venture summit west february 12 th , 2014 silicon valley

31
Venture Summit West February 12 th , 2014 Silicon Valley

Upload: elom

Post on 25-Feb-2016

45 views

Category:

Documents


0 download

DESCRIPTION

Venture Summit West February 12 th , 2014 Silicon Valley. Computer Graphics Generated Image NOT ACTUAL – Based on Codman Device . Super brief history. - PowerPoint PPT Presentation

TRANSCRIPT

Cal-X stars Business Accelerator 2013 Portfolio

Venture Summit WestFebruary 12th, 2014Silicon Valley

Computer Graphics Generated Image NOT ACTUAL Based on Codman Device

Super brief historyLeonhardt Ventures founded in 1982. Has since raised $145 million that has been invested in the development of over 28 innovations and companies. 21 direct Leonhardt patents and over 70 acquired or licensed patents or technologies.1982-1985 Built dozens of cardiac cath labs & ICUs around the world.1986-1994 Developed world leadership in polyurethane balloon cardiovascular catheters.1995-1998 Developed world leadership in stent grafts and percutaneous heart valves.1999 2008 Developed world clinical leadership in stem cell repair of damaged heart muscle. 2009 Launched Leonhardts Launchpads Life Science Incubator. 2008 to 2012 Developed world leadership in the development of electrical stimulation for stem cell therapies.2012 Launched Cal-X Stars Innovation & Business Accelerator.

Super brief historyMajor Exits Leonhardt Ventures and Core Manufacturing Team Pacesetter Systems $1 billion > Siemans/St. JudeAVE $4.3 billion > Medtronic (via WorldMed merger)Minimed $4.3 billion > MedtronicAdvanced Bionics $800 million > MedtronicWorld Medical Mfg. Corp. $70 million > AVEBioheart $60 million > IPO 2008 (stock price down since)Note We in no way attempt to claim full credit.

Market = 50 million+ people in heart failure. $40 billion +Magnitude Problem = 25 million about to die in next 5 years with current therapies.Current Pain = No other therapy regenerates scar tissue back to muscle.`

OUR SOLUTION =Implantable programmable Stem Cell & Growth Factor Pump.+MyoStim Electrical Stimulator.=3. HEART SCAR TISSUE CONVERTED TO BEATING PUMPING MUSCLE

Cost to Produce = $3000Sell price = $29,000Gross Profit = $26,000 per unitReimbursement = $58,000 for procedure = to CRT Pacer, less than LVADsTotal Annual Sales = $9 billion

Proven Team The Leonhardt and Core Manufacturing teams have had more than $15 billion in exits in this space already.Track Record = Pacemakers, Insulin Pump, Cardio Catheters, Stent Graft, Intravascular Lung Catheter, Pain Pump, Percuntaneous Heart Valve, Heart Pumps, Stem Cell Therapies, Stem Cell Recruiting Heart Pacer, Biological Pacers, Wireless sensors.

Myoblast Engraftment Post-Transplantation

Contractile muscle tissue growing in the scarred portion of the heart following treatment with myoblast injections.Human Heart, Proof of Concept* Hagege et al., Viability and Differentiation of Autologous Skeletal Myoblast Grafts in Ischemic Cardiomyopathy, Lancet, Vol. 361, 2003: 491-492

Bioheart MyoCell: Heart Failure Treatment Process

Scar tissue following heart attackInjection of skeletal myoblasts into scar tissue using deflecting-tip catheter

Cell manufacturing following thigh muscle biopsy132

p=0.50MARVEL Phase II/III Randomized, Double Blinded, Placebo Controlled American Heart Journal November 2011Mean Change in 6-Minute Walk Distance (meters)

n=6n=7n=6

Bio-LEONHARDT TEAMED WITH CORE MANUFACTURING

Leonhardt Vineyards established january 2000

Bio-Leonhardt Method Pre-Treat Scar1. Micro-RNAs (helps converts scar to muscle).2. Nutrient hydrogel3. Electrical stimulation via MyoStim Pacers of San Diego, California (produced at Core Manufacturing in Los Angeles).4. Growth factor infusion ie; VEGF, SDF-1, HGF5. Granulocyte colony stimulating factor.6. Endothelial progenitor cells derived from adipose tissue.Treat Scar1. TANAKA cardiac progenitor cells derived from skeletal muscle as developed in Japan 2. Cardiac stem cells delivered at rim edge of scar. 3. SDF-1 via Ono Pharmaceuticals in Japan. 4. Nutrient hydrogel 5. Electrical stimulation from MyoStim Pacers San Diego. 6. Injection of iPS cells with MicroRNAs. 7. Cardiobridge or Procyrion implantable pump to allow heart to rest during healing process.Post Treat Scar1. Repeat injections of all of the above.2. Continued electrical stimulation.3. Continued delivery of nutrient hydrogel and growth factors.

(1) The Kanno program stimulates angiogenesis (new blood vessel growth). (2) The Chachques-Leonhardt program recruits stem cells to injured heart tissue areas and proliferates them (includes resident cardiomyocytes).(3) The Leonhardt-Chachques program differentiates recruited and/or injected stem cells to beating heart muscle. (4) The Leonhardt program senses arrhythmia's-fibrillation and delivers a low voltage pulse to restart a patient's heart back to a normal beat. (5) The final program is a standard synchronization-pacing program.

Stimulation of AngiogenesisCapillary density in rat TA muscles. Number of capillaries was counted in at least 8 different fields, and capillary density was obtained by calculation of capillary/muscle fiber area.

The restroation of blood flow was associatd with new blood vessels, which were quantified in figure25

Investment OpportunityValuation = $5 millionRaising Seed Round = $1 million New investors = 20% OwnershipAmount Invested to Date = *$450,000Current Investors = Leonhardt Ventures, Airspeed Equity, Core Manufacturing LLC

Leonhardt Ventures Worlds first stem cell recruiting bra

Leohardt Ventures founded the first conscious capitalism Stock Exchange

Chart1-3.6695.5785.544.1147.5192.71

ControlLow DoseHigh Dose

Sheet1ControlLow DoseHigh DoseChange in 6 MWT-3.6695.5785.5To resize chart data range, drag lower right corner of range.