uicc hpv and cervical cancer curriculum chapter 6.c.2. methods of treatment - surgery prof. achim...

22
UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

Upload: internet

Post on 05-Apr-2015

108 views

Category:

Documents


2 download

TRANSCRIPT

Page 1: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

UICC

HPV andCERVICALCANCERCURRICULUM

Page 2: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

01 Chapitre 6.c.2

Méthodes de traitement – Chirurgie

Prof. Achim Schneider, MD, MPHCharité Universitätsmedizin Berlin, Germany

Page 3: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

02 Cancer Cervical

• Diagnostic

• Traitement

-Chirurgie

-Radiation

-Chimiothérapie

• Prognostic

• Suivi post thérapeutique

Page 4: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

03 Système FIGO

Stade I Stade II

Stade III Stade IV

Page 5: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

04 Options de traitement initial

PREMIER TRAITEMENT

Chirurgie

chirurgie Radiochimiothérapie

Radiothérapie

Radiochimiothérapie

Radiochimiothérapie Chirurgie

Chimiothérapie

Chimiothérapie Chirurgie

Page 6: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

05 Succès thérapeutique par stade

Source: FIGO Annual Report

Radiothérapie Chirurgie

Stade FIGO

Haza

rds R

ati

o

Page 7: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

06Comparaison chirurgie et radiothérapie chez les patientes de stade FIGO IB

CHIRURGIE RADIOTHERAPIE

Survie 85% 85%

Complicationssévères

Fistule urinaire 1 - 2% fistules urinaire ou

rectale:1,4 – 5,3%

Vagin RaccourcissementFibrose ou sténose

surtout chez les femmes ménopausées

Ovaire Peuvent être préservés

Castration, transposition hors du pelvis peut sauver la fonction

ovarienne dans 50% des cas

Effets chroniques

Vessie atone 3%Fibrose intestinale et/ou

vésicale 6 – 8%

Indications

Les meilleures candidates sont : < 70 ans, poids<

100 kg et en bonne condition générale

Toutes les patientes sont des candidates possibles

Mortalité 1%

< 1% (en raison d’embolies pulmonaires lors du traitement endo-

cavitaire)

Page 8: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

07 Hystérectomie radicale ou étendue

Page 9: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

08 Chirurgie des cancers cervicaux au stade IA2 - IIB

Friedrich Schauta 1849 - 1919

Ernst Wertheim 1864 - 1920

Page 10: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

09 Lymphadénectomie

Infrarénal gauche

infra-mésentérique gauche

Para-aortique droit

Pelvique Paramétriqu

e

Citerne lymphatique

Page 11: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

10 Hystérectomie radicale (1)

Vessie

Rectum

Page 12: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

11 Hystérectomie radicale (2)

Page 13: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

12 Résection des paramètres

Page 14: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

13 Plexus hypogastrique

Page 15: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

14 Hystérectomie radicale par voie base type III – Préservation du nerf

Sensibilité (+)Motricité +

Ute rusBla se

Ure te rBe c ke nb o d e n

Re ktumRectu

m

VessieUtérus

Plancher Pelvien

Page 16: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

15 Survie après hystérectomie radicale par voie basse• Stade IA - IB1, ganglion non envahi (pN0), pas

d’envahissement de l’espace lympho-vasculaire (L+V=0)

• Pas d’autres facteurs de risque

• n = 110 patientes

• Durée de suivi: 44 (1-89) months

• Survie

>36 mois: n = 70 (64%)

>60 mois: n = 36 (33%)

Page 17: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

16 Complications post hystérectomie radicale• Précoces

-Saignement

- Fistule

-Sténose urétérale

-Embolie Pulmonaire

- Infection

- Ileus

Page 18: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

17

• Tardive

- Lymphocèle

- Incontinence vésicale

-Constipation

-Sensibilité

Complications post hystérectomie radicale

Page 19: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

18 Trachélectomie radicale (1)

Daniel Dargent

Page 20: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

19 Trachélectomie radicale (2)

Page 21: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

20 Trachélectomie radicale (3)

• Conditions préalables

-Désir d’enfant

-pT1A1 L1

-pT1A2

-pT1B1 < 2 cm

-Pas d’ invasion vasculaire

-Ganglions non envahis (pN0)

-Résection endo-cervicale avec une marge de 0,5cm

- Longueur de col résiduel de 1 cm

Page 22: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - Surgery Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.2. Methods of treatment - SurgeryProf. Achim Schneider, MD, MPH

Slide

21

Merci

Cette présentation est consultable sur: www.uicc.org/curriculum