TO REDUCE MENOPAUSAL VASOMOTOR SYMPTOMS -

... Once -weekly Quinoestrol is as Effective as Cyclic Conjugated Oestrogens Once-weekly quinoestro] ('Estrovis'; \Varner-Chilcott Labs)eITectively relieved severe menopausal vasomotor ins13.bility in a multicentre trial in I S6 women. 79 96 and 21 %. respectively. complained of severe and moderale Ilushes. 31 % had undergone bilateral salpingo-oophorectomy. Patients were randomly assigned double-blind to I of 4 regimens - placebo. Quinoestrol (initially 0.\ mg qid for I wetk . followed by 0. \ mg or O.2mg once weekly). or cyclic conjugated oestrogens('Premarin', 1.2501& qid for 2 r days on and 7 days om. Treaunem continued for 24 weeks. Quin~trol and conjugated oestrogens were both significantly more effective than placebo in relieving vasomotor symptoms (p " 0.05). Greatest improvement was obtained with quinoe:moJ O.2mg. No Significant difference in symptom reJiefwas evident between the active drug groups. A few mild but non­debilitating side effects occurred with almost equal frequency in all groups. Severe nausea caused I patient on conjugated oeslrogens to leave the trial. Vaginitis. bacterial or parasitic, developed in 5 patients. equally distributed among the groups. Papanicolaou smears were normal throughout the study ~cepl in J patients with vaginit is. No significant changes were noted in laboratory tCSts in an}" of Ihe gro:..:ps. Baumgardner. S.H. t l al.: OtI6lcuics and Gyne<;oloay 51 : 445 (Apr 19181

INPHARMA 22nd JuIV. 1918 pl0