vitamin deficiency symptoms. vitamin a deficiency xeropthalmia in rat - dryness of the cornea early...

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Vitamin Deficiency Symptoms

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Page 1: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vitamin Deficiency Symptoms

Page 2: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vitamin A deficiency• Xeropthalmia in rat - dryness of the cornea• Early stages are curable

Page 3: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Cured with 6 days treatment with Vitamin A

Page 4: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Late Stages are incurable - Vitamin A deficiency

• Clouding of cornea, ulceration, keratomalacia

Page 5: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vitamin A deficiency Night Blindness

Imagine you are in the car at the left and this is what you see.

Page 6: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Car approaches, note sign on the right.

Page 7: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Car passes. Notice distance down the road, signs.

Normal vision

Page 8: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Car passes. Notice distance down the road, signs.Car passes. Notice distance down the road, signs.

Night BlindnessEye fails to adapt quickly to decreased light.

Page 9: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Follicular hyperkeratosis. Goose flesh. Pustulation occurs and is confused with acne.

Vitamin A deficiency. Human shoulder.

Page 10: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Histological section of skin. Hair follicle with hyperkeratosis. (Excess keratinized tissue).

Page 11: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Pellegra. Niacin deficiency. Dermatitis, diarrhea, dementia.

Page 12: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Same patient after niacin treatment.

Page 13: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Riboflavin deficiency. Generalized dermititis & growth failure. Marked keratitis of cornea.

Page 14: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

1 month of riboflavin treatment. Only slight traces of deficiency symptoms remain.

Page 15: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

2 months of riboflavin treatment. No signs remain.

Page 16: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Thiamin deficiency - Polyneuritis. Arched back & hyperextended legs, spastic gait, loss of balance.

Page 17: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Same rat as previous after 8 hrs treatment with Thiamin HCL.

Page 18: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Pantothenic acid deficiency in chick

Page 19: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Same chick as previous after 3 weeks treatment.

Page 20: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Biotin deficiency - egg white injury from avidin

Page 21: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

3 weeks therapy with biotin. Hair takes time to grow but it’s recovering.

Page 22: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

3 months therapy with biotin. Recovered. (fat rat)

Page 23: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Folic acid deficiency - stunted, poorly feathered, severely anemic.

Page 24: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Folic acid adequate chick of same age as last.(hard to believe, isn’t it)

Page 25: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Normal and rachitic bone. Vitamin D deficiency.

Page 26: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Advanced rickets

Page 27: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Normal rat seminiferous tubules of testis showing spermatatids. Vitamin E sufficient.

Page 28: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Intermediate stage of degeneration from Vit E deficiency. Sperm production has ceased. Still reversible.

Page 29: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Advanced degeneration. Tubules shrunken. Irreversible. Sterile.

Page 30: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Normal rat fetuses at 16 days of pregnancy.

Page 31: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vit E deficient rat at 16th day. Autolyzed fetuses & placenta.

Page 32: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Muscular dystrophy from Vit E deficiency. Guinea pig muscle fiber fragmentation, degeneration & necrosis. Lots of infiltrating neutraphils, etc.

Page 33: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Normal muscle should look more like this.

Page 34: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vit K deficiency. Spontaneous hemorrhages.

Page 35: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Normal Vit K sufficient bird for comparison.

Page 36: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vit K deficiency in man. Hemorrhagic disease of newborn. Reason for Vit K injection at birth.

It’s a brain of a baby.

Page 37: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vit A: Trachea, Keratinizing metaplasia. The flat layer of cells at the surface shouldn’t be there.

Page 38: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vit A: Kidney. Keratinized cells without nuclei shouldn’t be there. Metaplasia occuring.

Page 39: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vit A: Lung. Metaplasia & keritinization.

Page 40: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vit A: Uterus. Keratinizing of stratified squamous epithelium.

Page 41: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Farm Animals

The following slides, though not of the highest quality, illustrate some of the vitamin deficiencies in livestock.

Page 42: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vit A: 6 mo old calves. Calf in rear got 20 ml cod liver oil. Deficient calf in front was blind.

Page 43: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vit A: Emaciation, night blindness, scours.

Page 44: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vit A: Advanced xerophthalmia , clouded cornea.

Page 45: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vit A deficiency in diet of dam caused calf to be born blind & weak.

Page 46: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Section of damaged optic nerve showing constriction.

Page 47: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Blind steer walking into a fence. Vitamin A deficiency

Page 48: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Edema (anasarca) of the brisket. Vit A deficiency.

Page 49: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Advanced anasarca in hindquarters of steer. Vit A.

Page 50: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vit A deficiency in pig on the right

Xeropthalmia (on rt.)

Paralysis of hind limbs.

Page 51: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Lamb with stiff lambdisease from Vitamin Edeficiency.

Muscle showing white streaks where degeneration occurs.

Page 52: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Vitamin E deficiency: Mulberry Heart disease.Note massive white streaks of degeneration.

Page 53: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Pantothenic acid deficiency.Typical Goose Stepping - incoordination.

Page 54: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Thiamine deficiency - Polyneuritis

Page 55: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Thiamine: Polyneuritis. Baby lamb is functionalnonruminant. Head retraction, incoordination.

Page 56: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Riboflavin

Top pig is markedlysmaller, poor doing,poor hair coat andskin.

Page 57: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Riboflavin deficiency

Poor reproductive performance; stillborn pigs.

Page 58: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Niacin deficiency

Note difference in growth and condition.

Page 59: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Intestine: Compare this with the next slide showing Niacin deficiency.

Page 60: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Intestine: Niacin deficiency results in necrotic enteritis, ulceration. (Therefore extremely poor

absorption; scouring).

Page 61: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

B6 (Pyridoxine) deficiency Pig showing an epilectic-like seizure

Page 62: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

B6 (Pyridoxine) deficiency Pigs showing marked difference in growth

Page 63: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Biotin deficiency Skin lesions

Page 64: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

Biotin deficiencyEpithelial lesions on foot of chickens

Page 65: Vitamin Deficiency Symptoms. Vitamin A deficiency Xeropthalmia in rat - dryness of the cornea Early stages are curable

B12 deficiency

Note difference in growth and condition. Pig at top has not grown as well and hasrougher skin and hair coat.