vasculitis vasculitis dr. gehan mohamed dr. abdelaty shawky
out of 30
Post on 24-Dec-2015
Embed Size (px)
- Slide 1
- Vasculitis Vasculitis Dr. Gehan Mohamed Dr. Abdelaty Shawky
- Slide 2
- * Definition: Inflammation of the blood vessels Clinically often include constitutional signs and symptoms such as fever, myalgia, arthralgia, and malaise, or local manifestations of tissue ischemia.
- Slide 3
- * Causes of vasculitis: 1. infection: pathogens either cause direct invasion of vascular walls or indirectly induce a noninfectious, systemic immune-mediated vasculitis, for example, by generating immune complexes or triggering cross-reactivity. 2. Physical and chemical injury: such as irradiation, mechanical trauma, and toxins can also cause vascular damage.
- Slide 4
- 3. immune-mediated vasculitis: the vascular wall is damaged by different immune mechanisms; a.Immune complex deposition: a.Immune complex deposition: as in hypersensitivity to drugs, hepatitis B virus infection b.Anti-neutrophil cytoplasmic antibodies (ANCAs): b.Anti-neutrophil cytoplasmic antibodies (ANCAs): ANCAs are a heterogeneous group of autoantibodies directed against enzymes mainly found within the primary granules in neutrophils, in the lysosomes of monocytes, and in endothelial cells.
- Slide 5
- - The description of these autoantibodies is based on the immunofluorescent patterns of staining. - Two main patterns are recognized: one shows cytoplasmic localization of the staining (c-ANCA), and the most common target antigen is proteinase-3 (PR3), a neutrophil granule constituent. The second shows perinuclear staining (p-ANCA) and is usually specific for myeloperoxidase (MPO). - The disorders characterized by circulating ANCAs are called the ANCA-associated vasculitis.
- Slide 6
- c. Anti-endothelial cell antibodies: Antibodies to ECs, perhaps induced by defects in immune regulation, may predispose to certain vasculitis, such as those associated with SLE and Kawasaki disease.
- Slide 7
- * Classification of vasculitis: The systemic vasculitis are classified on the basis of : - the size and anatomic site of the involved blood vessels - histologic characteristics of the lesion, and - clinical manifestations. There is considerable clinical and pathologic overlap among these disorders
- Slide 8
- Slide 9
- 1. GIANT CELL (TEMPORAL) ARTERITIS -Is the most common form of systemic vasculitis in adults. -Affects old ages above the age of 50 years. - Is granulomatous inflammation of large sized arteries. - It affects principally the head arteries especially the temporal arteries, but also the vertebral and ophthalmic arteries and the aorta. Ophthalmic arterial involvement may lead to permanent blindness.
- Slide 10
- * Morphology: Characteristically, segments of affected arteries develop nodular thickenings with reduction of the lumen and may become thrombosed. Microscopically: granulomatous inflammation of the inner half of the media showing mononuclear infiltrate, multinucleate giant cells and fragmentation of the internal elastic lamina. The healed stage reveals collagenous thickening of the vessel wall with organization of the luminal thrombus. Sometimes transforms the artery into a fibrous cord.
- Slide 11
- * Pathogenesis: immunologic reaction against elastin. * Clinical Features: -Constitutional manifestations: fever, fatigue, weight loss. -Facial pain or headache, often most intense along the course of the superficial temporal artery, which may be painful to palpation. -Ocular symptoms (associated with involvement of the ophthalmic artery).
- Slide 12
- Slide 13
- 2. TAKAYASU ARTERITIS The illness is seen predominantly in females younger than age 40. This is a granulomatous vasculitis of large sized arteries especially aorta and ocular arteries. Clinically characterized principally ocular disturbances and marked weakening of the pulses in the upper extremities (pulseless disease).
- Slide 14
- * Morphology: Grossly: The affected vessel shows irregular thickening with intimal wrinkling. Microscopically: adventitial mononuclear infiltrate with perivascular cuffing of the vasa vasorum and granulomatous inflammation, with giant cells. Later, there is collagenous fibrosis involving all layers of the vessel wall.
- Slide 15
- Slide 16
- 3. POLYARTERITIS NODOSA (PAN) PAN is a systemic vasculitis of small or medium- sized muscular arteries (but not arterioles, capillaries, or venules), e.g. renal artery. Clinical manifestations result from ischemia and infarction of affected tissues and organs. Affects young adults. The course may be acute, subacute, or chronic.
- Slide 17
- The disease is fatal in most cases, either during an acute fulminant attack or following a protracted course, but therapy with corticosteroids and cyclophosphamide results in remissions or cures in 90% of cases.
- Slide 18
- * Morphology: Segmental transmural necrotizing inflammation with neutrophils,eosinophils and fibrinoid necrosis. The lumen may become thrombosed. Later, the acute inflammatory infiltrate disappears and is replaced by fibrous thickening of the vessel wall that may extend into the adventitia. Firm nodularity sometimes marks the lesions.
- Slide 19
- Slide 20
- * Complications of PAN: 1. Thrombosis with subsequent ischaemic complications. 2. Aneurysmal dilatation. 3. Rupture during acute attacks with fatal hemorrhage.
- Slide 21
- 4. KAWASAKI DISEASE (MUCOCUTANEOUS LYMPH NODE SYNDROME) -It is inflammation of the coronary arteries, usually in young children and infants (80% of cases are
View more >