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  • Slide 1
  • Translational Research - A Basic Science Perspective Translational research: translates basic science discoveries into clinical applications, and/or uses clinical observations to generate new research topics. Focus is on the integration of activities from bench to bedside. Translational research is increasingly a focus of funding agencies Makes it possible to expand your funding base Makes you eligible for new types of federal and, especially private, grants Often involves new collaborations with clinical colleagues Can involve prospective clinical trials, or extensive use of patient samples or information Translational research: translates basic science discoveries into clinical applications, and/or uses clinical observations to generate new research topics. Focus is on the integration of activities from bench to bedside. Translational research is increasingly a focus of funding agencies Makes it possible to expand your funding base Makes you eligible for new types of federal and, especially private, grants Often involves new collaborations with clinical colleagues Can involve prospective clinical trials, or extensive use of patient samples or information
  • Slide 2
  • Translational Projects Identify a translational opportunity - this can be a project that involves clinical specimens Identify a clinical colleague with whom to work This can be on-site or off-site On-site is better for grantsmanship purposes - easier to integrate. Needs to be a two-way street Better if the basic research plays some role in selecting patient samples to be used - what types of clinical specimens? Are specimens analyzed in some way so as to rule them in or out of the study? How does your research feed back into clinical practice and the understanding of disease? Identify a translational opportunity - this can be a project that involves clinical specimens Identify a clinical colleague with whom to work This can be on-site or off-site On-site is better for grantsmanship purposes - easier to integrate. Needs to be a two-way street Better if the basic research plays some role in selecting patient samples to be used - what types of clinical specimens? Are specimens analyzed in some way so as to rule them in or out of the study? How does your research feed back into clinical practice and the understanding of disease?
  • Slide 3
  • Basic Grantsmanship PI and a Co-PI - a joint R01 Both individuals need to benefit and play an active role Take IRB issues seriously - NIH spells out specific pieces of information that you must include regarding patient enrollment Seek advice from senior colleagues Prepare your grant sufficiently in advance so that you can show it to colleagues - no excuse for not doing this! PI and a Co-PI - a joint R01 Both individuals need to benefit and play an active role Take IRB issues seriously - NIH spells out specific pieces of information that you must include regarding patient enrollment Seek advice from senior colleagues Prepare your grant sufficiently in advance so that you can show it to colleagues - no excuse for not doing this!
  • Slide 4
  • Expanding your funding base Funding diversity when starting your lab Get your first R01, but plan for your second Have someone else read your grants Joint R01 grants, with you as Co-PI. Generally, you cant get your second R01 until you demonstrate productivity on your first. Joining with someone on an R01 is a way to get around this, to bring in an additional source of funding before you obtain your second grant. It also makes it much easier to write! Program projects Private awards and career development awards Funding diversity when starting your lab Get your first R01, but plan for your second Have someone else read your grants Joint R01 grants, with you as Co-PI. Generally, you cant get your second R01 until you demonstrate productivity on your first. Joining with someone on an R01 is a way to get around this, to bring in an additional source of funding before you obtain your second grant. It also makes it much easier to write! Program projects Private awards and career development awards
  • Slide 5
  • Career Development (K) Awards A series of grant programs, most designed to help young investigators, or mid career investigators Many are appropriate for translational research Specific requirements and guidelines may vary from institute to institute. This can be easily determined via web pages. Competition for these is not as intense as it is for R01 and R21 grants Many people do not know about these awards A series of grant programs, most designed to help young investigators, or mid career investigators Many are appropriate for translational research Specific requirements and guidelines may vary from institute to institute. This can be easily determined via web pages. Competition for these is not as intense as it is for R01 and R21 grants Many people do not know about these awards
  • Slide 6
  • K22 - NIH Career Transition Awards The primary objective of the K22 program is to help the awardee develop a strong, independent research career. This will be accomplished by supporting outstanding postdoctoral scientists as they move to their first academic position as assistant professors. The award will ease the transition so the recipient can concentrate on establishing a viable research laboratory prior to applying for research grant support. The award is for two years; you apply as a postdoc. If the grant is awarded, you have 12 months to start an academic position, at which point the grant begins. So, you take this grant with you.
  • Slide 7
  • K23 - Mentored Patient-Oriented Research The purpose of the Mentored Patient-oriented Research Career Development Award (K23) is to support the career development of investigators who have made a commitment to focus their research endeavors on patient-oriented research. This mechanism provides support for three to five years of supervised study and research for clinically trained professionals who have the potential to develop into productive, clinical investigators focusing on patient-oriented research. Clinically trained professionals or individuals with a clinical degree who are interested in further career development in biomedical research that is not patient- oriented, should apply for a Mentored Clinical Scientist Career Development (K08) Award
  • Slide 8
  • K24 - Midcareer Investigator Award in Patient-Oriented Research The purpose of the K24 is to provide support for clinicians to allow them protected time (75%) to devote to patient-oriented research and to act as mentors for beginning clinical investigators. The target candidates are outstanding clinical scientists who are actively engaged in patient-oriented research. Candidates are generally within 15 years of their specialty training. Candidates must be able to demonstrate the need for a period of intensive research focus as a means of enhancing their clinical research careers and must be committed to mentoring the next generation of patient- oriented researchers.
  • Slide 9
  • K25 Mentored Quantitative Research The K25 is meant to support investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. Examples of quantitative scientific and technical backgrounds considered appropriate for this award include, but are not limited to: mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry, and engineering. The K25 Award supports the career development of such investigators who make a commitment to basic or clinical biomedicine, bioengineering, bioimaging or behavioral research. This award provides support for a period of supervised study and research for productive professionals with quantitative backgrounds. It is intended for investigators from the postdoctoral level to the level of senior faculty.
  • Slide 10
  • One page maximum Should be self explanatory - tells a story, not just bare bones specific aims 3-5 Specific Aims Straight forwards Aims with best prelim data go first, put risky aims at the end Aims should talk to and build on one another Specific Aims
  • Slide 11
  • Specific Aims - provide enough information to make aims understandable D1. Explore the role of the bridging sheet region in receptor binding and virus infection. Does this region represent a conserved coreceptor binding site, does it govern coreceptor binding affinity, and is it involved in triggering the fusion-inducing conformational changes? D2. Examine the relationships between Env-coreceptor affinity and virus tropism, pathogenesis, and receptor density. We have developed technologies needed to rigorously measure Env-coreceptor binding constants, and can now study the relationship between this and viral tropism and pathogenicity using a panel of well characterized primary HIV, SIV, and SHIV Env proteins. D3. Determine how many receptor binding events are needed to activate HIV and SIV Env trimers, and explore the consequences this has for synergistic neutralization of HIV by different classes of entry inhibitors. Our preliminary studies indicate that multiple receptor binding events are needed, which in turn led us to hypothesize and subsequently demonstrate that HIV can be synergistically inhibited by different classes of entry inhibitors.
  • Slide 12
  • Three page maximum Dont forget Significance; I usually end this section with a specific paragraph on significance Tell what is known, what is not known, why it is important to study what is not known, and how your Aims will address this Refer to each Specific Aim,

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