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  • Ernest T. Hawk, Lynn M. Matrisian, William G. Nelson, Gary S. Dorfman, Lisa Stevens, Jennifer Kwok, Jaye Viner, Judith Hautala, and Oren Grad for the Translational Research Working Group “The Translational Research Working Group Developmental Pathways: Introduction and Overview” Clin. Cancer Res. 2008 14: 5664-5671. [Abstract] [Full Text] [PDF] Martin A. Cheever, Jeffrey Schlom, Louis M. Weiner, H. Kim Lyerly, Mary L. Disis, Addison Greenwood, Oren Grad, and William G. Nelson for the Translational Research Working Group “Translational Research Working Group Developmental Pathway for Immune Response Modifiers” Clin. Cancer Res. 2008 14: 5692-5699. [Abstract] [Full Text] [PDF] Gary S. Dorfman, Theodore S. Lawrence, and Lynn M. Matrisian for the Translational Research Working Group “The Translational Research Working Group Developmental Pathway for Interventive Devices” Clin. Cancer Res. 2008 14: 5700- 5706. [Abstract] [Full Text] [PDF] Sudhir Srivastava, Joe W. Gray, Brian J. Reid, Oren Grad, Addison Greenwood, and Ernest T. Hawk for the Translational Research Working Group “Translational Research Working Group Developmental Pathway for Biospecimen-Based Assessment Modalities” Clin. Cancer Res. 2008 14: 5672-5677. [Abstract] [Full Text] [PDF] Gary S. Dorfman, Daniel C. Sullivan, Mitchell D. Schnall, and Lynn M. Matrisian for the Translational Research Working Group The Translational Research Working Group “Developmental Pathway for Image-Based Assessment Modalities” Clin. Cancer Res. 2008 14: 5678-5684. [Abstract] [Full Text] [PDF] Richard L. Schilsky, Gary Gordon, Tona M. Gilmer, Sara A. Courtneidge, Lynn M. Matrisian, Oren Grad, and William G. Nelson on behalf of the Translational Research Working Group “The Translational Research Working Group Developmental Pathway for Anticancer Agents (Drugs or Biologics)” Clin. Cancer Res. 2008 14: 5685-5691. [Abstract] [Full Text] [PDF] Ernest T. Hawk, Addison Greenwood, Ellen R. Gritz, Anne McTiernan, Thomas Sellers, Stephen D. Hursting, Scott Leischow, and Oren Grad for the Translational Research Working Group “The Translational Research Working Group Developmental Pathway for Lifestyle Alterations” Clin. Cancer Res. 2008 14: 5707-5713. [Abstract] [Full Text] [PDF]

    http://clincancerres.aacrjournals.org/cgi/content/abstract/14/18/5664?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/content/full/14/18/5664?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/reprint/14/18/5664?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/content/abstract/14/18/5692?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/content/full/14/18/5692?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/reprint/14/18/5692?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/content/abstract/14/18/5700?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/content/full/14/18/5700?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/reprint/14/18/5700?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/content/abstract/14/18/5672?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/content/full/14/18/5672?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/reprint/14/18/5672?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/content/abstract/14/18/5678?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/content/full/14/18/5678?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/reprint/14/18/5678?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/content/abstract/14/18/5685?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/content/full/14/18/5685?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/reprint/14/18/5685?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/content/abstract/14/18/5707?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/content/full/14/18/5707?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT http://clincancerres.aacrjournals.org/cgi/reprint/14/18/5707?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Translational+pathway&searchid=1&FIRSTINDEX=0&fdate=1/1/2008&resourcetype=HWCIT

  • Fig. 1. Generic Developmental Pathway.The genericTRWG pathway is depicted as a flowchart, a schematic process representation widely used in engineering. Rounded rectangle at the top, origin of the process. Square-cornered rectangles, activity steps.Diamonds, conditional tests or decision steps.Unidirectional arrows, direction of the activity sequence, and the direction of transfer of supporting tools from their parallel development paths to the main path of modality development.The initial steps of the pathway (blue) are required to proceed through the pathway, with the blue diamonds representing the credentialing steps of scientific validation, clinical need, and feasibility. Subsequent steps include the development of supporting tools (red), the creation of the modality (green), preclinical development (purple), and early stage clinical trials (yellow).

    www.aacrjournals.orgClin Cancer Res 2008;14(18) September15, 2008 5668

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  • Fig. 1. Biospecimen-Based Assessment Modality (BM) Pathway.The BM pathway is depicted as a flowchart, a schematic process representation widely used in engineering. Rounded rectangle at the top, the origin of the process. Square-cornered rectangles, activity steps.Diamonds, conditional tests or decision steps.Unidirectional arrows, the direction of the activity sequence, and the direction of transfer of supporting tools from their parallel development paths to the main path of modality development. The three diamonds in the initial steps of the pathway (blue) are decisions required to proceed through the pathway and represent the credentialing step. Subsequent steps include the development of supporting tools (red), the creation of the modality (green), preclinical development (purple), and early stage clinical trials (yellow). For each activity or decision point, it is understood that there are many more variations that can occur, and that not all steps may occur in each instance.The pathway does not address the ways in which insights gained from late-stage clinical trials can influence the development process. Biospecimen-based assessment devices can be used for screening, early detection, diagnosis, prediction, prognosis, or response assessment.The pathways are conceived not as comprehensive descriptions of the corresponding real-world processes but as tools designed to serve specific purposes, including research program and project management, coordination of research efforts, and professional and lay education and communication.

    www.aacrjournals.orgClin Cancer Res 2008;14(18) September15, 2008 5674

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  • Fig. 1. Image-Based Assessment Modality (IM) pathway.The IM developmental pathway is depicted as a flowchart, a schematic process representation widely used in en