xdm quad single-use mixing system data … quad™ single-use mixing system ... xdm quad ™ mixers:...

XDM Quad™ Single-Use Mixing System

DATA SHEET

The Xcellerex XDM Quad Mixing System is designed for convenient and

efficient mixing of buffer, media, product, and other process fluids. The single-use

system eliminates the hassle of time-consuming and costly clean-in-place (CIP),

steam-in-place (SIP), and cleaning validation. The result is more efficient processing

and rapid batch-to-batch turnover time.

The XDM Quad is comprised of a full-featured and integrated rigid containment

system complete with motor and controls, and an irradiated USP Class VI, single-

use LDPE fluid contact layer bag equipped with a disposable bottom-mounted

impeller. The engagement between motor and disposable impeller is via a robust

magnetic coupling, and agitation is driven through stainless steel bearings within

the impeller, imparting high torque and rapid mixing to the system.

www.xcellerex.com • 1-866-Xcellerex

The XDM Quad Mixing System is available in 50L, 100L , 200L, 500L and 1000L sizes.

Key Features

l Powerful integrated magnetic agitator with compact VFD and AC motor

l Optimized, disposable impeller

l Square configuration offers enhanced mixing efficiency through natural baffling effect.

l Workable heights and low center of gravity increase level of safety

l Bottom is slanted on two planes for extremely low bag hold-up volume

l Compact unit with handles and casters for ease of mobility

l Fitted square bag minimizes bag wrinkles

l Real-time sensing and sampling capability via mixer window and bag probe ports, sampling port and thermowell for non-invasive temperature sensing

l Integrated holders for 50ml conical buffer tubes

l Bags have integrated 3” Tri-clamp port for powder addition

l Translucent lid is included for protection of bag and is equipped with securing feature for bag powder addition port and hopper

l 500L and 1,000L systems equipped with removable door for easy bag loading

l Two standard bag types: BASIC and PLUS (additional lines, probe ports, and con-nections)

l System also available in either polypropylene, single-wall stainless steel or jacketed stainless steel (for heating and cooling applications).

l Fully wash-down rated

The system delivers flexibility with the availability of two

standard bag types that include varying numbers of tubing lines

and connections, and sampling and sensing capabilities to ac-

commodate a wide array of applications. Key features of the bag

and rigid container also permit seamless transitioning between

powder-liquid and liquid-liquid mixing applications. The XDM

Quad Mixing System is available in either polypropylene, single-

wall stainless steel or or jacketed stainless steel (for heating and

cooling applications).

®


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200 L

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500 L

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1000

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41 x

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5.5 x

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MAT

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Func

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XDM QUAD OPTIONS & ACCESSORIESThe following options are available for all XDM Quad Mixing Systems:

u Dual pH/Conductivity Monitoring System

u pH probe

u Conductivity probe

u RTD probe

u Probe sheath assemblies

u Level indication (floor scale or load cells for stainless steel units)

u Temperature Control Unit for heating and cooling of jacketed stainless steel systems

NOTE: All probes and instrumentation are GMP compliant.


BAg ASSEMBlY DETAIlSXDM Quad Mixing Systems are available with two standard bag assembly types: BASIC and PLUS

SINglE-USE BAg SPECIFICATIONSBASIC BAg ASSEMBlY PlUS BAg ASSEMBlY

Port Description 50L 100L 200L 500L 1000L 50L 100L 200L 500L 1000L

A Fill Port: 3 inch tri-clamp powder addition port, capped • • • • • • • • • •

B C-flex® tubing, 4’ with clamp, plugged (ID indicated) ½ inch ½ inch ½ inch ½ inch ¾ inch ¾ inch ¾ inch ¾ inch ¾ inch ¾ inch

C ½ “ ID C-flex® tubing, 4’ with clamp, female MPX connector, plugged NA NA NA NA NA • • • • •

D Sample Line: 1/8” ID sample line with clamp, and luer lock connection NA NA NA NA NA • • • • •

E, F Probe Port: Female Kleenpack® Connector port for probe connection NA NA NA NA NA • • • • •

F Female Kleenpack® Connector port for probe connection NA NA NA NA NA • • • • •

G Thermowell: for non-invasive temperature sensing NA NA NA NA NA • • • • •

H Sample Line: 1/8” ID sample line with clamp, and luer lock connection • • • • • • • • • •

I Harvest/Drain: C-flex® tubing, 6’ with clamp, plugged (ID indicated) ½ inch ½ inch ½ inch ½ inch ¾ inch ½ inch ½ inch ½ inch ½ inch ¾ inch

SINglE-USE BAg SPECIFICATIONS50 liter 100 liter 200 liter 500 liter 1000 liter

DIMENSIONS Dimensions (inches LxWxH) 15.5 x 15.5 x 14.5 20 x 20 x 19 25 x 25 x 24 33 x 33 x 32 41 x 41 x 37

VOlUME Maximum 55L 125 L 246 L 571 L 1019 L

Nominal 50L 100 L 200 L 500 L 1000 L

Minimum (Mix) 17 L 28 L 44 L 76 L 117 L

Hold Up <20ml < 20 mL < 20 mL < 20 mL < 20 mL

FIlM Fluid Contact Layer LDPE (USP Class VI)

PRESSURE RATINg Maximum, operating 2 psi, 1 psi

IMPEllER # of Blades 3

Diameter 7.5”

Blade Height x Width 4.2” x 2.5”

Blade Pitch 57º

Material of Construction Molded HDPE impeller with 316 SS bearing

TEMPERATURE RANgE 2º – 60ºC

POWDER PORT Dimensions 3” TC

STERIlIZATION Gamma Irradiated

The XDM QUAD disposable impeller assembly is welded to the bottom of the bag.

All specifications are subject to change without notice.


XDM QUAD MIXER SYSTEM DETAIlS

uv

w

y

uMotor controller (fully wash down rated)

vConvenient buffer tube holders (4)

wAC motor and magnetic drive (fully wash down rated)

xHandles for ease of mobility

yNotches for supporting bag tubing (polypro. units)

zProbe port window and support bar for (A) pH/Conductivity, (B) inline sampling, and (C) temperature.

Detail of probe port window and support bar for inline sampling and sensing, such as pH, conductivity and temperature.

{

|

~

{ Removable lid with integrated support for powder addition port and hopper

| Hopper and 3-inch triclamp for easy powder addition

} Removable door for easy bag installation and removal (500L and 1000L only)

~ Mixer bottom is slanted on two planes toward drain for minimal holdup volume; Magnetic impeller drive is easily accessible

}

zA

B

x

C

0%

20%

40%

60%

80%

100%

0 20 40 60 80 100

Minutes

% D

iss

olv

ed

75% Corn Syrup, 274 cp



1% NaCL in Corn Syrup, XDM200

The XDM Quad demonstrates effective mixing even at high viscosities

6g/L NaCL, XDM500

The XDM Quad demonstrates rapid mixing of common salt solutions.

9.0

9.5

10.0

10.5

11.0

11.5

0 60 120 180 240 300

Time (seconds)

Co

nd

ucti

vit

y (

mS

/cm

)

APPlICATIONS AND PERFORMANCE DATA

DMEM/F-12 Medium, XDM500


The XDM Quad demonstrates effective mixing of common cell culture media.

XDM500

DMEM/F-12 Medium Mixing Study

Glucose & L-Gln Trends

0

1

2

3

4

5

6

7

8

9

10

0 60 120 180 240 300

Mix Time (Seconds)

Co

mp

on

en

t C

on

cen

trati

on

L-Gln (mmol/L)

Glucose (g/L)

XDM500


Sodium Trend

0

10

20

30

40

50

60

70

80

90

100

0 60 120 180 240 300

Mix Time (Seconds)

Co

mp

on

en

t C

on

ce

ntr

ati

on

[m

mo

l/L

]

Na+ (mmol/L)

XDM500


Potassium Trend

0

1

2

3

4

5

6

7

8

9

10

0 60 120 180 240 300

Mix Time (Seconds)

Co

mp

on

en

t C

on

ce

ntr

ati

on

[m

mo

l/L

]

K+ (mmol/L)

XDM500


Osmo Trend

0

50

100

150

200

250

300

350

400

0 60 120 180 240 300

Mix Time (Seconds)

[mO

sm

/kg

]

Osmo (mOsm/kg)

VIDEO DEMONSTRATION Base & Acid Addition / Phenolphthalein Dye Test, XDM500

A video demonstration of this mixing test is available at www.xcellerex.com/mixerdemo

SODIUM TREND

OSMOlaRITy TRENDPOTaSSIUM TREND

GlUcOSE & l-GlN TRENDS

u Buffer and Media Prepu pH adjustmentsu Resuspensionu Chromatography poolingu Viral inactivationu UF/DFu Formulationu Product Mixing

XDM QUAD APPlICATIONSu

Product Code Size Type

888-0141 50L Basic

888-0351 50L Plus

888-0164 100L Basic

888-0154 100L Plus

888-0165 200L Basic

888-0155 200L Plus

888-0166 500L Basic

888-0156 500L Plus

888-0167 1,000L Basic

888-0157 1,000L Plus

Ask about our made-to-order bags for UF/DF.

XDM Quad Bag Assembly Ordering Codes

Xcellerex, Inc. Toll Free: 1-866-Xcellerex170 Locke Drive Tel: 508-480-9235 Marlborough, MA 01752 [email protected] www.xcellerex.com rev. xdmQ-010711

TM

Product Code Size Type

XDM-50 50L Standard Polypropylene




XDM-50-S 50L Stainless Steel




XDM-1000-S 1,000L Stainless Steel

XDM-50-S-LC 50L Stainless Steel with Load Cells




XDM-1000-S-LC 1,000L Stainless Steel with Load Cells

XDM-50-T 50L Jacketed Stainless Steel




XDM-1000-T 1,000L Jacketed Stainless Steel

XDM-50-T-LC 50L Jacketed Stainless Steel with Load Cells




XDM-1000-T-LC 1,000L Jacketed Stainless Steel with Load Cells

* Various electrical requirements can be accommodated. Please specify at time of order.

XDM Quad System Ordering Codes*

ORDERINg INFORMATION

Product Code Description

888-0138 Probe Sheath Assemblies

XDM-Q-HH Hopper (includes fitting for fastening to 3” tri-clamp port)

XDM-Q-PB pH Probe

XDM-Q-CB Conductivity Probe

XDM-MTR-P-C pH/Conductivity Monitoring System

XDM-Q-RTD RTD for Temperature Measurement

Accessory Ordering Codes

For information on Xcellerex’s other innovative single-use technology, including XDR single-use bioreactors and the FlexFactory biomanufacturing platform, please visit www.Xcellerex.com

To order XDM Quad systems, bag assemblies or components,

please call 1.866.XCEllEREX

(1.866.923.5537) 1.508.480.9235

xdm quad single-use mixing system data … quad™ single-use mixing system ... xdm quad ™ mixers:...

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