the market for crispr/cas9 2016

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©2016 BioInformatics LLC www.gene2drug.com REPORT OVERVIEW Interactive Market Intelligence: The Market for CRISPR/Cas 9 Genome Editing Products MAY 2016 Report #16-008 New Updated Pricing Model Now starting at $3,500 Request a Live Demo or Purchase Today

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©2016 BioInformatics LLC www.gene2drug.com

REPORT OVERVIEW

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing ProductsMAY 2016

Report #16-008

New Updated Pricing Model Now starting at $3,500

Request a Live Demo or Purchase Today

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 2

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today

n TABLE OF CONTENTS

n STUDY SCOPE ..........................................................................................................................................................................3

n REPORT HIGHLIGHTS .......................................................................................................................................................4

n OVERVIEW .................................................................................................................................................................................6

n INTERACTIVE MARKET INTELLIGENCE .......................................................................................................... 8

n SELECTED DATA .................................................................................................................................................................10

n METHODOLOGY .................................................................................................................................................................. 12

n PRICING ...................................................................................................................................................................................... 13

n CURRENT 2016 REPORT TITLES ..........................................................................................................................16

n ABOUT BIOINFORMATICS LLC .............................................................................................................................. 17

Report #16-008

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 3

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today

STUDY SCOPE

n STUDY SCOPEThis Interactive Market Intelligence report will help you to compete in The Market for CRISPR/Cas9 Genome Editing Products:

n Estimate market size, share and growth by region, industry segment and product category

n Understand the drivers of brand loyalty and compare brand performance

n Measure customer satisfaction with CRISPR/Cas9 products

n Highlight the strengths and weaknesses of competitors and their customers’ likelihood-to-switch

n Compare to 2015 data to monitor trends and identify changes

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 4

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today

REPORT HIGHLIGHTS

n REPORT HIGHLIGHTSMarket Analytics

n Current and planned use of genome editing tools

n Length of time utilizing genome editing tools

n Importance of CRISPR/Cas9 in achieving experimental objectives

n Lab annual budget for CRISPR/Cas9 products and service

n Spending projections for next 12 months

n Number of CRISPR experiments per month

n Number of guide RNA’s designed per CRISPR target experiment

n Number of targets edited or controlled per experiment

n Expected growth in use of CRISPR

Brand Analytics

n●PrimarysupplierofCRISPR/Cas9products/services

n●OverallsatisfactionwithsuppliersofCRISPR/Cas9products/services

n●CurrentandfutureuseofCRISPR-relatedservices

Customer Analytics

n●Useofconsumables

n●OverallsatisfactionwithCRISPR/Cas9products/services

n●Likelihood-to-repurchaseCRISPR/Cas9products/servicesfromcurrentsupplier

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 5

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today

REPORT HIGHLIGHTS

n Report highlights (continued)

n●Likelihood-to-recommendcurrentsupplierofCRISPR/Cas9products/services

n●Likelihood-to-switchcurrentsupplierofCRISPR/Cas9products/services

n●Factorsinfluencingdecisiontoswitchsuppliers

n●Suppliertowhothecustomerwillswitch

Workflow Analytics

n●Primaryresearchobjectives

n●CRISPR/Cas9experimentaldesign

n●Modelsystemsused

n●DesigntoolsusedtogenerateguideRNAs

n●Satisfactionwithdesigntoolsused

n●FormatsusedwhengeneratingCas9proteinsandguideRNAs

n●Sourcesofvectors

n●DeliverymethodsforCAS9proteinandguideRNAformats

n●Cas9proteinorCas9variantscurrentlyusedandplantouse

n●Useoflibrary-basedapproachfordeliveringmultipleguideRNAs

n●SourcesofguideRNAlibraries

n●GuideRNAlibraryformats

n●UseofDNAforhomologousrecombination

n●TechniquesusedtoassurespecificityofCRISPR/Cas9genomeediting

n●FutureproductneedsforCRISPR/Cas9experiments

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 6

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today

OVERVIEW

n OVERVIEWSince BioInformatics LLC last published on the CRISPR/Cas9 genome-editing system,

thescientificcommunityhaswitnessedatorrentofnewpublicationswhileinstitutions,

both private and public alike, have poured over a billion dollars into R&D for the emerging

technique.Theirinvestmentwaswellfounded.In2015,CRISPR/Cas9wasseenasthekey

tounlockingtheelusivegenome,apredicationthat2016hasbeguntoseefulfilled.With

CRISPR/Cas9, researchers have found at their disposal a novel nuclease directing system

where the ease of use, rate of performance, and versatility are unparalleled by alternative

techniques.CRISPR/Cas9hasnotonlyrevitalizedgenomeengineering,ithasrevolutionized

thefield.

Since its advent, the CRISPR/Cas9 system has seen exponential increase in applications,

each of which constituted novel market trends. Some recent developments include:

n Introduction of synthetic crRNA and tracrRNA that bypass the endogenous steps needed to createsgRNA,effectivelyeliminatingtheneedforadditionalcloningandpurificationsteps.

n Cataloging of sgRNAs into libraries that can be screened for novelties, such as the up-regulation of oncogenes in cancer cells.

nModifiedCas9endonucleasesthatnickDNAtocreatesingle-strandedbreaksratherthanfull,double-strandedcleavage.Thismethodpromoteshomology-directedrepair(HDR),limitsoff-targeteffects,andincreasesthenumberofsequencesthatcanbeusedforsite-dependentgenemodifications.

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 7

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today n Overview (continued)

nIdentificationandanalysisofproteinbindingdomainstodirectdrugdevelopment.

nDirectingofchromosomalrecombinationforhigh-fidelitymappingoftraitsofinterest,which have in turn lead to the discovery of novel genes.

n Generation of ribonucleoprotein complexes from Cas9 and gDNA. These non-viral nucleasescleaveDNAimmediatelyuponinvasion,degradequicklyandskipnative,time-consuming Cas9 activation pathways.

n Combination of CRISPR/Cas9 with lambda red for recombineering. This allows for the knockout of disparate gene combinations, such as those pivotal in metabolic pathways.

The sheer volume of applications is staggering and, as with any breakthrough,

corporate giants have reoriented their priorities while emerging biotechs have sprung

up around the world, all in hopes to claim market share. In this rapidly evolving

environment, companies are faced with the challenge of leveraging their current

strengthstobreakintoafieldthatisflushwithnewcompetition.Inthesamewaythat

CRISPR/Cas9affordedscientiststheopportunitytoexpandtheirreach,sotodoes

our2016MarketforCRISPR/Cas9Reportequipsupplierswiththetoolstheyneedto

capitalize on this emergent technology.

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 8

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today

n INTERACTIVE MARKET INTELLIGENCEThe Market for CRISPR/Cas9 Genome Editing Products utilizes our ground

breaking Interactive Market Intelligence solution that is changing the way market

research is reported and used. Traditional market research reports delivered in print

or PDF depict data in standard charts and graphs. In contrast, Interactive Market

Intelligence incorporates dynamic data visualization that adds a new dimension to

marketanalytics.Fromcorporateboardroomstorepsinthefield,Interactive Market

Intelligence delivers market data through visually engaging and customizable

dashboards.Customizedviewofthedatacanbeeasilyexportedintooffline

presentations as needed.

INTERACTIVE MARKET INTELLIGENCE

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 9

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today n INTERACTIVE MARKET INTELLIGENCE (continued)

Interactive Market Intelligence is a web-based market research delivery platform

that provides data reporting superior to PDF reports, PowerPoint and other business

intelligence tools. Unlike a PowerPoint presentation which is linear and static, one of

the core features of Interactive Market Intelligence istheabilityofuserstofilter

and create literally hundreds of views of data—all easily obtainable from a small set

of core “key metrics” slides that include Market, Brand and Customer analytics in

well-definedsegmentsofthelifesciencemarket.

With your purchase of this report, we invite you to set up a meeting with our report

teamofscientificandbusinessanalysts.Wecanansweranyquestionsyoumay

have about the study results and we can share with you what we believe to be the

significanttrendsaffectingyourmarket.

INTERACTIVE MARKET INTELLIGENCE

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 10

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today

SELECTED DATA

MARKET ANALYTICS SNAPSHOT: INCIDENCE OF LABS USING CRISPR/Cas9

n SELECTED DATA

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 11

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today

SELECTED DATA

BRAND ANALYTICS: BRAND REPUTATION COMPARISON

n SELECTED DATA

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 12

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today

METHODOLOGY

n METHODOLOGYThis Interactive Market Intelligence report will be based on the responses of approximately

300 current end-users of CRISPR/Cas9 technology and several hundred users of competing

techniquesandplannedadopters.Theresultsarepresentedonlineusingourinnovative

Interactive Market Intelligence online dashboard and refreshed with biannual updates.

Request a Live Demo or Purchase Today

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 13

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today

PRICING

n PRICINGWhy Buy Our ReportsSource of Independent, Unbiased Research

Unlikereportsfromotherfirmsthatarebasedonanalyst’ssubjectivesummaryof

information from publicly available sources, our reports are based on the results of

detailedsurveysofhundreds—eventhousands—ofscientificandmedicalprofessionals

who buy your products.

Developed by a Team of Experts

Ourquestionnairesaredevelopedbyamultidisciplinaryteamofscientists,industry

veterans and market research experts with years of experience. These professionals

understandthatsurveyquestionsneedtobeaskedinawaythatensurestheanswers

will directly address the business challenges you face. Once the survey data is collected,

thissameteamcreatesauniquereportthepresentsthereaderwithathorough

understandingofthetopic,andthescientificandbusinessimplicationsoftheresults

based on sophisticated statistical analytics.

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 14

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today Carefully Selected Survey Participants

When others promote results from their online surveys, they fail to mention the

uncontrolled nature of their broadcast email invitations. To provide you with the most

valid and accurate results possible, the respondents to our surveys are members of

ouruniqueonlinepanel—TheScienceAdvisoryBoard®—which consists of thousands

verifiedlifescienceandbiomedicalprofessionalswhohaveagreedtotakepartinour

surveys, focus groups and other market research activities. These respondents are

carefullyselectedbasedontheirprofessionalqualifications,marketsegmentsand

geographic regions. We can even select them based on the products they use and

their preferred suppliers.

Complimentary Consulting Provided

Withyourpurchase,weofferonefreehourofconsultationwithourtalentedteam

ofscientificandbusinessanalystswhocreatedthereports.Duringthisconsultation,

wecanansweranyquestionsyoumayhaveaboutthesurveyresultsandwhatwe

believetobethesignificanttrendsaffectingthemarket.

PRICING

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 15

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today Custom Analysis & Research Available

If you’d like to delve deeper into the data from a study, we can always perform

custom cross-tabulations or other analysis on your behalf. We can even pose follow-

upquestionstorespondentswhoansweredinaparticularwayorconductacustom

study to extend your knowledge.

Takeadvantageoftheuniquecapabilitiesofthis Interactive Market Intelligence

analytics model from BioInformatics LLC accessible from anywhere at anytime on

your laptop or tablet.

All licenses are active for a 12-Month term.

Single User Log-In: $3,500

Up to 5 User Log-Ins: $5,500

Company-Wide License (for up to 25 User Log-Ins): $7,500

Includes access to the 2015 report to monitor trends and changes in the market.

With your purchase of this report, we also invite you to set up a meeting with our

reportteamofscientificandbusinessanalysts.Wecanansweranyquestionsyou

may have about the survey results, and we can also share what we believe to be the

significanttrendsaffectingyourmarket.

PRICING

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 16

Interactive Market Intelligence: The Market for CRISPR/Cas9 Genome Editing Products

Request a Live Demo or Purchase Today

n CURRENT 2016 REPORT TITLES:

Digital Marketing to Life Scientists: Building Digital Loyalty Now Available

The Market for Real-Time PCR Now Available

The Market for Cell-Based Assays Now Available

The Market for CRISPR/Cas9 Genome Editing Products Now Available

CLICK HERE FOR A COMPLETE LIST OF OUR REPORTS

@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005©2016 BioInformatics LLC www.gene2drug.com 17

n ABOUT BIOINFORMATICS LLC

BioInformatics LLC, along with our SDi division, is the premier research and advisory

firmservingthelifescienceandanalyticalinstrumentindustry.Since1994,wehave

beenprovidingoff-the-shelfreports,custom-designedstudiesandmarketanalysisthat

enable companies to understand their market and competitors through the eyes of the

most important information source of all — the people who buy their products.

By leveraging our online professional network of tens of thousands of biomedical

researchers, we have supported more than 500 companies and provided insights

that lead to better business decisions. Our expertise includes assessing the size and

attractivenessofmarkets,optimizingproductconfigurationsandpricing,validating

corporateacquisitions,measuringcustomers’brandloyalty,andevaluatingbrand

strength and positioning.

FormoreinformationaboutBioInformatics’productandserviceofferings,

please visit our website at www.gene2drug.com, call 703.778.3080 x15,

or email [email protected]

CLICK HERE FOR A COMPLETE LIST OF OUR REPORTS

Request a Live Demo or Purchase Today