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1 The GIANT Alliance Grenoble Innovation for Advanced New Technologies comment les grenoblois préparent le futur ANSTO, 8 April 2013 W.G. Stirling, CEA Commissariat à l’énergie atomique et aux énergies alternatives

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1

The GIANT Alliance Grenoble Innovation for Advanced New Technologies

comment les grenoblois préparent le futur

ANSTO, 8 April 2013

W.G. Stirling, CEA

Commissariat à l’énergie atomique et aux énergies alternatives

2

Members and partners of GIANT, objectives, key numbers

Centres of excellence

GIANT projects

GIANT international benchmarking

Campus building projects and urban development

Outline

3

aifsabroad.com

z720.net

Where is Grenoble?

4

The city benefits from the highest concentration of strategic

jobs in France after Paris, with 14% of the employments,

35,186 jobs, 45% of which specialized in design and

research.

Grenoble is also the largest research center in France after

Paris with 22,800 jobs (11,800 in public research, 7,500 in

private research and 3,500 PhD students)

Grenoble : Wikipedia 2011

5

A little history: Grenoble has been

transformed by science and technology 1967 ILL

European High Flux Reactor

1988 ESRF

European Synchrotron

Radiation Facility

2005 MINATEC

Micro and Nano-electronics

2009 GIANT

Innovation Partnership

1956 CEA (CENG)

1962 CNRS

and l’Université Joseph Fourier, Grenoble Institut Polytechnique,

Grenoble Ecole de Management …

6

The GIANT Campus

GIANT: the vision of Jean Therme,

Director CEA Grenoble

7

Academic Members

Grenoble Ecole de Management (GEM)

Institut Polytechnique de Grenoble (G-INP)

Université Joseph Fourier (UJF)

National Research Organizations

Centre national de la recherche scientifique (CNRS)

Commissariat à l’énergie atomique et aux énergies

alternatives (CEA)

European Large-scale Research Facilities

European Molecular Biology Laboratory (EMBL)

European Synchrotron Radiation Facility (ESRF)

Institut Laue Langevin (ILL)

Underpinned by local/regional/national/international authorities

GIANT: Founding Members

8

GIANT members are involved in a large number of partnerships

with industry, e.g.

Development with Sanofi-Aventis of diabetes therapies (CNRS,

G-INP, UJF)

R&D with Renault to develop electric vehicles (CEA)

Toyota programme on catalytic convertors (ESRF)

bioMérieux worldwide research centre on GIANT campus

Industrial partners

EADS

STMicroelectronics

Schneider Electric

Alcatel-Lucent

PSA

Siemens

GIANT: Industrial Partners

Texas Instruments

IBM

bioMérieux

Sanofi-Aventis

Astra Zeneca,

GlaxoSmithKline

….

9

The GIANT members are working together with a

common set of objectives:

to respond to major societal challenges;

information, energy and health

to remove barriers to create centres of excellence

to achieve a major urban transformation by

harmonizing urban and scientific development

GIANT: Objectives

10

Jean Therme Jérôme Vitré Stephen Cusack Francesco Sette Thierry Grange Brigitte Plateau Patrick Lévy Andrew Harrison

GIANT: Organization

Presidents, directors …

CEA J Therme CNRS J Vitre

EMBL S Cusack ESRF F Sette

GEM T Grange G-INP B Plateau

ILL A Harrison UJF P Levy

11

6 000 researchers

5 000 industrial jobs

5 000 students

300 inhabitants

GIANT tomorrow GIANT today 10 000 researchers

10 000 industrial jobs

10 000 students

10 000 inhabitants

100 000 visitors annually

5 000 publications annually

500 patents filed annually

4 billion € annual economic impact

1€ = 1.23 AUD = 1.28 $ US

GIANT: Key numbers

12

MINATEC

Information

NanoBio

Biology / biotech

GreEn

Energy

EPN Science Campus

Large European

scientific infrastructures

Technology

management

Basic research:

Physics, cryogenics, instrumentation …

Three technological centres: MINATEC, GreEn, NanoBio

Three transverse centres: EPN Science Campus (EMBL, ESRF, ILL)

Basic research (CNRS, CEA, G-INP, UJF …)

Technology management (GEM)

GIANT: Removing barriers to create

centres of excellence

13

Centres of excellence

14

Micro and nanoscience, and technology

Research and development, prototyping/demonstrators,

higher education (PHELMA), industrial partnerships …

GIANT: Centres of excellence

MINATEC: the model

15

Nanotec 300

Photos: P. Guillaume

MEMS 200

Industrial partnerships; proof of concept → prototyping → pre-production;

24/7 operation

Research: Platforms

16

Photos: P. Guillaume

Energy storage

Battery

Platform

Fuel Cell

Platform

Production of

renewable energy

PV, biomass,

wind, hydro-

Energy management / network

management / energy efficiency

GIANT: Centres of excellence

GreEn-ER

17

Photos: P. Guillaume

GIANT: Centres of excellence

GreEn-ER

University, research (G-INP, UJF, CNRS)

23000 m²; 77 M€ project

Building delivered: summer 2015

18

NanoBio1 and 2

• Micro- and nano-technologies

• Centre for applications in

biology and health

• Proteomics

Clinatec

• Micro- and nano-technologies for medicine

GIANT: Centres of excellence

NanoBio, biotechnologies and health

Structural biology at the European level

• Partnership for Structural Biology (PSB)

• Institut de Biologie Structurale, EMBL, ESRF, ILL

19

Three European

Research Infrastructures

are based in Grenoble:

EMBL, ESRF, ILL

EPN Science Campus set

up in 2010

EPN Science Campus

20

EPN Science Campus

Institut Laue-Langevin (ILL)

operates the most intense (reactor)

neutron source in the world, feeding

a suite of 40 high-performance

instruments

European Synchrotron Radiation

Facility (ESRF) is a world-leading

synchrotron radiation source hosting

41 cutting-edge experimental

stations

EMBL Grenoble is an outstation of

the EMBL organisation (HQ in

Heidelberg), specialising in research

in structural biology (in very close

proximity to the ILL and the ESRF)

21

GIANT: Regrouping - the 6 centres

Technology

management Basic

research

22

Industry

Industry

GIANT: Industry

Industry

Industry

23

Housing Housing and shops

GIANT: Future housing and shops

24

GIANT projects

25

The Technology Platform – Grenoble (TPG)

ILL, ESRF, CEA, CNRS - close together on GIANT campus

Unique portfolio of equipment and facilities for non-

destructive characterisation and analysis of materials

and processes, for

Industrial development of advanced materials

Techniques far beyond what is possible in industrial

laboratories - major opportunity for industry → competitive

advance in R&D programmes

GIANT: Cooperative projects between the

partners - science and technology; TPG

26

Objectives:

To analyse the needs of industrial users in order to

identify the best characterisation techniques made

available by the partners

To make available advanced sample preparation and

selection methods so as to optimise the use of

instrument beamtime at the large facilities

To help the industrial users in their data treatment and

interpretation

To provide expertise on each problem and on possible

solutions

In preparation phase

GIANT: Cooperative projects between the

partners - science and technology; TPG

27

des capteurs et dispositifs embarqués

17/01/2012 27

Complementarity:

optical, neutron, X-ray radiography

Optical image X-rays Neutrons

Circuit board with chips, memories, connections… …

GIANT: Cooperative projects between the

partners - science and technology; TPG

28

GIANT: Cooperative projects between the

partners - science and technology; ERC

Actions to help candidates for European Research Council

awards (recognised as very prestigious award / important

indicator)

Three types of award ERC Starting: young researcher 1.5 M€ / 5 years

ERC Consolidator: experienced researcher 2.0 M€ / 5 years

ERC Advanced: senior researcher 2.5 M€ / 5 years

And also o ERC Synergy: team of 2 to 4 researchers 15 M€ / 6 years

o ERC Proof of concept (ERC grant-holders) 150 k€ / 1 year

marketable innovation/TT

GIANT support / advice and training days

GIANT-level consideration of candidates and projects for

ERC support

29

0

2

4

6

8

10

12

14

16

18

2007 2008 2009 2010 2011 2012

M€

8.73

ERC Income (5 year grant) by year

Total 2007 – 2012 = 40.92 M€

17.86

8.01

4.22

2.1

0

Starting Grant

Advanced Grant

Proof of Concept

GIANT: Cooperative projects between the

partners - science and technology; ERC

http://erc.europa.eu/

30

ERC grant-holders 2008 - 2012

GIANT: Cooperative projects between the

partners - science and technology; ERC

31

ERC Starting Grants (totals)

GIANT: Cooperative projects between the

partners - science and technology; ERC

http://erc.europa.eu/

32

GIANT: Cooperative projects between the

partners - finance

CPER (Contrats de Projets Etat-Régions): 2007 - 2013 Local authority funding for education / research infrastructure

All GIANT partners

~ 110 M€

CAMPUS (Opération Campus): 2008 – 2018 Renovation of university infrastructure

Grenoble Université de l’innovation

G-INP, UJF, … , CEA

~ 180 M€

Investissement de l’avenir: 2010 - 2020 French state investment – preparing the future

IRT (Institut de Recherche Technologique): most GIANT

partners (IRT Nanoélectronique) – Grenoble no. 1

Labex, Equipex: GIANT partners – variable geometry

~ 300 M€

33

GIANT international benchmarking

NASA

34

GIANT: International benchmarking Objectives Major international trends (innovation campuses, R&D, …)

The position of GIANT on the international scene

Impacts of the economic crisis on R&D

Countries visited Germany, Brazil, Canada, China, Finland, France, India, Indonesia,

Israel, Japan, Mexico, Poland, Russia, Singapore, South Korea,

Switzerland, Taiwan, USA, UK (several sites/cities per country)

Organisations visited Local and central government, research support/finance organisations,

universities, private companies

Team Marcel Morabito, senior adviser CEA (Prof at Sciences Po, Paris; former Rector of the

Academy of Grenoble)

WGS

35

GIANT: Benchmarking - convergence

Strategic choices – convergence

Balance between fundamental and applied research

Global concept of innovation focused on major societal challenges:

Information/communication technologies

Health/biotechnologies

Renewable and clean energies

Growth of green technologies

Will to strengthen the links between

knowledge actors

Growth of importance of local interactions

Support to PMEs

UniversityResearchInstitute

Industry

Government

Strengthening linkage between Universities and Research Institutes

36

GIANT: international positioning

GIANT - in line with major projects/campuses whose objectives

are to:

Harmonize scientific and urban development – with science

at the heart of the city

Develop an architectural model favouring the integration of

the different stakeholders

Strengthen innovation by bringing together the different

knowledge actors – higher education, research, industry,

political authorities

Strengthen the links between fundamental and applied

research

Focus on issues of major societal interest and impact

37

GIANT: international positioning

GIANT

Compact site – rapid and easy communications

Involvement of Universities (including GEM), fundamental

research, applied research, industry

Mixture of national and international institutes/laboratories

Cosmopolitan, multi-national personnel and atmosphere

Students exposed to first class research

Strong involvement and support of local political authorities

38

Campus building projects

39

Joining town centre and GIANT campus

48 M€ project

Tramline in service: winter 2013

Transport infrastructure:

Extension of tram line B

40

Transport infrastructure:

Extension of tram line B

Joining the GIANT campus to city centre to University campus

41

Micro- and nano-technologies for medicine: diagnosis

and therapy (CEA, CHU)

Advanced operating theatre

20 M€ project: 3300 m²

Building delivered: December 2011

Life sciences/health research:

CLINATEC

42

New building for life sciences institute (CEA, CNRS, UJF)

On ILL/EMBL/ESRF campus (EPN Science Campus)

9300 m²; 21 M€ project

Building delivered: autumn 2013

Life sciences/health research:

Institut de Biologie Structurale (IBS2)

43

Life sciences/health research:

Institut de Biologie Structurale (IBS2)

44

Higher education, research:

PHELMA MINATEC 2

Technology transfer centre, lecture rooms, student space

9000 m²; 25 M€ project

Amphitheatre, 500-seat; 2000 m²

Buildings delivered: spring 2015

45

Fundamental and applied research:

ILL /ESRF Science Building

Joint scientific and technological projects

Library, theory, industrial relations, soft matter

partnership …

5000 m²; 12 M€ project

Building delivered: autumn 2013

46

Extensions to ESRF experimental hall → longer

beamlines → finer detail (nm)

13000 m²; 32 M€ project

Buildings delivered: May 2013

Fundamental and applied research:

ESRF Upgrade Programme, EX2

47

Science

48

Synchrotron X-ray imaging:

Australopithecus sediba

Australopithecus sediba (~ 2 Ma) : discovered in Malapa cave (40 km

from Johannesburg) in 2008 by Matthew, the son of Prof Lee Berger

(University of Witwatersrand)

Skull, teeth, part of lower jaw, humerus, parts of spinal column, pelvis …

Two AS specimens (reconstructed) with Lucy (Australopithecus

afarensis; 3.2 Ma), centre

Wikipedia

49

Synchrotron X-ray imaging:

Australopithecus sediba

Prof. Berger: “ the many advanced

features found in the brain and

body make it possibly the best

candidate ancestor for our genus,

the genus Homo, more so than

previous discoveries such as Homo

habilis”.

X-ray microtomography at ESRF

Highest resolution X-ray scans of

cranium of early human ancestor

Resolution of ~ 45 μm (human hair

diameter ~17 - 180 μm)

Reconstructed endocast (cranium

volume) is small, 420 cm3,

compared to human (~ 1350 cm3 )

or chimpanzee ( ~ 400 cm3 )

ID19 beamline, ESRF

50

Synchrotron X-ray imaging:

Australopithecus sediba

Left: cranium from (ID17) microtomography images

Right: endocast with surrounding matrix and cranium rendered

transparent; non-destructive, surface detail visible

References: Val et al , S Afr J Sci 107, 11/12 (2011); Carlson et al, Science 333

1402 (2011); and references therein

51

Synchrotron X-ray imaging:

Australopithecus sediba

Upper: scaled endocasts: human, Au.

sediba, Au. africanus (2.4 – 3.5 Ma),

chimpanzee; from below

Front brain structure (orbitofrontal

organisation) of Au. sediba more like

human than Au. africanus

Lower: as above; side view

Similarities between the

australopithecines and chimpanzees

Overall shape of brain resembles

humans more than chimpanzees

Brain structure suggests beginning of

major changes leading to human brain

(e.g. prefrontal cortex, considered

important in reasoning, planning … in

humans)

52

Urban development

53

Open Innovation Centre, hotel, restaurants, leisure facilities

Landscaping of river banks, parks, sports

Green mobility, tramway, bicycle tracks

Family and student housing, shops

A green neighbourhood within the city, offering excellent

living conditions and architectural coherence

GIANT: harmonizing urban and scientific

development - a vibrant community environment

54

Open Innovation Centre:

An interface between city and campus

Definition phase of project

Building delivered 2016 – 2017

55

S S

S

S

- with a common card

GIANT: integrated evironmentally friendly mobility

56

GIANT: Investing in the future

Learning, exploring, creating, living

Building a campus of excellence, comparable to ambitious

initiatives around the world

Attracting world-class researchers, engineers, innovators

Bringing together higher education, R&D, advanced industry

57

I would like to acknowledge the support of the

GIANT network partners who provided not only

information, but also illustrations and photos.

58 16/04/2013 Réunion xxx 58

Grenoble Innovation for

Advanced New Technologies

Thank you for your attention

and thanks to all the GIANT team

http://www.giant-grenoble.org/

W.G. Stirling, CEA Grenoble