What is HIC? What can we do for you?

Dr Claire Jones

Senior Software Engineer

HIC Services

http://medicine.dundee.ac.uk/hic

• Ran 130 active projects with turn over of 1.3M for 2013/14.

Development Team Clinical Information Bureau (CIB) Team

Data Linkage Service (DLS)

Data Linkage Service (DLS)

• Advise research staff on data linkage requirements

• Feasibility studies using aggregates to quantify population sizes

• Cohort identification and management Recruitment to clinical trials

• Creation of matched Case/Control groups

• New dataset acquisition

• Dataset curation (loading and cleaning of local and national dataset extracts)

• Link, anonymise and extract data

• Provision of Safe Haven

j.r.galloway@dundee.ac.uk

Jim Galloway

https://medicine.dundee.ac.uk/dataset-inventory

Demography

GRO ECHO

There was a 22% overall

reduction in all cause mortality with β blocker

use

Prescribing TARDIS

Biochemistry

Microbiology Haematology

The effect of β blockers in the management of chronic obstructive pulmonary disease (COPD)

Setting Tayside, Scotland (2001–2010) Population 5977 patients aged >50 years with a diagnosis of COPD.

Example of linkage using just HIC hosted data

BMJ. 2011; 342: d2549. 10.1136/bmj.d2549 P.M Short, S.I.W Lipworth, D.H.J Elder, S. Schembri, B.J. Lipworth.

Hospital admissions

GRO

More than 400 lives are being lost each year because breast cancer patients fail to take the

full course of the drug Tamoxifen due to "intolerable"

side-effects

Prescribing

Cohort study examining Tamoxifen adherence and its relationship to mortality in women with breast cancer

Example of linking HIC hosted data to clinical data set

Br J Cancer. 2008 December 2; 99(11): 1763–1768. 10.1038/sj.bjc.6604758 McCowan, J Shearer, P T Donnan, J A Dewar, M Crilly, A M Thompson and T P Fahey

Cohort of cancer patients collected from a Ninewells

clinic

Fire Service

What is the relationship

between vulnerable adults in the

different services?

Police NHS Social Services

HIC linking new data sets from different data custodians

What does HIC Safe Haven Offer Researchers?

• Safe and Secure • Complies with NHS Governance, HIC SOPs • Managed access control • Routine Backup of project data to secure storage

• Managed Service • Helpdesk • Hardware status monitored 24x7 • Built-in hardware resilience

• Collaborative working environment - shared data areas

• Accessible from anywhere within the EU

• Access to Extensive Software Library : • R, STATA, SPSS, MATLAB (if reqd.), Mathematica (if reqd.) • MSOffice 2012

• Archive of project data and results post project completion

Keith Milburn

k.milburn@dundee.ac.uk

Application Development Projects (ADP)

• Bespoke Software

• Web-based Data Collection

• Disease Registries

• Recruitment Tracking

• Randomisation for Clinical Trials

• Study Questionnaire Forms - either web-based or paper-based (or both)

• Texting Interventions

• NHS Network Hosting

Application Development Projects

Keith Milburn

k.milburn@dundee.ac.uk

Clinical Information Bureau (CIB)

• Project-specific data entry

• Adding missing data

• Patient paper record data entry

• Study questionnaire results

• Clerical support to studies

• Mailing Services

• Paper scanning and shredding

Patient Recruitment to Study Completion

Data Linkage - Follow-up of study participants by linking to routinely collected EHR

Data entry of project data from paper forms or adding missing data to study datasets

Aggregates of study feasibility and potential study recruitment

Recruitment mailings and questionnaires

Track the recruitment process via online tracking system

Bespoke web-based data collection tools

Duncan Heather

d.heather@dundee.ac.uk

Governance Support

What approvals do you need?

https://medicine.dundee.ac.uk/governance-approval-support

Project Support

• Service Level Agreements (SLA)

• Data Sharing Agreements

• Approvals forms

• PRFs from HIC Quotes

• Tracking of finance of project

Duncan Heather

d.heather@dundee.ac.uk

Research Data Management Platform (RDMP)

Research

Service

Data

Researchers spend months cleaning and transforming

datasets before they can do

Research

Researchers Do

Research

• Clean • Process • Transform • Standardise • Add metadata

Main goals of RDMP

• Automate the loading, storage, linkage and provision

• To clean, transform and add meta-data and domain knowledge to each data set to make them “research ready”.

• Link to images and genomic data.

• Reproducibility and historical information, user interfaces, additional security and an audit trail.

• To provide the High Performance Computing (HPC)

Profiling Dashboard: Community-dispensed Prescription Data (Prescribing)

*Consistency representation is based on 91.7% validated data

Accuracy - Defined Key & Mandatory Fields

Col. Name Accurate Missing Wrong Null Unavailable

CHI 99.96% 0.00% 0.00% 0.00% 0.04%

corrected_prescribed_date 99.96% 0.00% 0.00% 0.00% 0.04%

res_seqno 99.96% 0.00% 0.00% 0.00% 0.04%

dataMonth 99.96% 0.00% 0.00% 0.00% 0.04%

hb_code 99.96% 0.00% 0.00% 0.00% 0.04%

SCAN_REF_NO 73.27% 0.00% 26.69% 0.00% 0.04%

prescribed_date 99.96% 0.00% 0.00% 0.00% 0.04%

quantity 83.26% 0.00% 15.89% 0.81% 0.04%

directions 33.20% 0.00% 0.27% 66.49% 0.04%

no_of_packs 13.08% 0.00% 0.00% 86.88% 0.04%

line_no 73.23% 0.00% 0.00% 26.73% 0.04%

Approved_Name 98.83% 0.00% 0.00% 1.12% 0.04%

Inaccurate

99.96%

0.04%

Data Availability

Clean Data

Unclean Data

Unavailable Data

0.0% 1.1%0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

chi healthboardcode date

Consistency Representation*

Consistency Inconsistencies

13.34%

0.00% 0.00% 0.81%

66.49%

86.88%

0.04%

26.73%

1.12%0%

10%20%30%40%50%60%70%80%90%

100%

Attribute Completeness

Complete Incomplete

0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

CHI

corrected_prescribed_date

res_seqno

dataMonth

hb_code

SCAN_REF_NO

prescribed_date

quantity

directions

no_of_packs

line_no

Approved_Name

GREEN

AMBER

RED

0

200,000

400,000

600,000

800,000

1,000,000

1,200,000

1,400,0001

-198

9

11

-19

89

9-1

990

7-1

991

5-1

992

3-1

993

1-1

994

11

-19

94

9-1

995

7-1

996

5-1

997

3-1

998

1-1

999

11

-19

99

9-2

000

7-2

001

5-2

002

3-2

003

1-2

004

11

-20

04

9-2

005

7-2

006

5-2

007

3-2

008

1-2

009

11

-20

09

9-2

010

7-2

011

5-2

012

3-2

013

Dataset Time Series

Episodes Unique Patient

Research and

Analytics

Governance

Infrastructure and Data

Services MRI MEI DHSRU

CLS

SNM

Thanks for Listening! Any Questions?

hicservices@dundee.ac.uk