theories of aging, anti aging

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LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant Dr Ling Sien Ngan Anti Aging, Aesthetic Medical Practitioner

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Page 1: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Dr Ling Sien Ngan

Anti Aging, Aesthetic Medical Practitioner

Page 2: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Theories of Ageing

EeEe

Edith Cowan UniversityFaculty of Communications, Health & Science

Post Graduate Study in Andrology & Men’s Health

5 December 2004

Page 3: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

• Every single day, as we age , more and more people are dying of

cancer, or simply of old age

Page 4: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

•Are you doing something about it?

Page 5: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Lowel Anti Aging + Aesthetic Clinic , SS2 ,PJ

Page 6: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Mission:

to enhance QoL

through comprehensive & integrated

anti aging & aesthetic healthcare services.

Page 7: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

1) Anti aging medicine• Balanced diet• Nutritional supplementations + antioxidants• Detoxification ( chelation, colon hydrotherapy, FIR

sauna, ozoniser okamizu• Correct, moderate exercise.• Weight management• Syndrome X + Mx of chronic deg dse -CDD• Osteoporosis• Bio –identical hormones• Occupational health noise , chemical• Stress Mx: relaxation meditation , yoga

• Chemoprevention & cancer

Page 8: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Wellness IndustryWellness Industry

Sickness IndustrySickness Industry

Anti Aging Medicine is

Even here can still anti age !

Page 9: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Visible Oxidation damage in action• Free radical damage/oxidative

stress, same process causing:

-Iron to rust

-Cut apple turning brown

-Underlying initiator of diseases, e.g.:

Pigmentation, wrinkle repairable by cream

CAD Multiple sclerosis

Cancer Alzheimer’s dementia

Stroke Macular degeneration

Page 10: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Theories of Ageing

• Biologic, epidemiologic, + demographic data – an attempt to identify a cause or process;

• Ageing: an extremely complex, multifactorial process;

• Different theories not mutually exclusive;• Definition of ageing: open to various

interpretations.

Page 11: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Summary of Presentation

• Life span and Life expectancy.• Definition of Ageing.• What causes ageing?• Clinical approach to ageing.

Page 12: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Theories of Ageing

• Life span and Life expectancy.• Definition of Ageing.• What causes ageing?• Clinical approach to ageing.

Page 13: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Life Span

• Maximum life span is the theoretic species specific, longest duration of life, excluding premature unnatural life.– Jeanne Calment, died July 1997 at age of

122.

Lowland gorilla: 47 yrsHorse: 35 yrs

American hookworm: 15 yrsEarthworm: 6 yrs

Page 14: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Life Expectancy

• Life expectancy is the average number of additional years expected for a member of a population, regardless of cause of death.

Page 15: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Theories of Ageing

• Life span and Life expectancy. • Definition of Ageing.• What causes ageing?• Clinical approach to ageing.

Page 16: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

What is Ageing?

Page 17: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Ageing vs Senescence

• “Senescence”:– deteriorative processes that constitute

natural causes of death.

• “Ageing”:– processes of accruing maturity with the

passage of time, including...

George Martin. In: The ageing process, 1984

Page 18: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Ageing vs Senescence

Positive aspects like:- becoming wiser

- mellow

- evolution of life style

… “just like wine, improves as it ages but not as it senesces”.

Page 19: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Stages of Lifespan• Prenatal life

• Birth

• Postnatal life

– neonatal

– infancy

– childhood

• early

• middle

• late

– adolescence

– adulthood

– senescence

• Death

fertilisation-10months

• birth thru’week 23 wks - 1st birthday

2 - 6 yrs7 - 10 yrsprepubertal

6 yrs following puberty20 - 65 yrs from 65 yrs

EeEe

Page 20: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

What is Ageing?

EeEe

• A ubiquitous biologic process, characterised by a progressive, inevitable evolution and maturation until death.

Susan A Gaylord, Mark E Williams. In: Geriatrics Review Syllabus, 1990

Page 21: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Theories of Ageing

EeEe

• Life span and Life expectancy.• Definition of Ageing.• What causes ageing?• Clinical approach to ageing.

Page 22: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Ageing Process

EeEe

• primary ageing• secondary ageing

True primary ageing is an ongoing normal process.

Page 23: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Environmental hazards

EeEe

• Ionising radiation?• Pollutants?• Chemicals• Diet?• Ambient temperature?• Diseases?

Page 24: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Theories of Ageing

EeEe

“The scientific study of ageing has been an odd mixture of the accumulation of mountains of dismal evidence that shows that almost anything you can think of goes wrong with age, and proposals of simplistic theories that try to explain ageing in terms of single processes, ranging from defective testicles to shortened telomeres.”

Brian Charlesworth, an evolutionary biologist

Page 25: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Theories of Ageing

EeEe

• Research in ageing:– Traditional gerontologist– Evolutionary biologist

• 300 over theories till date!

Page 26: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Theories of Ageing

EeEe

• “Programmed” theories – the biological clocks.

• “Error” theories – identify environmental insults.

Page 27: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Theories of Ageing

EeEe

• Evolutionary

• Molecular

• Cellular

• Systemic

Brian T. Weinert and Poala S. Timiras . Theories of Ageing.

J Appl Physiol 95: 1706-1716, 2003.

Page 28: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Evolutionary Theoriesof Ageing

EeEe

• Mutation accumulation

• Disposable soma

• Antagonistic pleiotropy

Page 29: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Molecular Theoriesof Ageing

EeEe

• Gene regulation• Codon restriction• Error catastrophe• Somatic mutation• Dysdifferentiation

Page 30: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Cellular Theoriesof Ageing

EeEe

• Cellular senescence – Telomere theory

• Free radical

• Wear-and-tear

• Apoptosis

Page 31: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

System Theoriesof Ageing

EeEe

• Neuroendocrine

• Immunologic

• Rate-of-living

Page 32: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Theories of Ageing

EeEe

• Biological theories– genotropic– environmental

• Psycho-social theories:– Disengagement – Exchange – Labelling– Social Stratification– Political economy– Continuity

Page 33: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Summary of Presentation

EeEe

• Life span and Life expectancy.• Definition of Ageing.• What causes ageing?• Clinical approach to ageing.

Page 34: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Clinical Approach to Ageing

EeEe

True ageing vs disease statesBiologic ageing vs chronologic ageing

Promoting positive ageing

Page 35: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Positive Ageing: Pre-requisites

EeEe

• Ageing is not denied;• Perceptions and understanding of

ageing are not disempowering;• Differences between people are

acknowledged.

Mary Davies

Page 36: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Reconceptualisation of Ageing?

EeEe

Ageing exclusively characterised by declines in function & in health?

Substantial heterogeneity?

Existence of positive trajectories of ageing?

Possible avoidance of age-related diseases and disabilities?

Page 37: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

EeEe

Mechanisms of successful ageing

• Persistence of normal function and plasticity• Compensatory responses to restore function • Interventions to replace deficient function• Changing of health outcome by modifying risk

profiles• Prevention of diseases• Strengthening of social interactions and

support

Brian T. Weinert and Poala S. Timiras .

Page 38: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

EeEe

Promote Positive Ageing

• Acceptance of ageing• empowerment• individuality• physical activity• social contact/friendship• developing coping skills• valuing experience,

knowledge etc.

• Denial of ageing• disempowerment• being stereotyped• sedentary lifestyle• social withdrawal• psychological stress• overvaluing paid work

Brendan Kennelly

Encourage Avoid

Page 39: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Conclusion

EeEe

• Ageing process is multifactorial and complex;

• Research is still ongoing to determine the cause(s) or explain the process of ageing;

• None is conclusive;• One important goal: how does intervention

signals the body to delay ageing?• “Successful” ageing is possible.

Page 40: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Reading List

EeEe

• Brian T. Weinert and Poala S. Timiras . Theories of Ageing. J Appl Physiol 95: 1706-1716, 2003.

• Ageing: A natural history; 1995, RE Ricklefs, CE Finch (WH Freeman & Co).

• Evolutionary biology of aging; 1991, MR Rose (New York: Oxford University Press).

• The Aging Process: therapeutic implications; 1984, RN Butler, AG Bearn (Raven Press).

• Geriatrics Review Syllabus: A core curriculum;1989, JC Beck (American Geriatrics Society).

• Aging as a biological phenomenon: Review in Clinical Gerontology, Vol 1, No. 1, 1991.

Page 41: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

How to choose Miss universe supplements ?

• GMP --Supp manufacturing : poorly regulated --Pharm factory adherence > food factory pharm grade OTC

sure better• Label, full disclosure + address --Contain actual amount stated

Page 42: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Choose Ms universe supplement

• Where products marketed ? --Only locally in USA , < stringent --To Canada, Australia, Europe >

stringent send on-site inspection regularly

--3rd party certification on Quality of manufacturing

• QC testing ( dissolvability ) --3/9 prenatal Vit ever dissolved – Uni

of marryland

Page 43: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Antioxidant help good cell• Side effect of chemo, radio = oxidative stress to

normal cell• Taking ^ dose antioxidant ^ defense of normal

cell while on chemowhile chemo work at peak, side effect @

minimal--- win-win• Cancer cell receive double whammy

– Oxidative stress from antioxidant (now pro-oxidant)– Chemo stress

Page 44: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Vit E

Co Q10

B-carotene+ vit A

Against damage by chemo to lung, liver, kidney, heart, skin

Against damage by Adriamycin to heart

< side effect of chemo + radio Rx

All these antioxidant protect against damage to DNA of normal cell

From chemo + Radio Rx

Page 45: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

INTERNAL BEAUTY CARE

Page 46: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

If ageing can be halted...

EeEe

Would you choose to be in it?

Page 47: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

SEEKING A GOOD LIFE

STYLE? Physically and

emotionally strong

Age gracefully

Feel good factor

Page 48: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Page 49: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

Be all that you are Show it off

• VIBRANT

• RADIANT

• VITALITY

Thank you

Page 50: Theories of aging, anti aging

LOOK YOUNG, FEEL YOUNG, STAY YOUNG Dr Ling Sien Ngan , Anti Aging + Aesthetic Consultant

My contact

• E mail; [email protected]

• Web; www.aestheticandyou.com

• You tube; www.youtube.com/lowelantiaging

• Face book; www.facebook.com/drdavidling