The (ab)use of symptom scores in asthma clinical trials: a systematic review Geoff Frampton & Jonathan Shepherd Southampton Health Technology Assessments.

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  • The (ab)use of symptom scores in asthma clinical trials: a systematic review

    Geoff Frampton & Jonathan ShepherdSouthampton Health Technology Assessments Centre

  • BackgroundSouthampton Health Technology Assessments CentreSymptom scores in asthma clinical research

  • Scope of this presentation

  • BackgroundSouthampton Health Technology Assessments CentreIdeal features of patient-reported outcomes

  • Southampton Health Technology Assessments CentreTo determine by systematic review:Objective

  • Methods Southampton Health Technology Assessments Centre

  • Southampton Health Technology Assessments CentreResults87 randomized controlled trials (RCTs) published in 32 English language journals, 1985 to 2006

  • Southampton Health Technology Assessments CentreResults symptom assessments

  • Southampton Health Technology Assessments CentreResults symptom assessments

  • Southampton Health Technology Assessments CentreResults symptom assessments

  • -6210134Symptom scoreSouthampton Health Technology Assessments CentreResults circadian patterns

  • 134Southampton Health Technology Assessments CentreResults analysis methods

  • DiscussionSouthampton Health Technology Assessments Centre

  • The views and opinions expressed in this presentation are those of the authors and do not necessarily reflect those of the UK Department of Health

    Southampton Health Technology Assessments CentreIn conclusion, asthma clinical trials should2. Provide guidance on clinical interpretation1. Share the use of fewer, tested, symptom score instruments4. Explain the statistical testing rationale and any assumptions3. Precisely report the timing of symptom assessments