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Who do we think we are?

What constitutes our ego? How does brain activity translate into subjective ideas of our selvesand our environments? Georg Northoffseeks answers using multiple modes of inquiry and a

research team that spans the globe.

Georg Northoff has adopted an age-old strategy when grappling with the complex idea of self:hes got it surrounded. With doctoral degrees in neuroscience, psychiatry and philosophy, and a

transdisciplinary research group with global reach, Northoff peers into the mystery of

consciousness from almost every conceivable angle.

We are sure that such a transdisciplinary approach will open the door to a world of excitingfindings that will shed new light on our very human self, and our very human brain, Northoff

has written.

A worldof findings, indeed. While most Northoff-led investigation takes place at the Universityof Ottawa Institute of Mental Health Research and McGills Montreal Neurological Institute,

Northoff also collaborates with other scientists in Berlin, Bologna, Vienna, Beijing, Hong Kong,

Shanghai, Zrich, and other cities.

At the root of it all is the following question: How do our brains constitute subjective experience

of our selves and environments? Through what mechanisms do we fashion what Northoff calls

the basic sense of subjectivity?

As an example, Northoff points to the personal significance individuals might attach to theiriPhone. How is it possible that this little thing acquires such a personal meaning for you, and

not for me? he asks.

Northoff holds the Canada Research Chair for Mind, Brain Imaging and Neuroethics, as well as

the EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health. Despite his titles and

distinctions, hes genuinely humbled by the complexity of his research.

That said, however, Northoff dismisses as irrelevant such tangential questions as the perennial

debate on whether theres a distinction between mind and brain/body.

Consciousness and self are deeply ingrained in how the brain functions, Northoff contends. Itis not something that comes on top. It is something that is always already there.

Northoff and colleagues use a range of functional imaging techniques to investigate drug-induced changes in the prefrontal neural activity of depressive and schizophrenic patients. One

breakthrough on the subject of depression in recent years stems directly from how we experience

the self.

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In depression you completely focus on your own self, and you are completely detached from

your environment, Northoff notes, something that corresponds with abnormally high activityin the midline region of the brain. One application he sees for such knowledge: better drugs, and

more targeted therapeutic approaches.

In his latest book, released in the fall of 2011, Northoff offers another innovative blend ofdisciplines: neuroscience and psychoanalysis.Neuropsychoanalysis in Practice grapples with theessence of the Ego, and explores how the brain makes distinctions between states that are

neuronal (of the brain) and psychodynamic (of the psyche).

Northoff is at work on two further volumes exploring consciousness and the brain. Far fromascribing to a quest for some kind of post-human Utopia, hes much more interested in human

imperfectionparticularly how that must be somehow based on how the brain functions. We

can learn much more about the opportunities when we know about the limitations, Northoff

reasons.

A rare kind of curiosity that spans disciplines began when an inspiring high-school teacherengaged him in philosophy. I wanted to study philosophy in conjunction with a particular

science, something more concrete, Northoff says. At the time you couldnt really study

neuroscience, so if you wanted to know something about the brain, you had to go into medicine.

Medical school led to psychiatry, but neuroscience beckoned. Philosophy was always firmly in

the picture, along with Northoffs willingness to blend disciplines and genres. His 2009 book,

The Search for the Ego, was billed as a neurophilosophical mystery novel that crosses

academic boundaries to address a wider audience.

With neurophilosophy, as with the rest of his work, Northoff is not afraid to innovate. The

central question that keeps arising in his research is this: Which definition of self should be used?There are as many definitions as there are philosophers, Northoff points out with a laugh.

He believes, however, that a research methodology must be rooted in hard science. Which ofthe logical definitions of self match with the actual empirical data? Northoff asks. Which is in

line with the brain?

And then, after considering the data, he concludes, maybe we should change the definition.