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Volume 4Supplement 2September 2010

BMCProceedings

Abstracts of the 16th International Charles Heidelberger Symposium on Cancer Research

Coimbra, Portugal26-28 September 2010

BMC-Proceedings-ICHSCR-ofc.indd 1BMC-Proceedings-ICHSCR-ofc.indd 1 14/09/2010 15:23:0514/09/2010 15:23:05

Volume 4 Supplement 2September 2010

BMCProceedings

Abstracts of the 16th International Charles Heidelberger

Symposium on Cancer Research


Committees

The Organization of the 16th International Charles Heidelberger Symposium on Cancer Research acknowledges the support of:• FCTUC (Faculdade de Ciências e Tecnologia da Universidade de Coimbra)• CIUC (Centro de Informática da Universidade de Coimbra)• DIIC-UC (Divisão de Identidade, Imagem e Comunicação da Universidade de Coimbra)• Turismo de Coimbra• Turismo Centro de Portugal• Bentham Science Publishers

International Advisory Committee

Eli Huberman (USA)Johan Lillehaug (Norway)Joseph Landolph (USA)Karl Heinrich Link (Germany)Robert Langenbach (USA)Toshio Kuroki (Japan)

Symposium Executive Committee

Eli Huberman (USA)Johan Lillehaug (Norway)Joseph Landolph (USA)Karl Heinrich Link (Germany)

Secretariat

Ana Paula Parreira

Symposium Chairs

Carlos Freire de Oliveira (Portugal) Joseph Landolph (USA)Eli Huberman (USA) Maria Carmen Alpoim (Portugal)

Local Organizing Committee

Ana Castro Jardim (FMUC) Joana Felício Cerveira (FCTUC)Ana Daniela Sampaio (FCTUC) Leonardo Manuel Ferreira (FCTUC)Ana Margarida Urbano (FCTUC) Luís Miguel Pires (FMUC)António Jorge Guiomar (FCTUC) Maria Carmen Alpoim (FCTUC)Armando Cristovão (FCTUC) Maria Filomena Botelho (FMUC)Carlos Freire de Oliveira (FMUC) Marta Pinto Coelho (FMUC)Isabel Maria Abrantes (FCTUC) Paula Vasconcelos Morais (FCTUC)Isabel Marques Carreira (FMUC)

Local Programme Committee

Ana Margarida Urbano (FCTUC) Maria Carmen Alpoim (FCTUC)Carlos Freire de Oliveira (FMUC) Maria Filomena Botelho (FMUC)Isabel Marques Carreira (FMUC) Paula Vasconcelos Morais (FCTUC)

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BMCProceedings

Contents

Opening Lecture

O1 Inflammation, senescence and cancer: interweaving microRNA, inflammatory cytokines and p53 networksCurtis C. Harris

Session 1 - Cancer Etiology and Epidemiology

O2 Gene-environment in the induction of cancerHerman Autrup

O3 Gene variants and lung cancer riskNina E Landvik, Shanbeh Zienolddiny, Vidar Skaug, Aage Haugen

O4 Polychlorinated biphenyls (PCB), UV radiation, and cutaneous malignant melanomaRichard P Gallagher, Tim K Lee, Jean-Philippe Weber, Alain Leblanc, Marilyn Borugian, J Mark Elwood, Amy C MacArthur, Zenaida Abanto, John J Spinelli

P1 Abstract not submitted for publishing

P2 Association between night shift work, melatonin and estradiol in nursesBeata Peplonska, Agnieszka Bukowska, Jolanta Gromadzinska, Wojciech Sobala, Edyta Reszka, Jenny A S Lie

P3 Mastermind-like 1 (MAML-1) as a new metastatic marker in esophageal squamous cell carcinomaMohammad M Forghanifard, Moein Farshchian, Reza Raeisossadati, Mohammad N Forghani, Meysam Moghbeli, Hussein Naseh, Mohammad R Abbaszadegan

P4 Polymorphisms of GSTM1, GSTT1, GSTP1 and CYP1A1 genes and susceptibility to lung cancerPaula Mota, Michelle Horta, Luis Mesquita, Henriqueta Silva

P5 Obesity and breast cancer: inflammatory and adipocytokine correlations

Paulo C Matafome, Ana L Gomes, Manuel Gomes, Lélita C Santos, Ana B Sarmento, Raquel F Seiça

P6 Polymorphisms of estrogen receptors, ERα and GPR30: association with breast cancer susceptibility and prognosisSusana M Alves, Luís Mesquita, Rita Sousa, Fátima Peralta, Henriqueta C Silva

P7 Breast cancer and environmental factorsJ Vicente Paulo, Lélita Santos, Graça Fernandes

P8 Primary bone lymphomaC Pissarro C Azevedo, P José A F F Tavares, M Isabel P Portela, A José L C P Santos, J Manuel P S Casanova

Session 2 - Molecular Carcinogenesis

O5 Regulation of DNA damage responses by mismatch repairAnatoly Zhitkovich

O6 Insoluble Ni compound-induced gene amplification/gene silencing causes over-expression of microtubules/microfilaments, cell shape changes, and de-regulation of global gene expression/Ca+2 gradients, inducing morphological/ neoplastic transformation of 10T1/2 mouse embryo cellsJoseph Landolph, Aruni DeSilva, Duy Mai, Jim K. Lin, Jimmy Zheng


BMCProceedings

Contents

O7 The bioenergetic signature of cancerJosé M. Cuezva

O8 Roles of beta-arrestin1/2 in prostaglandin-mediated signaling and tumor developmentRobert Langenbach, Huei-Chen Lao, Kyung-Soo Chun

O9 PINK1/BRPK inhibits apoptotic cell death and enahances cellular invasiveness through an activation of mTORC2 pathwayHitoshi Murata, Masakiyo Sakaguchi, Ken Kataoka, Nam-ho Huh

O10 Receptor for activated C-kinase (RACK1) plays a central role in Ras-mediated signal transductionJohan R Lillehaug, Line M Myklebust, Arnt Raae, Bodil Bjørndal

P9 The role of CD26 and CD40 expression in therapeutic response - experimental study in oral cancer linesJoana P N Batista, Sílvia S Neves, A Cristina Gonçalves, Vera Alves, Ana Sarmento-Ribeiro, Marília Dourado


P11 Evaluation of the role of miR-34b in modulation of radioresistance in non-small cell lung cancerJoana B Silva, Sílvia S Neves, A Cristina Gonçalves, Margarida Marques, Luís Mesquita, Filomena Botelho, A Bela Sarmento-Ribeiro, Henriqueta C Silva

P12 P-cadherin expression in feline mammary tissuesA Catarina Figueira, Júlio Carvalheira, M Manuela Lacerda, M Fátima Gärtner

P13 Regucalcin, a calcium-binding protein, is a new target gene in human prostate cancer?Cláudio J Maia, Cátia V Vaz, Carina G Peres, Cecília R A Santos, Sílvia Socorro

P14 MicroRNA-21 in lung cancer: overexpression in metastasis of pulmonary adenocarcinomas and squamous cell carcinomasMaria R Silva, Paulo Santos, Isabel Velada, Catarina Gomes, M João d’Aguiar, Lia Teixeira, João Dinis, Susana Carmona, Luisa Cortes, Lina Carvalho

P15 Involvement of mitochondrial and survival signaling in berberine-induced apoptosis in melanoma cellsAna Burgeiro, Consuelo Gajate, El H Dakir, Paulo J Oliveira, Faustino Mollinedo

P16 Metabolic changes in human bronchial epithelial cells upon chronic exposure to hexavalent chromiumLeonardo M R Ferreira, Maria S Santos, M Carmen Alpoim, Ana M Urbano

P17 Cr(VI)-induced malignant transformation of a bronchial epithelial cell line association with altered mitochondria and bioenergetic phenotypesAna Sampaio, Luís Mendes, Ana C Gonçalves, Margarida Abrantes, Ana B Sarmento, Filomena Botelho, Paulo Oliveira, Vilma Sardão, Rui Carvalho, Ana M Urbano and M Carmen Alpoim

Session 3 - Tumor Microenvironment and Tumor Cell Biology

O11 Tumor Microenvironment Controls the Rate of Cancer Progression and MetastasisRaghu Kalluri

O12 Metabolism and metastasis: in the bone marrow and beyondSérgio Dias

O13 The Immune Biology of Microsatellite Unstable CancerMagnus von Knebel-Doeberitz

O14 Targeting secreted heat shock protein-90alpha (Hsp90α) to prevent breast cancer progressionZhengwei Zhao, Chieh-Fang Cheng, Rosie Kim, Mei Chen, David T Woodley, Wei Li


BMCProceedings

Contents

O15 JAKs and STATs in ChemoresistanceAna Costa-Pereira

O16 Autophagy turns specific: the discovery of p62 and NBR1 as autophagy cargo receptorsGeir Bjørkøy



P20 Relation between autophagy and the resistence of glioblastoma cells to temozolomideAnália Carmo, Helena Carvalheiro, Maria C Lopes

P21 GLUT expression and 18F-FDG uptake in breast cancer cell linesAna M Abrantes, Mónica Martins, Ana C Gonçalves, Maria C Rodrigues, Ana C Mamede, Sónia D Tavares, José M Lima, Adriano Rodrigues, Ana B Sarmento-Ribeiro, Maria F Botelho

P22 MDR modulation in colorectal adenocarcinoma cell lines: kinetic studies using 99mTc-sestamibiJoão Casalta-Lopes, A Margarida Abrantes, Joana Rio, Mafalda Laranjo, Bárbara Oliveiros, A Cristina Gonçalves, Ana B. Sarmento-Ribeiro, M. Filomena Botelho

P23 Phenotypic analysis of breast cell lines – triple negative cells vs expressing hormonal receptorsMafalda Laranjo, Maria J Carvalho, Artur Paiva, A Margarida Abrantes, Isabel Torgal, Carlos F Oliveira, M Filomena Botelho


P25 A nonconjugated naphthalene derivative of meso-tetra-(3-hydroxy)-phenyl-porphyrin as a sensitizer for photodynamic therapyAbílio J F N Sobral, Ana M Urbano, Pedro Silva, Sofia M Fonseca, Cláudia T Arranja, Hugh D Burrows

P26 Polyaromatic hydrocarbons accentuate malignant phenotype of the PC3 prostate cancer cell lineMariana O Freitas, José Oliveira, Ana M Fernandes, Maria I Coutinho, Vera Alves, Anabela Mota-Pinto, Ana B Sarmento-Ribeiro

P27 MGBG–cisplatin combination chemotherapy against breast cancerRaquel F Gonsalves, Maria P M Marques

P28 Melanoma skin cancer: could chromone derivatives be efficient chemopreventors?Mafalda M Dias, Maria P M Marques

P29 Exosomes from human ovarian carcinoma SKOV3 cells are enriched in glycosylated proteins Cristina Escrevente, Peter Altevogt, Júlia Costa

P30 Delocalized lipophilic cations as a new therapeutic approach in cancerA Barbosa Ribeiro, A Luísa Ferreira, A Cristina Gonçalves, Sílvia Neves, A Maria Araújo, Filipa Carvalho, João Carvalho, Rui M Santos, Vera Alves, Teresa Silva, José M Nascimento-Costa, Ana B Sarmento-Ribeiro

P31 Cytotoxic effect induced by combination of polyamines metabolites and endocannabinoid, anandamide, on human cancer cells: a new anticancer strategy A Lúcia M Batista-de-Carvalho, G Tempera, N Viceconte, S Saccoccio, E Bidollari, M Nalli, Enrico Morera, Giorgio Ortar, Enzo Agostinelli

P32 An in vitro tumor-fibroblast interaction model of human oral squamous cell carcinomaJozséf Dudás, M Bitsche, V Schartinger, G M Sprinzl, H Riechelmann

P33 Physiologic parameters variation in ICR mice during a chemical induced liver carcinogenesis experimentIvo Conceição-Pereira, Nuno M Paula-Santos, Filipa O Pereira, Maria J Pires, Luis F Palomino, Aura A Colaço, Paula A Oliveira

P34 Role of VEGF signalling in the regulation of KDR expression in endothelial and tumoral microenvironmentJacinta Serpa, Cheila Torre, Francisco Caiado, Sérgio Dias


BMCProceedings

Contents

P35 EP4-mediated prostanoid signalling promotes oral cancer progressionKaren Sapienza, Stewart Sale, Angela Hague, Ian.R. Hart, J.ohn F. Marshall, Gareth.J. Thomas

P36 Role of notch pathway and HNF1 in cell death induced by HDACs inhibitors in ovarian cancer cell lines, serous and clear cellsFernanda Silva, Jacinta Serpa, Germana Domingues, Gabriela Silva, António Almeida, Ana Félix

P37 TRAP1 and SORCIN cooperate in a survival pathway responsible for inducing drug-resistance in human colorectal carcinoma (CRC)Matteo Landriscina, Francesca Maddalena, Gabriella Laudiero, Maria R Amoroso, Annamaria Piscazzi, Valentina Lombardi, Alberto Fersini, Franca Esposito

P38 Dll4 blockade interferes with the bone marrow vascular niche and perturbs hematopoietic recovery following myeloablationLeonor Remédio, Tânia Carvalho, Sérgio Dias

P39 Short-chain sphingolipids for enhanced cellular uptake of liposome-encapsulated amphiphilic anti-cancer drugsLília R C Pedrosa, Albert van Hell, Wim van Blitterswijk, Ann L B Seynhaeve, Alexander M M Eggermont, Timo L M ten Hagen, Marcel Verheij, Gerben A Koning

P40 Osteosarcoma contains a subpopulation of cancer stem-like cells that are highly resistant to radiotherapySara R M Neves, Aurio O G Lopes, Anália do Carmo, Antero J Abrunhosa, Paulo C P S Simões, Artur A Paiva, M Filomena Botelho, Célia M F Gomes

P41 Indentification of cancer stem-like cells in osteosarcoma and their implications in response to chemotherapyÁurio O Lopes, Sara R Neves, Anália do Carmo, Artur A Paiva, Maria Botelho, Célia M Gomes

P42 Metabolic responses of A549 lung cells to cisplatin and radiation exposure studied by 1H NMR spectroscopyAna F Ladeirinha, Inês D Lamego, Ana M Gil, Joana B Melo, Isabel M Carreira, Iola F Duarte

P43 In vivo pulmonary metastatic profile of breast cancer cell lines expressing hormonal receptors versus triple negativeM João Carvalho, A Margarida Abrantes, Mafalda Laranjo, Francisco Falcão, Sofia Cabrita, M Filomena Botelho, Carlos F de Oliveira, Isabel Torgal

P44 New targeted therapies in myelodysplastic syndrome: the role of farnesyltransferase and proteasome inhibitorsA Cristina Gonçalves, Ana Oliveira, Diana Moreira, Silvia Neves, Vera Alves, Teresa Silva, Luís Mesquita, Henriqueta Coimbra, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro

P45 Targeted gene silencing for cancer treatmentLígia C G da Silva, José S Ramalho, M Conceição P de Lima, Sérgio Simões, João N Moreira

P46 Recombinant trail: a synergistic effect in myeloid leukemiasFilipa Carvalho, A Sofia Coelho, Cátia Domingues, João A Carvalho, André Ribeiro, Rui M Santos, A Cristina Gonçalves , Vera Alves, Teresa Silva, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro

P47 Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?Ana S Ribeiro, Laura C Carreto, André Albergaria, Bárbara Sousa, Sara Ricardo, Fernanda Milanezi, Raquel Seruca, Manuel A Santos, Fernando Schmitt, J oanaParedes

P48 Contribution of Thomsen-Friedenreich antigens to bladder cancer malignancy: Characterization of cell line modelsPaulo F Severino, Mylène A Carrascal, Helena Gouveia, M Guadalupe Cabral, Manuela Correia, Nadia Malagolini, Mariella Chiricolo, Fabio Dall’Olio, Paula AVideira

P49 Antitumoral effect of farnesiltransferase and mtor inhibitors in hepatocellular carcinoma: in vitro studiesAna M Araújo, Sílvia S Neves, Ana L Ferreira, Diogo Branco, Ana B Sarmento-Ribeiro, José M Nascimento-Costa


BMCProceedings

Contents

P50 Metalloproteinase inhibitors as a potential therapeutic approach in multiple myeloma: a preliminary studyA Sofia Pais, A Cristina Gonçalves, Catarina Geraldes, José M Nascimento-Costa, Ana B Sarmento-Ribeiro

P51 Novel antitumor DNA monoalkylating agents: Synthesis and biological evaluationAna F Brito, M Isabel Soares, Mafalda Laranjo, A Margarida Abrantes, José A Paixão, Ana M Beja, Manuela R Silva, Teresa P Melo, M Filomena Botelho

P52 The effect of cisplatin in 5637 bladder cancer cell lineRosário Pinto-Leite, Regina Arantes-Rodrigues, M Luís Cardoso, Lúcio Santos, Paula A Oliveira

Session 4 - Cancer Genetics and Epigenetics

O17 CDH3/P-cadherin overexpression in breast carcinomas: its regulatory mechanisms, the role in cell invasion, and the association with cancer stem cell propertiesJoana Paredes

O18 Spontaneous development of lung adenocarcinoma in the CADM1 gene-deficient miceMasayoshi Nagata, Mika Sakurai-Yageta, Daisuke Yamada, Taketo Kawai, Yumi Tsuboi, Takeshi Ito, Akihiko Ito, Midori Yoshida, Yoshinori Murakami

O19 The FRAGILOME project, a strategy for the discovery of new gene biomarkers in cancerManfred Schwab

O20 Gene amplification in breast cancer – looking for the molecular mechanismsSergei Kovalenko

O21 Molecular Genetic Study of Female Cancers in Novosibirsk, RussiaLyudmila F Gulyaeva

O22 E-cadherin mediated cellular effects and molecular partners. Gastric cancer as an invasive modelJoana Figueiredo, Joana Simões-Correia, Joana Fernandes, Ana R Mateus, Gianpaolo Suriano, Joana Paredes, Carla Oliveira, Raquel Seruca

P53 Identification of copy number variations of chromosomes 7, 9 and 10 in human glioblastomas by SNP-arraysInês Crespo, Maria D Tabernero, Ana B Nieto, Olinda Rebelo, Hermínio Tão, Fernando Gomes, Catarina R Oliveira, Maria C Lopes, Alberto Orfao

P54 Circadian gene variants and MT6s level in nurses under different work shifts – preliminary resultsEdyta Reszka, Beata Peplonska, Edyta Wieczorek, Jolanta Gromadzinska, Wojciech Sobala, Wojciech Wasowicz, Agnieszka Bukowska, Jenny A Lie

P55 MFSD2A is a novel lung tumour suppressor gene whose expression is modulated by a 5’-region polymorphismFrancesca Colombo, Monica Spinola, Felicia S Falvella, James P Sullivan, David S Shames, Luc Girard, Paola Spessotto, John D Minna, Tommaso A Dragani

P56 FGFR4 GLY388ARG polymorphism modulates cancer patients’ survival in pooled analysisElisa Frullanti, Tommaso A Dragani

P57 KRAS and EGFR mutations coexisting in lung adenocarcinomaVitor Sousa, Ana Alarcão, Patricia Couceiro, Maria R Silva, Maria J d’Aguiar, Lia Teixeira, Lina Carvalho

P58 Modulation of DNA damage prevention and signaling pathways in diet induced colon cancer preventionDalila F N Pedro, Alice A Ramos, Cristóvão F Lima, Fátima Baltazar, Cristina Pereira-Wilson


BMCProceedings

Contents

P59 MIR-143 over-expression reduces the growth of xenograft tumors from colon carcinoma cellsPedro M Borralho, Sofia Gomes, Raquel T Lima, Rui E Castro, Maria H Vasconcelos, Cecília M P Rodrigues

P60 Histone deacetylation - a new epigenetic target in cancer João A Carvalho, Emília Cortesão, José D Branco, Ana C Gonçalves, Sílvia Neves, Filipa Carvalho, André Ribeiro, Vera Alves, Teresa Silva, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro

P61 EGFR unusual mutation status in lung adenocarcinomasAna Alarcão, Vitor Sousa, Patrícia Couceiro, Maria Silva, Maria J. d’Aguiar, Lia Teixeira, Lina Carvalho

P62 Identification of a common deletion region in 10q26 associated with human gliomasMargarida Alves, Paulo Liberato, Ana Rita Conde, Manuela Mafra, Alexandra Inverno, Ana Teresa Maia, Denise Bagrel, Isabel Carreira, Miguel Brito, Carolino Monteiro

P63 STEAP1 expression in prostate cancer and its regulation by androgensInês Gomes, Cecília R A Santos, Sílvia Socorro, Carlos Lopes, Cláudio J Maia

P64 EGFR/erb-1, HER2/erb-2, CK7, LP34, Ki67 and p53 expression in preneoplastic lesions of bronchial epitheliumLina Carvalho, Joana E Santo, Ana Alarcão, Patricia Couceiro, Maria R Silva, Ana Gomes, Maria J d’Aguiar, Lia Teixeira, Vitor Sousa

Session 5 - Translational Cancer Medicine

O23 Quality control in colon and rectal cancer surgeryKarl-Heinrich Link

O24 Detecting tumor responses to treatment using hyperpolarized 13C magnetic resonance spectroscopic imagingKevin M Brindle

O25 Tumor-tailored treatment of colorectal cancer: from bench to bedside?Marko Kornmann

O26 Targeting non-viral vectors to tumor cells and the tumor microenvironmentVera Moura, Manuela Lacerda, Paulo Figueiredo, M Luísa Corvo, M Eugénia M Cruz, M Conceição P. de Lima, Sérgio Simões, João N Moreira

O27 Adjuvant therapy in colorectal cancer – studies of the FOGT groupLudger Staib, Marko Kornmann, Karl-Heinrich Link

O28 “Omic” landscapes of breast cancer - the end of the beginningCarlos Caldas

O29 Bacterial anticancer weapons: a promising tool to fight cancerAnanda M Chakrabarty

P65 Improving the classification of brain tumors in mice with perturbation enhanced (PE)-MRSIRui V Simões, Sandra Ortega-Martorell, Teresa Delgado-Goñi, Yann le Fur, Marti Pumarola, Ana P Candiota, Patrick J Cozzone, Margarida Juliá-Sapè, Carles Arús

P66 NMR metabonomic study of lung cancer: metabolic profiling of tissuesCláudia M Rocha, António S Barros, Ana M Gil, Brian J Goodfellow, Isabel M Carreira, João Bernardo, Ana Gomes, Vítor Sousa, Lina Carvalho, Iola F Duarte

P67 NMR metabonomic study of lung cancer: metabolic profiling of urine and blood plasmaJoana Carrola, Cláudia M Rocha, António S Barros, Ana M Gil, Brian J Goodfellow, Isabel M Carreira, João Bernardo, Ana Gomes, Vitor Sousa, Lina Carvalho, Iola F Duarte

http://www.uc.pt/en/congressos/16ICHSCR | [email protected]

SCIENTIFIC PROGRAM

DDAAYY 11 Sunday, 26 September 2010

09H00−09H30 OOppeenniinngg CCeerreemmoonnyy Joseph Landolph (USA), Eliezer Huberman (USA), Maria Carmen Alpoim (Portugal) and Carlos de Oliveira (Portugal)

09H30−10H30

OOppeenniinngg LLeeccttuurree Curtis Harris, Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD, USA

Interweaving p53, Innate Immune and MicroRNA Networks in Human Carcinogenesis and Molecular Epidemiology

10H30−11H00 Coffee Break

SSeessssiioonn 11 –– CCaanncceerr EEttiioollooggyy aanndd EEppiiddeemmiioollooggyy

11H00−11H30 Herman Autrup

School of Public Health, University of Aarhus, Aarhus, Denmark

Gene-environment Interaction in Cancer Development

11H30−12H00

Aage Haugen Section of Toxicology, National Institute of Occupational Health, Oslo,

Norway Institute of Biotechnology, Norwegian University of Science and

Technology, Trondheim, Norway

Gene Variants and Lung Cancer Risk

12H00−12H30

Richard Gallagher Cancer Control Research, British Columbia Cancer Agency,

Vancouver, BC, Canada School of Population and Public Health, University of British Columbia,

Vancouver, BC, Canada

Polychlorinated Biphenyls (PCB), UV Radiation, and Cutaneous Malignant Melanoma

12H30−14H00 Lunch

SSeessssiioonn 22 −− MMoolleeccuullaarr CCaarrcciinnooggeenneessiiss

14H00−14H30 Anatoly Zhitkovich

Department of Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, RI, USA

Regulation of DNA Damage Responses by Mismatch Repair

14H30−15H00

Joseph Landolph

Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

School of Pharmacy, University of Southern California, CA, USA

USC/Norris Comprehensive Cancer Center, University of Southern California, CA, USA

Insoluble Ni Compound-induced Gene Amplification/Gene Silencing Causes Over-expression of Microtubules/Microfilaments, Cell Shape Changes, and Deregulation of Global Gene Expression/Ca

2+

Gradients, Inducing Morphological/Neoplastic Transformation of 10T1/2 Mouse Embryo Cells

15H00−15H30

José Manuel Cuezva

Centro de Biología Molecular “Severo Ochoa”, Universidad Autónoma de Madrid, Spain

CIBER de Enfermedades Raras, Instituto de Salud Carlos III, Universidad Autónoma de Madrid, Madrid, Spain

The Bioenergetic Signature of Cancer


16H00−16H30

Robert Langenbach

Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA

Roles of Beta-arrestin1/2 in Prostaglandin-mediated Signaling and Tumor Development

16H30−17H00 Nam-ho Huh

Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

PINK1/BRPK Inhibits Apoptotic Cell Death and Enhances Cellular Invasiveness Through an Activation of mTORC2 Pathway

17H00−17H30 Johan Lillehaug

Department of Molecular Biology, University of Bergen, Bergen, Norway

Receptor for Activated C-Kinase (RACK1) Plays a Central Role in Ras-mediated Signal Transduction

DDAAYY 22 Monday, 27 September 2010

SSeessssiioonn 33 −− TTuummoorr MMiiccrrooeennvviirroonnmmeenntt aanndd TTuummoorr CCeellll BBiioollooggyy

09H00−09H30 Raghu Kalluri

Harvard Medical School, Harvard University, Boston, MA, USA Beth Israel Deaconess Medical Center, Boston, MA, USA

The Role of Fibroblasts and Pericytes in Cancer Progression and Metastasis

09H30−10H00

Sérgio Dias

Centro de Investigação em Patobiologia Molecular (CIPM), Portuguese Institute of Oncology (IPOFG), Lisbon, Portugal

Instituto Gulbenkian de Ciência, Oeiras, Portugal

Metabolism and Metastasis: In the Bone Marrow and Beyond

10H00−10H30

Magnus von Knebel Doeberitz

Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany

Clinical Cooperation Unit, Applied Tumor Biology (G105), German Cancer Research Center (DKFZ), Heidelberg, Germany

The Immune Biology of Microsatellite Unstable Cancer


11H00−11H30

Wei Li

Department of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA

USC-Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA

Targeting Secreted Heat Shock Protein-90alpha (Hsp90α) to Prevent Breast Cancer Progression

11H30−12H00

Ana Costa-Pereira

Division of Cancer, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK

Hammersmith Hospital, London, UK

JAKs and STATs in Chemoresistance

12H00−12H30 Geir Bjørkøy

AFT, Sør-Trøndelag University College (HiST), Trondheim, Norway

Autophagy Turns Specific: The Discovery of p62 and NBR1 as Autophagy Cargo Receptors

12H30−14H00 Lunch

SSeessssiioonn 44 −− CCaanncceerr GGeenneettiiccss aanndd EEppiiggeenneettiiccss

14H00−14H30 Joana Paredes

Cancer Genetics Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal

CDH3/P-Cadherin Overexpression in Breast Carcinomas: Its Regulatory Mechanisms, the Role in Cell Invasion, and the Association With Cancer Stem Cell Properties

14H30−15H00 Yoshinori Murakami

Division of Molecular Pathology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Spontaneous Development of Lung Adenocarcinoma in the Cadm1 Gene-Deficient Mice

15H00−15H30 Manfred Schwab

German Cancer Research Center (DKFZ), Heidelberg, Germany

The FRAGILOME Project, a Strategy for the Discovery of New Gene Biomarkers in Cancer


16H00−16H30

Sergei Kovalenko

Laboratory of Gene Engineering, Institute of Molecular Biology and Biophysics, Academy of Medical Sciences, Siberian Branch, Novosibirsk, Russia

Novosibirsk State University, Novosibirsk, Russia

Gene Amplification in Breast Cancer Cells: Molecular Mechanisms and Possible Prognostic Value

16H30−17H00

Lyudmila Gulyaeva

Laboratory of Molecular Carcinogenesis, Institute of Molecular Biology and Biophysics, Russian Academy of Medical Sciences, Siberian Division, Novosibirsk, Russia

Medical Department, Novosibirsk State University, Novosibirsk, Russia

Molecular Genetic Study of Female Cancers in Novosibirsk, Russia

17H00−17H30 Raquel Seruca

Cancer Genetics Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal

E-Cadherin Mediated Cellular Effects and Molecular Partners. Gastric Cancer as an Invasive Model

DDAAYY 33 Tuesday, 28 September 2010

SSeessssiioonn 55 −− TTrraannssllaattiioonnaall CCaanncceerr MMeeddiicciinnee

09H00−09H30 Karl-Heinrich Link

Surgical Center and Asklepios Tumor Treatment Center Rhein-Main (ATC), Asklepios Paulinen Klinik (APK), Wiesbaden, Germany

Quality Control in Colon and Rectal Cancer Surgery

09H30−10H00 Kevin Brindle

Department of Biochemistry, University of Cambridge, UK Cancer Research UK, Cambridge Research Institute, Cambridge, UK

Detecting Tumour Responses to Treatment Using Hyperpolarized 13

C Magnetic Resonance Spectroscopic Imaging

10H00−10H30 Marko Kornmann

Hospital for General, Visceral and Transplantation Surgery, Ulm University, Ulm, Germany

Tumor-tailored Treatment of Colorectal Cancer: From Bench to Bedside?


11H00−11H30 João Nuno Moreira

Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal Centre for Neurosciences and Cell Biology, Coimbra, Portugal

Targeting Non-viral Vectors to Tumor Cells and the Tumor Microenvironment

11H30−12H00 Ludger Staib

Department of General and Visceral Surgery, Klinikum Esslingen, Esslingen, Germany

Adjuvant Therapy in Colorectal Cancer – Studies of the FOGT Group

12H00−12H30

Carlos Caldas

Department of Oncology, University of Cambridge, Cambridge, UK Cambridge Experimental Cancer Medicine Centre, Cambridge, UK Cancer Research UK, Cambridge Research Institute, Cambridge

Breast Cancer Research Unit, Cambridge, UK NIHR Cambridge Biomedical Research Centre, Cambridge, UK

'Omic' Landscapes of Breast Cancer – The End of the Beginning

12H30−13H00 Ananda M. Chakrabarty

Department of Microbiology & Immunology, University of Illinois College of Medicine, Chicago, IL, USA

Bacterial Anticancer Weapons: A Promising Tool to Fight Cancer

13H00−14H30 Lunch

Afternoon Half-day Tour

Committees

Symposium Chairs

Carlos Freire de Oliveira (Portugal), Eli Huberman (USA), Joseph Landolph (USA), Maria Carmen Alpoim (Portugal)

Local Organizing Committtee

Ana Castro Jardim (FMUC), Ana Daniela Sampaio (FCTUC), Ana Margarida Urbano (FCTUC), António Jorge Guiomar (FCTUC), Armando Cristovão (FCTUC), Carlos Freire de Oliveira (FMUC), Isabel Maria Abrantes (FCTUC), Isabel Marques Carreira (FMUC), Joana Felício Cerveira (FCTUC), Leonardo Manuel Ferreira (FCTUC), Luís Miguel Pires (FMUC), Maria Carmen Alpoim (FCTUC), Maria Filomena Botelho (FMUC), Marta Pinto Coelho (FMUC), Paula Vasconcelos Morais (FCTUC)


Ana Margarida Urbano (FCTUC), Carlos Freire de Oliveira (FMUC), Isabel Marques Carreira (FMUC), Maria Carmen Alpoim (FCTUC), Maria Filomena Botelho (FMUC), Paula Vasconcelos Morais (FCTUC)


Eli Huberman (USA), Johan Lillehaug (Norway), Joseph Landolph (USA), Karl Heinrich Link (Germany), Robert Langenbach (USA), Toshio Kuroki (Japan)


Eli Huberman (USA), Johan Lillehaug (Norway), Joseph Landolph (USA), Karl Heinrich Link (Germany)

Secretariat

Ana Paula Parreira

Acknowledgements

The Organization of the 16th International Charles Heidelberger Symposium on Cancer Research acknowledges the support of:

• FCTUC (Faculdade de Ciências e Tecnologia da Universidade de Coimbra)

• CIUC (Centro de Informática da Universidade de Coimbra)

• DIIC-UC (Divisão de Identidade, Imagem e Comunicação da Universidade de Coimbra)

• Turismo de Coimbra

• Turismo Centro de Portugal

• Bentham Science Publishers

LIST OF PARTICIPANTS

AUSTRALIA

Stewart, Bernard W. SE Sydney Public Health Unit, Sidney, Australia [email protected]

AUSTRIA

Dudás, Jozséf Medical University Innsbruck, ENT-Clinic, Innsbruck, Austria [email protected]

CANADA

Gallagher, Richard P. Cancer Control Research Program, British Columbia Cancer Agency, Vancouver, BC, Canada; School of Population and Public Health, University of British Columbia; Vancouver, BC, Canada [email protected]

CZECH REPUBLIC

Mejsnar, George A. Cytolab Ltd, Praha, Czech Republic [email protected]

DENMARK

Autrup, Herman School of Public Health, University of Aarhus, Aarhus, Denmark [email protected]

GERMANY

von Knebel Doeberitz, Magnus Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany, and Clinical Cooperation Unit, Applied Tumor Biology (G105), German Cancer Research Center (DKFZ), Heidelberg, Germany [email protected]

Kornmann, Marko Department of General, Visceral, and Transplantation Surgery, University of Ulm, Ulm, Germany [email protected]

Link, Karl-Heinrich Surgical Center and Asklepios Tumortreatment Center Rhein-Main (ATC), Asklepios Paulinen Klinik (APK), Wiesbaden, Germany [email protected]

Schwab, Manfred German Cancer Research Center (DKFZ), Heidelberg, Germany [email protected]

Staib, Ludger Department of General and Visceral Surgery, Klinikum Esslingen, Esslingen, Germany [email protected]

IRAN

Forghanifard, Mohammad M. Islamic Azad University, Damghan, Iran [email protected]

ITALY

Colombo, Francesca Fondazione IRCCS Istitito Nazionale Tumori, Milan, Italy [email protected]

Frullanti, Elisa Fondazione IRCCS Istitito Nazionale Tumori, Milan, Italy [email protected]

Landriscina, Matteo University of Foggia, Department of Medical Sciences, Clinical Oncology Unit, Foggia, Italy [email protected]

JAPAN

Huh, Nam-ho Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan [email protected]

Kuroki, Toshio University of Tokyo, Research Center for Science Systems [email protected]

Murakami, Yoshinori Division of Molecular Pathology, Institute of Medical Science, University of Tokyo,Tokyo, Japan [email protected]

NORWAY

Bjørkøy, Geir AFT, Sør-Trøndelag University College (HiST), Trondheim, Norway University College of Sør-Trøndelag; University of Tromsø, Norway [email protected]

Haugen, Aage Section of Toxicology, National Institute of Occupational Health, Oslo Norway; Institute of Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway [email protected]

Lillehaug, Johan R. Department of Molecular Biology, University of Bergen, Bergen, Norway [email protected]

POLAND

Bukowska, Agnieszka Noffer Institute of Occupational Medicine, Lodz, Poland [email protected]

Reszka, Edyta Noffer Institute of Occupational Medicine, Lodz, Poland [email protected]

PORTUGAL

Abrantes, Ana M. Biophysics/Biomathematics Institute, IBILI, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Abrantes, Isabel M. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal [email protected]

Alarcão, Ana

Instituto de Anatomia Patológica - Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Alpoim, Maria C. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal [email protected]

Alves, Susana M. Serviço de Genética Médica da Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Arantes, Regina M. Department of Veterinary Sciences, CECAV, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal [email protected]

Araújo, Ana M. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Batista, Joana P. Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal [email protected]

Batista de Carvalho, Ana Molecular Physical-Chemistry R&D Unit, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal [email protected]

Borralho, Pedro M. Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy of the University of Lisbon (FFUL), Lisbon, Portugal [email protected]

Botelho, Maria F. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Brito, Ana F. Biophysics/Biomathematics Institute; Faculty of Medicine; University of Coimbra, Coimbra, Portugal. [email protected]

Burgeiro, Ana A. CNC - Centro de Neurociências e Biologia Celular, Coimbra, Portugal [email protected]

Carmo, Anália G. CNBC - Center for Neuroscience and Cell Biology, Coimbra, Portugal [email protected]

Carrola, Joana Q. CICECO, Aveiro, Portugal [email protected]

Carvalho, Filipa V. Medicine Faculty of the University of Coimbra, Coimbra, Portugal [email protected]

Carvalho, João A. Faculty of Medicine of the University of Coimbra, Coimbra, Portugal [email protected]

Carvalho, Lina M. Instituto de Anatomia Patológica, FMUC, Coimbra, Portugal [email protected]

Carvalho, M. João CIMAGO, Medicine Faculty of the University of Coimbra /Gynaecology Service, University Hospitals of Coimbra / Biophysics and Biomathematics Institute, IBILI, Medicine Faculty of Coimbra, Coimbra, Portugal [email protected]

Carreira, Isabel M. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Cerveira, Joana F. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal [email protected]

Coelho, Marta P. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Cortesão, Emília N. University Hospitals of Coimbra/ACIMAGO, Coimbra, Portugal [email protected]

Crespo, Ana I. Faculdade de Farmácia da Universidade de Coimbra, Coimbra, Portugal [email protected]

Cristovão, Armando J. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal [email protected]

Cruz, Rui S. College of Health Technologies of Coimbra, Coimbra, Portugal [email protected]

Dias, Mafalda M. Molecular Physical-Chemistry R&D Unit, University of Coimbra, Coimbra, Portugal [email protected]

Dias, Sérgio Angiogenesis Laboratory, Centro de Investigação em Patobiologia Molecular (CIPM), Portuguese Institute of Oncology (IPOFG), and Instituto Gulbenkian de Ciência, Lisbon, Portugal. [email protected]

Dourado, Marília A. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Escrevente, Cristina I. Instituto de Tecnologia Química e Biológica, Oeiras, Portugal [email protected]

Ferreira, Ana L. Faculty of Medicine, University of Coimbra, Coimbra, Portugal [email protected]

Ferreira, Leonardo M. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal [email protected]

Figueira, Ana C. Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (ICBAS-UP), Porto, Portugal [email protected]

Freitas, Mariana O. General Pathology Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal [email protected]

Gomes, Ana I. Banco de Tumores, Hospitais da Universidade de Coimbra, Coimbra, Portugal [email protected]

Gomes, Célia M. Biophysics/Biomathematics Institute, IBILI, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Gonçalves, Ana C. Medicine Faculty, Coimbra University, Coimbra, Portugal [email protected]

Gonsalves, Raquel F. Molecular Physical-Chemistry R&D Unit, University of Coimbra, Coimbra, Portugal [email protected]

Guiomar, António J. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal [email protected]

Jardim, Ana C. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Ladeirinha, Ana F. Cytogenetics Laboratory and CNC, Faculty of Medicine, University of Coimbra, Coimbra, Portugal [email protected]

Laranjo, Mafalda S. Biophysics/Biomathematics Institute, IBILI, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Lopes, Áurio O. Institute of Biophysics and Biomathematics - IBILI - FMUC, Coimbra, Portugal [email protected]

Lopes, João C. Biophysics/Biomathematics Institute, IBILI, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Lopes, Maria C. Centro de Neurociências e Biologia Celular; Universidade de Coimbra; CIMAGO/FMUC, Coimbra, Portugal [email protected]

Maia, Cláudio J.

Universidade da Beira Interior, Covilhã, Portugal [email protected]

Matafome, Paulo N. Centro de Investigação em Meio Ambiente, Genética e Oncobiologia (CIMAGO), Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Mendes, Luís Faculdade de Ciências e Tecnologia, Universidade de Coimbra [email protected]

Monteiro, Carolino J. Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal [email protected]

Morais, Paula V. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal [email protected]

Moreira, João N. Faculty of Pharmacy and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal [email protected]

Mota, Paula M. Instituto de Genética Médica, Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal [email protected]

Mota-Pinto, Anabela Faculdade de Medicina da Unievsridade de Coimbra, Coimbra, Portugal [email protected]

Moura, Vera L. Centro de Neurociências e Biologia Celular, Coimbra, Portugal [email protected]

Nascimento-Costa, José Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Neves, Sara R. IBILI, Coimbra, Portugal [email protected]

Neves, Sílvia S. ACIMAGO, Faculty of Medicine, University of Coimbra, Coimbra, Portugal [email protected]

Nobre, Rui J. CNBC - Center for Neuroscience and Cell Biology, Coimbra, Portugal [email protected]

Oliveira, Carlos F. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Oliveira, Paula A. Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal [email protected]

Pais, Ana S. Faculty of Medicine of the University of Coimbra, Coimbra, Portugal [email protected]

Paredes, Joana Cancer Genetics Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal [email protected]

Paulo, Judy V. Faculdade de Medicina da Universidade de Coimbra / IPO-FG Coimbra, Coimbra, Portugal [email protected]

Pedro, Dalila F. CBMA, Department of Biology, Minho University, Braga, Portugal [email protected]

Pires, Luís M. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Pissarro, Cristina A. Portuguese Oncology Institute, Coimbra, Portugal [email protected]

Prazeres, Hugo IPATIUP, Porto, Portugal [email protected]

Remédio, Leonor V. CIPM, IPOLFG, EPE, Lisbon, Portugal [email protected]

Ribeiro, Ana S. IPATIMUP, Porto, Portugal [email protected]

Ribeiro, André B. Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal [email protected]

Rocha, Cláudia M. CICECO, Aveiro, Portugal [email protected]

Rodrigues, Vítor L. Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal [email protected]

Sampaio, Ana D. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal [email protected]

Santos, Ana T. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Santos, Catarina G. Hospitais da Universidade de Coimbra (HUC), Coimbra, Portugal [email protected]

Santos, Nuno R. IBB/CBME, Universidade do Algarve, Faro, Portugal [email protected]

Santos, Rui C. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal [email protected]

Sarmento-Ribeiro, Ana B. CIMAGO, Faculty of Medicine, University of Coimbra, Coimbra, Portugal [email protected]

Serpa, Jacinta Grupo de Angiogénese-CIPM-Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisboa, Portugal [email protected]

Seruca, Raquel Cancer Genetics Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal [email protected]

Severino, Paulo F. Departamento de Imunologia da Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisboa, Portugal [email protected]

Silva, Daniela S. CIMAGO, Faculty of Medicine, University of Coimbra, Coimbra, Portugal [email protected]

Silva, Fernanda Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisboa, Portugal [email protected]

Silva, Henriqueta C. Genetic Department, Faculty of Medicine, University of Coimbra, Coimbra, Portugal [email protected]

Silva, Joana B. Faculty of Medicine of the University of Coimbra, Coimbra, Portugal [email protected]

Silva, Lígia C. Center for Neuroscience and Cell Biology, Coimbra, Portugal [email protected]

Silva, Maria R. Instituto de Anatomia Patológica, Faculdade de Medicina da Universidade de Coimbra (FMUC), Coimbra, Portugal [email protected]

Sobral, Abílio J. Chemistry Department, Faculty of Sciences and Technology of the University of Coimbra, Coimbra, Portugal [email protected]

Socorro, Sílvia M. Universidade da Beira Interior, Covilhã, Portugal [email protected]

Sousa, Vítor M. Faculty of Medicine of the University of Coimbra, Coimbra, Portugal [email protected]

Urbano, Ana M. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal [email protected]

REPUBLIC OF KOREA

Kim, Ji-hyun Department of Life and Nanopharmaceutical Science, Kyung-hee University, Seoul, Republic of Korea [email protected]

Yang, Yeong-in Department of Life and Nanopharmaceutical Science, Kyung-hee University, Seoul, Republic of Korea [email protected]

RUSSIA

Gulyaeva, Lyudmila M. Laboratory of Molecular Carcinogenesis, Institute of Molecular Biology and Biophysics, Russian Academy of Medical Sciences, Siberian Division, Novosibirsk, Russia; Medical Department, Novosibirsk State University, Novosibirsk, Russia [email protected]

Kovalenko, Sergei Laboratory of Gene Engineering, Institute of Molecular Biology and Biophysics, Academy of Medical Sciences, Siberian Branch, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia [email protected]

SPAIN

Cuezva, José M. Centro de Biología Molecular Severo Ochoa, CIBER de Enfermedades Raras, ISCIII Universidad Autónoma de Madrid, Madrid, Spain [email protected]

UNITED KINGDOM

Brindle, Kevin M. Department of Biochemistry, University of Cambridge, UK; Cancer Research UK Cambridge Research Institute, Cambridge, UK [email protected]

Caldas, Carlos Department of Oncology, University of Cambridge, Cambridge, UK; Cambridge Experimental Cancer Medicine Centre, Cambridge, UK; Cancer Research UK Cambridge Research Institute; Cambridge Breast Cancer Research Unit; NIHR Cambridge Biomedical Research Centre, Cambridge, UK [email protected]

Costa-Pereira, Ana Division of Cancer, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK; Hammersmith Hospital, London, UK [email protected]

Sapienza, Karen Institute of Cancer, Department of Tumour Biology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK [email protected]

THE NETHERLANDS

Pedrosa, Lília R. Erasmus MC, Rotterdam, The Netherlands [email protected]

UNITED STATES OF AMERICA

Chakrabarty, Ananda M. Department of Microbiology & Immunology, University of Illinois College of Medicine, Chicago, IL, USA [email protected]

Harris, Curtis C. Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD, USA curtis@[email protected]

Huberman, Eliezer NovaDrug, Chicago, IL, USA and School of Pharmacy University of Illinois in Chicago, IL, USA [email protected]

Jurka, Elzbieta Peninsula Pathologists Medical Group, San Francisco, USA [email protected]

Kalluri, Raghu Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA [email protected]

Landolph, Joseph Cancer Research Laboratory, USC Cancer Center, Departments of Molecular Microbiology/Immunology and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA [email protected]

Langenbach, Robert Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA [email protected]

Li, Wei Department of Dermatology and the USC-Norris Comprehensive Cancer Center, the University of Southern California Keck School of Medicine, Los Angeles, CA, USA [email protected]

Samaniego, Felipe UT M.D. Anderson Cancer Center, Houston, USA [email protected]

Simões, Rui V. Memorial Sloan-Kattering Cancer Center, New York, USA [email protected]

Zhitkovich, Anatoly Department of Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, RI, USA [email protected]


BMCProceedings

Abstracts of the 16th International Charles Heidelberger

Symposium on Cancer Research


Committees

The Organization of the 16th International Charles Heidelberger Symposium on Cancer Research acknowledges the support of:• FCTUC (Faculdade de Ciências e Tecnologia da Universidade de Coimbra)• CIUC (Centro de Informática da Universidade de Coimbra)• DIIC-UC (Divisão de Identidade, Imagem e Comunicação da Universidade de Coimbra)• Turismo de Coimbra• Turismo Centro de Portugal• Bentham Science Publishers


Eli Huberman (USA)Johan Lillehaug (Norway)Joseph Landolph (USA)Karl Heinrich Link (Germany)Robert Langenbach (USA)Toshio Kuroki (Japan)


Eli Huberman (USA)Johan Lillehaug (Norway)Joseph Landolph (USA)Karl Heinrich Link (Germany)

Secretariat

Ana Paula Parreira

Symposium Chairs

Carlos Freire de Oliveira (Portugal) Joseph Landolph (USA)Eli Huberman (USA) Maria Carmen Alpoim (Portugal)

Local Organizing Committee

Ana Castro Jardim (FMUC) Joana Felício Cerveira (FCTUC)Ana Daniela Sampaio (FCTUC) Leonardo Manuel Ferreira (FCTUC)Ana Margarida Urbano (FCTUC) Luís Miguel Pires (FMUC)António Jorge Guiomar (FCTUC) Maria Carmen Alpoim (FCTUC)Armando Cristovão (FCTUC) Maria Filomena Botelho (FMUC)Carlos Freire de Oliveira (FMUC) Marta Pinto Coelho (FMUC)Isabel Maria Abrantes (FCTUC) Paula Vasconcelos Morais (FCTUC)Isabel Marques Carreira (FMUC)


Ana Margarida Urbano (FCTUC) Maria Carmen Alpoim (FCTUC)Carlos Freire de Oliveira (FMUC) Maria Filomena Botelho (FMUC)Isabel Marques Carreira (FMUC) Paula Vasconcelos Morais (FCTUC)

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Lalit Dandona (India)

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Toshiaki A Furukawa (Japan)

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Contents

Opening Lecture

O1 Inflammation, senescence and cancer: interweaving microRNA, inflammatory cytokines and p53 networksCurtis C. Harris

Session 1 - Cancer Etiology and Epidemiology

O2 Gene-environment in the induction of cancerHerman Autrup

O3 Gene variants and lung cancer riskNina E Landvik, Shanbeh Zienolddiny, Vidar Skaug, Aage Haugen

O4 Polychlorinated biphenyls (PCB), UV radiation, and cutaneous malignant melanomaRichard P Gallagher, Tim K Lee, Jean-Philippe Weber, Alain Leblanc, Marilyn Borugian, J Mark Elwood, Amy C MacArthur, Zenaida Abanto, John J Spinelli


P2 Association between night shift work, melatonin and estradiol in nursesBeata Peplonska, Agnieszka Bukowska, Jolanta Gromadzinska, Wojciech Sobala, Edyta Reszka, Jenny A S Lie

P3 Mastermind-like 1 (MAML-1) as a new metastatic marker in esophageal squamous cell carcinomaMohammad M Forghanifard, Moein Farshchian, Reza Raeisossadati, Mohammad N Forghani, Meysam Moghbeli, Hussein Naseh, Mohammad R Abbaszadegan

P4 Polymorphisms of GSTM1, GSTT1, GSTP1 and CYP1A1 genes and susceptibility to lung cancerPaula Mota, Michelle Horta, Luis Mesquita, Henriqueta Silva

P5 Obesity and breast cancer: inflammatory and adipocytokine correlations

Paulo C Matafome, Ana L Gomes, Manuel Gomes, Lélita C Santos, Ana B Sarmento, Raquel F Seiça

P6 Polymorphisms of estrogen receptors, ERα and GPR30: association with breast cancer susceptibility and prognosisSusana M Alves, Luís Mesquita, Rita Sousa, Fátima Peralta, Henriqueta C Silva

P7 Breast cancer and environmental factorsJ Vicente Paulo, Lélita Santos, Graça Fernandes

P8 Primary bone lymphomaC Pissarro C Azevedo, P José A F F Tavares, M Isabel P Portela, A José L C P Santos, J Manuel P S Casanova

Session 2 - Molecular Carcinogenesis

O5 Regulation of DNA damage responses by mismatch repairAnatoly Zhitkovich

O6 Insoluble Ni compound-induced gene amplification/gene silencing causes over-expression of microtubules/microfilaments, cell shape changes, and de-regulation of global gene expression/Ca+2 gradients, inducing morphological/ neoplastic transformation of 10T1/2 mouse embryo cellsJoseph Landolph, Aruni DeSilva, Duy Mai, Jim K. Lin, Jimmy Zheng


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O7 The bioenergetic signature of cancerJosé M. Cuezva

O8 Roles of beta-arrestin1/2 in prostaglandin-mediated signaling and tumor developmentRobert Langenbach, Huei-Chen Lao, Kyung-Soo Chun

O9 PINK1/BRPK inhibits apoptotic cell death and enahances cellular invasiveness through an activation of mTORC2 pathwayHitoshi Murata, Masakiyo Sakaguchi, Ken Kataoka, Nam-ho Huh

O10 Receptor for activated C-kinase (RACK1) plays a central role in Ras-mediated signal transductionJohan R Lillehaug, Line M Myklebust, Arnt Raae, Bodil Bjørndal

P9 The role of CD26 and CD40 expression in therapeutic response - experimental study in oral cancer linesJoana P N Batista, Sílvia S Neves, A Cristina Gonçalves, Vera Alves, Ana Sarmento-Ribeiro, Marília Dourado


P11 Evaluation of the role of miR-34b in modulation of radioresistance in non-small cell lung cancerJoana B Silva, Sílvia S Neves, A Cristina Gonçalves, Margarida Marques, Luís Mesquita, Filomena Botelho, A Bela Sarmento-Ribeiro, Henriqueta C Silva

P12 P-cadherin expression in feline mammary tissuesA Catarina Figueira, Júlio Carvalheira, M Manuela Lacerda, M Fátima Gärtner

P13 Regucalcin, a calcium-binding protein, is a new target gene in human prostate cancer?Cláudio J Maia, Cátia V Vaz, Carina G Peres, Cecília R A Santos, Sílvia Socorro

P14 MicroRNA-21 in lung cancer: overexpression in metastasis of pulmonary adenocarcinomas and squamous cell carcinomasMaria R Silva, Paulo Santos, Isabel Velada, Catarina Gomes, M João d’Aguiar, Lia Teixeira, João Dinis, Susana Carmona, Luisa Cortes, Lina Carvalho

P15 Involvement of mitochondrial and survival signaling in berberine-induced apoptosis in melanoma cellsAna Burgeiro, Consuelo Gajate, El H Dakir, Paulo J Oliveira, Faustino Mollinedo

P16 Metabolic changes in human bronchial epithelial cells upon chronic exposure to hexavalent chromiumLeonardo M R Ferreira, Maria S Santos, M Carmen Alpoim, Ana M Urbano

P17 Cr(VI)-induced malignant transformation of a bronchial epithelial cell line association with altered mitochondria and bioenergetic phenotypesAna Sampaio, Luís Mendes, Ana C Gonçalves, Margarida Abrantes, Ana B Sarmento, Filomena Botelho, Paulo Oliveira, Vilma Sardão, Rui Carvalho, Ana M Urbano and M Carmen Alpoim

Session 3 - Tumor Microenvironment and Tumor Cell Biology

O11 Tumor Microenvironment Controls the Rate of Cancer Progression and MetastasisRaghu Kalluri

O12 Metabolism and metastasis: in the bone marrow and beyondSérgio Dias

O13 The Immune Biology of Microsatellite Unstable CancerMagnus von Knebel-Doeberitz

O14 Targeting secreted heat shock protein-90alpha (Hsp90α) to prevent breast cancer progressionZhengwei Zhao, Chieh-Fang Cheng, Rosie Kim, Mei Chen, David T Woodley, Wei Li


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O15 JAKs and STATs in ChemoresistanceAna Costa-Pereira

O16 Autophagy turns specific: the discovery of p62 and NBR1 as autophagy cargo receptorsGeir Bjørkøy



P20 Relation between autophagy and the resistence of glioblastoma cells to temozolomideAnália Carmo, Helena Carvalheiro, Maria C Lopes

P21 GLUT expression and 18F-FDG uptake in breast cancer cell linesAna M Abrantes, Mónica Martins, Ana C Gonçalves, Maria C Rodrigues, Ana C Mamede, Sónia D Tavares, José M Lima, Adriano Rodrigues, Ana B Sarmento-Ribeiro, Maria F Botelho

P22 MDR modulation in colorectal adenocarcinoma cell lines: kinetic studies using 99mTc-sestamibiJoão Casalta-Lopes, A Margarida Abrantes, Joana Rio, Mafalda Laranjo, Bárbara Oliveiros, A Cristina Gonçalves, Ana B. Sarmento-Ribeiro, M. Filomena Botelho

P23 Phenotypic analysis of breast cell lines – triple negative cells vs expressing hormonal receptorsMafalda Laranjo, Maria J Carvalho, Artur Paiva, A Margarida Abrantes, Isabel Torgal, Carlos F Oliveira, M Filomena Botelho


P25 A nonconjugated naphthalene derivative of meso-tetra-(3-hydroxy)-phenyl-porphyrin as a sensitizer for photodynamic therapyAbílio J F N Sobral, Ana M Urbano, Pedro Silva, Sofia M Fonseca, Cláudia T Arranja, Hugh D Burrows

P26 Polyaromatic hydrocarbons accentuate malignant phenotype of the PC3 prostate cancer cell lineMariana O Freitas, José Oliveira, Ana M Fernandes, Maria I Coutinho, Vera Alves, Anabela Mota-Pinto, Ana B Sarmento-Ribeiro

P27 MGBG–cisplatin combination chemotherapy against breast cancerRaquel F Gonsalves, Maria P M Marques

P28 Melanoma skin cancer: could chromone derivatives be efficient chemopreventors?Mafalda M Dias, Maria P M Marques

P29 Exosomes from human ovarian carcinoma SKOV3 cells are enriched in glycosylated proteins Cristina Escrevente, Peter Altevogt, Júlia Costa

P30 Delocalized lipophilic cations as a new therapeutic approach in cancerA Barbosa Ribeiro, A Luísa Ferreira, A Cristina Gonçalves, Sílvia Neves, A Maria Araújo, Filipa Carvalho, João Carvalho, Rui M Santos, Vera Alves, Teresa Silva, José M Nascimento-Costa, Ana B Sarmento-Ribeiro

P31 Cytotoxic effect induced by combination of polyamines metabolites and endocannabinoid, anandamide, on human cancer cells: a new anticancer strategy A Lúcia M Batista-de-Carvalho, G Tempera, N Viceconte, S Saccoccio, E Bidollari, M Nalli, Enrico Morera, Giorgio Ortar, Enzo Agostinelli

P32 An in vitro tumor-fibroblast interaction model of human oral squamous cell carcinomaJozséf Dudás, M Bitsche, V Schartinger, G M Sprinzl, H Riechelmann

P33 Physiologic parameters variation in ICR mice during a chemical induced liver carcinogenesis experimentIvo Conceição-Pereira, Nuno M Paula-Santos, Filipa O Pereira, Maria J Pires, Luis F Palomino, Aura A Colaço, Paula A Oliveira

P34 Role of VEGF signalling in the regulation of KDR expression in endothelial and tumoral microenvironmentJacinta Serpa, Cheila Torre, Francisco Caiado, Sérgio Dias


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P35 EP4-mediated prostanoid signalling promotes oral cancer progressionKaren Sapienza, Stewart Sale, Angela Hague, Ian.R. Hart, J.ohn F. Marshall, Gareth.J. Thomas

P36 Role of notch pathway and HNF1 in cell death induced by HDACs inhibitors in ovarian cancer cell lines, serous and clear cellsFernanda Silva, Jacinta Serpa, Germana Domingues, Gabriela Silva, António Almeida, Ana Félix

P37 TRAP1 and SORCIN cooperate in a survival pathway responsible for inducing drug-resistance in human colorectal carcinoma (CRC)Matteo Landriscina, Francesca Maddalena, Gabriella Laudiero, Maria R Amoroso, Annamaria Piscazzi, Valentina Lombardi, Alberto Fersini, Franca Esposito

P38 Dll4 blockade interferes with the bone marrow vascular niche and perturbs hematopoietic recovery following myeloablationLeonor Remédio, Tânia Carvalho, Sérgio Dias

P39 Short-chain sphingolipids for enhanced cellular uptake of liposome-encapsulated amphiphilic anti-cancer drugsLília R C Pedrosa, Albert van Hell, Wim van Blitterswijk, Ann L B Seynhaeve, Alexander M M Eggermont, Timo L M ten Hagen, Marcel Verheij, Gerben A Koning

P40 Osteosarcoma contains a subpopulation of cancer stem-like cells that are highly resistant to radiotherapySara R M Neves, Aurio O G Lopes, Anália do Carmo, Antero J Abrunhosa, Paulo C P S Simões, Artur A Paiva, M Filomena Botelho, Célia M F Gomes

P41 Indentification of cancer stem-like cells in osteosarcoma and their implications in response to chemotherapyÁurio O Lopes, Sara R Neves, Anália do Carmo, Artur A Paiva, Maria Botelho, Célia M Gomes

P42 Metabolic responses of A549 lung cells to cisplatin and radiation exposure studied by 1H NMR spectroscopyAna F Ladeirinha, Inês D Lamego, Ana M Gil, Joana B Melo, Isabel M Carreira, Iola F Duarte

P43 In vivo pulmonary metastatic profile of breast cancer cell lines expressing hormonal receptors versus triple negativeM João Carvalho, A Margarida Abrantes, Mafalda Laranjo, Francisco Falcão, Sofia Cabrita, M Filomena Botelho, Carlos F de Oliveira, Isabel Torgal

P44 New targeted therapies in myelodysplastic syndrome: the role of farnesyltransferase and proteasome inhibitorsA Cristina Gonçalves, Ana Oliveira, Diana Moreira, Silvia Neves, Vera Alves, Teresa Silva, Luís Mesquita, Henriqueta Coimbra, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro

P45 Targeted gene silencing for cancer treatmentLígia C G da Silva, José S Ramalho, M Conceição P de Lima, Sérgio Simões, João N Moreira

P46 Recombinant trail: a synergistic effect in myeloid leukemiasFilipa Carvalho, A Sofia Coelho, Cátia Domingues, João A Carvalho, André Ribeiro, Rui M Santos, A Cristina Gonçalves , Vera Alves, Teresa Silva, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro

P47 Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?Ana S Ribeiro, Laura C Carreto, André Albergaria, Bárbara Sousa, Sara Ricardo, Fernanda Milanezi, Raquel Seruca, Manuel A Santos, Fernando Schmitt, J oanaParedes

P48 Contribution of Thomsen-Friedenreich antigens to bladder cancer malignancy: Characterization of cell line modelsPaulo F Severino, Mylène A Carrascal, Helena Gouveia, M Guadalupe Cabral, Manuela Correia, Nadia Malagolini, Mariella Chiricolo, Fabio Dall’Olio, Paula AVideira

P49 Antitumoral effect of farnesiltransferase and mtor inhibitors in hepatocellular carcinoma: in vitro studiesAna M Araújo, Sílvia S Neves, Ana L Ferreira, Diogo Branco, Ana B Sarmento-Ribeiro, José M Nascimento-Costa


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P50 Metalloproteinase inhibitors as a potential therapeutic approach in multiple myeloma: a preliminary studyA Sofia Pais, A Cristina Gonçalves, Catarina Geraldes, José M Nascimento-Costa, Ana B Sarmento-Ribeiro

P51 Novel antitumor DNA monoalkylating agents: Synthesis and biological evaluationAna F Brito, M Isabel Soares, Mafalda Laranjo, A Margarida Abrantes, José A Paixão, Ana M Beja, Manuela R Silva, Teresa P Melo, M Filomena Botelho

P52 The effect of cisplatin in 5637 bladder cancer cell lineRosário Pinto-Leite, Regina Arantes-Rodrigues, M Luís Cardoso, Lúcio Santos, Paula A Oliveira

Session 4 - Cancer Genetics and Epigenetics

O17 CDH3/P-cadherin overexpression in breast carcinomas: its regulatory mechanisms, the role in cell invasion, and the association with cancer stem cell propertiesJoana Paredes

O18 Spontaneous development of lung adenocarcinoma in the CADM1 gene-deficient miceMasayoshi Nagata, Mika Sakurai-Yageta, Daisuke Yamada, Taketo Kawai, Yumi Tsuboi, Takeshi Ito, Akihiko Ito, Midori Yoshida, Yoshinori Murakami

O19 The FRAGILOME project, a strategy for the discovery of new gene biomarkers in cancerManfred Schwab

O20 Gene amplification in breast cancer – looking for the molecular mechanismsSergei Kovalenko

O21 Molecular Genetic Study of Female Cancers in Novosibirsk, RussiaLyudmila F Gulyaeva

O22 E-cadherin mediated cellular effects and molecular partners. Gastric cancer as an invasive modelJoana Figueiredo, Joana Simões-Correia, Joana Fernandes, Ana R Mateus, Gianpaolo Suriano, Joana Paredes, Carla Oliveira, Raquel Seruca

P53 Identification of copy number variations of chromosomes 7, 9 and 10 in human glioblastomas by SNP-arraysInês Crespo, Maria D Tabernero, Ana B Nieto, Olinda Rebelo, Hermínio Tão, Fernando Gomes, Catarina R Oliveira, Maria C Lopes, Alberto Orfao

P54 Circadian gene variants and MT6s level in nurses under different work shifts – preliminary resultsEdyta Reszka, Beata Peplonska, Edyta Wieczorek, Jolanta Gromadzinska, Wojciech Sobala, Wojciech Wasowicz, Agnieszka Bukowska, Jenny A Lie

P55 MFSD2A is a novel lung tumour suppressor gene whose expression is modulated by a 5’-region polymorphismFrancesca Colombo, Monica Spinola, Felicia S Falvella, James P Sullivan, David S Shames, Luc Girard, Paola Spessotto, John D Minna, Tommaso A Dragani

P56 FGFR4 GLY388ARG polymorphism modulates cancer patients’ survival in pooled analysisElisa Frullanti, Tommaso A Dragani

P57 KRAS and EGFR mutations coexisting in lung adenocarcinomaVitor Sousa, Ana Alarcão, Patricia Couceiro, Maria R Silva, Maria J d’Aguiar, Lia Teixeira, Lina Carvalho

P58 Modulation of DNA damage prevention and signaling pathways in diet induced colon cancer preventionDalila F N Pedro, Alice A Ramos, Cristóvão F Lima, Fátima Baltazar, Cristina Pereira-Wilson


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P59 MIR-143 over-expression reduces the growth of xenograft tumors from colon carcinoma cellsPedro M Borralho, Sofia Gomes, Raquel T Lima, Rui E Castro, Maria H Vasconcelos, Cecília M P Rodrigues

P60 Histone deacetylation - a new epigenetic target in cancer João A Carvalho, Emília Cortesão, José D Branco, Ana C Gonçalves, Sílvia Neves, Filipa Carvalho, André Ribeiro, Vera Alves, Teresa Silva, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro

P61 EGFR unusual mutation status in lung adenocarcinomasAna Alarcão, Vitor Sousa, Patrícia Couceiro, Maria Silva, Maria J. d’Aguiar, Lia Teixeira, Lina Carvalho

P62 Identification of a common deletion region in 10q26 associated with human gliomasMargarida Alves, Paulo Liberato, Ana Rita Conde, Manuela Mafra, Alexandra Inverno, Ana Teresa Maia, Denise Bagrel, Isabel Carreira, Miguel Brito, Carolino Monteiro

P63 STEAP1 expression in prostate cancer and its regulation by androgensInês Gomes, Cecília R A Santos, Sílvia Socorro, Carlos Lopes, Cláudio J Maia

P64 EGFR/erb-1, HER2/erb-2, CK7, LP34, Ki67 and p53 expression in preneoplastic lesions of bronchial epitheliumLina Carvalho, Joana E Santo, Ana Alarcão, Patricia Couceiro, Maria R Silva, Ana Gomes, Maria J d’Aguiar, Lia Teixeira, Vitor Sousa

Session 5 - Translational Cancer Medicine

O23 Quality control in colon and rectal cancer surgeryKarl-Heinrich Link

O24 Detecting tumor responses to treatment using hyperpolarized 13C magnetic resonance spectroscopic imagingKevin M Brindle

O25 Tumor-tailored treatment of colorectal cancer: from bench to bedside?Marko Kornmann

O26 Targeting non-viral vectors to tumor cells and the tumor microenvironmentVera Moura, Manuela Lacerda, Paulo Figueiredo, M Luísa Corvo, M Eugénia M Cruz, M Conceição P. de Lima, Sérgio Simões, João N Moreira

O27 Adjuvant therapy in colorectal cancer – studies of the FOGT groupLudger Staib, Marko Kornmann, Karl-Heinrich Link

O28 “Omic” landscapes of breast cancer - the end of the beginningCarlos Caldas

O29 Bacterial anticancer weapons: a promising tool to fight cancerAnanda M Chakrabarty

P65 Improving the classification of brain tumors in mice with perturbation enhanced (PE)-MRSIRui V Simões, Sandra Ortega-Martorell, Teresa Delgado-Goñi, Yann le Fur, Marti Pumarola, Ana P Candiota, Patrick J Cozzone, Margarida Juliá-Sapè, Carles Arús

P66 NMR metabonomic study of lung cancer: metabolic profiling of tissuesCláudia M Rocha, António S Barros, Ana M Gil, Brian J Goodfellow, Isabel M Carreira, João Bernardo, Ana Gomes, Vítor Sousa, Lina Carvalho, Iola F Duarte

P67 NMR metabonomic study of lung cancer: metabolic profiling of urine and blood plasmaJoana Carrola, Cláudia M Rocha, António S Barros, Ana M Gil, Brian J Goodfellow, Isabel M Carreira, João Bernardo, Ana Gomes, Vitor Sousa, Lina Carvalho, Iola F Duarte

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