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UNIVERSIT DI PISA

ElectromagneticRadiationsElectromagneticRadiationsd Bi l i l I id Bi l i l I iandBiologicalInteractionsandBiologicalInteractions

LaureaMagistraleinLaureaMagistraleinBiomedicalBiomedical EngineeringEngineeringFirstFirstsemestersemester (6(6creditscredits),),academicacademic yearyear 2011/122011/12

Prof.PaoloProf.PaoloNepaNepa

Exposure systems

p.nepa@iet.unipi.itp.nepa@iet.unipi.it

Exposuresystems

1

EditedEdited byby Dr.Dr.AndaAnda GuraliucGuraliuc15/12/2011

LectureContentLectureContent

Biological effectsBiologicaleffectsExposuresystems

TEMcell/GTEMcellRackLoopAntennaArrayHornantenna&dielectriclensWPCcellShorted waveguideShortedwaveguideFerrisWheelexposuresystem

215/12/2011

IntroductionIntroduction

The electromagnetic field source expansion, such as antennas for mobile phones andwireless communication systems, has increased the human exposure levels to EM fieldsd d h i f d i kand generated the perception of damage risk.

Despite a large amount of research works, more than thousands of publications, thescientific community is still involved in studying the interaction mechanism betweeny y gelectromagnetic waves and living matter, because there is no complete and definitiveunderstanding of the biological effects of EM fields.

To study the EM fields biological tissue effects different experiments can be required: ininTo study the EM fields biological tissue effects different experiments can be required: ininvivovivo (on rats, mice etc.) and inin vitrovitro (on biological tissues).

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EMfieldEMfield BiologicalsysteminteractionBiologicalsysteminteraction

The interaction of EM fields with a biological system can result in pathological effects whoseorigin is to be found in the biological mechanisms of interaction.

Source EMenergy Biologicalsystem Pathophysiological effects(macromolecularresonance;membranepotential&DNAdamage)

AbsorbedEMenergyBiophysicalmechanismsofinteraction

MicroscopicstudiesMacroscopicstudies pMolecularandcellularbiology

pDosimetry

Thermaleffects Nonthermaleffects

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InteractionInteraction biologicaleffectbiologicaleffect damagedamage

When a human body interacts with an EM field, its electricInteractionInteractionequilibrium is definitely disturbed, but there is not necessarily abiological effect or a damage.

When morphologic and functional variations occur in thebody/organs.

BiologicaleffectBiologicaleffect

It occurs when the effect exceeds the effectiveness limits ofDamageDamagebody adapting mechanisms.

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BiologicaleffectsBiologicaleffects

thermalthermal The energy carried by a wave passes through a biological tissue and is dissipated withinthe tissue itself as heat, which produces a temperature increase.the tissue itself as heat, which produces a temperature increase.Are indirect interaction: EM field> heat>biological effectsWhen the temperature increases, the body reacts: it tries to eliminate the excess heat

and keep its temperature constant.If the temperature elevation is above a certain level, there is a local or general

h th i

EffectsEffects

nonnonthermalthermal

hyperthermia.Thermal effects hazards are well established and safety levels are well documented.

Can be classified as microthermal (e.g. auditory effect that occurs for pulsemodulated microwave exposure radar emissions).Are direct interactions of EM fields with biological cells.Depends on the field intensity, frequency and signal shape.Are not as well understood: specifically, mechanisms are not fully explored nor

consistently documented.

LevelLevel ParameterParameter EffectsEffects

ThermalThermalBody

Absorbed powerdensityGeneraltemperatureincrease

Organs Localtemperatureincrease

NonNonthermalthermal

CellculturesForceson charges(ions,electrons)

andondipolarmolecules(permanentorinduced)

MacromolecularresonanceMembranepotentialdamage

DNA damageDormanttumorcellreactivation

Cell(membrane/nucleus)

Molecule

6

AtAt risk?risk?Are those tissues with lower blood concentration:

eyes gallbladder testes

because are unable to dissipate heat through the activethermoregulatory mechanism of blood flow

EffectsduetodifferentfrequencyoftheEMfieldEffectsduetodifferentfrequencyoftheEMfield

cause nonthermal effectscause electric currents in the human body able to influence excitable cellsthe effects depend on the current density induced in the bodya strong EM field can produce central nervous system disorders, blood

LowfrequencyhighfieldsLowfrequencyhighfields

pressure increases and cardiac arrhythmias

cause thermal effectshigh frequency radiations are absorbed and dissipated inside the body as

h theatthe effects depend on the intensity, duration and frequency of the EM fieldif the increase of body heat exceeds a certain level, the effect is equal to that

produced by fever or extreme heat, and leads to a reduction of mental activityand a disturbance of body functions

HighfrequencyfieldsHighfrequencyfields

the eyes are particularly affected

LowfrequencylowfieldsLowfrequencylowfieldsare of interest for longterm exposurecause predominantly nonthermal effects because the intensity is not high

h i ifi l h ienough to significantly change tissue temperaturecan influence the cellular membrane permeability and melatonin metabolismthere are many research studies that statistically connect the lowfrequency

low fields (above 0.4T) to the childhood leukemia occurrence

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StudiesandresearchStudiesandresearch

EpidemiologicstudiesEpidemiologicstudiesEpidemiologicstudiesEpidemiologicstudies are mainly related to the cancer risk and reproductive effects inresidential and employment environments

InvivostudiesInvivostudiesInvivostudiesInvivostudies regard systems like: nervous, endocrine, cardiovascular,immune, reproductive etc.

InvitrostudiesInvitrostudiesInvitrostudiesInvitrostudies are studies at cellular membrane level on ions flow alterationand protein behavior are studies at cellular nucleus level on DNA damage, dormantg ,tumor cell reactivation, growth cell rate alteration

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EpidemiologicstudiesEpidemiologicstudiesEpidemiologyEpidemiology is the study of healthevent, healthcharacteristic, or healthdeterminant patterns in apopulationpopulation.EpidemiologyEpidemiology is a study designed to investigate hypothesized causal relationships; tries to determine whydisease is occurring and is based on tests hypothesis.

The quality indicators for the epidemiological studies are: Good definition of the study population Representative control group of the population which generated the cases High rates of participation and not associated with disease state and /or exposure Complete, accurate and precise information on exposure and disease

The qualityindicators fortheepidemiologicalstudies are:

p p p Appropriate methods of analysis with information on accuracy and variability of the relative risk estimations

The exposure estimation is particularly difficult in the epidemiology of electromagnetic fields for thefollowing reasons:following reasons:

the exposure is imperceptible due to multiple sources highly variable over time and over short distances the relevant exposure period is prior to the period when it can be realistically measured the appropriate exposure metric is unknown, and there are no reference biological data about it

In the absence of experimental evidence, and given the methodological uncertainties inthe epidemiological literature there is currently no chronic disease for which a stable connection with EM

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the epidemiological literature, there is currently no chronic disease for which a stable connection with EMfields exposure can be established.

ExposuresystemsExposuresystems

Exposure systems are mostly used in bioelectromagnetic experiments to study thebiological effects of electromagnetic fields.

One key aspect in the study of the biological effects of EM field exposure conditions isOne key aspect in the study of the biological effects of EM field exposure conditions isto create the exposure conditions: known, controlled and repeatable. These will allow tocorrelate the biological effect to the cause that produce it.

The characteristics and effectiveness of an exposure system depends on:

natureandsizeoftheexposedobject experimentduration frequency power microclimeconditions

1015/12/2011

ExposuresystemsExposuresystems

Exposure systems classification:Exposure systems classification:

propagating systems: TEM/GTEM cells and various waveguides (rectangular, circular,radial coplanar) Their advantage is versatility and RF field uniformityradial, coplanar). Their advantage is versatility and RF field uniformity.

radiating systems: consists of commercial or ad hoc antennas, like horn, microstripantennas, loop antennas, generally exposing samples in the far field region. They allowsimultaneous sample exposure, but have low uniformity of dose among samples andreduced efficiency in terms of SAR per unit of input power.

resonant systems: shortedwaveguide Are closed and compact are easily placed in anresonant systems: shortedwaveguide. Are closed and compact, are easily placed in anincubator for environmental conditions control. The positioning of the sample is criticaldue to extremely localized region of field uniformity.

special re

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