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  • Idaho State Police Forensic Services

    TOXICOLOGY ANALYTICAL METHODS

  • Toxicology Analytical Methods Revision 9 Issue Date: 08/13/2019Table of Contents

    Page 2 of 143 Issuing Authority: Quality Manager All printed copies are uncontrolled

    Table of Contents Table of Contents .........................................................................................................................................2

    Revision History ............................................................................................................................................6

    Revision #......................................................................................................................................................6

    Description of Changes.................................................................................................................................6

    Toxicology AM #1: Enzyme Immunoassay Screening for Drugs-of-Abuse in Urine......................................8

    1.0 Background/References .....................................................................................................................8

    2.0 Scope ................................................................................................................................................10

    3.0 Equipment/Reagents ........................................................................................................................11

    4.0 Procedure .........................................................................................................................................12

    Toxicology AM #2: General Extraction of Urine for Basic/Neutral or Acidic/Neutral Compounds ............16

    1.0 Background/References ...................................................................................................................16

    2.0 Scope ................................................................................................................................................16

    3.0 Equipment/Reagents ........................................................................................................................16

    4.0 Procedure .........................................................................................................................................17

    Toxicology AM #3: Qualitative 11-nor-9-THC-D9-COOH (Carboxy-THC) in Urine.......................................20

    1.0 Background/References ...................................................................................................................20

    2.0 Scope ................................................................................................................................................21

    3.0 Equipment/Reagents ........................................................................................................................21

    4.0 Procedure .........................................................................................................................................22

    Toxicology AM #4: Cocaine and Cocaine Metabolites in Urine .................................................................26

    1.0 Background/References ...................................................................................................................26

    2.0 Scope ................................................................................................................................................27

    3.0 Equipment/Reagents ........................................................................................................................27

    4.0 Procedure .........................................................................................................................................29

    5.0 Work Instructions .............................................................................................................................32

    Toxicology AM #5: Qualitative Benzodiazepines and Ancillary Compounds in Urine ...............................33

    1.0 Background/References ...................................................................................................................33

    2.0 Scope ................................................................................................................................................35

    3.0 Equipment/Reagents ........................................................................................................................35

    4.0 Procedure .........................................................................................................................................37

    5.0 Work Instructions .............................................................................................................................40

  • Toxicology Analytical Methods Revision 9 Issue Date: 08/13/2019Table of Contents

    Page 3 of 143 Issuing Authority: Quality Manager All printed copies are uncontrolled

    6.0 Comments.........................................................................................................................................41

    Toxicology AM #6: Screening for Gamma-Hydroxybutyrate (GHB) in Urine .............................................42

    1.0 Background/References ...................................................................................................................42

    2.0 Scope ................................................................................................................................................44

    3.0 Equipment/Reagents ........................................................................................................................44

    4.0 Procedure .........................................................................................................................................45

    Toxicology AM #7: Enzyme-Linked Immunosorbent Assay (ELISA) Screening for Drugs of Abuse............48

    1.0 Background/References ...................................................................................................................48

    2.0 Scope ................................................................................................................................................49

    3.0 Equipment/Reagents ........................................................................................................................50

    4.0 Procedure .........................................................................................................................................53

    5.0 Comments.........................................................................................................................................58

    Toxicology AM #8: Basic and Neutrals Drugs in Blood ..............................................................................60

    1.0 Background/References ...................................................................................................................60

    2.0 Scope ................................................................................................................................................60

    3.0 Equipment/Reagents ........................................................................................................................61

    4.0 Procedure .........................................................................................................................................62

    Toxicology AM #9: Acidic and Neutral Drugs in Blood...............................................................................66

    1.0 Background/References .............................................................................................................66

    2.0 Scope ..........................................................................................................................................66

    3.0 Equipment/Reagents ..................................................................................................................66

    4.0 Procedure ...................................................................................................................................68

    5.0 Work Instructions .......................................................................................................................70

    Toxicology AM #13: LCMS-QQQ Confirmation of Benzodiazepines and Z drugs in Blood and Urine........71

    1.0 Background/References ...................................................................................................................71

    2.0 Scope ................................................................................................................................................72

    3.0 Equipment/Reagents ........................................................................................................................72

    4.0 Procedure .........................................................................................................................................75

    5.0 Comments.........................................................................................................................................79

    Toxicology AM #16: Pipette Calibration and Intermediate Checks ...........................................................80

    1.0 Background/References ...................................................................................................................80

    2.0 Scope ..................

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