERE ASTHMA. FROM MECHANISMS TO

TREATMENT (part I)

11.00-11.10 Break

11.10-13.30 Workshop 1*AUTOIMMUNITY

Workshop - Joint SIICA-SIAAIC SEVERE ASTHMA.

FROM MECHANISMS TO TREATMENT (part II)

Workshop 2*INNATE IMMUNITY AND

INFLAMMATION I

13.30-14.30 Sponsored SessionBecton Dickinson Italia

Sponsored SessionGlaxoSmithKline

14.30-16.30Symposium

IMMUNE CHECK POINTS AND CANCER IMMUNOTHERAPY

Workshop AUTOIMMUNE MECHANISMS

AND DISEASES


18.00-18.45 SIICA President Lecture

18.45-20.00 SIICA ASSEMBLY


9.00-11.00

Symposium - Joint SIICA-FOCISIMMUNODEFICIENCIES

Workshop CHRONIC LYMPHOCYTIC

LEUKEMIA. FROM BASIC SCIENCETO TREATMENT (part I)


11.30-13.30Workshop - Joint

SIICA-EAACI-OGÄIINNOVATIVE IMMUNOTHERAPY

IN ALLERGY

WorkshopCHRONIC LYMPHOCYTIC

LEUKEMIA. FROM BASIC SCIENCE TO TREATMENT (part II)

Workshop 3*ADAPTIVE IMMUNITY

13.30-14.30 Sponsored Lunch Session Shire

Sponsored Lunch Session Beckman Coulter

14.30-16.30

Symposium MUCOSAL IMMUNOLOGY

14.30-15.15Lecture

SEVERE ASTHMA: HOW TO NAVIGATE

AN INCREASINGLY COMPLEX THERAPEUTIC SCENARIO

16.30-17.30 Break & Poster Session II - (P8.1-P12.40) - Poster Area

17.30-19.00Workshop 4*

INNATE IMMUNITY AND INFLAMMATION II

Workshop 5*NEUROIMMUNOLOGY

Workshop 6*IMMUNODEFICIENCIES

19.00-19.45 KEYNOTE LECTURE

TUESDAY, 30 MAY 2017

Room Nicolaus (Floor -1) Room Cassiopea (Floor 1)

8.30-10.30Symposium

INNATE IMMUNITYWorkshop 7*

TUMOR IMMUNOLOGY I

10.30-11.30 Break & Poster Session II - (P8.1-P12.40) - Poster Area

11.30-13.00Workshop 8*

TUMOR IMMUNOLOGY II

13.00-13.30 SIICA GENERAL ASSEMBLY (VOTING RESULT)

WEDNESDAY, 31 MAY 2017

TIME TABLE

* These sessions include selected abstracts

11



28 May 2017

14.45-15.15 Room Nicolaus - Floor -1

OPENING CEREMONY


OPENING LECTUREChairperson: A. Vacca (Italy)

L1 The yin yang of macrophages, innate immunity and cancer A. Mantovani (Italy)


SYMPOSIUM Joint SIICA-AINI IMMUNE-MEDIATED NEUROLOGICAL DISEASES Chairpersons: G. Borsellino (Italy), M. Trojano (Italy)

S1.1 A role for leukocyte trafficking in Alzheimer’s disease G. Constantin (Italy)

S1.2 Myasthenia Gravis, a paradigmatic antibody-mediated autoimmune disease F. Baggi (Italy)

S1.3 Mechanisms of immunomodulation by mesenchymal stem cells: implications for the treatment of autoimmunity A. Uccelli (Italy)

S1.4 Myeloid cell extracellular vesicles during neuroinflammation R. Furlan (Italy)

S1.5 Emerging roles of specialized pro-resolving lipid mediators in adaptive immunity and neuroinflammation A. Leuti, J. Dalli*, A. Jacobsson**, E. Bisicchia, V. Sasso, M.T. Viscomi, L. Battistini, M. Maccarrone, C. Serhan*, V. Chiurchiu (Italy,*USA, **Sweden)

12

28 M

ay 2

017


EFIS LECTUREChairperson: A. Santoni (Italy)

L2 Development and plasticity of human innate lymphoid cells J. Di Santo (France)

18.45

WELCOME COCKTAIL

13



29 May 2017


SYMPOSIUM IMMUNOREGULATIONChairpersons: V. Barnaba (Italy), J. Wienands (Germany)

S2.1 Novel pathways in macrophage activation A. Viola (Italy)

S2.2 Heterogeneity and functional specialization of dendritic cells in response to LPS: implications for immunity and tolerance F. Fallarino (Italy)

S2.3 Integrating metabolism and immunity C. Procaccini (Italy)

S2.4 In vivo imaging of antiviral immune responses M. Iannacone (Italy)

S2.5 An epigenetic snapshot of IL-10 competent B cells S. Tonon, F. Mion, J. Dong*, H.-D. Chang*, A. Radbruch*, N. Tamassia, M.A. Cassatella, C.E.M. Pucillo (Italy, *Germany)

11.00-11.10 Break


WORKSHOP 1AUTOIMMUNITYChairpersons: O. Acuto (United Kingdom), G. Valesini (Italy)

W1.1 T-cell proapoptotic and antifibrotic activity against autologous skin fibroblasts in vitro is associated with IL-17A axis modulation in systemic sclerosis S. Vettori, G. Barra, G. Pasquale, L. Pellecchia, L. Vicedomini, R. De Palma (Italy)

W1.2 CD4+ memory-stem T cells: novel players in rheumatoid arthritis B.C. Cianciotti, E. Ruggiero, C. Campochiaro, G. Oliveira, M. Baldini, M. Doglio, A.A. Manfredi, E. Baldissera, F. Ciceri, N. Cieri, C. Bonini (Italy)

14

29 M

ay 2

017


WORKSHOP 1AUTOIMMUNITY (cont.) W1.3 Development of a novel epitope-based diagnostic assay for systemic

sclerosis G. Moroncini, M. Mozzicafreddo, M. Cuccioloni, A. Grieco, C. Paolini, C. Tonnini, E. Avvedimento, S. Salvucci, A. Funaro, A. Gabrielli (Italy)

W1.4 IL-17 polarization of mucosal invariant T cells derives from the activation of two different pathways D. Di Liberto, G. Guggino, F. Ciccia, M. Lo Pizzo, G. Sireci, F. Dieli, L. Saieva, R. Alessandro, G. Triolo (Italy)

W1.5 Plant-based virus-derived nanoparticles (VNPs) displaying Lipocalin to use as coating reagent in ELISA assay for the diagnosis of Sjogren’s syndrome E. Tinazzi, R. Beri, L. Avesani, E. Bartoloni, A. Puccetti, C. Lunardi (Italy)

W1.6 Targeted nanoparticles-based diagnosis and treatment of rheumatoid arthritis F. Colombo, L. Nunez*, P. Durigutto, S. Biffi, E. Rampazzo, B. Belmonte, D. Sblattero, A. Gulino, P.L. Meroni, F. Tedesco, P. Macor (Italy, *USA)

W1.7 IL-21 promotes Granzyme B-dependent NK/plasmacytoid dendritic cell functional interaction in cutaneous lupus erythematosus V. Salvi, W. Vermi, A. Cavani, S. Lonardi, T. Carbone, F. Facchetti, D. Bosisio, S. Sozzani (Italy)

W1.8 MIR 106A, MIR 19A-B, MIR 20A and MIR21A regulate Vγ9Vδ2 Functions participating in the inflammatory responses occurring in rheumatoid arthritis G. Guggino, V. Orlando, L. Saieva, F. Ciccia, I. Chalcarz, R. Alessandro, F. Dieli, N. Caccamo, G. Triolo (Italy)


Sponsored Session Becton Dickinson Italia

15



29 May 2017


SYMPOSIUM IMMUNE CHECK POINTS AND CANCER IMMUNOTHERAPYChairpersons: R. De Palma (Italy), S.D. Ferrini (Italy)

S3.1 Immunotherapy in lung cancer treatment F. Ciardiello (Italy)

S3.2 Immune checkpoint inhibitors in cancer therapy G. Melillo (USA)

S3.3 Immune checkpoint inhibition by extracellular matrix M.P. Colombo (Italy)

S3.4 Anti-PD1 therapy effects on T cell repertoire and functions in patients with NSLC cancer: a preliminary study to identify biomarkers of efficacy G. Barra, G. Pasquale, C. Della Corte, F. Papaccio, F. Ciardiello, F. Morgillo, R. De Palma (Italy)

S3.5 IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4

treatment in melanoma patients R. Tallerico, C.M. Cristiani, E. Staaf*, C. Garofalo, R. Sottile*, M. Capone, Y. Pico de Coaña*, G. Madonna , E. Palella, M. Wolodarski*, V. Carannante*, D. Mallardo, E. Simeone, A.M. Grimaldi, S. Johansson*, P. Frumento*, E. Gulletta, A. Anichini, F. Colucci**, G. Ciliberto, R. Kiessling*, K. Kärre*, P.A. Ascierto, E. Carbone (Italy, *Sweden, **United Kingdom)

16.30-18.00 Break & POSTER SESSION I – (P1.1-P7.18)

16

29 M

ay 2

017


SIICA PRESIDENT LECTUREChairperson: L. Moretta (Italy)

L3 Innate immunity in the myeloma microenvironment: new perspectives to overcome drug resistance A. Vacca (Italy)


SIICA ASSEMBLY

17



29 May 2017

09.00-10.45 Room Cassiopea - Floor 1

WORKSHOP Joint SIICA-SIAAICSEVERE ASTHMA. FROM MECHANISMS TO TREATMENT (part I)Chairpersons: L. Fabbri (Italy), A. Vacca (Italy) WS1.1 Basic mechanisms in severe asthma. An overview G. Pelaia (Italy)

WS1.2 Innate and adaptive response in airway inflammation E. Maggi (Italy)

WS1.3 Eosinophilia and steroid sensitivity and resistance A. Papi (Italy)

WS1.4 Asthma/COPD overlap syndrome P. Paggiaro (Italy)

10.45-11.10 Break


WORKSHOP Joint SIICA-SIAAIC SEVERE ASTHMA. FROM MECHANISMS TO TREATMENT (part II)Chairpersons: G.W. Canonica (Italy), O. Resta (Italy)

WS1.5 Clinical phenotypes and biomarkers of severe asthma G.W. Canonica (Italy)

WS1.6 Anti-IgE therapy: past, present and future L. Macchia (Italy)

WS1.7 Biologicals. The great view L. Fabbri (Italy)

WS1.8 Targeted therapy of severe asthma K.F. Chung (United Kingdom)

WS1.9 Investigating wasp venom allergy: a B cell proliferation assay M. Albanesi, L. Giliberti, M.P. Rossi, D. Di Bona, M.F. Caiaffa, L. Macchia (Italy)

18

29 M

ay 2

017


Sponsored Lunch SessionGlaxoSmithKline


WORKSHOP AUTOIMMUNE MECHANISMS AND DISEASESChairpersons: C. D’Agostino (Italy), A. Gabrielli (Italy)

WS2.1 Mechanisms of autoimmunity S. Sozzani (Italy)

WS2.2 Targeted therapy in SLE A. Doria (Italy)

WS2.3 Rheumatoid arthritis G. Valesini (Italy)

WS2.4 Systemic sclerosis and pulmonary hypertension A. Gabrielli (Italy)

WS2.5 New advances in therapy of psoriasis G. Girolomoni (Italy)

WS2.6 Gut inflammation and cutaneous barrier leakage drive skin autoimmunity in Omenn syndrome R. Rigoni, E. Fontana, V. Marrella, V. Maina, A. Villa, B. Cassani (Italy)

19



29 May 2017

11.10-13.30 Room Unicorno - Floor -1

WORKSHOP 2 INNATE IMMUNITY AND INFLAMMATION IChairpersons: T. Broker (Germany), A. Moretta (Italy)

W2.1 The fibrinolytic and innate immune systems cooperate to control and eliminate microbial skin infections W. Santus, F. Mingozzi, S. Barresi, A. Broggi*, I. Orlandi, G. Stamerra, M. Vai, A. Polissi, I. Zanoni*, F. Granucci (Italy, *USA)

W2.2 PTX3 and factor H functionally cooperate in promoting phagocytosis and killing of Aspergillus fumigatus R. Parente, F. Petroni, M. Sironi, S. Valentino, B. Bottazzi, A. Mantovani, A. Inforzato, M. Gobbi (Italy)

W2.3 Quantitative and qualitative profiles of circulating monocytes may help identifying tuberculosis infection and disease stages M.P. La Manna, V. Orlando, F. Dieli, P. Di Carlo, A. Cascio, G. Cuzzi, F. Palmieri, D. Goletti, N. Caccamo (Italy)

W2.4 Role of neutrophils in an imiquimod-induced mouse model of psoriasis D. Bevilacqua, S. Costa, O. Marini, E. Caveggion, C. Abram*, C.A. Lowell*, G. Girolomoni, M.A. Cassatella, P. Scapini (Italy, *USA)

W2.5 Innate immune role of the long pentraxin PTX3 in the control of Streptococcus pneumoniae invasive infections R. Porte, R. Parente, M. Sironi, F. Pasqualini, M.L. Barbagallo, R. Silva-Gomes, S. Davoudian, T. Van der Poll*, C. Garlanda, B. Bottazzi, A. Mantovani (Italy, *The Netherlands)

W2.6 Complement protein C1Q production in malignant pleural mesothelioma L. Amadio, A. Mangogna, C. Agostinis, R. Vidergar, M. Confalonieri, C. Tripodo, O. Radillo, R. Bulla (Italy)

W2.7 Characterization of a conditional and reporter mouse model for the atypical chemokine receptor 2 V. Mollica Poeta, M. Massara, O. Bonavita, E. Setten, M. Locati, R. Bonecchi (Italy)

20

30 M

ay 2

017


SYMPOSIUM Joint SIICA-FOCIS IMMUNODEFICIENCIES Chairpersons: F. Dammacco (Italy), C. Piccirillo (Canada)

S4.1 HIV functional cure: myth or reality? G. Pantaleo (Switzerland)

S4.2 Hyper IGE syndromes: diseases and pathogenesis R. Badolato (Italy)

S4.3 Unraveling platelet defects in Wiskott Aldrich syndrome A. Villa (Italy) S4.4 Inborn errors of FOXP3+ regulatory T cell development and fun-

ction in humans C. Piccirillo (Canada)

S4.5 Evaluation of health-related quality of life using CVID_QoL que-stionnaire: impact of clinical, immunological and therapy-related factors on burden of disease in common variable immunodeficien-cy F. Pulvirenti, S. Tabolli, C. Milito, V. Villella, A.J. Bastidas Parlanti*, I. Quinti (Italy, *Spain)


21



30 May 2017


WORKSHOP Joint SIICA-EAACI-OGÄIINNOVATIVE IMMUNOTHERAPY IN ALLERGYChairpersons: L. Cosmi (Italy), W. Pickl (Austria)

WS3.1 Immunological mechanisms and clinical efficacy of the recombinant B cell epitope-based grass pollen allergy vaccine BM32

R. Valenta (Austria)

WS3.2 Immunotherapy of birch pollen allergy with a highly immunogenic hypoallergen: pre-clinical studies F. Ferreira (Austria)

WS3.3 Immunotherapy of birch pollen allergy with a highly immunogenic hypoallergen: clinical study design L. Jongejan (The Netherlands)

WS3.4 New horizons in anaphylaxis M.A. Muraro (Italy)

WS3.5 Chronic urticaria: physiopathology and new perspectives for therapy M. Triggiani (Italy)


Sponsored Lunch SessionShire

22

30 M

ay 2

017


SYMPOSIUM MUCOSAL IMMUNOLOGYChairpersons: C. Garlanda (Italy), C.E.M. Pucillo (Italy)

S5.1 Epigenetic regulation of ILC functionality G. Sciumè (Italy)

S5.2 Type III interferon control of intestinal inflammation I. Zanoni (USA)

S5.3 Adaptive and innate immunity in the gut mucosa of patients with glu-ten-related disorders

A. Di Sabatino (Italy)

S5.4 Mucosal immune dysregulation and microbiota in primary immune defi-ciency

B. Cassani (Italy)

S5.5 MFSD2A promotes epoxygenation of docosahexaenoic acid in gut en-dothelium to generate pro-resolving lipid mediators and dampen intesti-nal inflammation F. Ungaro, C. Tacconi*, L. Massimino, P.A. Corsetto, C. Correale, P. Fonteyne, A. Piontini, V. Garzarelli, F. Calcaterra, S. Della Bella, A. Spi-nelli, M. Carvello, A.M. Rizzo, S. Vetrano, L. Petti, G. Fiorino, F. Furfaro, D. Mavilio, K.R. Maddipati**, A. Malesci, S. D’Alessio, S. Danese (Italy, *Switzerland, **USA)

16.30-17.30 Break & POSTER SESSION II – (P8.1-P12.40)

23



30 May 2017


WORKSHOP 4INNATE IMMUNITY AND INFLAMMATION II Chairpersons: F. Bazzoni (Italy), C. Watzl (Germany)

W4.1 Human circulating group 2 innate lymphoid cells promote IgE production and can be shifted in vitro toward IFN-γ producing cells B. Rossettini, L. Maggi, G. Montaini, A. Mazzoni, M. Capone, M.C. Rossi, V. Santarlasci, F. Liotta, O. Rossi, E. Maggi, L. Cosmi, F. Annunziato (Italy)

W4.2 Neutrophil dysfunction in an inducible mouse model of glycogen storage disease type 1b F. Raggi, A.L. Pissavino, R. Resaz, D. Segalerba, L. Mastracci, F. Grillo, A. Puglisi, M.C. Bosco, L. Varesio, A. Eva (Italy)

W4.3 IP4 is the second messenger required for Ca2+ entry in dendritic cells through plasma membrane IP3R3 L. Marongiu, M. Di Gioia*, V. Poli*, L. Sironi, I. Zanoni*, F. Granucci (Italy, USA)

W4.4 Group V secreted phospholipase A2 mediates the production of angiogenic and anti-angiogenic factors from human neutrophils S. Loffredo, A.L. Ferrara, F. Borriello, R. Iannone, M.R. Galdiero, G. Varricchi, G. Lambeau*, V. Gigantino, P. Esposito, M. Cassatella, F. Granata, G. Marone (Italy, *France)

W4.5 KIR2DL3 and the KIR ligand groups HLA-A-Bw4 and HLA-C2 predict the outcome of hepatitis B virus infection D. Di Bona, A. Ajello, C. Colomba, M. Bilancia, G. Accardi, M.F. Caiaffa, G. Candore, L. Macchia, C. Caruso (Italy)


KEYNOTE LECTUREChairperson: F. Annunziato (Italy)

L4 Bone marrow - A special place for the maintenance of immunological memory

A. Radbruch (Germany)

24

30 M

ay 2

017


WORKSHOP CHRONIC LYMPHOCYTIC LEUKEMIA. FROM BASIC SCIENCE TO TREATMENT (part I)Chairpersons: R. Foà (Italy), V. Pistoia (Italy)

WS4.1 Genetic characterization of CLL cells D. Rossi (Switzerland)

WS4.2 Clinical implications of gene mutations in CLL G. Gaidano (Italy)

WS4.3 Immunologic and molecular evaluation of CLL K. Stamatopoulos (Greece)

WS4.4 From monoclonal B-cell lymphocytosis to CLL P.P. Ghia (Italy)



WORKSHOP CHRONIC LYMPHOCYTIC LEUKEMIA. FROM BASIC SCIENCE TO TREATMENT (part II)Chairpersons: G. Semenzato (Italy), G. Specchia (Italy)

WS4.5 New inhibitors for all patients??? R. Foà (Italy)

WS4.6 New monoclonal antibodies for CLL A. Cuneo (Italy)

WS4.7 Perspectives for therapy of tumor-associated thrombosis E. Grandone (Italy) WS4.8 Systems for anti-emesis in patients with lymphoproliferative tumors L. Celio (Italy)

WS4.9 Integrated CLL scoring system had prognostic activity on young and early-stage chronic lymphocytic leukemia A. Visentin, F. Frezzato, S. Imbergamo, V. Trimarco, V. Martini, F. Severin, F. Raggi, L. Bonaldi, E. Scomazzon, L. Martinello, F. Piazza, M. Facco, G. Semenzato, L. Trentin (Italy)

25



30 May 2017


KEYNOTE LECTURE Chairperson: L. Macchia (Italy)

L5 Severe asthma: how to navigate an increasingly complex therapeutic scenario

J.C. Virchow (Germany)


WORKSHOP 5NEUROIMMUNOLOGYChairpersons: R. De Palma (Italy), V. Pistoia (Italy)

W5.1 Nasal treatment of experimental autoimmune Myasthenia Gravis with a recombinant fusion protein containing the acetylcholine receptor Tcell-epitope 146-162 A. Consonni, E. Rinaldi, M. Miotti, M. Verolin*, S. Sharma*, K. Schon*, C. Lebrero-Fernandez*, N. Lycke*, R. Mantegazza, F. Baggi (Italy, *Sweden)

W5.2 Neuroinflammation and bipolar disorder. A multiparametric analysis by flow citometry S. Di Toro, A.M. Finardi, F. Benedetti, C. Lorenzi, S. Poletti, D. Angelini, L. Battistini, G. Borsellino, R. Furlan (Italy)

W5.3 FoxP3 isoforms and T regulatory cell exhaustion in multiple sclerosis M. Sambucci, F. Gargano, M. De Bardi, S. Ruggieri, V. De Rosa, C. Gasperini, G. Matarese, L. Battistini, G. Borsellino (Italy)

W5.4 Early, norepinephrine-dependent, activation of the hematopoietic niche

upon induction of experimental autoimmune encephalomyelitis T. Vigo, N. Kerlero de Rosbo, A. Uccelli (Italy)

W5.5 Neuroinflammation and autoimmunity: a comparison between cerebrospinal fluid of patients with neuro-Behçet’s disease and multiple sclerosis E. Bonechi, A. Aldinucci, A. Barilaro, T. Biagioli, G. Emmi, M.M. D’Elios, C. Ballerini (Italy)

26

30 M

ay 2

017


WORKSHOP 3 ADAPTIVE IMMUNITYChairpersons: S. Abrignani (Italy), F. Di Rosa (Italy)

W3.1 Eomes is expressed by non-classic Th1 cells and is involved in their phenotype stability A. Mazzoni, M.C. Rossi, M. Capone, L. Maggi, V. Santarlasci, G. Montaini, B. Rossettini, F. Liotta, L. Cosmi, F. Annunziato (Italy)

W3.2 T cell costimulation blockade blunts pressure overload-induced heart failure M. Kallikourdis, E. Martini, P. Carullo, C. Sardi, G. Roselli, C. Greco, D. Vignali, F. Riva, A.M. Ormbostad Berre*, T.O. Stølen*, A. Fumero, G. Faggian, E. Di Pasquale, L. Elia, C. Rumio, D. Catalucci, R. Papait, G. Condorelli (Italy, *Norway)

W3.3 Human cytotoxic T lymphocytes form dysfunctional immune synapses with B cells characterized by non-polarized lytic granule release V. Zurli, G. Wimmer, V. Candi, A. Gamberucci, A. Gozzetti, G. Campoccia, M. Bocchia, C.T. Baldari, A. Kabanova (Italy)

W3.4 Inhibition of notch-mediated crosstalk between endothelial cells and plasmacells reduces angiogenesis in multiple myeloma patients I. Saltarella, A. Lamanuzzi, P. Leone, V. Racanelli, R. Ria, A. Vacca (Italy)

W3.5 Drugs-loaded nanoparticles: a new approach for the treatment of B-cell malignancies S. Capolla, R. Bomben, S. Zorzet, S. Biffi, G. Pozzato, C. Tripodo, G. Larsen*, L. Nùñez*, P. Macor (Italy, *USA)

W3.6 Cytomegalovirus contributes to age-related dysfunctions in the maintenance of immunological memory in the bone marrow L. Pangrazzi, E. Naismith, B. Grubeck Loebenstein, K. Trieb (Austria)

W3.7 T-cell phenotype and function during human acute ZIKA Virus infection E. Cimini, C. Castilletti, A. Sacchi, R. Casetti, V. Bordoni, A. Romanelli, F. Turchi, F. Martini, N. Tumino, E. Nicastri, A. Corpolongo, A. Di Caro, G. Kobinger*, A. Zumla**, G. Ippolito, M.R. Capobianchi, C. Agrati (Italy, *Canada, **United Kingdom)

27



30 May 2017


Sponsored Lunch SessionBeckman Coulter


WORKSHOP 6IMMUNODEFICIENCIESChairpersons: R. Badolato (Italy), A. Cossarizza (Italy)

W6.1 CD8+CD28-CD127loCD39+ Treg Expansion: a New Pathogenic Mechanism for HIV Infection? D. Fenoglio, C. Dentone, A. Signori, A. Parodi, F. Kalli, G. Nasi, M. Curto, S. Negrini, E. Fiorillo, V. Orrù, A. Di Biagio, G. Cenderello, V. Bartolacci, P. De Leo, E. Mantia, G. Orofino, B. Bruzzone, L.A. Nicolini, L. Tamarasso, F. Ivaldi, M. Giacomini, S. Bhagani*, G. Filaci (Italy, *United Kingdom)

W6.2 HIV-infected patients with low CD4/CD8 ratio show altered expression of the inflammasome components AIM2, PYCARD and IL-1β S. Pecorini, S. De Biasi, E. Bianchini, M. Digaetano, M. Pinti, L. Gibellini, D. Lo Tartaro, C. Mussini, A. Cossarizza, M. Nasi (Italy)

W6.3 Precursor B-cell acute lymphoblastic leukemia presenting with hemophagocytic lymphohistiocytosis in two children with heterozygous A91V mutation of the perforin (PRF1)gene R. Koronica, P. Muggeo, G. Arcamone, F. De Leonardis, E. Sieni, B. Martire, N. Santoro (Italy)

W6.4 Immunodeficiency behind encephalopathy A. Tozzo, E. Corsini, A. Ardissone, S. Franceschetti, T. Granata (Italy)

W6.5 Analysis of the molecular mechanisms of C1-inhibitor deficiency induced angioedema F. Bossi, R. Bulla, P. Spath*, F. Tedesco, O. Radillo, M. Cicardi (Italy, *Switzerland)

28

31 M

ay 2

017


SYMPOSIUM INNATE IMMUNITYChairpersons: M. Cassatella (Italy), G. Ferlazzo (Italy)

S6.1 The emerging split nature of human γδ T lymphocytes in cancer F. Dieli (Italy)

S6.2 Regulatory RNAS in macrophage activation M. Locati (Italy )

S6.3 Genomic regulation of innate immune cell activation R. Ostuni (Italy)

S6.4 Neutrophil heterogeneity in acute and chronic inflammatory conditions P. Scapini (Italy)

S6.5 IL-1R8: a novel checkpoint regulating anti-tumor and anti-viral activity of NK cells M. Molgora, E. Bonavita, A. Ponzetta, M. Barbagallo, F. Gianni, B. Popovic, S. Jaillon, F. Riva, G. Bernardini, S. Jonjic, A. Santoni, A. Mantovani, C. Garlanda (Italy)


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31 May 2017


WORKSHOP 8 TUMOR IMMUNOLOGY II Chairpersons: V. Bronte (Italy), M. Locati (Italy)

W8.1 Galectin-3 has an immunosuppressive role in the early phases of prostate cancer development and lymph node invasion S. Caputo, C.S. Brambillasca, M. Grioni, E. Jachetti, M. Freschi, C. Doglioni, R. Galli, M. Bellone (Italy)

W8.2 Role of complement in cancer-related inflammation E. Magrini, S. Di Marco, K. Berthenet, M.L. Barbagallo, A. Ponzetta, A. Mantovani, C. Garlanda (Italy)

W8.3 Natural killer (NK) cells and multiple myeloma (MM)-derived endothelial cells: molecular interactions and their possible shaping by interleukin-27 B. Casu, A. Dondero, F. Bellora, C. Cantoni, S. Gaggero, A. Vacca, A. Frassanito, C. De Luisi, A. Moretta, C. Bottino, R. Castriconi (Italy)

W8.4 NK cells control breast cancer and related cancer stem cell hematological spread R. Tallerico, L. Conti, S. Lanzardo, R. Sottile*, C. Garofalo, A.K. Wagner*, M.H. Johansson*, C.M. Cristiani, K. Kärre*, E. Carbone, F. Cavallo (Italy, *Sweden)

W8.5 The protein osteoactivin produced by tumor-associated macrophages accelerates tumor growth and promotes cancer cell stemness M. Liguori, A. Vacchini, E.M. Borroni, F. Pasqualini, F.S. Colombo, A. Mantovani, P. Allavena, C. Belgiovine (Rozzano)


SIICA GENERAL ASSEMBLY (VOTING RESULT)

30

31 M

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WORKSHOP 7TUMOR IMMUNOLOGY IChairpersons: E. Carbone (Italy), F. Novelli (Italy)

W7.1 Neutrophils exert an anti-tumoral role in 3MCA-induced sarcoma carcinogenesis A. Ponzetta, M. Barbagallo, M. Molgora, E. Bonavita, M.R. Galdiero*, E. Magrini, N. Polentarutti, C. Garlanda, A. Mantovani, S. Jaillon (Italy, *United Kingdom)

W7.2 IL-18 receptor marks functional CD8 T cells in non-small cell lung cancer E. Timperi, C. Focaccetti, D. Gallerano, M. Panetta, S. Spada, P. Visca, F. Facciolo, A. Prelaj, F. Longo, D. Diso, F. Venuta, P. Nisticò, V. Barnaba (Italy)

W7.3 MYCN is an immunosuppressive oncogene dampening the expression of ligands for Natural Killer cell-activating receptors in human high-risk neuroblastoma E. Brandetti, I. Veneziani, O. Melaiu, A. Pezzolo, A. Castellano, R. Boldrini, E. Ferretti, D. Fruci, L. Moretta, V. Pistoia, F. Locatelli, L. Cifaldi (Italy)

W7.4 Loss of cross-presentation and increased Th17-polarizing potential in subsets of lung resident dendritic cells during cancer growth N. Caronni, F. Simoncello, K.E. Cervantes Luevano, G.M. Piperno, R. Alonso Ramirez Lemoine*, O. Lantz*, F. Benvenuti (Italy, *France)

W7.5 miRNAs profile of bone marrow fibroblasts in multiple myeloma: relationship with disease progression and drug-resistance V. Desantis, L. Di Marzo, I. Craparotta, L. Beltrame, S. Marchini, M. Arciuli, F. Visino, F. Calabria, A. Gallone, M. D’Incalci, M.A. Frassanito, A. Vacca (Italy)

W7.6 The interplay between anti-CD20 therapeutic antibodies and “memory” natural killer cells C. Capuano, S. Battella, C. Pighi, L. Franchitti, A. Santoni, R. Galandrini, G. Palmieri (Italy)


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POSTER AREAPOSTER SESSION I - 29-30 MAY 2017

P1 - ALLERGY AND ANAPHYLAXIS

P1.1 Fennel (Foeniculum vulgare) allergy L. Masciopinto, M. Di Giacomo, L. Giliberti, A. Nico, M.P. Rossi, M. ALbanesi, D. Di Bona, M.F. Caiaffa, L. Macchia (Italy)

P1.2 Allergy to lipid transfer protein: genetic basis M. Valentini, E. Nucera, S. Mezzacappa, A. Rizzi, A. Aruanno, R. Chini, A. Buonomo, G. Di Sante, G. Migliara, A. Piermattei, F. Ria, D. Schiavino (Italy)

P2 - AUTOIMMUNITY

P2.1 Th17 cells are enriched in skin-derived T cell lines from herpetiform dermatitis patients M. Capone, V. Santarlasci, M. Caproni, A.S. Calabrò, L. Maggi, A. Mazzoni, M. Rossi, G. Montaini, B. Rossettini, G. Lami, L. Cosmi, F. Annunziato, F. Liotta (Italy)

P2.2 EBV-specific CD8+ T cells are exhausted and senescent in multiple sclerosis patients G. Guerrera, D. Angelini, S. Ruggieri, F. Gargano, C. Gasperini, R. Placido, G. Borsellino, L. Battistini (Italy)

P2.3 Rituximab induces a reduction of Lymphocyte CD3+ activated in patients with autoimmune diseases S. Cicco, A. Solimando, A. Polito, M. Guarascio, S. Battaglia, P. Leone, F. Dammacco, V. Racanelli, A. Vacca (Italy)

P2.4 Flogosis and heart involvement in large vessel vasculitis S. Cicco, X. Mersini, S. Noviello, A. Cirulli, S. Longo, P. Leone, S. Battaglia, F. Dammacco, V. Racanelli, A. Vacca (Italy)

P2.5 Proinflammatory MAIT cells react to gut flora yeasts in multiple sclerosis F. Gargano, D. Angelini, B. Serafini, L. Rizzetto, M.C. Buscarinu, G. Guerrera, E. Piras, V. Annibali, M. De Bardi, S. Ruggieri, C. Gasperini, G. Ristori, G. Borsellino, D. Cavalieri, M. Salvetti, C. De Filippo, L. Battistini (Italy)

P2.6 Rituximab down regulates antigen–specific T cell repertoire in Myasthenia gravis patients F. Ria, M. Marino, A. Piermattei, M. Valentini, G. Di Sante, A. Evoli, E. Bartoccioni (Italy)

P2.7 Skin to blood recirculation of memory CD4+ T cells in psoriasis patients

C. Cozzi, M. Diani, M. Galasso, C. Cigni, S. Volinia, F. Granucci, G. Altomare, E. Reali (Italy)

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P2.8 A 5-year follow up study in systemic lupus erythematosus: changes in clinical and laboratory parameters C. Cardamone, R. Parente, G. De Feo, T. Bucci, M. Triggiani (Italy)

P2.9 Immunological tolerance mechanisms controlling human autoreactive CD8+ T cells in healthy and autoimmune conditions I. Cammarata, C. Martire, A. Citro, G. Peruzzi, R. Scrivo, E. Cariani, C. Carone, G. Valesini, V. Barnaba (Italy)

P2.10 Chitinase 3-Like-1 is produced by human Th17 cells and correlates with the level of inflammation in juvenile idiopathic arthritis patients M. Capone, L. Maggi, V. Santarlasci, M. Rossi, A. Mazzoni, G. Montaini, R. Cimaz, M. Ramazzotti, G. Barra, M.P. Piccinni, R. De Palma, F. Liotta, E. Maggi, F. Annunziato, L. Cosmi (Italy)

P2.11 Retrospective and prospective longitudinal evaluation of a cohort of patients affected by Systemic sclerosis complicated by pulmonary arterial hypertension E. Tinazzi, F. Confente, G. Patuzzo, C. Lunardi (Italy)

P2.12 Rai signaling in astrocytes plays a critical role in shaping the central nervous system microenvironment during experimental autoimmune encephalomyelitis D. De Tommaso, C. Ulivieri, F. Finetti, G. Pellicci, M.M. D’Elios, C. Ballerini, C.T. Baldari (Italy)

P2.13 Effect of belimumab treatment on refractory systemic Lupus erythematosus: clinical and biological response M. Prete, P. Leone, M.A Frassanito, V. Desantis, S. Cicco, V. Racanelli, A. Vacca (Italy)

P3 - B CELLS

P3.1 Regulatory atypical B cells are expanded in patients with active tuberculosis V. Orlando, M.P. La Manna, N. Caccamo, F. Dieli (Italy)

P3.2 A consolidation phase in immune memory F. Mantile, A. Capasso, A. Prisco, P. De Berardinis (Italy)

P3.3 Flow cytometry assessment of switched memory B cells in the diagnosis of primary antibody defects: a real life experience M. Martini, C. Tontini, A. Berretta, A. Corsi, A. Marchionni, S. Agolini, M. Cognigni, N. Viola, A. Costantini, A. Gabrielli, L. Butini (Italy)

P3.4 Inhibition of mammalian target of Rapamycin (mTOR) through the dual mTOR inhibitor PP242 as antiangiogenic strategy in multiple myeloma A. Lamanuzzi, I. Saltarella, B. Nico, D. Ribatti, A. Vacca, R. Ria (Italy)

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P4 - IMMUNODEFICIENCIES

P4.1 Increased plasma concentrations of angiogenic and lymphangiogenic factors in patients with hereditary angioedema with C1-INH deficiency A.L. Ferrara, S. Loffredo, M. Bova, A. Petraroli, C. Suffritti, F. Boriello, A. Zanichelli, R. Iannone, M.R. Galdiero, G. Varricchi, H. Farkas*, M. Triggiani, M. Cicardi, G. Marone (Italy, *Hungary)

P4.2 Monocytes and polymorphonuclear leukocytes function in patients with common variable immune disorders on replacement treatment with intravenous immunoglobulin A. Prezzo, F.M. Cavaliere, C. Bilotta, M. Iacobini, I. Quinti (Italy)

P4.3 The lack of BTK does not impair monocytes and polymorphonuclear cells function in X-linked agammaglobulinemia F.M. Cavaliere, A. Prezzo, C. Bilotta, M. Iacobini, I. Quinti (Italy)

P4.4 Antibiotic prophylaxis in primary antibody deficiency patients: study design C. Milito, F. Pulvirenti, S. Tabolli, M. Carrabba, G. Fabio, M.C. Pietrogrande, F. Cinetto, C. Agostini, A. Plebani, A. Matucci, A. Pecoraro, G. Spadaro, B. Martire, I. Quinti (Italy)

P4.5 IgM and IgA anti-pneumococcal capsular polysaccharides as prognostic tool for Common Variable Immunodeficiency: a longitudinal study F. Pulvirenti, F.M. Cavaliere, C. Milito, R. Carello, A.M. Pesce, I. Quinti (Italy)

P4.6 Clinical feature s of idiopathic non cirrhotic portal hypertension in primary antibody defects: natural history, immunology and new perspectives for an unrecognized complication F. Pulvirenti, C. Milito, M. Valente, G. D’Amati, O. Riggio, I. Pentassuglio, I. Quinti (Italy)

P4.7 Clearance of reactivated HIV-1 reservoirs by natural killer cells M.G. Desimio, E. Giuliani, M. Doria (Italy)

P4.8 Early diagnosis of PI3Kδ syndrome in a 2 years old girl with recurrent otitis medias and enlarged spleen F. Saettini, M.A. Pelagatti, D. Sala, R. Badolato, A. Biondi (Italy)

P5 - INNATE IMMUNE AND INFLAMMATION

P5.1 Dendritic cells activation is associated with sustained virological response to Telaprevir treatment of HCV-infected patients A. Sacchi, N. Tumino, F. Turchi, G. Refolo, G.M. Fimia, F. Ciccosanti, M. Montalbano, R. Lionetti, C. Taibi, G. D’Offizi, R. Casetti, V. Bordoni, E. Cimini, F. Martini, C. Agrati (Italy)

P5.2 Characterization of innate immune cells from sputum of MTB exposed subjects N. Tumino, F. Turchi, D. Goletti, G. Gualano, F. Palmieri, R. Casetti, V. Bordoni, E. Cimini, F. Martini, C. Agrati, A. Sacchi (Italy)

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P5.3 Role of MyD88-signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells S. Costa, D. Bevilacqua, O. Marini, S. Lonardi, W. Vermi, M.A. Cassatella, G. Girolomoni, P. Scapini (Italy)

P5.4 Skin fungal infections: role of the site and route of infection on T cell activation and efficiency of recall responses L. Gornati, I. Orlandi, G. Stamerra, M. Vai, I. Zanoni*, F. Granucci (Italy, *USA)

P5.5 Expression of PTX3 by lymphatic endothelial cells and role as a gate keeper against microbial dissemination M. Sironi, A. Doni, S. Valentino, M. Calvi, M. Nebuloni, F. Pasqualini, A.R. Gomes, A. Vecchi, C. Garlanda, B. Bottazzi, A. Mantovani (Italy)

P5.6 Role of hypoxia and the triggering receptor expressed on myeloid cells in human macrophage polarization F. Raggi, S. Pelassa, D. Pierobon, M. Giovarelli, F. Penco, L. Varesio, M.C. Bosco (Italy)

P5.7 Synergistic action of pentraxin 3 toward myeloperoxidase-mediated bacteria killing K. Daigo, D. Morone, S. Valentino, M. Sironi, F. Petroni, A. Doni, A. Inforzato, B. Bottazzi, A. Mantovani (Italy)

P5.8 Functional role of FcepsilonRI/IgE/antigen complexes exposed by murine mast cell derived exosomes M. Lecce, R. Molfetta, L. Quatrini, B. Zitti, A. Zingoni, L. Masuelli, G. Caracciolo, A. Santoni, R. Paolini (Italy)

P5.9 Bioassay to assess the effect of environmental doses of bisphenol-A on human immune-competent cells A. Camarca, S. Picascia, R. Valentino, C. Gianfrani (Italy)

P5.10 Pre-eclampsia is associated with defective production of C1q by invasive trophoblast C. Agostinis, F. Bossi, O. Radillo, G. Ricci, T. Stampalija, L. Lo Bello, R. Vidergar, L. Amadio, F. Tedesco, R. Bulla (Italy)

P5.11 GM-CSF and IL-3 modulate human monocyte TNF-α production and renewal in in vitro models of trained immunity R. Iannone, F. Borriello, S. Di Somma, S. Loffredo, E. Scamardella, M.R. Galdiero, M. Braile, P. Esposito, G. Varricchi, F. Granata, G. Portella, G. Marone (Italy)

P5.12 Genetic variation in autophagy-related genes influences the risk and phenotype of buruli ulcer R. Silva-Gomes, C. Capela, A. Dodji Dossou*, G.E. Sopoh*, M. Makoutode**, J.F. Menino, A. Gabriel Fraga, C. Cunha, A. Carvalho, F. Rodrigues, J. Pedrosa (Portugal, *Benin)

P5.13 Asbestos fibers reduce the expression of C1q in macrophages L. Amadio, A. Mangogna, C. Agostinis, R. Vidergar, E. Trevisan, V. Borelli, R. Bulla (Italy)

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P5.14 Role of the atypical receptor CCRL2 in the pathogenesis of rheumatoid arthritis A. Del Prete, C. Mazzon, F. Sozio, D. Bosisio, L. Gazzurelli, L. Tiberio, E. Scanziani, A. Vecchi, C. Laudanna, A. Mantovani, S. Sozzani (Italy)

P5.15 Mitochondrial monoamine oxidase-derived reactive oxygen species are involved in human macrophage M2 differentiation and activation V. Costiniti, R. Tavano, A. Viola, M. Canton (Italy)

P5.16 Regulation of the expression of IL-1R8, a regulatory member of the Interleukin-1 receptor family D. Supino, M. Molgora, A. Ponzetta, M. Barbagallo, E. Magrini, K. Berthenet, F. Gianni, F. Asgari, C. Perucchini, S. Jaillon, A. Mantovani, C. Garlanda (Italy)

P5.17 Efficiency of interferon alpha-2-b subcutaneous paraspinal injection in reducing of herniated disc tissue A. Tkachev, A. Smirnova (Russia)

P5.18 STAT3 and STAT5 drive the pro-angiogenic NK cell polarization in colorectal cancer patients A. Bruno, B. Bassani, D.G. D’Urso, S. Zanellato, I. Aida, L. Boni, L. Mortara, D. Noonan, A. Albini (Italy)

P5.19 Pleural effusion NK cells from metastatic tumors display pro-angiogenic features and pleural effusion fluids block their response to IL-2 treatment S. Zanellato, B. Bassani, A. Bosi, A. Musco, D.G. D’Urso, M. Cattoni, C. Sampietro, A. Imperatori, L. Dominioni, A. Bruno, L. Mortara, D. Noonan (Italy)

P5.20 Extracellular vesicles derived from licensed mesenchymal stem cells: a tunable approach to regulate angiogenesis R. Angioni, A. Tolomeo, S. Herkenne, B. Calì, M. Muraca, A. Viola (Italy)

P6 - MUCOSAL IMMUNITY

P6.1 Immunogenicity of a bivalent adjuvanted glycoconjugate vaccine against Salmonella Typhimurium and Salmonella Enteritidis F. Fiorino, S. Rondini, F. Micoli, L. Lanzilao, R. Alfini, F. Mancini, C. MacLennan*, D. Medaglini (Italy, *United Kingdom)

P6.2 Regulation of DNAM-1 family receptors and their ligands in physiological and pathological gut mucosa infiltrate and epithelium T cell populations L. Franchitti, S. Battella, A. Santoni, G. Palmieri (Italy)

P6.3 Role of the atypical chemokine receptor CCRL2 in a model of intestinal inflammation T. Schioppa, A. Del Prete, F. Sozio, A. Piontini, L. Melocchi, W. Vermi, S. Vetrano, S. Sozzani (Italy)

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P7 - NEUROIMMUNOLOGY

P7.1 Activation state and functionality of dendritic cells from peripheral blood of amyotrophic lateral sclerosis patients M. Rusconi, F. Gerardi, A. Lizio, C. Lunetta, I. Zanoni*, F. Granucci (Italy, *USA)

P7.2 Effect of mimetic nerve growth factor TrkA agonist MT2 non peptide molecule in EAE and cuprizone model A. Sibilla, E. Bonechi, A. Aldinucci, L. Massacesi, F. Cozzolino, C. Ballerini (Italy)

P7.3 Dysregulation of repressor element 1-silencing transcription factor in a mouse model of multiple sclerosis V. Petrosino, S. Criscuolo, F. Buffolo, F. Cesca, N. Kerlero de Rosbo, F. Benfenati, A. Uccelli (Italy)

P7.4 Differential use of the hydroxycarboxylic acid receptor-2 pathways triggered by monomethyl fumarate in different cells B. Parodi, N. Kerlero de Rosbo, A. Uccelli (Italy)

P7.5 A possible role for nerve glial antigen 2 in dendritic cell activation G. Ferrara, S. Morando, F. Ivaldi, N. Kerlero de Rosbo, A. Uccelli (Italy)

P7.6 Exploring the role of microRNAs in the intra-thymic pathogenesis of myasthenia gravis C. Barzago, P. Cavalcante, S. Marcuzzo, S. Bonanno, T. Motta, C. Antozzi, F. Baggi, P. Bernasconi, R. Mantegazza (Italy)

P7.7 Neuroinflammation and peripheral glutamate uptake in multiple sclerosis: a correlation study M. Gironi, C. Zoia, M. Saresella, G. Cavaletti, M. Clerici, G. Comi, C. Ferrarese, R. Furlan (Italy)

P7.8 An optimized protocol of differential centrifugation isolates distinct microvesicle subpopulations from myeloid cells A. Nigro, A. Romano, A. Finardi, M.M. Ferraro, A. Gaballo, D.E. Manno, A. Quattrini, R. Furlan (Italy)

P7.9 Annexin A1 (ANXA1): potential regulator of adaptive immune response in multiple sclerosis (MS) A. Colamatteo, E. Maggioli*, S. Cassano, M. Galgani, S. Bruzzaniti, G. Matarese, E. Solito*, V. De Rosa (Italy, *United Kingdom)

P7.10 Ataxic sensory neuronopathy as sentinel symptom of primary Sjögren’s syndrome: a case report I. Tempesta, G. Conca, E. Luciannatelli, A. Iaffaldano, T. Francavilla, M. Guido, G. Libro, C. Tortorella, I.L. Simone (Italy)

P7.11 T cells from patients with primary progressive form of multiple sclerosis display altered metabolism and mitochondrial functionality E. Bianchini, S. De Biasi, M. Nasi, L. Gibellini, S. Pecorini, A.M. Simone, D. Ferraro, F. Vitetta, P. Sola, A. Cossarizza, M. Pinti (Italy)

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P7.12 IL-27,butnotIL-35,inhibitsneuroinflammationthroughmodulatingGM-CSFexpression A. Finardi, H. Descamps, F. Colombo, C. Maiorino, F. Ruffini, M. Patrone, M. Degano, G. Martino, L. Muzio, B. Becher*, G. Casella(Italy,*Switzerland)

P7.13 Monogenicmetabolicdiseasesasmodelstostudycomplexautoimmunedisorderslikemultiplesclerosis F. Carbone, D. Melis, T. Micillo, C. La Rocca, V. De Rosa, S. Bruzzaniti, R. Lanzillo, V. Brescia Morra, G. Matarese(Italy)

P7.14 MonocytemicrovesiclesaspossibletargetforFingolimodactioninmultiplesclerosis A. Amoruso, M. Blonda, R. Grasso, V. Di Francescantonio, C. Avolio(Italy)

P7.15 IsolationandcharacterizationofautoreactiveCD4+Tcellsinnarcolepticpatients E. Armentani, D. Latorre, U. Kallweit, M. Perez, F. Mele, F. Zellini, M. Manconi, R. Khatami, M. Tafti, C. Bassetti, F. Sallusto(Switzerland)

P7.16 Amodelofthebloodbrainbarriertoinvestigateimmunetraffickinginneurologicaldisorders E. Lauranzano, R. Molteni, F. Filipello, R. Pardi, M. Matteoli (Italy)

P7.17 Multiplesclerosistreatmentsaffectmonocytederivedmicrovesicleproduction M. Blonda(Italy)

P7.18 DysregulatedIRF-1pathwayinperipheralBcellsofMSpatients R. Reniè, M. Salvetti, V. Annibali, R. Umeton, M. Severa, M.P. Etna, S. Giglio, S. Romano, M. Ferraldeschi, M.C. Buscarinu, A. Vecchione, A. Annese, C. Policano, R. Mechelli, G. Mattei, D.F. Angelini, E.M. Coccia, G. Ristori(Italy)

POSTER AREAPOSTER SESSION II - 30-31 MAY 2017

P8 - CHRONIC LYMPHOCYTIC LEUKEMIA

P8.1 PrognosticandpredictiveactivityofIGVHmutationin patients with chronic lymphocytic leukemia A. Visentin, M. Facco, V. Martini, F. Frezzato, S. Imbergamo, F. Severin, F. Raggia, V. Trimarco, L. Martinello, E. Scomazzon,F.Piazza,G.Semenzato, L.Trentin(Italy)

P8.2 TheE3ubiquitinligasec-CblintheregulationofBCR signalling in chronic lymphocityc leukemia V. Martini, R. Molfetta, F. Severin, V. Trimarco, F. Frezzato, F. Raggi, L. Martinello, A. Visentin, M.Facco,G.Semenzato,R.Paolini,L.Trentin(Italy)

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P8.3 Nocodazole treatment leads to neoplastic cell apoptosis in the chronic lymphocytic leukemia mouse model Eu-TCL1 F. Severin, V. Martini, M. Azzolini, L. Leanza, F. Frezzato, V. Trimarco, F. Raggi, L. Martinello, A. Visentin, M. Facco, M. Zoratti, I. Szabò, G. Semenzato, L. Trentin (Italy)

P8.4 HSP70 role in survival of neoplastic B lymphocytes from chronic lymphocytic leukemia patients F. Raggi, F. Frezzato, V. Martini, V. Trimarco, F. Severin, L. Martinello, E. Scomazzon, A. Visentin, M. Facco, F. Piazza, G. Semenzato, L. Trentin (Italy)

P8.5 HSP70 expression in chronic lymphocytic leukemia cells is controlled by its transcription factor via RAS-dependent pathways F. Frezzato, F. Raggi, B. Accordi, S. Bresolin, F. Severin, V. Martini, V. Trimarco, L. Martinello, A. Visentin, M. Facco, G. Basso, G. Semenzato, L. Trentin (Italy)

P8.6 TLR9 stimulation induces heterogeneous IkBζ expression that protects chronic lymphocytic leukemia cells and unleashes IgM secretion E. Fonte, M.G. Vilia, D. Reverberi, L. Scarfò, P. Ranghetti, U. Orfanelli, S. Cenci, G. Cutrona, P. Ghia, M. Muzio (Italy)

P8.7 p66Shc deficiency promotes CXCR4/CCR7 recycling in chronic lymphocytic leukemia N. Capitani, L. Patrussi, F. Cattaneo, N. Manganaro, A. Gamberucci, F. Frezzato, V. Martini, A. Visentin, P.G. Pelicci, M.M. D’Elios, L. Trentin, G. Semenzato, C. Baldari (Italy)

P8.8 Ectopic expression of ILT3 controls BCR-dependent activation of AKT in B-cell chronic lymphocytic leukemia V. Zurli, G. Wimmer, V. Candi, E. Cencini, A. Gozzetti, F. Cattaneo, F. Sanseviero, M. Bocchia, C.T. Baldari, A. Kabanova (Italy)

P8.9 Bortezomib reduces interleukin 6 production and impairs cells survival in large granular lymphocytes leukemia G. Calabretto, A. Teramo, G. Barilà, C. Ercolin, M. Leoncin, C. Vicenzetto, A. Cabrelle, M. Facco, G. Semenzato, R. Zambello (Italy)

P8.10 Lack of p66Shc in the CLL mouse model Eµ-TCL1 exacerbates nodal and extranodal infiltration of leukemic cells which can undergo Richter’s transformation L. Patrussi, N. Capitani, C. Ulivieri, F. Cattaneo, N. Manganaro, M. Granai, S. Gobessi, D. Efremov, L. Leoncini, C.T. Baldari (Italy)

P9 - CYTOKINES AND CHEMOKINES

P9.1 Chemokine receptors expression on circulating monocytes and neutrophils in high grade glioma patients M. Massara, E. Lugli, M. Conti Nibali, M. Rossi, L. Bello, M. Simonelli, M. Locati, R. Bonecchi (Italy)

P9.2 Cytokines-lymphoid progenitors interplay in treated acute HIV infection V. Bordoni, D. Viola, A. Sacchi, R. Casetti, E. Cimini, N. Tumino, F. Martini, C. Pinnetti, A. Antinori, A. Ammassari, C. Agrati (Italy)

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P9.3 A paracrine circuit involving c-KIT and stem cell factor promotes cancer stem cell survival in ovarian cancer A. Pastò, G. Pilotto, E.L. Mazzoldi, M.O. Nicoletto, A. Amadori (Italy)

P9.4 Common effects of IFNγ and IL27 on the HLA class I antigen presentation machinery in human cancer cells G. Carbotti (Italy)

P9.5 Modifications of IL-17 type cytokines in patients with hereditary angioedema as expression of a systemic activation process F. Arcoleo, M. Lo Pizzo, E. Cillari (Italy)

P9.6 Synergistic production of TNFα and IFNα by human pDCs incubated with IFNλ3 and IL-3 G. Finotti, N. Tamassia, M.A. Cassatella (Italy)

P9.7 Angiogenic and fibrotic mediators in IgG4-related disease R. Capecchi, F. Pratesi, A. Tavoni, P. Migliorini, I. Puxeddu (Pisa)

P10 - SEVERE ASTHMA

P10.1 Analysis of omalizumab influence on mast cell-bound IgE F.M. Frisenda, A.S. Rucco, I. Fiorino, G. Kourtis, F. Loconte, C. Pasculli, M.L. Taurino, L. D’Elia, M. Albanesi, D. Di Bona, M.F. Caiaffa, L. Macchia (Italy)

P10.2 The effects of montelukast and zileuton on bronchial hyperresponsiveness, airway inflammation and airway smooth muscle remodeling M. Syrczova (Russia)

P11 - T CELLS

P11.1 ISA-2011B, a phosphatidylinositol 4-phosphate 5-kinase a inhibitor, impairs CD28-dependent costimulatory and pro-inflammatory signals in human T lymphocytes M. Kunkl, N. Porciello, M. Mastrogiovanni, C. Capuano, F. Lucantoni, C. Moretti, J.L. Persson*, R. Galandrini, R. Buzzetti, L. Tuosto (Italy, *Sweden)

P11.2 HIV-specific CD8 T cells producing macrophage inflammatory protein-1β are associated to worse immune reconstitution during chronic infection R. Casetti, C. Pinnetti, A. Sacchi, G. De Simone, V. Bordoni, E. Cimini, N. Tumino, F. Besi, D. Viola, F. Turchi, V. Mazzotta, A. Antinori, F. Martini, A. Ammassari, C. Agrati (Italy)

P11.3 Genome wide analysis reveals new factors contributing to human Th17 cell differentiation program A. Capone, M. Bianco, C. Naro, M. De Bardi, L. Battistini,

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E. Volpe, C. Sette (Italy)

P11.4 A phenotypical and functional characterisation of the immune cells in the human bone marrow and the impact of ageing, senescence and Cytomegalovirus E. Naismith, B. Weinberger, L. Pangrazzi, K. Trieb, B. Grubeck-Loebenstein (Austria)

P11.5 Immune characterization of the HBHA-specific response in Mtb-infected patients with or without HIV infection T. Chiacchio, G. Delogu, V. Vanini, G. Cuzzi, F. De Maio, C. Pinnetti, A. Sampaolesi, A. Antinori, D. Goletti (Italy)

P11.6 Modulation QuantiFERON-TB-Plus response in patients with active tuberculosis and latent infection during treatment E. Petruccioli, T. Chiacchio, V. Vanini, G. Cuzzi, D. Cirillo, L. Petrone, F. Palmieri, G. Ippolito, D. Goletti (Italy)

P11.7 Pbx-regulating-protein 1 (Prep1) as a novel transcription factor linking immunity and metabolism D. Faicchia, C. Procaccini, S. Cabaro, A. Liotti, F. Oriente, V. Gigantino, S. Bruzzaniti, F. Blasi, P. Formisano, G. Marone, F. Beguinot, G. Matarese (Italy)

P11.8 The intestinal T Cell Lines as a sensitive bioassay for validation of gluten detoxifying strategies S. Picascia, A. Camarca, G. Mamone, S. Vitale, I.S. Pultz*, A. Di Luccia, C. Gianfrani (Italy, *USA)

P11.9 IL-10 producing CCR6+T-cells are a distinct population of B-helper T-cells that play a pathogenic role in systemic lupus erythematosus F. Facciotti, P. Larghi, N. Gagliani*, A. Penatti, M. Paroni, B. Haringer*, I. Kastirr, M. Pagani, S. Abrignani, P.L. Meroni, R. Flavell**, J. Geginat (Italy, *Germany, **USA)

P11.10 The intraflagellar transport protein IFT20 is required for autophagy in T lymphocytes C. Cassioli, F. Finetti, A. Onnis, V. Cianfanelli*, F. Cecconi, C. Baldari (Italy, *Denmark)

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P12 - TUMOR IMMUNOLOGY

P12.1 Mouse breast tumor growth and metastasis inhibition via immunotargeting of the cancer stem cell antigen xCT L. Conti, S. Lanzardo, E. Bolli, V. Rolih, A. Ballatore, R. Ruiu, G. Donofrio*, J.P. O’Rourke*, F. Pericle*, F. Cavallo (Italy, *USA)

P12.2 The treatment of malignant melanoma with a chimeric DNA vaccine against CSPG4: an effective way to overcome immune tolerance in dogs and humans F. Riccardo, E. Bolli, G. Barutello, V. Rolih, M. Arigoni, S. Occhipinti, E. Quaglino, S. Lanzardo, S. Ferrone*, P. Buracco, F. Cavallo (Italy, *USA)

P12.3 Discovery of new chemotherapy-associated antigens induced by immunogenic cell death in lung adenocarcinoma with a reverse tumor immunology strategy A. Grimaldi, C. Focaccetti, G. Peruzzi, G. Del Bene, S. Spada, F. Longo, P. Nisticò, C. Mancone, V. Barnaba (Italy)

P12.4 Pancreatic cancer-related inflammation: in vivo screening to identify key targetable molecules C. Roux, R. Curto, G. Mucciolo, F. Novelli, T.W. Mak*, P. Cappello (Italy, *Canada)

P12.5 Identification of chemotherapy-induced antigens suitable for immunotherapy in pancreatic cancer patients S. Bulfamante, G. Mandili, M. Principe, E. Mazza, L. Follia, G. Ferrero, A. Evangelista, P. Cappello, F. Novelli (Italy)

P12.6 Exploiting DNA vaccination against ROS1 as an immunotherapeutic weapon against non small cell lung cancer F. Riccardo, G. Barutello, M. Arigoni, L. Conti, C. Musiu, D.L. Longo, R. Calogero, M. Volante, M. Papotti, F. Cavallo, E. Quaglino (Italy)

P12.7 Distinctive features of tumor-infiltrating gamma-delta T lymphocytes in human colorectal cancer E. Lo Presti, S. Meraviglia, G. Pizzolato, V. Catalano, G. Cicero, J.J. Fournie*, F. Dieli (Italy, *France)

P12.8 γδ T cells producing IL17 or IFN-γ are recruited to the tumor site in squamous cell cancer and differentially correlate to the tumor stage E. Lo Presti, S. Meraviglia, F. Toia, S. Oieni, S. Buccheri, A. Turdo, L.M. Mangiapane, F. Dieli (Italy)

P12.9 Functional characterization of specific immune response and comparison of oral and intestinal human microbiota in patients with colorectal cancer E. Russo, G. Bacci, E. Niccolai, A. Taddei, F. Ricci, M.N. Ringressi, C. Chielini, C. Fagorzi, R. Borrelli, P. Bechi, A. Mengoni, R. Fani, A. Amedei (Italy)

P12.10 Interplay between bone marrow endothelial cells and CD8 T cells in multiple myeloma P. Leone, G. Di Lernia, A. Solimando, I. Saltarella, R. Ria, P. Ditonno, V. Racanelli, A. Vacca (Italy)

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P12.11 Monitoring of melanoma clinical progression by circulating NK and T cells immunoprofiling C.M. Cristiani, R. Tallerico, V. Ventura, M. Capone, G. Madonna, D. Mallardo, C. Garofalo, E. Staaf*, E. Simeone, A.M. Grimaldi, G. del Zotto, E. Gulletta, G. Ciliberto, A. Moretta, P.A. Ascierto, E. Carbone (Italy, *Sweden)

P12.12 Nuclear factor of activated T cells (NFAT), cancer-initiating cells and chemoresistance V. Corlianò, M.C. Soncini, I. Zanoni*, F. Granucci (Italy, *USA)

P12.13 Darpin® MP0250, a new antiangiogenic drug in multiple myeloma: in vitro and in vivo studies L. Rao, K. De Veirman, D. Giannico, I. Saltarella, V. Desantis, U. Fielder*, A. Harstrick*, D. Ribatti, K. Vanderkerken**, A. Vacca (Italy, *Switzerland, **Belgium)

P12.14 Synergistic effect of Bortezomib and Chloroquine in multiple myeloma treatment G. Di Lernia, I. Saltarella, P. Leone, A. Solimando, R. Ria, V. Racanelli, A. Vacca (Italy)

P12.15 JAM-A role as a prognostic factor and new therapeutic target in multiple myeloma A.G. Solimando, A. Brandl*, K. Mattenheimer*, C. Graf*, M. Ritz*, A. Ruckdeshel*, T. Stühmer*, M. Rudelius*, M.A. Frassanito, V. Desantis, G. Di Lernia, A. Rosenwald*, F. Jakob*, A. Vacca, H. Einsele*, A. Beilhack* (Italy, *Germany)

P12.16 Functional characterization of epidermal growth factor receptors in endothelial cells from patients with multiple myeloma L. Rao, D. Giannico, I. Catacchio, A. Vacca (Italy)

P12.17 Neutrophil plasticity in thyroid cancer M.R. Galdiero, T. Lansione, S. Loffredo, A.L. Ferrara, F. Borriello, R. Iannone, G. Varricchi, G. Marone (Italy)

P12.18 Study of the T-cell response in patients affected by advanced non-small cell lung cancer (NSCLC) treated with PD-1 inhibitor M.C. Rossi, L. Maggi, M. Capone, A. Mazzoni, P. Petreni, V. Santarlasci, G. Montaini, B. Rossettini, F. Mazzoni, F. Di Costanzo, F. Liotta, E. Maggi, F. Annunziato, L. Cosmi (Italy)

P12.19 Role of peroxisome proliferator activated receptor β/δ in the pathophysiology of multiple myeloma D. Giannico, L. Rao, G. Fracchiolla, A. Vacca (Italy)

P12.20 Exosomes-mediate crosstalk in multiple myeloma progression and drug resistance L. Di Marzo, V. Desantis, I. Saltarella, A. Lamanuzzi, M. Arciuli, T. Annese, A. Gallone, B. Nico, A. Vacca, M.A. Frassanito (Italy)

P12.21 Pancreatic cancer and innovative treatment: the seeming paradox to block the immune response

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E. Niccolai, F. Ricci, G. Nannini, A. Taddei, M.N. Ringressi, S. Rolla, F. Cianchi, P. Bechi, F. Novelli, A. Amedei (Italy)

P12.22 Decreased Treg level in bone marrow of low risk myelodysplastic syndrome patients correlates with the occurence of clonal expansion of citotoxic effectors A. Giovazzino, V. Rubino, A.T. Palatucci, S. Leone, V. Pernice, G. Cerciello, F. Pane, F. Alfinito, G. Terrazzano, G. Ruggiero (Italy)

P12.23 Tumor-derived MSCs inhibition of T cells is enhanced by IFN-γ and TNF-α not only through IDO, but also through IL4I1 and PDL1 pathway G. Montaini, A. Mazzoni, B. Rossettini, M. Capone, M.C. Rossi, V. Santarlasci, L. Maggi, O. Gallo, L. Cosmi, F. Liotta, F. Annunziato (Italy)

P12.24 COX-2 expression discriminates cancer-promoting from cancer-inhibitory inflammation across a wide range of malignancies E. Bonavita, S. Zelenay (United Kingdom)

P12.25 Drug-induced senescent Multiple Myeloma cells elicit NK cell activation and proliferation by direct or exosome-mediated IL-15 trans-presentation C. Borrelli, B. Ricci*, E. Vulpis, A. Zingoni, M. Cippitelli, C. Fionda, M.R. Ricciardi, M.T. Petrucci, A. Soriani, A. Santoni (Italy, *USA)

P12.26 Modulation of CXCR3/CXCL10 axis affects migration of natural killer cell

population in multiple myeloma V. Bonanni, E. Vulpis, H. Stabile, M.R. Ricciardi, M.T. Petrucci, A. Gismondi, A. Zingoni, A. Santoni, G. Bernardini (Italy)

P12.27 Immune homeostiasis and early pet response in pediatric Hodgkin lymphoma T. Perillo, P. Muggeo, C. Novielli, R. Daniele, M. Grassi, V. Muggeo, N. Santoro (Italy)

P12.28 BACH1 (BTB and CNC homology 1), the oncogenic regulator enhances migration of HT-29 colon cancer cells S. Davoudian, N. Shajari*, S. Salehi*, B. Mansoori*, A. Mohammadi*, B. Baradaran* (Italy, *Iran)

P12.29 Interleukin (IL)-15 induces a potent anti-tumor activity in natural killer (NK) cells isolated from malignant pleural effusions and overcomes the inhibitory effect of pleural fluid D. Croxatto, S. Martini, L. Chiossone*, F. Scordamaglia, C.F. Simonassi, L. Moretta, M.C. Mingari, P. Vacca (Italy, *France)

P12.30 Anti-tumor immunization of mothers delays neuroblastoma development in cancer-prone offspring G. Barutello, C. Voena, F. Riccardo, A. Réal, R. Chiarle, F. Cavallo (Italy)

P12.31 B cells in cancer immunology: the effects of intestinal cancer macroenvironment on B cell effector and regulatory functions F. Mion, S. Vetrano, S. Tonon, V. Valeri, A. Piontini, A. Burocchi, L. Petti, B. Frossi, A. Gulino, C. Tripodo, M.P. Colombo, C.E. Pucillo (Italy)

P12.32 Rapamycin impairs antitumor CD8+ T-cell responses and vaccine-induced tumor eradication

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N. Chaoul, C. Fayolle, B. Desrues, M. Oberkampf, A. Tang, D. Ladant, C. Leclerc (France)

P12.33 High OX40 expression identifies fully activated ovarian tumor-infiltrating Treg and correlates with reduced PFS A. Burocchi, R. Zappasodi*, B. Belmonte, A. Gulino, C. Bassani, M. Bagnoli, D. Mezzanzanica, D. Lorusso, F. Raspagliesi, C. Tripodo, M. Di Nicola, M.P. Colombo (Italy, *USA)

P12.34 Re-educating antigen-presenting cells: an interferon-gamma delivery system for anticancer therapy F. Castro, M.L. Pinto, A.M. Silva, M.A. Barbosa, S.G. Santos, R.M. Gonçalves, M.J. Oliveira (Portugal)

P12.35 A new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response G. Barra, E. Manzo, C. Gallo, G. Nuzzo, A. Cutignano, C. Sansone, A. Ianora, D. Fenoglio, A. Parodi, G. Pasquale, G. Filaci, A. Leonardi, A. Fontana, R. De Palma (Italy)

P12.36 N6-isopentenyladenosine triggers anti-glioma innate immune response dependent on the p53 status of cells through the induction of ULPB2 and MICA/B M. Abate, C. Laezza, A. D’Alessandro, S. Pisanti, R. Ranieri, M. Bifulco, E. Ciaglia (Italy)

P12.37 Immune-related urinary molecules as a diagnostic and prognostic biomarkers in prostatic cancer S. Occhipinti, M. Maniaci, E. Lombardi, P. Gontero, M. Giovarelli (Italy)

P12.38 28-color, 30 parameter flow cytometry to dissect the complex heterogeneity of tumor infiltrating T cells in human lung adenocarcinoma J. Brummelman, F. Colombo, F. Clemente, F. De Paoli, G. Rotta, P. Novellis, G. Veronesi, A. Roberto, E. Lugli (Italy)

P12.39 Role of the atypical chemokine receptor CCRL2 in colon cancer T. Schioppa, A. Del Prete, F. Sozio, L. Melocchi, M. Bugatti, W. Vermi, S. Sozzani (Italy)

P12.40 Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization S. Pesce, M. Greppi, G. Tabellini, F. Rampinelli, S. Parolini, D. Olive, L. Moretta, A. Moretta, E. Marcenaro (Italy)

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