the olin story

The OLIN Story The OLIN Story

Bo LundbäckBo Lundbäck

byby

U SA

AFRIC A

R USSIA

Norrbotten

Umeå

Stockholm

Göteborg

Kiruna

LuleåPiteå

U SA

AFRIC A

R USSIA

Norrbotten

Umeå

Stockholm

Göteborg

Kiruna

LuleåPiteå

far awayfar away

in the peripheryin the peripheryof Europeof Europe

USA

AFRICA

RUSSIA

Norrbotten

Stockholm

Göteborg

The OLIN Studies- mainly epidemiologic studies of asthma, COPD, OSAS and allergy - in progress since 1985-50 000 subjects from children to elderly are or have been participating

USA

AFRICA

RUSSIA

Norrbotten

Stockholm

Göteborg


The methods include cross-sectional, longitudinal och case-referent studies but also clinical studies and studies of heath economics

USA

AFRICA

RUSSIA

Norrbotten

Stockholm

Göteborg


The methods include cross-sectional, longitudinal och case-referent studies but also clinical studies and studies of heath economics

From the OLIN Studies so far 10 completed PhD-theses, in addition7 PhD-theses partly based on OLIN-data, and> 10 from closely co-working projects

>> 100 original articles and review papers

A Quarter of a Century A Quarter of a Century

A Quarter of a Century

How did it start?How did it start?

In school books in early 1980:s In school books in early 1980:s

In school books in early 1980:s

Asthma prevalence 2%Asthma prevalence 2%

In school books in early 1980:s

Asthma prevalence 2%Asthma prevalence 2%and so was chronic bronchitis and so was chronic bronchitis

Aims at start in 1985:

How common are OADs?- asthma?- chronic bronchitis?

and its obstructive form?- airway allergies?

And what are their main determinants?

-





A prevalence study in three stages- A cross-sectional postal questionnaire survey- Structured interviews and lung function tests- Validation studies including methacholine tests





A prevalence study in three stages- A cross-sectional postal questionnaire survey- Structured interviews and lung function tests- Validation studies including methacholine tests Asthma prevalence not 2 but 6%

The first years were turbulent The first years were turbulent

The first years were turbulent The first years were turbulent

The Central Hospital´s chief physician:The Central Hospital´s chief physician:

-””Such studies have not been done in Sweden previouslySuch studies have not been done in Sweden previouslyand should not be done here, and not by us”and should not be done here, and not by us”

Supporters and contributors during the first years Supporters and contributors during the first years

Position during the early yearsPosition during the early years

Ola DahlinOla Dahlin Vice chairman of the county/province council Vice chairman of the county/province council Hugo HagstadHugo Hagstad MD, Head of Respiratory Medicine Dept, BodenMD, Head of Respiratory Medicine Dept, Boden

Anders LindmanAnders Lindman MD, Chief physician of Primary Care, BodenMD, Chief physician of Primary Care, BodenUrban Janlert Urban Janlert MD, Community Medicine, LuleåMD, Community Medicine, Luleå

Mai LindströmMai Lindström SRN anaestesia nurse/research assistantSRN anaestesia nurse/research assistantKarin Lundbäck Karin Lundbäck SRN anaestesia nurse/research assistantSRN anaestesia nurse/research assistant



Ola DahlinOla Dahlin Vice chairman of the province council Vice chairman of the province council Hugo HagstadHugo Hagstad MD, Head of Respiratory Medicine Dept, BodenMD, Head of Respiratory Medicine Dept, Boden



Leif RosenhallLeif Rosenhall MD, PhD, Head of Respir Med Dept, Umeå Univ Hosp MD, PhD, Head of Respir Med Dept, Umeå Univ Hosp Nils Stjernberg Nils Stjernberg MD, PhD, researcher/physician at NIOH, UmeåMD, PhD, researcher/physician at NIOH, Umeå

Elsy JönssonElsy Jönsson MSc, statistician at NIOH, responsible for the data base MSc, statistician at NIOH, responsible for the data base Lennarth NyströmLennarth Nyström MSc, statistician at University of UmeåMSc, statistician at University of Umeå

Richard Forrest Richard Forrest MD, PhD, internal med, medical English writing MD, PhD, internal med, medical English writing Anders Odén Anders Odén PhD, statistician at University of GothenburgPhD, statistician at University of Gothenburg

Ann-Christin Jonsson Ann-Christin Jonsson SRN primary care/research assistantSRN primary care/research assistantEva RönmarkEva Rönmark SRN anaestesia, health educator/research assistantSRN anaestesia, health educator/research assistant



Ola DahlinOla Dahlin Vice chairman of the province council Vice chairman of the province council Hugo HagstadHugo Hagstad MD, Head of Respiratory Medicine Dept, BodenMD, Head of Respiratory Medicine Dept, Boden



Leif RosenhallLeif Rosenhall MD, PhD, Head of Respir Med Dept, Umeå Univ Hosp MD, PhD, Head of Respir Med Dept, Umeå Univ Hosp Nils Stjernberg Nils Stjernberg MD, PhD, researcher/physician at NIOH, UmeåMD, PhD, researcher/physician at NIOH, Umeå

Elsy JönssonElsy Jönsson MSc, statistician at NIOH MSc, statistician at NIOH Lennarth NyströmLennarth Nyström MSc, statistician at University of UmeåMSc, statistician at University of Umeå

Richard Forrest Richard Forrest MD, PhD, internal med, medical English writing MD, PhD, internal med, medical English writing Anders Odén Anders Odén PhD, statistician at University of GothenburgPhD, statistician at University of Gothenburg

Ann-Christin Jonsson Ann-Christin Jonsson SRN primary care/research assistantSRN primary care/research assistantEva RönmarkEva Rönmark SRN anaestesia, health educator/research assistentSRN anaestesia, health educator/research assistent

The OLIN Studies continued

Supporters and advicers during the first years Supporters and advicers during the first years


Gunnar BomanGunnar Boman Professor of respiratory medicine, Univ of Uppsala Professor of respiratory medicine, Univ of Uppsala Bengt-Eric SkooghBengt-Eric Skoogh Professor of respiratory medicine, Univ of Gothenburg Professor of respiratory medicine, Univ of Gothenburg

Amund Gulsvik Amund Gulsvik Professor of respiratory medicine, Univ of Bergen , Norway Professor of respiratory medicine, Univ of Bergen , Norway Per BakkePer Bakke MD, Dept of respiratory medicine, Univ of Bergen , Norway MD, Dept of respiratory medicine, Univ of Bergen , Norway

The OLIN Studies continued…

Nordic Scientific Advisory Board since 1989Nordic Scientific Advisory Board since 1989

The OLIN Studies 1992 – The OLIN Studies 1992 –

Can an increase in asthma prevalence be Can an increase in asthma prevalence be documented? - And if so, why?documented? - And if so, why?New cohort recruited; same age as in 1985; same areas New cohort recruited; same age as in 1985; same areas An increase of 1%-unit over 7 years was found An increase of 1%-unit over 7 years was found



Further, our first study of asthma incidence Further, our first study of asthma incidence



Further, our first study of asthma incidence Further, our first study of asthma incidence

Enlargement of the study base from 6610 to Enlargement of the study base from 6610 to approximarely 24000approximarely 24000Decision of the studies long term nature Decision of the studies long term nature

Supporters during the first ten years Supporters during the first ten years



Amund Gulsvik Amund Gulsvik Professor of respiratory medicine, Univ of Bergen , Norway Professor of respiratory medicine, Univ of Bergen , Norway Per BakkePer Bakke MD, dept of respiratory medicine, Univ of Bergen , Norway MD, dept of respiratory medicine, Univ of Bergen , Norway

Tore ÖbergTore Öberg Head of the economy department at the province government Head of the economy department at the province government Ulf ÖhmanUlf Öhman Director of the province government Director of the province government

Per Malmberg Per Malmberg Professor & head of Medical /Lung Dept, NIOH, Stockholm Professor & head of Medical /Lung Dept, NIOH, Stockholm Göran Sundlöf Göran Sundlöf Associate prof & head of Department of Medicine, Central Associate prof & head of Department of Medicine, Central

Hospital of Norrbotten, BodenHospital of Norrbotten, Boden

Håkan ForsbergHåkan Forsberg MD, PhD, Dept of Medicine, Central Hosp of Norrbotten, Boden MD, PhD, Dept of Medicine, Central Hosp of Norrbotten, BodenStaffan Andersson Staffan Andersson MD, PhD, Dept of Clin Physiol , Central Hosp of Norrbotten, B-n MD, PhD, Dept of Clin Physiol , Central Hosp of Norrbotten, B-n

The OLIN Studies 1995-1996

The OLIN Studies 1995-1996 The OLIN Studies 1995-1996

Start of the European Community Concerted Action Start of the European Community Concerted Action on the Epidemiology of COPD on the Epidemiology of COPD

Co-work between Pisa, OLIN, Bergen and Co-work between Pisa, OLIN, Bergen and Gronnigen, Barcelona, Paris and LondonGronnigen, Barcelona, Paris and Londonheaded by headed by Carlo Giuntini Carlo Giuntini and and Giovanni Viegi Giovanni Viegi , Pisa , Pisa


Start of the European Community Concerted Action on the Start of the European Community Concerted Action on the Epidemiology of COPD Epidemiology of COPD

Co-work between Pisa, OLIN, Bergen and Co-work between Pisa, OLIN, Bergen and Gronnigen, Barcelona, Paris and LondonGronnigen, Barcelona, Paris and Londonheaded by headed by Carlo Giuntini Carlo Giuntini and and Giovanni Viegi Giovanni Viegi , Pisa , Pisa

Start of the Start of the FinEsSFinEsS studies studies on the epidemiology on the epidemiology of asthma, allergy, COPD, chronic bronchitis and respiratory of asthma, allergy, COPD, chronic bronchitis and respiratory symptoms in symptoms in Finland, Estonia Finland, Estonia and and SwedenSweden

Sample size: 64 000 subjects in eight centers Sample size: 64 000 subjects in eight centers


Prospective case-referent study of indoor, outdoor Prospective case-referent study of indoor, outdoor and occupational environment on asthma based on and occupational environment on asthma based on incident cases of asthma and matched controls incident cases of asthma and matched controls (OLIN (OLIN V) V) Co-work between OLIN, NIOH and University of UmeåCo-work between OLIN, NIOH and University of Umeå


Prospective case-referent study of indoor, outdoor and Prospective case-referent study of indoor, outdoor and occupational environment on asthma based on incident occupational environment on asthma based on incident cases of asthma and matched controls cases of asthma and matched controls (OLIN V) (OLIN V) Co-work Co-work between OLIN, NIOH and University of Umeåbetween OLIN, NIOH and University of Umeå

Result: Obesity is a risk factor in both men and women, and for Result: Obesity is a risk factor in both men and women, and for both allergic and non-allergic asthma (ERJ 2005) both allergic and non-allergic asthma (ERJ 2005)


Prospective case-referent study of indoor, outdoor and occupational environment Prospective case-referent study of indoor, outdoor and occupational environment on asthma based on incident cases of asthma and matched controls on asthma based on incident cases of asthma and matched controls (OLIN V) (OLIN V) Co-Co-work between OLIN, NIOH and University of Umeåwork between OLIN, NIOH and University of Umeå

Result: Obesity is a risk factor in both men and women, and for both allergic and non-Result: Obesity is a risk factor in both men and women, and for both allergic and non-allergic asthma (ERJ 2005)allergic asthma (ERJ 2005)

Enlarged questionnaire survey and clinical follow-ups of the OLIN Studies 1Enlarged questionnaire survey and clinical follow-ups of the OLIN Studies 1 st st

cohort cohort (OLIN VI)(OLIN VI) Aims: Aims: asthma:asthma: incidence (2/1000/y), risk factors, remission (1/100/y) incidence (2/1000/y), risk factors, remission (1/100/y)COPD:COPD: first sufficiently powered studies on first sufficiently powered studies on prevalence, incidence, risk factors prevalence, incidence, risk factors

””Not 15% but 50% of smokers develop COPD” Not 15% but 50% of smokers develop COPD”


Start of the first OLIN paediatric study (Start of the first OLIN paediatric study (OLIN VIIOLIN VII))

Combines clinical and environmental epidemiologyCombines clinical and environmental epidemiologywith molecular epidemiologywith molecular epidemiology

Prospective study of all children in primary school classas 1 and 2 in Luleå, Piteå and Prospective study of all children in primary school classas 1 and 2 in Luleå, Piteå and Kiruna, n=3525Kiruna, n=3525

Annual follow-ups, both open and closed cohort Annual follow-ups, both open and closed cohort


Start of the first OLIN paediatric study (Start of the first OLIN paediatric study (OLIN VIIOLIN VII))

Combines clinical and environmental epidemiologyCombines clinical and environmental epidemiologywith molecular epidemiologywith molecular epidemiology

Prospective study of all children in primary school classas 1 and 2 in Luleå, Piteå and Prospective study of all children in primary school classas 1 and 2 in Luleå, Piteå and Kiruna, n=3525Kiruna, n=3525

Annual follow-ups, both open and closed cohort Annual follow-ups, both open and closed cohort

Collaboration with UVa, Charlottesville, USA, i.e.Collaboration with UVa, Charlottesville, USA, i.e.Thomas Platts-Mills and his staffThomas Platts-Mills and his staff

Matthew Perzanowski, USAin sub-urban Kiruna, now associate professor at University of Columbia, New York City, leaving for work by skiing when finalizing his PhD thesisin Sweden in 2003 titled: “Molecular epidemiology ofallergen exposure, sensitizationand asthma in school children -Obstructive Lung Disease in Northern Sweden - Thesis V”ISBN 91-7305-376-7

University of Umeå, Swedenwith affiliation toThe OLIN Studies, Luleå,Karolinska Institutet, Stockholm, and particularly University of Virginia, Charlottesville, USA

The OLIN Studies of adults 2002-2004The OLIN Studies of adults 2002-2004

Clinical follow-ups including lung function of all previously clinically examined Clinical follow-ups including lung function of all previously clinically examined adult cohorts adult cohorts Aims: Aims: incidence and determinants of COPD incidence and determinants of COPD

rapid decline in lung function rapid decline in lung function ETS and COPD ETS and COPD interaction of risks of COPD interaction of risks of COPD overlap syndrome (OSAS and COPD)overlap syndrome (OSAS and COPD)health economic studies of asthma and COPD health economic studies of asthma and COPD long term long term

outcome of asthma outcome of asthma

The OLIN Studies of adults 2002-2004The OLIN Studies of adults 2002-2004

Clinical follow-ups including lung function of all previously clinically examined adult Clinical follow-ups including lung function of all previously clinically examined adult cohorts cohorts Aims: Aims: incidence and determinants of COPD incidence and determinants of COPD

rapid decline in lung function rapid decline in lung function ETS and COPD ETS and COPD interaction of risks of COPD interaction of risks of COPD overlap syndrome (OSAS and COPD)overlap syndrome (OSAS and COPD)health economic studies of asthma and COPD lhealth economic studies of asthma and COPD l ong term outcome of asthma ong term outcome of asthma

The OLIN Studies 2005The OLIN Studies 2005Start of the prospective OLIN COPD Study Start of the prospective OLIN COPD Study

The OLIN 2006 surveysThe OLIN 2006 surveys

Has the prevalence and incidence of asthma and symptoms increased over the past 10 Has the prevalence and incidence of asthma and symptoms increased over the past 10 or 20 years?or 20 years?

-In adults? In adults? -The OLIN-FinEsS-cohort from 1996 re-investigated The OLIN-FinEsS-cohort from 1996 re-investigated - A new cohort of 8000 was recruited A new cohort of 8000 was recruited

-In children? In children? -The paediatric OLIN-cohort from 1996 re-investigated The paediatric OLIN-cohort from 1996 re-investigated - A new cohort with the same age distribution (7-8 y olds) from the same areas was recruited A new cohort with the same age distribution (7-8 y olds) from the same areas was recruited

Supporters during the first years Supporters during the first years


Amund Gulsvik Amund Gulsvik Professor of respiratory medicine, Univ of Bergen , Norway Professor of respiratory medicine, Univ of Bergen , Norway Per BakkePer Bakke MD, dept of respiratory medicine, Univ of Bergen , Norway MD, dept of respiratory medicine, Univ of Bergen , Norway

Tore ÖbergTore Öberg Head of the economy department at the province government Head of the economy department at the province government Ulf ÖhmanUlf Öhman Director of the province government Director of the province government

Per Malmberg Per Malmberg Professor & head of Medical Dept, NIOH, Stockholm Professor & head of Medical Dept, NIOH, Stockholm Göran Sundlöf Göran Sundlöf Associate prof & head of Department of Medicine, Central Associate prof & head of Department of Medicine, Central

Hospital of Norrbotten, BodenHospital of Norrbotten, Boden

Håkan ForsbergHåkan Forsberg MD, PhD, Dept of Medicine, Central Hosp of Norrbotten, Boden MD, PhD, Dept of Medicine, Central Hosp of Norrbotten, BodenStaffan Andersson Staffan Andersson MD, PhD, Dept of Clin Physiol , Central Hosp of Norrbotten, B-n MD, PhD, Dept of Clin Physiol , Central Hosp of Norrbotten, B-n

Kjell LarssonKjell Larsson Professor at Inst of Environmental Med, Karolinska InstitutetProfessor at Inst of Environmental Med, Karolinska InstitutetSven-Erik DahlénSven-Erik Dahlén Professor at Inst of Environmental Med, Karolinska InstitutetProfessor at Inst of Environmental Med, Karolinska Institutet

Jan Lötvall Jan Lötvall Professor, chair, Krefting Research Centre, Univ of Gothenburg Professor, chair, Krefting Research Centre, Univ of Gothenburg

The OLIN Studies: First published Swedish results of - Prevalence of adult asthma using methods including validation of results

- Incidence of asthma in adults - Remission of asthma in adults - Incidence of asthma in children - Incidence of allergic sensitisation in children

- Prevalence of COPD

- Prevalence of COPD using different international guidelines

- Incidence of COPD

- Long term (20 y) follow-up of COPD

- Population study based health economics of asthma and COPD

The OLIN Studies: First published Swedish results of - Prevalence of adult asthma using methods including validation of results

Lundbäck et al, ERJ 1991; Eur J Epidemiol 1992; Allergy 1993- Incidence of asthma in adults Rönmark et al, Allergy 1997; (Lundbäck et al, Respir Med 2001)- Remission of asthma in adults Rönmark et al, Thorax 1999- Incidence of asthma in children Rönmark et al, Pediatrics 2001; Perzanowski et al, AJRCCM 2002- Incidence of allergic sensitisation in children

Rönmark et al, JACI 2003- Prevalence of COPD

Lundbäck et al, Respir Med 2003- Prevalence of COPD using different international guidelines

Lindberg et al, Respiration 2005- Incidence of COPD

Lindberg et at, Chest 2005; Chest 2006-Long term follow-up (20 y) of COPD

Lundbäck et al, COPD 2009- Population study based health economics of asthma and COPD

Jansson et al, Chest 2002 (COPD); Respir Med 2007 (asthma)

Norrbotten

Umeå

Stockholm

Göteborg

Kiruna

LuleåPiteå

Norrbotten, Sweden

•Half of smokers develop COPD sooner or later.1

•1-2 smokers of 100 develop COPD every year; the corresponding proportion among never smokers is 1-2 of 1000.2

•One fourth of incident cases of COPD has a rapid decline in lung function.3

•Different phenotypes of COPD have different prognosis. 4

•The annual societal costs in Sweden of COPD amounts to about 10 billion SEK. 5

1 Lundbäck B, Respir Med 2003 2 Lindberg A, Chest 2007.3 Lindberg A, Chest 2005 4 Lundbäck B, COPD 2009. 5 Jansson S-A, Chest 2002

Norrbotten

Umeå

Stockholm

Göteborg

Kiruna

LuleåPiteå

Topics that require research collaboration with other centresinclude

U SA

AFRIC A

R USSIA

Norrbotten

Umeå

Stockholm

Göteborg

Kiruna

LuleåPiteå

Phenotypingof asthma and COPD

U SA

AFRIC A

R USSIA

Norrbotten

Umeå

Stockholm

Göteborg

Kiruna

LuleåPiteå


Genetics of COPD (and asthma)

U SA

AFRIC A

R USSIA

Norrbotten

Umeå

Stockholm

Göteborg

Kiruna

LuleåPiteå



Allergic sensitisation and inflammation

U SA

AFRIC A

R USSIA

Norrbotten

Umeå

Stockholm

Göteborg

Kiruna

LuleåPiteå

Studies requiring Studies requiring pooled data, examples:pooled data, examples:

cancer in allergy

smoking COPD

cancer



Allergic sensitisation and inflammation

Phenotyping of OADWest Sweden Asthma StudyUniversity of Gothenburg


Geneticis of OADJuha Kere´s network, Karolinska Institutet


Geneticis of OADJuha Kere´s network, Karolinska Institutet

Genetics of COPDDe Code,Reykjavik

Molecular epidemiologyin pediatric asthma and allergyAsthma and Allergy Research Centre,UVa, Charlottesville and School of Public Health,Columbia University, NY

USA

AFRICA

RUSSIA

Molecular epidemiologyin pediatric asthma and allergyAsthma and Allergy Research Centre,Uva, Charlottesville and School of Public Health,Columbia University, NY

USA

AFRICA

RUSSIA

Molecular epidemiologyin pediatric asthma and allergyUniversity of Otago,Wellington, New Zealand

3 4

5

6 7

8

1

2 3

4

5

6

7

8

1

2

Helsinki

Lapland

Stockholm

Örebro

Norrbotten

Tallinn

Narva

Saaremaa

1996: 8000 invited per center, 20 – 69 years old2006-2010: follow-up studies + studies of new cohorts in progress

Studies of pooled data mainly within the FinEsS Studies and the West Sweden Studies

Krefting Research Centre

In progress: West Sweden Asthma Study

planned:West SwedenCOPD Study

Jan LötvallBo LundbäckGöran WennergrenKjell Torén

Norrbotten

Umeå

Stockholm

Göteborg

Kiruna

LuleåPiteå

Research co-operation within large scale studies

- FinEsSFinEsS- ECRHS/RhineECRHS/Rhine- GA2LENGA2LEN

Supervision at (among others):

- - Hanoi Medical University, VietnamHanoi Medical University, Vietnam- Yogjakarta University, Indonesia- Yogjakarta University, Indonesia- University of Helsinki, Finland University of Helsinki, Finland - Estonian Inst for Health DevelopmentEstonian Inst for Health Development

Collaboration within research organisations, mainly

- European Respiratory Society (ERS)European Respiratory Society (ERS)- Eur Academy of Allergy & Clin Immunol (EAACI)Eur Academy of Allergy & Clin Immunol (EAACI)- Nordic Respiratory Academy (NORA)Nordic Respiratory Academy (NORA)

Nordic Scientific Advisory Board (status 2009)

Sweden

Gunnar Boman, Uppsala (since 1989)Bengt-Erik Skoogh, Gtbg (since 1991) Claes-Göran Löfdahl, Lund (since 1991) Christer Janson, Uppsala (since 1991) Kjell Larsson, Sthlm (since 1992)Sven Larsson, Gtbg (since 1996)Bengt Järvholm, Umeå (since 1996)

Sven-Erik Dahlén, SthlmBarbro Dahlén, SthlmKarl Franklin, UmeåKerstin Löfdahl, Gtbg Juha Kere, SthlmJan Lötvall, Gtbg Gunilla Hedlin, SthlmLeif Bjermer, LundKjell Torén, GtbgEllinor Ädelroth, Umeå

Norway

Jacob Boe, Oslo (1996) Amund Gulsvik, Bergen (1996)

Per Bakke, BergenErnst Omenaas, Bergen

Denmark Ronald Dahl, AarhusBirthe Hellkvist, Aarhus

Finland Anssi Sovijärvi, Helsinki

Iceland Eva Halapi, Reykjavik

The main contributors of the OLIN studies & network

The OLIN Study Group in Luleå, Univ. of Umeå , Gothenburg, Luleå & Karolinska Institutet, Stockholm,

Previous co-workers, all categories:Leif Rosenhall, Nils StjernbergElsy Jönsson, Lennarth Nyström Mai Lindström, Karin LundbäckAnne Lundkvist, Karin Östling, Eva Lundgren, Lena Gustafsson, Kerstin Björnström-Kemi, Aina JohnssonBerit Borggren, Karin Öhman (and many others) Current team of research assistants: Ann-Christine Jonsson, Sigrid SundbergOla Bernhof, Britt-Marie Eklund, Helena Backman PhD-fellows:Martin Andersson, Caroline Stridsman, Berne Eriksson, Katja Warm, Stig HagstadInvolved post docs: Sven-Arne Jansson, Ulf HedlundLinnea Hedman, Anders Bjerg, Lars-Gunnar Larsson Current external contributors, among others:Staffan Andersson , Thomas Sandström, Juha Kere, Kjell Larsson, Anders BlombergSteering committee:

Eva RönmarkAnne LindbergBo Lundbäck

Many thanks for fruitful co-work to

University of Virginia, Charlottesville, andUniversity of Columbia, New York, USAThomas Platts-Mills, Matthew Perzanowski, John Vaughan, Natalie Custis, Judith Woodfolk,David Riposo, Elisabeth Erwin CNR and Univ of, Pisa, Italy Carlo Giuntini, Giovanni Viegi, Laura Carrozzi,Univ of Bergen, NorwayAmund Gulsvik, Per Bakke, Univ of Helsinki, Finland & Tallinn, EstoniaAnssi Sovijärvi, Paula Pallasaho, Jyrki Kotaniemi, Ari Lindqvist, Annette Kainu, Maria JuuselaLii Jannus-Pruljan, Helle-Mai Loit, Mari MerenUniv of Hanoi, Vietnam & Yogjakarta, IndonesiaHoang Thi Lam & Firdy Perema

Funded mainly bySwedish Research Council, Heart-Lung FoundationVårdal, Northern Sweden University RegionSwedish Asthma and Allergy FoundationSwedish Cancer - Allergy FoundationNorrbotten´s local health authorityNIH & European Unions grants vid research net works Additional support mainly fromGSK, Phadia, ALK, AstraZeneca and Boehringer Ing


is a long timeis a long time

The OLIN Studies will go onThe OLIN Studies will go on

The OLIN Studies will go onThe OLIN Studies will go on

Thank you for listening !

the olin story

Documents

clinical studies

participatingthe olin

studies of heath economics

chronic bronchitis

prevalence study

community medicine

years position

obstructive form