translational research strategies in cic biogune
TRANSCRIPT
Translational Research strategies in CIC bioGUNE
Arkaitz Carracedo
Investigación e innovación en salud en Euskadi
What does it mean To be translational?
What does it mean To be translational?
What does it mean To be translational? 2 models to approach a translational strategy:
Model 1: Synergy by proximity Model 2: Synergy by strategy
The AC lab Translational strategy CIC bioGUNE: A technological Research center for cooperative Research -Bioscience institute -Spirit-headed by the Department of Industry -Conceived to translate basic Research into health-related commercial strategies
The AC lab Translational strategy Translational SWOT analysis of CIC bioGUNE WEAKNESSES Location: Long distance from local hospital
The AC lab Translational strategy Definition: A technological Research center for cooperative Research
Traslational fitness: How to get there The AC lab strategy
How to turn Weaknesses into Opportunities
Traslational fitness: How to get there
Cancer discussion group
The AC lab strategy
Traslational fitness: How to get there The AC lab strategy Biobank 2011: Strategic Alliance
AC
Pathologist
Urologists
Local
National
MSSM
Basurto Donostia
Others…
Traslational fitness: How to get there The AC lab strategy Biobank 2011: Strategic Alliance AC Lab : Basque Biobank Aims: To increase the visibility of biobanking in the Basque Country To spirit-head a Prostate Cancer prospective study as proof-of-concept To collaborate in methodological advances to improve sample acquisition and processing
Traslational fitness: How to get there The AC lab strategy Biobank: Achievements
AC
Traslational fitness: How to get there The AC lab strategy Biobank: Achievements
Pathologist
Urologists
Prostate Cancer Hyperplasia
Scheduled for surgery – informed consent
Week before surgery
Day of surgery
Paraffin-embedded tissue
Fresh-frozen diagnosed tissue
Fasting serum, plasma, urine and blood DNA
Physical parameters and blood biochemistry
2012-2016: 800 patients enrolled
Follow up, association studies of recurrence
Outcome: -6 publications -1 patent -2 collaborations with Pharmas for product validation
The AC lab strategy Computational biology
Traslational fitness: How to get there
The AC lab strategy Computational biology 2014: Collaborative initiative with Genomics Platform Aims: To train informatician / statistician in biological informatics To exploit publicly accessible cancer datasets To develop a webtool to potentiate computational biology in untrained basic scientists
Traslational fitness: How to get there
Liquid biopsy *Strategic alliances with OMICs labs
Integration of experimental and observational models
Mouse models of cancer
Patient specimens
Molecular and celular biology
Plasma Urine
An example: Biomarker search in PCa
The advantage of CIC bioGUNE: OMICs OMICs that are good for biomarker Discovery Transcriptomics Peptidomics NMR metabolomics
An example: Biomarker search in PCa
The advantage of CIC bioGUNE: OMICs Urine extracelular vesicles
An example: Biomarker search in PCa
Hiperplasiabenigna
Adenocarcinomade próstata
The advantage of CIC bioGUNE: OMICs Urine extracelular vesicles
An example: Biomarker search in PCa
Hiperplasiabenigna
Adenocarcinomade próstata
The advantage of CIC bioGUNE: OMICs Urine extracelular vesicles
Urine CDH3 mRNA
An example: Biomarker search in PCa
The advantage of CIC bioGUNE: OMICs
Perspective: Do urine exosomes “inform” about the molecular make up of PCa?
Tumor alterations Urine alterations
An example: Biomarker search in PCa
An example: Precision medicine in cancer
WHO will develop aggressive disease?
HOW is PCa aggressiveness controlled?
Relevant questions for the urologists
Selection criteria:
-Consistently altered throughout datasets
-Associated to disease aggressiveness
An example: Precision medicine in cancer
An example: Precision medicine in cancer
The AC lab strategy Discussion group on cancer
Traslational fitness: How to get there
Cancer discussion group
The AC lab strategy Discussion group on cancer 2014: Created in answer to the following needs: Loss of Perspective in Research: To remember who the enemy is Relevant question often come from other participants in the disease Dissemination of Research is of essence to scientific wellness
Traslational fitness: How to get there
Cancer discussion group
The AC lab strategy Discussion group on cancer Cancer as a compendium of diseases Clinical testing of drugs Biobanking Nutrition and cancer Biomarkers Psychological treatment Patient advocacy Testimony Ethics in science
Traslational fitness: How to get there
Oncologists
Advocates
Patients
Scientists Psychologists
Journalists
Nurses
Clinicians
Thank you!
Collaborations J. Falcón (SPA)
JL. Iovanna (FRA) R. Gomis (SPA) C.Cordon (USA) P. Pinton (ITA) R. Barrio (BIO)
H.U.Basurto Servicio de Urología Servicio de Patología
Servicio de enfermería Biobanco