tissue engineered airway transplanted with no rejection

Inpharma 1666 - 29 Nov 2008 Tissue engineered airway transplanted with no rejection A multinational team of scientists and clinicians have collaborated to create and successfully transplant a tissue-engineered airway, which did not require subsequent immunosuppression; a summary of their work was presented in The Lancet. Preclinical work by team members had shown that after in vitro generation, tracheal matrices could be grafted into animals without an immunological response. So, when a 30-year old woman with post- tuberculous chronic tracheitis and secondary severe bronchomalacia of the left main bronchus failed to respond to conventional treatment, the team and the patient agreed to attempt such a transplantation rather than undergo left carinal total pneumonectomy, a procedure associated with high rates of morbidity and mortality. To create the bioengineered human trachea, the team began by decellularising a tracheal segment from a deceased female donor to form the airway matrix. They then prepared cultures of the recipient’s epithelial cells and chondrocytes, and using a bioreactor, seeded these cells onto the matrix. The bioengineered airway was then transplanted for the diseased airway, and the left lung ventilated well immediately. The postoperative period was uneventful, and the patient was discharged after 10 postoperative days; she was reported to be well since, able to walk up two flights of stairs and care for her children. Serological testing at 14 days, 1 month and 2 months showed a complete absence of HLA antibodies, and bronchoscopy, at 1 month, revealed that the graft to be indistinguishable from native tissue, and local mucosal bleeding indicate successful revascularisation. Lung function tests at 2 months were within the normal range for age and sex. Macchiarini P, et al. Clinical transplantation of a tissue-engineered airway. Lancet 372: 2023-2030, No. 9655, 13 Dec 2008 801020762 1 Inpharma 29 Nov 2008 No. 1666 1173-8324/10/1666-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

Post on 12-Dec-2016

212 views

Category:

Documents

0 download

Report

Download

Embed Size (px):

TRANSCRIPT

Inpharma 1666 - 29 Nov 2008

Tissue engineered airwaytransplanted with no rejection

A multinational team of scientists and clinicians havecollaborated to create and successfully transplant atissue-engineered airway, which did not requiresubsequent immunosuppression; a summary of theirwork was presented in The Lancet.

Preclinical work by team members had shown thatafter in vitro generation, tracheal matrices could begrafted into animals without an immunologicalresponse. So, when a 30-year old woman with post-tuberculous chronic tracheitis and secondary severebronchomalacia of the left main bronchus failed torespond to conventional treatment, the team and thepatient agreed to attempt such a transplantation ratherthan undergo left carinal total pneumonectomy, aprocedure associated with high rates of morbidity andmortality.

To create the bioengineered human trachea, the teambegan by decellularising a tracheal segment from adeceased female donor to form the airway matrix. Theythen prepared cultures of the recipient’s epithelial cellsand chondrocytes, and using a bioreactor, seeded thesecells onto the matrix. The bioengineered airway wasthen transplanted for the diseased airway, and the leftlung ventilated well immediately.

The postoperative period was uneventful, and thepatient was discharged after 10 postoperative days; shewas reported to be well since, able to walk up two flightsof stairs and care for her children. Serological testing at14 days, 1 month and 2 months showed a completeabsence of HLA antibodies, and bronchoscopy, at1 month, revealed that the graft to be indistinguishablefrom native tissue, and local mucosal bleeding indicatesuccessful revascularisation. Lung function tests at2 months were within the normal range for age and sex.Macchiarini P, et al. Clinical transplantation of a tissue-engineered airway. Lancet372: 2023-2030, No. 9655, 13 Dec 2008 801020762

Airway Mini-residency: Intro to Airway Orthodontics

Recommendations for airway control and difficult airway ... · Recommendations for airway control and difficult ... — broncopleural fistula ... RECOMMENDATIONS FOR AIRWAY CONTROL

Clinical Outcomes of Transplanted Modified Bone Marrow

Non-Invasive Multiphoton Imaging of Islets Transplanted

… Rejection Transplantation Biology:. Kidney rejection:

AIRWAY MANAGEMENT - cicmwrecks.files.wordpress.com · AIRWAY MANAGEMENT Annelise Kerr 1 AIRWAY MANAGEMENT AIRWAY MANAGEMENT 1 Describe the anatomy of the upper airway, larynx and

2017 (v3.0) Proposed changes to v2.1 of the Criteria for ... · Transplant rejection occurs when a recipient’s immune system attacks a transplanted organ or tissue. Despite the

Airway assessment & Recognition of difficult airway

Assessing Ecosystem Recovery in Transplanted

Airway hyperresponsivness Bronchoconstriction Reversible airway obstruction

auto-transplanted ewe

Orthodontic Treatment, Including Transplanted …...Orthodontic Treatment, Including Transplanted Teeth and Dento-Alveolar Osteotomy, for Dental Ankylosis after Multidisciplinary Treatment