turning rwd into rwe

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Copyright © 2014 Oracle and/or its affiliates. All rights reserved. | Real World Data Opportunity and Challenges Oracle ConfidenCal – Internal/Restricted/Highly Restricted 1 Intel, the Intel logo, Xeon, and Xeon Inside are trademarks or registered trademarks of Intel CorporaCon in the U.S. and/or other countries.

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Page 1: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

RealWorldDataOpportunityandChallenges

OracleConfidenCal–Internal/Restricted/HighlyRestricted

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1

Intel,theIntellogo,Xeon,andXeonInsidearetrademarksorregisteredtrademarksofIntelCorporaConintheU.S.and/orothercountries.

Page 2: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

SafeHarborStatementThefollowingisintendedtooutlineourgeneralproductdirecCon.ItisintendedforinformaConpurposesonly,andmaynotbeincorporatedintoanycontract.Itisnotacommitmenttodeliveranymaterial,code,orfuncConality,andshouldnotberelieduponinmakingpurchasingdecisions.Thedevelopment,release,andCmingofanyfeaturesorfuncConalitydescribedforOracle’sproductsremainsatthesolediscreConofOracle.

OracleConfidenCal–Internal/Restricted/HighlyRestricted 2

Page 3: Turning RWD into RWE

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OutcomesMaSer

“The biggest influence of health reform is that there is no new money for health care delivery. There is money only for improved outcomes. You can explain it in four words: no outcome, no income. It’s that simple”

- David B Nash, Founding Dean of Thomas Jefferson School of Population Health

2

The ability to demonstrate the needed outcomes to payers will be the differentiator as our system

continues to evolve and address costs

“The biggest influence of health reform is that there is no new money for health care delivery. There is money only for improved outcomes. You can explain it in four words: no outcome, no income. It’s that simple”

- David B Nash, Founding Dean of Thomas Jefferson School of Population Health

2

The ability to demonstrate the needed outcomes to payers will be the differentiator as our system

continues to evolve and address costs

Page 4: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

PharmaceuCcalsOpportuniCes5Opportuni+estoCreateValuewithData

BusinessDevelopmentR&D

SAFETY MARKETACCESS

FindUnmetMedicalNeed

TargetIdenCficaCon

ManageDiversePartnerData

FindAllRelated

Research

LeverageSignalsinThird-PartySources

RapidlyDiscoverLargerContextof

Care

EnterNewMarkets

DefendPricing

ImproveAdherence

IdenCfyKOLsmoreprecisely

MANUFACTURING

CLINICALTRIALS

AccelerateAdapCveClinical

Trials

RapidlyIdenCfyandValidateTargetCohort

TrackandImprove

Adherence

ReduceBadBatches

BeSerPredictVatfailures

RootCauseacrossALL

SupplyChain

Page 5: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

OutcomesMaSer

“Ialsostartedtoshi_ourbusinessawayfromatransacConalmodelthatwasfocusedonphysicallysellingthedrugstodeliveringanoutcome-basedapproachtoaddvaluebeyondjustthepill.Ireallybelievethatinthefuture,companieslikeNovarCsaregoingtobepaidonpa+entoutcomesasopposedtosellingthepill.”

– Joseph Jimenez, CEO, Novartis

Page 6: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

“YoucanbuildabeSermousetrapbutcanyouproveit”AnonymousEpidemiologist

EvidenceMaSers

Page 7: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

Source:WSJStudiosSurvey2015

96%

DataCapitalChallenge

98%81%

GrowthinSupplyofandDemandforData

ReportIncreaseinDataVolumeInLastYear

PlantoExpandTheirAnaly+csTeams

CiteLosingRevenueDueto

Ineffec+veuseofInforma+on

Page 8: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

Source:WSJStudiosSurvey2015

62%

DataCapitalChallengeinPharma

72%73%

GrowthinSupplyofandDemandforData

Source:WSJStudiosSurvey2015

ReportIncreaseinDataVolumeInLastYear

PlantoExpandTheirAnaly+csTeams

CiteLosingRevenueDueto

Ineffec+veuseofInforma+on

Page 9: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

Source:WSJStudiosSurvey2015

DataCapitalChallengeinPharma

72%

GrowthinSupplyofandDemandforData

MoreData

MoreAnalyCcs

LostRevenue?

Page 10: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

What’sGoingOnTheChallengeofDataSupply

OracleConfidenCal–Internal 10

Whatareyoulosingwhileyouwaitfordata?

74%ofresponderssaysittakedaystogetaccesstonewlycaptureddatawhile40%indicateweeks.1

1RexerAnalyCcsSurvey

Page 11: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

CommuniCesGeneraCngDataSupplyNotinyourWarehouseoryourapplica+on

Page 12: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.| OracleConfidenCal–Internal 12

Whatareyoulosingwhileyouwait?

60%ofrespondentsindicateittakesbetween3weeksand1yeartodeploynewmodelsintoproducCon.1

1RexerAnalyCcsSurvey.

What’sgoingonTheChallengeofOpera+onalizingAnaly+cs

Page 13: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

Thistakestoolong

DataSupply AnalyCcsDemand

Page 14: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

HowfastcanyouturnRealWorldDataintoRealWorldEvidence

RealWorldData AnalyCcsEvidence

Page 15: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

ResultsfromClientCaseStudy

20%to80%LessAccurateAnaly+cs

Act1:Workaroundtheproblembutcreateanother

DataSupply AnalyCcsDemandWorkWithSample Sizeittoyourlaptop

Page 16: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

ResultsfromClientCaseStudy

40%to500%MoreAccurate

Act2:Co-locatealldatawithanalyCcengines

DataSupply AnalyCcsDemand

Page 17: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

Step1:ManageandBuyOnce,AnalyzeManyTimesRealWorldDataReservoir

InsuranceClaimsData

ClinicalData

Prescrip+onData

FAERS,MAUDE

Argus

Siebel

§ RealWorldEvidence§ Biomarkerdiscovery

§ ProtocolvalidaConandpaCentrecruitment

§ PaCentstraCficaCon§ SafetyandcomparaCveeffecCveness

§ PopulaConhealth§ Precisionmedicine

§ …

ENABLES

Page 18: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

Step2:MachineLearningLabBringAnalyCcsTOtheDataReservoir

OracleConfidenCal–Internal/Restricted/HighlyRestricted

MachineLearningDirectlyonDataReservoir

CloneDatatoLab

OracleCloudPlaoormCombinesDataManagement,MachineLearningand

ComputeResources

ProtectedProduc+onBIandDataWarehouse

RealWorldData

MachineLearningIncluded

BringYourOwn

Page 19: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

Step3:Opera+onalizeBringAnalyCcsTOtheapplicaConsandfrontline

OracleConfidenCal–Internal/Restricted/HighlyRestricted

MachineLearningDirectlyonDataReservoir

CloneData

ManageAnyDataAccessViaSQL

ScaleComputeOn-Demand

ProtectedProduc+onApplica+onsandDataWarehouse

MachineLearningIncluded

BringYourOwn

SynctoProd

RealWorldApplicaCons

Page 20: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

DataScienceLab

CreateEnvironment

AccelerateData+Analy+csMakeExis+ngTeamProduc+ve

Analy+csSharedService

ProvideAnaly+cSkills

DevelopSkillsPartnerforSkills

Analy+csProductFactory

Analy+cProducts

EmbeddedandSharedAcrosstheEnterprise

CapabilityRoadmap

HybridDeployment

Page 21: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

PrescripCons:Tacklingfraudanderrors

•  2million‘ghostpaCents’costNHS£540m

•  8millionprescripConsprocessedperday

•  Opportunityformisuseofdrugs

•  PrescripCons,reimbursementsandbenefitspayments–errorscauseover&underpayments

•  IntegraConofstructured&unstructuredtoenablemorepowerfulinsightsintobehavioranduseofdrugsthroughprescripCons

•  Geomappingtoshowareasofhotspots–highusersanddrugcosts

ReducingfraudanderrorwithintheNHSprescrip+onservice

Page 22: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

Business Challenge •  Link database information on genes,

proteins, metabolic pathways,compounds, ligands, etc. to original sources.

•  Increase productivity for accessing, sharing, searching, navigating, cross-linking, analyzing internal /external data

ConsolidatedKnowledgeLayer

Solution •  Semantic integration layer using RDF graph •  Rich domain-specific terminology (biology,

chemistry and medicine) 1.6 M terms •  Terminology Hub: 8 GB of referential data

(ontologies) that cross-reference various data repositories.

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Page 23: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.| 23

EUPublicaConsOfficeLinkedMetadataPlaoormforEuropeanUnion

Objectives §  Commonmetadatamodelsupports:

§  SearchanddiscoveryofEUPublicaCons§  MulCpledomainsandlanguages

Solution §  ValidateandtagEUlaw,tenders,andpublicitytostandardizedvocabularies

§  UnifiedRDFgraphmetadatamodel§  Supportsdiscoveryofcontentthroughuser’sterminologyandlanguage

§  ProvidesvarietyofdisseminaConmodes

§  Evolvingdatamodelthatflexiblysupportsavarietyofbusinessusecases

§  Scalability:§  OverbillionRDFtriplesinOracleGraphDB§  2.5TBofcompresseddatainOracleDB§  Linksto3.9TB(60M)filesofEUpubs

§  Reliabilityandmaintainability§  OracleASM(AutomaCcStorageManagement)§  Twofailoversystems

Benefits

Page 24: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.| OracleConfidenCal–Internal/Restricted/HighlyRestricted 24

EnablingServiceLayers

UnifiedDataManagementasaService

IntelligenceasaService

MachineLearningasaService

DataIngestandOriginaConasaService

IntelligentApplicaConsandBusinessInsight

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Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

Developer

Security

InfrastructureasaService–Compute,Storage,Archive

OracleConfidenCal–Internal/Restricted/HighlyRestricted 25

OracleCloudPlaoormDataManagement

UnifiedDataManagementasaService

IntelligenceasaService

MachineLearningasaService

DataIngestandOriginaConasaService

IntelligentApplicaCon

OpenAPI’s

DR/BackUp

Dev/Test

Page 26: Turning RWD into RWE

Copyright©2014Oracleand/oritsaffiliates.Allrightsreserved.|

DataManagementMaturityModel:CREATEVALUEfromDATAforPharma

QuickWins DataManagementPlaoorm BusinessInsight Business

OpCmizaConBusiness

TransformaCon

DataStagingforanydatafrompartnersandinformaConvendorsSimplifyDataCaptureDeliveryforAnalyCcsScaleSASpredicCveanalyCcs

ImplementaCollaboraCveDataReservoirfordataAs-IsExtendDataWarehousetohandlenewdatatypes

SelfServiceDataIngestandData-DrivenDiscoverySupportanalyCcsonalldatastructuredandunstructured

AccelerateMarketAccesswithRealWorldDataImproveSafetySignalDetecCon

CompleteViewofDiseaseTreatmentfromDiagnosCcstoAdherenceOutcome-BasedPrecisionMedicine

Maturity&Capability

Page 27: Turning RWD into RWE